Affiliations

Distinguished Professor, Microbiology, Immunology & Molecular Genetics

Sherie L. and Donald G. Morrison Chair, Molecular Immunology

The research in our laboratory is diverse and revolves around our interests in gene regulation, molecular immunology, stem cell biology, and oncogenesis/leukemogenesis. One major area of interest is the molecular mechanisms of pro-inflammatory gene regulation, with an emphasis on transcriptional cascades induced by inflammatory stimuli and the contributions of chromatin structure to the selective regulation of pro-inflammatory genes. A second interest is the selective functions of the five members of the NF-κB family of transcription factors. We also study the mechanisms by which Ikaros family proteins regulate lymphocyte development and leukemogenesis, and the mechanisms by which developmentally regulated genes acquire competence for transcriptional activation in embryonic stem cells and induced pluripotent stem cells.

Stephen T. Smale is a molecular immunologist and biochemist who arrived at UCLA in 1990 as an Assistant Professor in the Department of Microbiology and Immunology within the UCLA School of Medicine. In 1999, he was promoted to Professor and, in 2014, to Distinguished Professor, in the Department of Microbiology, Immunology, and Molecular Genetics, which spans the UCLA College of Letters and Science and the David Geffen School of Medicine. From 1990 to 2007, he was also a Howard Hughes Medical Institute Investigator. Dr. Smale graduated Magna Cum Laude from Cornell University, with Honors and Distinction in Chemistry. He received his Ph.D. in Biochemistry from the University of California, Berkeley under the mentorship of Dr. Robert Tjian. He then was a Helen Hay Whitney Foundation postdoctoral fellow with Nobelist Dr. David Baltimore at the Whitehead Institute, MIT. At UCLA, Dr. Smale previously served as Vice Chair of the Department of Microbiology, Immunology, and Molecular Genetics, Director of Basic and Translational Research for the UCLA Jonsson Comprehensive Cancer Center, Director of the Howard Hughes Medical Institute Science Education Program, Co-Director of the UCLA-Caltech Medical Scientist Training Program, founding Chair of the School of Medicine's Research Initiative in Immunity, Inflammation, infection, and Transplantation (I3T), and Vice Dean for Research in the David Geffen School of Medicine. The research in Dr. Smale's laboratory focuses on gene regulation during inflammatory and innate immune responses and during lymphocyte development and leukemogenesis.

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