Login to the DGSOM Faculty Profiles
Brigitte N. Gomperts, M.D.

Mailing Address:
200 UCLA Medical Plaza
Ste 265
Los Angeles, CA 90095 BOX 951752, A2-410 MDCC
Los Angeles, CA 90095

Affiliations
Affiliations
Director, Histiocytosis Center
Associate Professor, Pediatric Hematology/Oncology, Pulmonary and Critical Care Medicine
Member, CTSI, Center for Duchenne Muscular Dystrophy, Child Health Research, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, I3T Theme, JCCC Cancer and Stem Cell Biology Program Area, Jonsson Comprehensive Cancer Center
Biography:

A member of the UCLA's Jonsson Comprehensive Cancer Center, Gomperts is an Associate Professor of Pediatrics and Pulmonary Medicine. She joined the UCLA faculty in 2003 after completing a pediatric residency and pediatric hematology/oncology fellowship at Washington University in St. Louis, MO. She earned her medical degree from the University of Witwatersrand in Johannesburg, South Africa.

Gomperts is also affiliated with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and the Molecular Biology Institute. She's a member of the American Thoracic Society, the American Association for Cancer Research, and the International Society for Stem Cell Research.

Gomperts work is funded by the National Institutes of Health, National Heart, Lung and Blood Institute, California Institute for Regenerative Medicine, Department of Defense, American Thoracic Society, Concern Foundation and Tobacco-Related Disease Research Program.

She is currently co-director of the Jonsson Comprehensive Cancer Center Stem Cell and Biology Program.

Publications

A selected list of publications:

Gomperts Brigitte N, Walser Tonya C, Spira Avrum, Dubinett Steven M   Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer Cancer prevention research (Philadelphia, Pa.), 2013; 6(1): 4-7.
Ooi Aik T, Ram Sonal, Kuo Alan, Gilbert Jennifer L, Yan Weihong, Pellegrini Matteo, Nickerson Derek W, Chatila Talal A, Gomperts Brigitte N   Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation American journal of translational research, 2012; 4(2): 219-28.
Hegab Ahmed E, Ha Vi Luan, Darmawan Daphne O, Gilbert Jennifer L, Ooi Aik T, Attiga Yasser S, Bisht Bharti, Nickerson Derek W, Gomperts Brigitte N   Isolation and in vitro characterization of Basal and submucosal gland duct stem/progenitor cells from human proximal airways Stem cells translational medicine, 2012; 1(10): 719-24.
Hegab Ahmed E, Ha Vi Luan, Attiga Yasser S, Nickerson Derek W, Gomperts Brigitte N   Isolation of basal cells and submucosal gland duct cells from mouse trachea Journal of visualized experiments : JoVE, 2012; 1(67): e3731.
Hegab Ahmed E, Nickerson Derek W, Ha Vi Luan, Darmawan Daphne O, Gomperts Brigitte N   Repair and regeneration of tracheal surface epithelium and submucosal glands in amouse model of hypoxic-ischemic injury Respirology (Carlton, Vic.), 2012; .
Chang Vivian Y, Quintero-Rivera Fabiola, Baldwin Erin E, Woo Kathy, Martinez-Agosto Julian A, Fu Cecilia, Gomperts Brigitte N   B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis Pediatric blood & cancer, 2011; 56(3): 470-3.
Gomperts Brigitte N, Spira Avrum, Massion Pierre P, Walser Tonya C, Wistuba Ignacio I, Minna John D, Dubinett Steven M   Evolving concepts in lung carcinogenesis Seminars in respiratory and critical care medicine, 2011; 32(1): 32-43.
Hegab Ahmed E, Ha Vi Luan, Gilbert Jennifer L, Zhang Kelvin Xi, Malkoski Stephen P, Chon Andy T, Darmawan Daphne O, Bisht Bharti, Ooi Aik T, Pellegrini Matteo, Nickerson Derek W, Gomperts Brigitte N   Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential Stem cells (Dayton, Ohio), 2011; 29(8): 1283-93.
Gomperts Brigitte N, Spira Avrum, Elashoff David E, Dubinett Steven M   Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection Cancer prevention research (Philadelphia, Pa.), 2010; 3(4): 420-3.
Ooi Aik T, Mah Vei, Nickerson Derek W, Gilbert Jennifer L, Ha Vi Luan, Hegab Ahmed E, Horvath Steve, Alavi Mohammad, Maresh Erin L, Chia David, Gower Adam C, Lenburg Marc E, Spira Avrum, Solis Luisa M, Wistuba Ignacio I, Walser Tonya C, Wallace William D, Dubinett Steven M, Goodglick Lee, Gomperts Brigitte N   Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer Cancer research, 2010; 70(16): 6639-48.
Bekmezian Arpi, Gomperts Brigitte, Weisleder Pedro, Patraitis Cynthia, Thibodeau Patrice, Parker-Mello Kelly   Index of suspicion Pediatrics in review / American Academy of Pediatrics, 2009; 30(1): 15-21.
Nickerson Derek W, Presson Angela P, Weigt Stephen S, Gregson Aric L, Belperio John A, Gomperts Brigitte N   Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation PloS one, 2009; 4(6): e5925.
Bekmezian Arpi, Gomperts Brigitte   Case 1: A limping child...with abdominal pain Paediatrics & child health, 2008; 13(9): 775-7.
Mehrad Borna, Keane Michael P, Gomperts Brigitte N, Strieter Robert M   Circulating progenitor cells in chronic lung disease Expert review of respiratory medicine, 2007; 1(1): 157-65.
Gomperts Brigitte N, Strieter Robert M   Fibrocytes in lung disease Journal of leukocyte biology, 2007; 82(3): 449-56.
Keane Michael P, Gomperts Brigitte N, Weigt Samuel, Xue Ying Ying, Burdick Marie D, Nakamura Hiromi, Zisman David A, Ardehali Abbas, Saggar Rajan, Lynch Joseph P, Hogaboam Cory, Kunkel Steven L, Lukacs Nicholas W, Ross David J, Grusby Michael J, Strieter Robert M, Belperio John A   IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome Journal of immunology (Baltimore, Md. : 1950), 2007; 178(1): 511-9.
Gomperts Brigitte N, Kim Linda J, Flaherty Scott A, Hackett Brian P   IL-13 regulates cilia loss and foxj1 expression in human airway epithelium American journal of respiratory cell and molecular biology, 2007; 37(3): 339-46.
Gomperts Brigitte N, Belperio John A, Fishbein Michael C, Keane Michael P, Burdick Marie D, Strieter Robert M   Keratinocyte growth factor improves repair in the injured tracheal epithelium American journal of respiratory cell and molecular biology, 2007; 37(1): 48-56.
Gomperts Brigitte N, Strieter Robert M   Stem cells and chronic lung disease Annual review of medicine, 2007; 58(3): 285-98.
Strieter Robert M, Gomperts Brigitte N, Keane Michael P   The role of CXC chemokines in pulmonary fibrosis The Journal of clinical investigation, 2007; 117(3): 549-56.
Strieter Robert M, Burdick Marie D, Mestas Javier, Gomperts Brigitte, Keane Michael P, Belperio John A   Cancer CXC chemokine networks and tumour angiogenesis European journal of cancer (Oxford, England : 1990), 2006; 42(6): 768-78.
Gomperts Brigitte N, Strieter Robert M   Chemokine-directed metastasis Contributions to microbiology, 2006; 13(3): 170-90.
Gomperts Brigitte N, Belperio John A, Rao P Nagesh, Randell Scott H, Fishbein Michael C, Burdick Marie D, Strieter Robert M   Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury Journal of immunology (Baltimore, Md. : 1950), 2006; 176(3): 1916-27.
Strieter Robert M, Burdick Marie D, Gomperts Brigitte N, Belperio John A, Keane Michael P   CXC chemokines in angiogenesis Cytokine & growth factor reviews, 2005; 16(6): 593-609.
Belperio John A, Keane Michael P, Burdick Marie D, Gomperts Brigitte N, Xue Ying Ying, Hong Kurt, Mestas Javier, Zisman David, Ardehali Abbas, Saggar Rajan, Lynch Joseph P, Ross David J, Strieter Robert M   CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury Journal of immunology (Baltimore, Md. : 1950), 2005; 175(10): 6931-9.
Belperio John A, Keane Michael P, Burdick Marie D, Gomperts Brigitte, Xue Ying Ying, Hong Kurt, Mestas Javier, Ardehali Abbas, Mehrad Borna, Saggar Rajan, Lynch Joseph P, Ross David J, Strieter Robert M   Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome The Journal of clinical investigation, 2005; 115(5): 1150-62.
Gomperts Brigitte N, Gong-Cooper Xiulan, Hackett Brian P   Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells Journal of cell science, 2004; 117(Pt 8): 1329-37.
Ooi Aik T, Gower Adam C, Zhang Kelvin X, Vick Jessica L, Hong Longsheng, Nagao Brian, Wallace W Dean, Elashoff David A, Walser Tonya C, Dubinett Steven M, Pellegrini Matteo, Lenburg Marc E, Spira Avrum, Gomperts Brigitte N   Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis Cancer prevention research (Philadelphia, Pa.), 2014; 7(5): 487-95.
Gomperts Brigitte N   Induction of multiciliated cells from induced pluripotent stem cells Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(17): 6120-1.
Sucre Jennifer M S, Wilkinson Dan, Vijayaraj Preethi, Paul Manash, Dunn Bruce, Alva-Ornelas Jackelyn A, Gomperts Brigitte N   A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology American journal of physiology. Lung cellular and molecular physiology, 2016; 310(10): L889-98.
Hegab Ahmed E, Ha Vi Luan, Bisht Bharti, Darmawan Daphne O, Ooi Aik T, Zhang Kelvin Xi, Paul Manash K, Kim Yeon Sun, Gilbert Jennifer L, Attiga Yasser S, Alva-Ornelas Jackelyn A, Nickerson Derek W, Gomperts Brigitte N   Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation Stem cells and development, 2014; 23(6): 664-75.
Ooi Aik T, Gomperts Brigitte N   Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA Clinical cancer research : an official journal of the American Association for Cancer Research, 2015; 21(11): 2440-4.
Perdomo Catalina, Campbell Joshua D, Gerrein Joseph, Tellez Carmen S, Garrison Carly B, Walser Tonya C, Drizik Eduard, Si Huiqing, Gower Adam C, Vick Jessica, Anderlind Christina, Jackson George R, Mankus Courtney, Schembri Frank, O'Hara Carl, Gomperts Brigitte N, Dubinett Steven M, Hayden Patrick, Belinsky Steven A, Lenburg Marc E, Spira Avrum   MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(47): 18946-51.
Paul Manash K, Bisht Bharti, Darmawan Daphne O, Chiou Richard, Ha Vi L, Wallace William D, Chon Andrew T, Hegab Ahmed E, Grogan Tristan, Elashoff David A, Alva-Ornelas Jackelyn A, Gomperts Brigitte N   Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling Cell stem cell, 2014; 15(2): 199-214.