A selected list of publications:
Xia Y, Ramgopal Y, Li H, Shang L, Srinivas P, Kickhoefer VA, Rome LH, Preiser PR, Boey F, Zhang H, Venkatraman SS
Immobilization of Recombinant Vault Nanoparticles on Solid Substrates
ACS Nano,
2010; 4(3):
1417-24.
Kong, L. B., Siva, A. C., Kickhoefer, V. A., Rome, L. H., Stewart, P. L.
RNA location and modeling of a WD40 repeat domain within the vault
,
2000; 6(6):
890-900.
Kar Upendra K, Jiang Janina, Champion Cheryl I, Salehi Sahar, Srivastava Minu, Sharma Sherven, Rabizadeh Shahrooz, Niazi Kayvan, Kickhoefer Valerie, Rome Leonard H, Kelly Kathleen A
Vault nanocapsules as adjuvants favor cell-mediated over
antibody-mediated immune responses following immunization of mice
PloS one,
2012; 7(7):
e38553.
Xia Yun, Ramgopal Yamini, Li Hai, Shang Lei, Srinivas Parisa, Kickhoefer Valerie A, Rome Leonard H, Preiser Peter R, Boey Freddy, Zhang Hua, Venkatraman Subbu S
Immobilization of recombinant vault nanoparticles on solid substrates
ACS nano,
2010; 4(3):
1417-24.
Kickhoefer, V. A., Han, M., Raval-Fernandes, S., Poderycki, M. J., Moniz, R. J., Vaccari, D., Silvestry, M., Stewart, P. L., Kelly, K. A., Rome, L. H.
Targeting vault nanoparticles to specific cell surface receptors
ACS Nano,
2009; 3(1):
27-36.
Champion Cheryl I, Kickhoefer Valerie A, Liu Guangchao, Moniz Raymond J, Freed Amanda S, Bergmann Liisa L, Vaccari Dana, Raval-Fernandes Sujna, Chan Ann M, Rome Leonard H, Kelly Kathleen A
A vault nanoparticle vaccine induces protective mucosal immunity
PloS one,
2009; 4(4):
e5409.
Kickhoefer Valerie A, Han Muri, Raval-Fernandes Sujna, Poderycki Michael J, Moniz Raymond J, Vaccari Dana, Silvestry Mariena, Stewart Phoebe L, Kelly Kathleen A, Rome Leonard H
Targeting vault nanoparticles to specific cell surface receptors
ACS nano,
2009; 3(1):
27-36.
Ng, B.C., Yu, M., Gopal, A., Rome, L.H., Monbouquette, H.G., Tolbert, S.H.
Encapsulation of semiconducting polymers in vault protein cages
Nano Letters,
2008; 8(10):
3503-9.
Yu, M., Ng, B.C., Rome, L.H., Tolbert, S.H., Monbouquette, H.G.
Reversible pH lability of cross-linked vault nanocapsules
Nano Letters,
2008; 8(10):
3510-5.
Esfandiary, R., Kickhoefer, V.A., Rome, L.H., Joshi, S.B., Middaugh, C.R.
Structural stability of vault particles
Journal of Pharmaceutical Sciences,
2008; 98(4):
1376-86.
Anderson, D.H., Kickhoefer, V.A., Sievers, S.A., Rome, L.H., Eisenberg, D.
Draft crystal structure of the vault shell at 9-A resolution
PLoS biology,
2007; 5(11):
e318.
Kaddis, C.S., Lomeli, S.H., Yin, S., Berhane, B., Apostol, M.I., Kickhoefer, V.A., Rome, L.H., Loo, J.A.
Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility
Journal of the American Society for Mass Spectrometry,
2007; 18(7):
1206-16.
Poderycki, M.J., Kickhoefer, V.A., Kaddis, C.S., Raval-Fernandes, S., Johansson, E., Zink, J.I., Loo, J.A., Rome, L.H.
The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior
Biochemistry,
2006; 45(39):
12184-93.
Slesina, M., Inman, E.M., Moore, A.E., Goldhaber, J.I., Rome, L.H., Volknandt, W.
Movement of vault particles visualized by GFP-tagged major vault protein
Cell and Tissue Research,
2006; 324(3):
403-10.
Kickhoefer, V.A., Garcia, Y., Mikyas, Y., Johansson, E., Zhou, J.C., Raval-Fernandes, S., Minoofar, P., Zink, J.I., Dunn, B., Stewart, P.L., Rome, L.H.
Engineering of vault nanocapsules with enzymatic and fluorescent properties
Proceedings of the National Academy of Sciences of the United States of America,
2005; 102(12):
4348-52.
Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V.A., Rome, L.H., Stewart, P.L.
Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP
Journal of Molecular Biology,
2004; 344(1):
91-105.
Liu, Y., Snow, B.E., Kickhoefer, V.A., Erdmann, N., Zhou, W., Wakeham, A., Gomez, M., Rome, L.H., Harrington, L.
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo
Molecular and Cellular Biology,
2004; 24(12):
5314-23.
Kickhoefer, V.A., Emre, N., Stephen, A.G., Poderycki, M.J., Rome, L.H.
Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene
Gene,
2003; 309(2):
65-70.
Hu, Y., Stephen, A.G., Cao, J., Tanzer, L.R., Slapak, C.A., Harrison, S.D., Devanarayan, V., Dantzig, A.H., Starling, J.J., Rome, L.H., Moore, R.E.
A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells
International journal of cancer,
2002; 97(2):
149-56.
Stephen, A. G., Raval-Fernandes, S., Huynh, T., Torres, M., Kickhoefer, V. A., Rome, L. H.
Assembly of vault-like particles in insect cells expressing only the major vault protein
J Biol Chem,
2001; 276(26):
23217-20.
Siva, A. C., Raval-Fernandes, S., Stephen, A. G., LaFemina, M. J., Scheper, R. J., Kickhoefer, V. A., Rome, L. H.
Up-regulation of vaults may be necessary but not sufficient for multidrug resistance
Int J Cancer,
2001; 92(2):
195-202.
Kickhoefer, V. A., Liu, Y., Kong, L. B., Snow, B. E., Stewart, P. L., Harrington, L., Rome, L. H.
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle
J Cell Biol,
2001; 152(1):
157-64.
Marbois, B. N., Faull, K. F., Fluharty, A. L., Raval-Fernandes, S., Rome, L. H.
Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry
Biochim Biophys Acta,
2000; 1484(1):
59-70.
Schroeijers A B, Siva A C, Scheffer G L, de Jong M C, Bolick S C, Dukers D F, Slootstra J W, Meloen R H, Wiemer E, Kickhoefer V A, Rome L H, Scheper R J
The Mr 193,000 vault protein is up-regulated in multidrug-resistant
cancer cell lines
Cancer research,
2000; 60(4):
1104-10.
Buehler Daniel C, Marsden Matthew D, Shen Sean, Toso Daniel B, Wu Xiaomeng, Loo Joseph A, Zhou Z Hong, Kickhoefer Valerie A, Wender Paul A, Zack Jerome A, Rome Leonard H
Bioengineered vaults: self-assembling protein shell-lipophilic core
nanoparticles for drug delivery
ACS nano,
2014; 8(8):
7723-32.
Sharma Sherven, Zhu Li, Srivastava Minu K, Harris-White Marni, Huang Min, Lee Jay M, Rosen Fran, Lee Gina, Wang Gerald, Kickhoefer Valerie, Rome Leonard H, Baratelli Felicita, St John Maie, Reckamp Karen, Chul-Yang Seok, Hillinger Sven, Strieter Robert, Dubinett Steven
CCL21 Chemokine Therapy for Lung Cancer
International trends in immunity,
2013; 1(1):
10-15.
Zhu Ye, Jiang Janina, Said-Sadier Najwane, Boxx Gale, Champion Cheryl, Tetlow Ashley, Kickhoefer Valerie A, Rome Leonard H, Ojcius David M, Kelly Kathleen A
Activation of the NLRP3 inflammasome by vault nanoparticles expressing
a chlamydial epitope
Vaccine,
2015; 33(2):
298-306.
Ding Ke, Zhang Xing, Mrazek Jan, Kickhoefer Valerie A, Lai Mason, Ng Hwee L, Yang Otto O, Rome Leonard H, Zhou Z Hong
Solution Structures of Engineered Vault Particles
Structure (London, England : 1993),
2018; 26(4):
619-626.e3.
Zhang Qin, Jeppesen Dennis K, Higginbotham James N, Graves-Deal Ramona, Trinh Vincent Q, Ramirez Marisol A, Sohn Yoojin, Neininger Abigail C, Taneja Nilay, McKinley Eliot T, Niitsu Hiroaki, Cao Zheng, Evans Rachel, Glass Sarah E, Ray Kevin C, Fissell William H, Hill Salisha, Rose Kristie Lindsey, Huh Won Jae, Washington Mary Kay, Ayers Gregory Daniel, Burnette Dylan T, Sharma Shivani, Rome Leonard H, Franklin Jeffrey L, Lee Youngmin A, Liu Qi, Coffey Robert J
Supermeres are functional extracellular nanoparticles replete with
disease biomarkers and therapeutic targets
Nature cell biology,
2021; 23(12):
1240-1254.
Rayo Josep, Gregor Rachel, Jacob Nicholas T, Dandela Rambabu, Dubinsky Luba, Yashkin Alex, Aranovich Alexander, Thangaraj Manikandan, Ernst Orna, Barash Eran, Malitsky Sergey, Florea Bogdan I, Krom Bastiaan P, Wiemer Erik A C, Kickhoefer Valerie A, Rome Leonard H, Mathison John C, Kaufmann Gunnar F, Overkleeft Herman S, Cravatt Benjamin F, Zor Tsaffrir, Janda Kim D, Ulevitch Richard J, Kravchenko Vladimir V, Meijler Michael M
Immunoediting role for major vault protein in apoptotic signaling
induced by bacterial
Proceedings of the National Academy of Sciences of the United States of America,
2021; 118(12):
1240-1254.
Nagasawa Daniel T, Yang Jian, Romiyo Prasanth, Lagman Carlito, Chung Lawrance K, Voth Brittany L, Duong Courtney, Kickhoefer Valerie A, Rome Leonard H, Yang Isaac
Bioengineered recombinant vault nanoparticles coupled with NY-ESO-1
glioma-associated antigens induce maturation of native dendritic
cells
Journal of neuro-oncology,
2020; 148(1):
1-7.
Voth Brittany L, Pelargos Panayiotis E, Barnette Natalie E, Bhatt Nikhilesh S, Chen Cheng Hao Jacky, Lagman Carlito, Chung Lawrance K, Nguyen Thien, Sheppard John P, Romiyo Prasanth, Mareninov Sergey, Kickhoefer Valerie A, Yong William H, Rome Leonard H, Yang Isaac
Intratumor injection of CCL21-coupled vault nanoparticles is
associated with reduction in tumor volume in an in vivo model of
glioma
Journal of neuro-oncology,
2020; 147(3):
599-605.
Fulcher Jennifer A, Tamshen Kyle, Wollenberg Alexander L, Kickhoefer Valerie A, Mrazek Jan, Elliott Julie, Ibarrondo F Javier, Anton Peter A, Rome Leonard H, Maynard Heather D, Deming Timothy, Yang Otto O
Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to
Inhibit Human Immunodeficiency Virus Type 1 Infection
Bioconjugate chemistry,
2019; 30(8):
2216-2227.
Jeppesen Dennis K, Fenix Aidan M, Franklin Jeffrey L, Higginbotham James N, Zhang Qin, Zimmerman Lisa J, Liebler Daniel C, Ping Jie, Liu Qi, Evans Rachel, Fissell William H, Patton James G, Rome Leonard H, Burnette Dylan T, Coffey Robert J
Reassessment of Exosome Composition
Cell,
2019; 177(2):
428-445.e18.