Email Address:
larsdreier@ucla.edu
Lab Number:
(310) 206-1701
Office Phone Number:
(310) 206-1701
Laboratory Address:
Gonda Center, Room 3309
Mailing Address:
David Geffen School of Medicine at UCLA
Department of Neurobiology
695 Charles E. Young Dr. South
Gonda Center, Room 3309
Los Angeles, CA 90095
Office Address:
Gonda 3506C
Affiliations |
Assistant Professor, Neurobiology |
Member, Brain Research Institute, Cell & Developmental Biology GPB Home Area |
Recent evidence indicates that regulated degradation of synaptic proteins is an important mechanism to control synapse formation and function. Ubiquitin-dependent degradation is a major pathway for regulated protein degradation. In this pathway, ubiquitin ligases conjugate the small protein ubiquitin to target proteins destined for degradation. We are currently characterizing the function of ubiquitin ligase mutants that affect synapse structure and synaptic transmission at various synapses. The activity of ubiquitin ligases is antagonized by deubiquitinating enzymes that remove ubiquitin from target proteins (in a similar way, protein kinases and phosphatases antagonize each other). Deubiquitinating enzymes are probably as important as ubiquitin ligases in regulating protein degradation, but very few have been characterized to date. The C. elegans genome encodes about 300 ubiquitin ligases and 50 deubiquitinating enzymes. In RNAi based screens, we are now identifying deubiquitinating enzymes that affect synaptic transmission and synapse structure.
Dr. Lars Dreier joined the Department of Neurobiology as an Assistant Professor in 2006. Lars did his Ph.D. work in the Department of Cell Biology, Harvard Medical School, Boston, in the lab of Tom Rapoport, reconstituting the transport of secretory proteins through the Endoplasmic Reticulum (ER) membrane and characterizing the formation of the ER in vitro. In 2000, he joined the lab of Josh Kaplan at the University of California, Berkeley, where he started to work on ubiquitin-dependent regulation of glutamate receptors in C. elegans. Lars moved with the Kaplan lab back to Boston in 2002.