A selected list of publications:
Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O'Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL, Khakh BS.
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway,
Neuron,
2014; 82(2):
413-29..
Cui Yijun, Ostlund Sean B, James Alex S, Park Chang Sin, Ge Weihong, Roberts Kristofer W, Mittal Nitish, Murphy Niall P, Cepeda Carlos, Kieffer Brigitte L, Levine Michael S, Jentsch James David, Walwyn Wendy M, Sun Yi E, Evans Christopher J, Maidment Nigel T, Yang X William
Targeted expression of μ-opioid receptors in a subset of striatal
direct-pathway neurons restores opiate reward
Nature neuroscience,
2014; 17(2):
254-61.
Southwell Amber L, Warby Simon C, Carroll Jeffrey B, Doty Crystal N, Skotte Niels H, Zhang Weining, Villanueva Erika B, Kovalik Vlad, Xie Yuanyun, Pouladi Mahmoud A, Collins Jennifer A, Yang X William, Franciosi Sonia, Hayden Michael R
A fully humanized transgenic mouse model of Huntington disease
Human molecular genetics,
2013; 22(1):
18-34.
Yu-Taeger Libo, Petrasch-Parwez Elisabeth, Osmand Alexander P, Redensek Adriana, Metzger Silke, Clemens Laura E, Park Larry, Howland David, Calaminus Carsten, Gu Xiaofeng, Pichler Bernd, Yang X William, Riess Olaf, Nguyen Huu Phuc
A novel BACHD transgenic rat exhibits characteristic neuropathological
features of Huntington disease
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2012; 32(44):
15426-38.
Shirasaki Dyna I., Greiner Erin R., Al-Ramahi Ismael, Gray Michelle, Boontheung Piamanee, Geschwind Daniel H, Botas Juan, Coppola Giovanni, Horvath Steve, Loo Joseph A, Yang X William.
Network organization of the huntingtin proteomic interactome in Mammalian brain
Neuron,
2012; 75(1):
41-57.
Gafni Juliette, Papanikolaou Theodora, Degiacomo Francesco, Holcomb Jennifer, Chen Sylvia, Menalled Liliana, Kudwa Andrea, Fitzpatrick Jon, Miller Sam, Ramboz Sylvie, Tuunanen Pasi I, Lehtimäki Kimmo K, Yang X William, Park Larry, Kwak Seung, Howland David, Park Hyunsun, Ellerby Lisa M
Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of
Mutant Huntingtin Protein But Is Not Necessary for Production of a 586
Amino Acid Proteolytic Fragment
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2012; 32(22):
7454-7465.
Jiang Mali, Wang Jiawei, Fu Jinrong, Du Lin, Jeong Hyunkyung, West Tim, Xiang Lan, Peng Qi, Hou Zhipeng, Cai Huan, Seredenina Tamara, Arbez Nicolas, Zhu Shanshan, Sommers Katherine, Qian Jennifer, Zhang Jiangyang, Mori Susumu, Yang X William, Tamashiro Kellie L K, Aja Susan, Moran Timothy H, Luthi-Carter Ruth, Martin Bronwen, Maudsley Stuart, Mattson Mark P, Cichewicz Robert H, Ross Christopher A, Holtzman David M, Krainc Dimitri, Duan Wenzhen
Neuroprotective role of Sirt1 in mammalian models of Huntington's
disease through activation of multiple Sirt1 targets
Nature medicine,
2012; 18(1):
153-8.
Miller Jason, Arrasate Montserrat, Brooks Elizabeth, Libeu Clare Peters, Legleiter Justin, Hatters Danny, Curtis Jessica, Cheung Kenneth, Krishnan Preethi, Mitra Siddhartha, Widjaja Kartika, Shaby Benjamin A, Lotz Gregor P, Newhouse Yvonne, Mitchell Emily J, Osmand Alex, Gray Michelle, Thulasiramin Vanitha, Saudou Frédéric, Segal Mark, Yang X William, Masliah Eliezer, Thompson Leslie M, Muchowski Paul J, Weisgraber Karl H, Finkbeiner Steven
Identifying polyglutamine protein species in situ that best predict
neurodegeneration
Nature chemical biology,
2011; 7(12):
925-34.
Tao Jifang, Wu Hao, Lin Quan, Wei Weizheng, Lu Xiao-Hong, Cantle Jeffrey P, Ao Yan, Olsen Richard W, Yang X William, Mody Istvan, Sofroniew Michael V, Sun Yi E
Deletion of astroglial Dicer causes non-cell-autonomous neuronal
dysfunction and degeneration
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2011; 31(22):
8306-19.
Wilburn Brian, Rudnicki Dobrila D, Zhao Jing, Weitz Tara Murphy, Cheng Yin, Gu Xiaofeng, Greiner Erin, Park Chang Sin, Wang Nan, Sopher Bryce L, La Spada Albert R, Osmand Alex, Margolis Russell L, Sun Yi E, Yang X William
An antisense CAG repeat transcript at JPH3 locus mediates expanded
polyglutamine protein toxicity in Huntington's disease-like 2 mice
Neuron,
2011; 70(3):
427-40.
Graham Rona K, Deng Yu, Carroll Jeffery, Vaid Kuljeet, Cowan Catherine, Pouladi Mahmoud A, Metzler Martina, Bissada Nagat, Wang Lili, Faull Richard L M, Gray Michelle, Yang X William, Raymond Lynn A, Hayden Michael R
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin
influences caspase-6 activation in vivo
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2010; 30(45):
15019-29.
Pouladi Mahmoud A, Xie Yuanyun, Skotte Niels Henning, Ehrnhoefer Dagmar E, Graham Rona K, Kim Jeong Eun, Bissada Nagat, Yang X William, Paganetti Paolo, Friedlander Robert M, Leavitt Blair R, Hayden Michael R
Full-length huntingtin levels modulate body weight by influencing
insulin-like growth factor 1 expression
Human molecular genetics,
2010; 19(8):
1528-38.
Gu Xiaofeng, Greiner Erin R, Mishra Rakesh, Kodali Ravindra, Osmand Alex, Finkbeiner Steven, Steffan Joan S, Thompson Leslie Michels, Wetzel Ronald, Yang X William
Serines 13 and 16 are critical determinants of full-length human
mutant huntingtin induced disease pathogenesis in HD mice
Neuron,
2009; 64(6):
828-40.
Menalled Liliana, El-Khodor Bassem F, Patry Monica, Suárez-Fariñas Mayte, Orenstein Samantha J, Zahasky Benjamin, Leahy Christina, Wheeler Vanessa, Yang X William, MacDonald Marcy, Morton A Jennifer, Bates Gill, Leeds Janet, Park Larry, Howland David, Signer Ethan, Tobin Allan, Brunner Daniela
Systematic behavioral evaluation of Huntington's disease transgenic
and knock-in mouse models
Neurobiology of disease,
2009; 35(3):
319-36.
Lu Xiao-Hong, Fleming Sheila M, Meurers Bernhard, Ackerson Larry C, Mortazavi Farzad, Lo Victor, Hernandez Daniela, Sulzer David, Jackson George R, Maidment Nigel T, Chesselet Marie-Francoise, Yang X William
Bacterial artificial chromosome transgenic mice expressing a truncated
mutant parkin exhibit age-dependent hypokinetic motor deficits,
dopaminergic neuron degeneration, and accumulation of proteinase
K-resistant alpha-synuclein
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2009; 29(7):
1962-76.
Gray Michelle, Shirasaki Dyna I, Cepeda Carlos, André Véronique M, Wilburn Brian, Lu Xiao-Hong, Tao Jifang, Yamazaki Irene, Li Shi-Hua, Sun Yi E, Li Xiao-Jiang, Levine Michael S, Yang X William
Full-length human mutant huntingtin with a stable polyglutamine repeat
can elicit progressive and selective neuropathogenesis in BACHD mice
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2008; 28(24):
6182-95.
Gu Xiaofeng, Li Chenjian, Wei Weizheng, Lo Victor, Gong Shiaoching, Li Shi-Hua, Iwasato Takuji, Itohara Shigeyoshi, Li Xiao-Jiang, Mody Istvan, Heintz Nathaniel, Yang X William
Pathological cell-cell interactions elicited by a neuropathogenic form
of mutant Huntingtin contribute to cortical pathogenesis in HD mice
Neuron,
2005; 46(3):
433-44.