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Paul A Krogstad, M.D.

Laboratory Address:
177 BSRB

Office Address:
177C BSRB

Affiliations
Affiliations
Professor, Pediatrics, Pediatric Infectious Diseases, Molecular & Medical Pharmacology
Member, Care 4 Kids, Youth, and Moms, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular Pharmacology GPB Home Area
Research Interests
My laboratory studies the microbiology, immunology, and pathogenesis of human immunodeficiency virus (HIV) infection. As a pediatric infectious disease specialist, I am also involved in the clinical development of new therapeutic approaches to HIV infection in children, and examining mechanisms of resistance to new antiretroviral agents. In addition, members of the laboratory examine the replication of members of the picornavirus family (coxsackie B (CVB) and the human parechovirus type 1 (HPEV-1).
Biography:

Paul A. Krogstad, MD is a Professor with a joint appointment in the Departments of Pediatrics and Molecular and Pharmacology, and serves as the Fellowship Director for the Pediatric Infectious Diseases Fellowship Program. Dr. Krogstad's laboratory focuses on molecular virology and the pathogenesis of viral diseases. Major areas of interest include studying the role that cellular proteins play in promoting the assembly of viral proteins into infectious HIV particles, and their release from lymphocytes and other infected cells. His studies of HIV pathogenesis currently include the impact of HIV on T cell production and turnover in HIV infected children and adolescents. These studies may suggest new forms of therapy for HIV infection which target viral-cellular interactions, and in new approaches to the reversing immunological impact of HIV on immunological ontogeny. Dr. Krogstad?s laboratory research also includes molecular approaches to the identification of novel agents involved in idiopathic liver failure, and cellular factors involved in Coxsackie myocarditis. In addition, he has lead and collaborated in several studies of new drugs for the treatment of HIV, and leads the instruction of the module in the David Geffen School of Medicine on anti-infective agents. Dr. Krogstad has received numerous teaching awards (including The Robert C. Neerhout Teaching Award in 2003) and was the recipient of the Pediatric AIDS Foundation Scholar Award in 1991 and the Elizabeth Glaser Scientist Award (the Foundation?s highest scientific honor) in 2000 for his excellence in the field.

Publications

A selected list of publications:

Phung Jennifer, Krogstad Paul, Mathern Gary W   Etiology associated with developing posthemispherectomy hydrocephalus after resection-disconnection procedures Journal of neurosurgery. Pediatrics, 2013; .
Cammock C, Halnon NJ, Singletary M, Skoczylas J, Blanchard J, Bohm R, Chi L, Krogstad P   Myocarditis, Disseminated infection, and Early Viral Persistence Following Experimental Coxsackievirus B Infection of Cynomolgus Monkeys, PLOS-One, 2013; In press: .
Phung Jennifer, Mathern Gary W, Krogstad Paul   Timing and predictors of fever and infection after craniotomy for epilepsy in children The Pediatric infectious disease journal, 2013; 32(5): 450-9.
Zuo J, Quinn KK, Kye S, Cooper P, Damoiseaux R, and Krogstad P   Fluoxetine is a Potent Inhibitor of Coxsackievirus Replication, Antimicrobial Agents and Chemotherapy, 2012; 6: 4838-4844.
Zuo Jun, Quinn Kevin K, Kye Steve, Cooper Paige, Damoiseaux Robert, Krogstad Paul   Fluoxetine is a potent inhibitor of coxsackievirus replication Antimicrobial agents and chemotherapy, 2012; 56(9): 4838-44.
Zuo J, Suen J, Wong A, Lewis M, Ali A, Belzer M, Church J, Yang OO, and Krogstad P.   Functional Analysis of HIV-1 Nef Gene Variants from Adolescent and Adult Survivors of Pediatric Infection. , AIDS Research Human Retroviruses , 2012; 28: 486-92..
Zuo Jun, Suen Jeffrey, Wong Alanna, Lewis Martha, Ayub Ali, Belzer Marvin, Church Joseph, Yang Otto O, Krogstad Paul   Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection AIDS research and human retroviruses, 2012; 28(5): 486-92.
Marsden Matthew D, Krogstad Paul A, Zack Jerome A   Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens Antiviral therapy, 2012; 17(7): 1375-9.
Mangione-Smith Rita, Krogstad Paul   Antibiotic prescription with asthma medications: why is it so common? Pediatrics, 2011; 127(6): 1174-6.
Krogstad Paul, Aldrovandi Grace   Editorial: developmental regulation of P-glycoprotein and HIV therapy: spare the thymus but spoil the child? Journal of leukocyte biology, 2011; 90(4): 639-41.
Mochon A Brian, Garner Omai B, Hindler Janet A, Krogstad Paul, Ward Kevin W, Lewinski Michael A, Rasheed James K, Anderson Karen F, Limbago Brandi M, Humphries Romney M   New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies Journal of clinical microbiology, 2011; 49(4): 1667-70.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur   A broad-spectrum antiviral targeting entry of enveloped viruses Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(7): 3157-62.
Kitchen Christina M R, Krogstad Paul, Kitchen Scott G   In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1 The open medical informatics journal, 2010; 4(7): 225-32.
Zuo Jun, Church Joseph, Belzer Marvin, Kitchen Christina, Ank Bonnie, Schmid Ingrid, Krogstad Paul   Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy AIDS research and human retroviruses, 2010; 26(6): 681-4.
Rudy Bret J, Kapogiannis Bill G, Lally Michelle A, Gray Glenda E, Bekker Linda-Gail, Krogstad Paul, McGowan Ian   Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials Journal of acquired immune deficiency syndromes (1999), 2010; 54 Suppl 1(4): S31-42.
Chatila Talal A, Krogstad Paul   Crouching tigers, hidden dragons: the interplay of pathogens and hosts Pediatric research, 2009; 65(5 Pt 2): 1R-2R.
Bekmezian Arpi, Vargas Jorge, Krogstad Paul   Jaundice in a neonate with congenital diaphragmatic hernia Paediatrics & child health, 2009; 14(6): 389-92.
Miller John P, Geng Yongzhi, Ng Hwee L, Yang Otto O, Krogstad Paul   Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector Vaccine, 2009; 27(30): 3992-4000.
Kitchen Christina Mr, Nuño Miriam, Kitchen Scott G, Krogstad Paul   Enfuvirtide antiretroviral therapy in HIV-1 infection Therapeutics and clinical risk management, 2008; 4(2): 433-9.
Krogstad Paul, Hammon Rebecca, Halnon Nancy, Whitton J Lindsay   Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant The Pediatric infectious disease journal, 2008; 27(7): 668-9.
Krogstad Paul, Cherry James D   Quadrivalent human vaccine - a call to action and for additional research Pediatric research, 2007; 62(5): 527.
Krogstad Paul A   Resistance to antiretroviral drugs: a threat to the prevention and treatment of pediatric HIV infection The Journal of infectious diseases, 2007; 195(10): 1393-5.
Lee JC, Boechat MI, Belzer M, Church JA, De Ville J, Nielsen K, Weston S, Geng Y, Dunaway T, Kitchen C, and Krogstad PA   Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy, AIDS, 2006; 20: 667-674.
Yang OO, Church J, Kitchen CMR, Kilpatrick R, Ali A, Geng Y, Killian MS, Lubong R, Ng H, Suen J, Bryson Y, Jamieson B, and Krogstad P   Genetic and stochastic influences on the interaction of HIV-1 and CTL in identical twins Journal of Virology , 2005; 79: 15368-75.