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Louis Bouchard, Ph.D.

Laboratory Address:
Young Hall 2104 and 2042

Work Address:
Department of Chemistry and Biochemistry
607 Charles E Young Dr East / Young Hall 3048B
University of California, Los Angeles, CA 90095

Affiliations
Affiliations
Associate Professor, Biophysics and Structural Biology, Chemistry and Biochemistry, Nanoscience and Materials, Physical Chemistry
Member, CTSI, California NanoSystems Institute, JCCC Cancer and Stem Cell Biology Program Area, Jonsson Comprehensive Cancer Center, Molecular Biology Institute
Research Interests

Our laboratory is developing multifunctional vehicles for biosensing, medical imaging, localized therapy and drug delivery.  Imaging methods have focused on MRI and optical detection.  Therapies include photodynamic therapy and delivery of anticancer drugs.  We are interested in all aspects of the research including chemical synthesis, characterization, detection and clinical trials of cancer-related problems.    We also work on tissue engineering problems as well as the localized regulation of immune response using advanced biomaterials.

Biography

Dr. Bouchard obtained a bachelor’s degree in physics and business management from McGill University in Montréal, Canada, a Master’s degree in medical biophysics from the University of Toronto and a Ph.D. in Chemistry from Princeton University. His doctoral dissertation explores the use of multiple quantum coherence and long-range dipolar interactions in condensed matter to characterize heterogeneous material microstructure. During his time in the lab of Alex Pines at UC Berkeley he developed novel approaches and methodologies to portable, low-field NMR and MRI, microfluidics and hyperpolarization methods to the study of chemical reactions. He joined the UCLA faculty during the summer of 2008 to pursue research in physical chemistry and biomedicine.

Publications

A selected list of publications:

Compton R, Osher S, Bouchard L   Hybrid regulatization for MRI reconstruction with field inhomogeneity correction, Inverse Probl. Imag, 2013; 7: 1215-1233.
Sharma R, Bouchard LS   Strongly hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles, Sci. Rep, 2012; 2: 277.
Majedi Fatemeh S, Hasani-Sadrabadi Mohammad Mahdi, Thauland Timothy J, Li Song, Bouchard Louis-S, Butte Manish J   T-cell activation is modulated by the 3D mechanical microenvironment Biomaterials, 2020; 252: 120058.
Majedi Fatemeh S, Hasani-Sadrabadi Mohammad Mahdi, Thauland Timothy J, Li Song, Bouchard Louis-S, Butte Manish J   Augmentation of T-Cell Activation by Oscillatory Forces and Engineered Antigen-Presenting Cells Nano letters, 2019; 19(10): 6945-6954.
Kaltschnee Lukas, Jagtap Anil P, McCormick Jeffrey, Wagner Shawn, Bouchard Louis-S, Utz Marcel, Griesinger Christian, Glöggler Stefan   Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst Chemistry (Weinheim an der Bergstrasse, Germany), 2019; 25(47): 11031-11035.
Archer Brian J, Uberruck Till, Mack Julia J, Youssef Khalid, Jarenwattananon Nanette N, Rall Deniz, Wypysek Denis, Wiese Martin, Blumich Bernhard, Wessling Matthias, Iruela-Arispe M Luisa, Bouchard Louis-S   Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI IEEE transactions on bio-medical engineering, 2019; 66(3): 821-830.
Yang Shengjun, McCormick Jeffrey, Mamone Salvatore, Bouchard Louis-S, Glöggler Stefan   Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States Angewandte Chemie (International ed. in English), 2019; 58(9): 2879-2883.
Jarenwattananon Nanette N, Bouchard Louis-S   Breakdown of Carr-Purcell Meiboom-Gill spin echoes in inhomogeneous fields The Journal of chemical physics, 2018; 149(8): 084304.
McCormick Jeffrey, Korchak Sergey, Mamone Salvatore, Ertas Yavuz N, Liu Zhiyu, Verlinsky Luke, Wagner Shawn, Glöggler Stefan, Bouchard Louis-S   More Than 12 % Polarization and 20 Minute Lifetime of Angewandte Chemie (International ed. in English), 2018; 57(33): 10692-10696.
Hasani-Sadrabadi Mohammad Mahdi, Majedi Fatemeh S, Bensinger Steven J, Wu Benjamin M, Bouchard Louis-S, Weiss Paul S, Moshaverinia Alireza   Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk Advanced materials (Deerfield Beach, Fla.), 2018; 30(23): e1706780.
Majedi Fatemeh S, Hasani-Sadrabadi Mohammad Mahdi, Kidani Yoko, Thauland Timothy J, Moshaverinia Alireza, Butte Manish J, Bensinger Steven J, Bouchard Louis-S   Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells Advanced materials (Deerfield Beach, Fla.), 2018; 30(7): e1706780.
Mack Julia J, Mosqueiro Thiago S, Archer Brian J, Jones William M, Sunshine Hannah, Faas Guido C, Briot Anais, Aragón Raquel L, Su Trent, Romay Milagros C, McDonald Austin I, Kuo Cheng-Hsiang, Lizama Carlos O, Lane Timothy F, Zovein Ann C, Fang Yun, Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Navab Mohamad, Fogelman Alan M, Bouchard Louis S, Iruela-Arispe M Luisa   NOTCH1 is a mechanosensor in adult arteries Nature communications, 2017; 8(1): 1620.
Koumoulis Dimitrios, Taylor Robert E, McCormick Jeffrey, Ertas Yavuz N, Pan Lei, Che Xiaoyu, Wang Kang L, Bouchard Louis-S   Effects of Cd vacancies and unconventional spin dynamics in the Dirac semimetal Cd The Journal of chemical physics, 2017; 147(8): 084706.
McCormick Jeffrey, Grunfeld Alexander M, Ertas Yavuz N, Biswas Akash N, Marsh Kristofer L, Wagner Shawn, Glöggler Stefan, Bouchard Louis-S   Aqueous Ligand-Stabilized Palladium Nanoparticle Catalysts for Parahydrogen-Induced Analytical chemistry, 2017; 89(13): 7190-7194.
Yang Yuqi, Chen Shizhen, Liu Lianhua, Li Sha, Zeng Qingbin, Zhao Xiuchao, Li Haidong, Zhang Zhiying, Bouchard Louis-S, Liu Maili, Zhou Xin   Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation ACS applied materials & interfaces, 2017; 9(28): 23400-23408.
Lake Michael P, Bouchard Louis-S   Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells PloS one, 2017; 12(6): e0179295.
Yang Shengjun, Yuan Yaping, Jiang Weiping, Ren Lili, Deng He, Bouchard Louis S, Zhou Xin, Liu Maili   Hyperpolarized Chemistry (Weinheim an der Bergstrasse, Germany), 2017; 23(32): 7648-7652.
Zeng Qingbin, Guo Qianni, Yuan Yaping, Yang Yuqi, Zhang Bin, Ren Lili, Zhang Xiaoxiao, Luo Qing, Liu Maili, Bouchard Louis-S, Zhou Xin   Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized Analytical chemistry, 2017; 89(4): 2288-2295.
Youssef Khalid, Jarenwattananon Nanette N, Archer Brian J, Mack Julia, Iruela-Arispe M Luisa, Bouchard Louis-S   4-D Flow Control in Porous Scaffolds: Toward a Next Generation of Bioreactors IEEE transactions on bio-medical engineering, 2017; 64(1): 61-69.
Koumoulis Dimitrios, Scheifers Jan P, St Touzani Rachid, Fokwa Boniface P T, Bouchard Louis-S   Direct Chemical Fine-Tuning of Electronic Properties in Sc Chemphyschem : a European journal of chemical physics and physical chemistry, 2016; 17(19): 2972-2976.
Yang Shengjun, Jiang Weiping, Ren Lili, Yuan Yaping, Zhang Bin, Luo Qing, Guo Qianni, Bouchard Louis-S, Liu Maili, Zhou Xin   Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction Analytical chemistry, 2016; 88(11): 5835-40.
Jarenwattananon Nanette N, Bouchard Louis-S   Erratum: Motional Averaging of Nuclear Resonance in a Field Gradient [Phys. Rev. Lett. 114, 197601 (2015)] Physical review letters, 2016; 116(21): 219903.
Guo Qianni, Zeng Qingbin, Jiang Weiping, Zhang Xiaoxiao, Luo Qing, Zhang Xu, Bouchard Louis-S, Liu Maili, Zhou Xin   A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized (129)Xe Molecular Clamp Probe Chemistry (Weinheim an der Bergstrasse, Germany), 2016; 22(12): 3967-70.
Glöggler S, Grunfeld A M, Ertas Y N, McCormick J, Wagner S, Bouchard L-S   Surface ligand-directed pair-wise hydrogenation for heterogeneous phase hyperpolarization Chemical communications (Cambridge, England), 2016; 52(3): 605-8.
Youssef Khalid, Jarenwattananon Nanette N, Bouchard Louis-S   Feature-Preserving Noise Removal IEEE transactions on medical imaging, 2015; 34(9): 1822-9.
Glöggler S, Wagner S, Bouchard L-S   Hyperpolarization of amino acid derivatives in water for biological applications Chemical science, 2015; 6(7): 4261-4266.
Koumoulis Dimitrios, Morris Gerald D, He Liang, Kou Xufeng, King Danny, Wang Dong, Hossain Masrur D, Wang Kang L, Fiete Gregory A, Kanatzidis Mercouri G, Bouchard Louis-S   Nanoscale β-nuclear magnetic resonance depth imaging of topological insulators Proceedings of the National Academy of Sciences of the United States of America, 2015; 112(28): E3645-50.
Jarenwattananon Nanette N, Bouchard Louis-S   Motional averaging of nuclear resonance in a field gradient Physical review letters, 2015; 114(19): 197601.
Glöggler Stefan, Grunfeld Alexander M, Ertas Yavuz N, McCormick Jeffrey, Wagner Shawn, Schleker P Philipp M, Bouchard Louis-S   A nanoparticle catalyst for heterogeneous phase para-hydrogen-induced polarization in water Angewandte Chemie (International ed. in English), 2015; 54(8): 2452-6.
Jarenwattananon Nanette N, Glöggler Stefan, Otto Trenton, Melkonian Arek, Morris William, Burt Scott R, Yaghi Omar M, Bouchard Louis-S   Thermal maps of gases in heterogeneous reactions Nature, 2013; 502(7472): 537-40.
Mack Julia J, Youssef Khalid, Noel Onika D V, Lake Michael P, Wu Ashley, Iruela-Arispe M Luisa, Bouchard Louis-S   Real-time maps of fluid flow fields in porous biomaterials Biomaterials, 2013; 34(8): 1980-6.
Koumoulis Dimitrios, Chasapis Thomas C, Taylor Robert E, Lake Michael P, King Danny, Jarenwattananon Nanette N, Fiete Gregory A, Kanatzidis Mercouri G, Bouchard Louis-S   NMR probe of metallic states in nanoscale topological insulators Physical review letters, 2013; 110(2): 026602.
Zurbuchen Mark A, Lake Michael P, Kohan Sirus A, Leung Belinda, Bouchard Louis-S   Nanodiamond landmarks for subcellular multimodal optical and electron imaging Scientific reports, 2013; 3(2): 2668.
Sharma Ramesh, Bouchard Louis-S   Strongly hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles Scientific reports, 2012; 2(2): 277.
Youssef K, Mack JJ, Iruela-Arispe ML, Bouchard LS   Macro-scale Topology Optimization for Controlling Internal Shear Stress in a Porous Scaffold Bioreactor Biotechn. Bioeng, 2012; 109: 1844-1854.
Michalak David J, Xu Shoujun, Lowery Thomas J, Crawford C W, Ledbetter Micah, Bouchard Louis-S, Wemmer David E, Budker Dmitry, Pines Alexander   Relaxivity of gadolinium complexes detected by atomic magnetometry Magnetic resonance in medicine, 2011; 66(2): 605-8.
Bouchard LS, Acosta VM, Bauch E, Budker D   Detection of the Meissner effect with a diamond magnetometer New J. Phys, 2011; 13: 025017.
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McFadden Carson, Bouchard Louis-S   Universality of cluster dynamics Physical review. E, Statistical, nonlinear, and soft matter physics, 2010; 82(6 Pt 1): 061125.
Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT   Heteronuclear Zero Quantum Coherence Nz-Exchange Experiment That Resolves Resonance Overlap and Its Application To Measure the Rates of Heme Binding to the IsdC Protein J. Am. Chem. Soc, 2010; 132(28): 9522-9523.
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Acosta VM, Bauch E, Ledbetter MP, Waxman A, Bouchard LS, Budker D   Temperature dependence of the nitrogen-vacancy magnetic resonance in diamond, Phys. Rev. Lett, 2010; 104: 070801.
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Kelso N, Lee SK, Bouchard LS, Demas V, Muck M, Pines A, Clarke JC   Distortion-Free Magnetic Resonance Imaging in the Zero-Field Limit, Journal of Magnetic Resonance, 2009; 200: 285-290.
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Bouchard LS, Anwar MS, Liu GL, Hann B, Xie H, Gray JW, Wang X, Pines A, Chen FF   Picomolar Sensitivity MRI and Photoacoustic Imaging of Cobalt Nanoparticles, Proc. Natl. Acad. Sci. USA, 2009; 106: 4085-4089.
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Franck JM, Demas V, Martin RW, Bouchard LS, Pines A   Shimmed matching pulses: Simultaneous control of rf and static gradients for inhomogeneity correction, Journal of Chemical Physics, 2009; 131: 234506.
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Paulsen Jeffrey L, Bouchard Louis S, Graziani Dominic, Blümich Bernhard, Pines Alexander   Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(52): 20601-4.
Paulsen JL, Bouchard, LS, Graziani N, Bluemich B, Pines A   Volume selective magnetic resonance imaging using an adjustable, single-sided, portable sensor, Proc. Natl. Acad. Sci. USA, 2008; 105: 20601-20604.
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Verpillat F, Ledbetter M P, Xu S, Michalak D J, Hilty C, Bouchard L-S, Antonijevic S, Budker D, Pines A   Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(7): 2271-3.
Bouchard Louis-S, Burt Scott R, Anwar M Sabieh, Kovtunov Kirill V, Koptyug Igor V, Pines Alexander   NMR imaging of catalytic hydrogenation in microreactors with the use of para-hydrogen Science (New York, N.Y.), 2008; 319(5862): 442-5.
Bouchard LS, Kovtunov KV, Burt SR, Anwar MS, Koptyug IV, Sagdeev RZ, Pines A   Parahydrogen-enhanced gas-phase magnetic resonance imaging, Angewandte Chemie Intl Ed , 2007; 46: 4064–4068 (ranked Very Important Paper).
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Anwar M Sabieh, Hilty Christian, Chu Chester, Bouchard Louis-S, Pierce Kimberly L, Pines Alexander   Spin coherence transfer in chemical transformations monitored by remote detection NMR Analytical chemistry, 2007; 79(7): 2806-11.
Jachmann R C, Trease D R, Bouchard L-S, Sakellariou D, Martin R W, Schlueter R D, Budinger T F, Pines A   Multipole shimming of permanent magnets using harmonic corrector rings The Review of scientific instruments, 2007; 78(3): 035115.
Bouchard Louis-S, Kovtunov Kirill V, Burt Scott R, Anwar M Sabieh, Koptyug Igor V, Sagdeev Renad Z, Pines Alexander   Para-hydrogen-enhanced hyperpolarized gas-phase magnetic resonance imaging Angewandte Chemie (International ed. in English), 2007; 46(22): 4064-8.
Bouchard LS, Warren WS   Multiple-quantum vector field imaging by magnetic resonance J. Magn. Reson, 2005; 177(1): 1-13.
Bouchard LS, Wehrli FW, Chin CL, Warren WS   Structural anisotropy and internal magnetic fields in trabecular bone: coupling solution and solid dipolar interactions J. Magn. Reson, 2005; 176(1): 27-36.
Shannon Kerry L, Branca Rosa T, Galiana Gigi, Cenzano Silvia, Bouchard Louis-Serge, Soboyejo Winston, Warren Warren S   Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo Magnetic resonance imaging, 2004; 22(10): 1407-12.
Ledbetter M P, Savukov I M, Bouchard L-S, Romalis M V   Numerical and experimental studies of long-range magnetic dipolar interactions The Journal of chemical physics, 2004; 121(3): 1454-65.
Tang XP, Chin CL, Bouchard LS, Warren WS, Wehlri FW   Observing Bragg-like diffraction via multiple coupled nuclear spins Phys. Lett. A, 2004; 326: 114-25.
Bouchard LS, Warren WS   Reconstruction of porous material geometry by stochastic optimization based on NMR measurements of the dipolar field J. Magn. Reson, 2004; 170: 299-309.
Bouchard LS, Warren WS   Tensorial character of magnetization diffusion in periodic lattices Phys. Rev. B, 2004; 70(224426): .
Chin Chih-Liang, Tang Xiaoping, Bouchard Louis-S, Saha Punam K, Warren Warren S, Wehrli Felix W   Isolating quantum coherences in structural imaging using intermolecular double-quantum coherence MRI Journal of magnetic resonance (San Diego, Calif. : 1997), 2003; 165(2): 309-14.
Bouchard Louis-Serge, Rizi Rahim R, Warren Warren S   Magnetization structure contrast based on intermolecular multiple-quantum coherences Magnetic resonance in medicine, 2002; 48(6): 973-9.
Bouchard LS, Bronskill MJ   Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices Med. Phys, 2000; 27: 1141-5.
Bouchard L S, Bronskill M J   Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices Medical physics, 2000; 27(5): 1141-5.