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Saman Sadeghi, Ph.D.

Work Address:
780 Westwood Plaza
Los Angeles, CA 90095

Affiliations
Affiliations
Associate Professor In-Residence, Molecular & Medical Pharmacology
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, Crump Institute for Molecular Imaging, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Research Interests
Dr. Sadeghi's research team is working to improve synthesis methods and develop new PET tracers to support emerging research projects. Current projects include: Development of more efficient synthetic pathways to label radiopharmaceutical molecules for cancer diagnostics; Miniaturized on chip analytical techniques for separation and identification of solvents and impurities associated with synthesis of common PET probes; Developing electrochemical regioselective synthesis techniques and platforms for direct nucleophilic [18F] fluorination; Electrochemically assisted solvent exchange and automated flow-through synthesizers.
Biography

Dr. Sadeghi is the Director of the Ahmanson Biomedical Cyclotron Facility (BMC). BMC produces a wide variety of PET biomarkers for clinical and research PET scans with more than 2,000 PET probe productions per year.

Publications

A selected list of publications:

Waldmann Christopher M, Gomez Adrian, Marchis Phillip, Bailey Sean T, Momcilovic Milica, Jones Anthony E, Shackelford David B, Sadeghi Saman   An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[(18)F]Fluorobenzyl-Triphenylphosphonium ([(18)F]FBnTP) Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2017; .
Balandeh Mehrdad, Waldmann Christopher, Shirazi Daniela, Gomez Adrian, Rios Alejandra, Allison Nathanael, Khan Asad, Sadeghi Saman   Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF) Journal of the Electrochemical Society, 2017; 164(9): G99-G103.
Waldmann Christopher M, Lebedev Artem, Allison Nathaniel, Sadeghi Saman   An automated synthesizer for electrochemical (18)F-fluorination of organic compounds Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2017; 127: 245-252.
Lebedev Artem, Jiao Jing, Lee Jason, Yang Fan, Allison Nathanael, Herschman Harvey, Sadeghi Saman   Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor PloS one, 2017; 12(5): e0176606.
Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B   Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer Cell reports, 2017; 18(3): 601-610.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G   [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(15): 4027-32.
Banu Khaleda, Shimura Takayoshi, Sadeghi Saman   Selective detection and recovery of gold at tannin-immobilized non-conducting electrode Analytica chimica acta, 2015; 853: 207-13.
He Qinggang, Wang Ying, Alfeazi Ines, Sadeghi Saman   Electrochemical nucleophilic synthesis of di-tert-butyl-(4-[18F]fluoro-1,2-phenylene)-dicarbonate Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2014; 92: 52-7.
Mosessian Sherly, Duarte-Vogel Sandra M, Stout David B, Roos Kenneth P, Lawson Gregory W, Jordan Maria C, Ogden Amanda, Matter Cheryl, Sadeghi Saman, Mills George Q, Schelbert Heinrich R, Radu Caius G, Czernin Johannes, Couto Marcelo, Phelps Michael E   INDs for PET molecular imaging probes-approach by an academic institution Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2014; 16(4): 441-8.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G   Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication The Journal of experimental medicine, 2014; .
Cheung Shilin, Ly Jimmy, Lazari Mark, Sadeghi Saman, Keng Pei Yuin, van Dam R Michael   The separation and detection of PET tracers via capillary electrophoresis for chemical identity and purity analysis Journal of pharmaceutical and biomedical analysis, 2014; 94C: 12-18.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G   Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography Journal of medicinal chemistry, 2013; 56(17): 6696-708.
Michael Thompson, Larisa-Emilia Cheran, Saman Sadeghi   Sensor Technology in Neuroscience RSC Detection Science Series, 2013; .
Shah Gaurav J, Ding Huijiang, Sadeghi Saman, Chen Supin, Kim Chang-Jin Cj, van Dam R Michael   On-demand droplet loading for automated organic chemistry on digital microfluidics Lab on a chip, 2013; .
Sadeghi Saman, Liang Vincent, Cheung Shilin, Woo Suh, Wu Curtis, Ly Jimmy, Deng Yuliang, Eddings Mark, van Dam R Michael   Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers Applied radiation and isotopes, 2013; 75: 85-94.
Ding Huijiang, Sadeghi Saman, Shah Gaurav J, Chen Supin, Keng Pei Yuin, Kim Chang-Jin C J, van Dam R Michael   Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips Lab on a chip, 2012; 12(18): 3331-40.
Sadeghi, S; Thompson, M.   Electrochemistry, Emergent Patterns and Inorganic Intelligent Response Molecular and Supramolecular Information Processing, 2012; Katz, Evgeny (ed.): .
Sadeghi Saman, Ding Huijiang, Shah Gaurav J, Chen Supin, Keng Pei Yuin, Kim Chang-Jin Cj, van Dam R Michael   On chip droplet characterization: A practical, high-sensitivity measurement of droplet impedance in digital microfluidics Analytical chemistry, 2012; .
Keng Pei Yuin, Chen Supin, Ding Huijiang, Sadeghi Saman, Shah Gaurav J, Dooraghi Alex, Phelps Michael E, Satyamurthy Nagichettiar, Chatziioannou Arion F, Kim Chang-Jin Cj, van Dam R Michael   Micro-chemical synthesis of molecular probes on an electronic microfluidic device Proceedings of the National Academy of Sciences of the United States of America, 2011; .
Sadeghi Saman, Thompson Michael   Towards information processing from nonlinear physical chemistry: a synthetic electrochemical cognitive system Bio Systems, 2011; 102(2-3): 99-111.
Sadeghi, S., W. A. MacKay, R. M. van Dam, M. Thompson   Algorithm for real-time detection of signal patterns using phase synchrony: an application to an electrode array Measurement Science and Technology , 2011; 22: 025802.
Sadeghi Saman, Thompson Michael   Temporal patterns and oscillatory voltage perturbation during an electrochemical process Physical chemistry chemical physics : PCCP, 2010; 12(25): 6795-809.
Cheran, L. E., S. Johnstone, S. Sadeghi, M. Thompson   Work-function measurement by high-resolution scanning Kelvin nanoprobe Measurement Science and Technology, 2007; 18: 567.
Cheran Larisa-Emilia, Sadeghi Saman, Thompson Michael   Scanning Kelvin nanoprobe detection in materials science and biochemical analysis The Analyst, 2005; 130(12): 1569-76.
Thompson Michael, Cheran Larisa-Emilia, Zhang Mingquan, Chacko Melissa, Huo Hong, Sadeghi Saman   Label-free detection of nucleic acid and protein microarrays by scanning Kelvin nanoprobe Biosensors & bioelectronics, 2005; 20(8): 1471-81.
D Chen, S Sadeghi, S Mann   On the design of HI-based biofeedback interfaces, IEEE Systems, Man and Cybernetics, 2002; 7: .
D Chen, S Sadeghi, S Mann   HI-Cam: intelligent biofeedback signal processing, Proceedings. Fifth International Symposium on Wearable computers , 2001; 178-180.