Affiliations

Co-Director, NMR Core (DOE)

Lab Director, Clubb Lab

Professor, Chemistry and Biochemistry, Biochemistry, Molecular Biology

Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular Biology Institute

Staff, Nuclear Magnetic Resonance (NMR) Core Facility (DOE)

Researcher, Biochemistry, Biophysics and Structural Biology, Chemical Biology

My laboratory studies how bacteria display and utilize virulence factors during infections. Our primary research tool is multi-dimensional heteronuclear nuclear magnetic resonance (NMR) spectroscopy, which is used to investigate the structure and dynamics of proteins and their complexes in solution. We also employ a wide range of other techniques in our research, including X-ray crystallography, and cellular and biochemical methods. Three related research projects are ongoing. (1) We are studying sortase enzymes that are used by gram-positive bacteria to attach proteins to their cell wall and to assemble pili. We are also developing sortase inhibitors that could function as potent anti-infective agents. (2) We are investigating how the pathogen Staphylococcus aureus captures heme-iron from human hemoglobin. As this source of iron is preferentially used by S. aureus during infections this work may facilitate the development of new anti-infective agents that inhibit microbial heme acquisition. (3) We are using sortase enzyme technology to engineer microbial surfaces. Our objective is to create industrially useful microbes for biofuel production. A more detailed description of these projects can be found at our website: http://www.biochemistry.ucla.edu/biochem/Faculty/Clubb/

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