Heather D. Agnew, Ph.D.

Work Address:
6160 Bristol Parkway
Suite 200
Culver City, CA 90230

Member, Molecular Pharmacology GPB Home Area
Adjunct Assistant Professor, Molecular & Medical Pharmacology

A selected list of publications:

B. Farrow, S. A. Hong, E. Romero, B. Lai, M. B. Coppock, K. M. Deyle, A. S. Finch, D. N. Stratis-Cullum, H. Agnew, S. Yang, and J. R. Heath.   A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen ACS Nano, 2013; 7(10): 9452-9460.
S. W. Millward, H. D. Agnew, S. Pitram, B. T. Lai, R. D. Rohde, and N. Hardman.   Protein Catalysed Capture Agents for Molecular Imaging, International Hospital Equipment & Solutions, 2013; (March/April): 14-16.
S. W. Millward, H. D. Agnew, B. Lai, S. S. Lee, J. Lim, A. Nag, S. Pitram, R. Rohde, and J. R. Heath.   In Situ Click Chemistry: From Small Molecule Discovery to Synthetic Antibodies Integr Biol, 2013; 5(1): 87-95.
C. H. Sohn, H. D. Agnew, J. E. Lee, M. J. Sweredoski, R. L. J. Graham, G. T. Smith, S. Hess, G. Czerwieniec, J. A. Loo, J. R. Heath, R. J. Deshaies, and J. L. Beauchamp.   Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions Anal Chem, 2012; 84(6): 2662-2669.
S. W. Millward, R. K. Henning, G. A. Kwong, S. Pitram, H. D. Agnew, K. M. Deyle, A. Nag, J. Hein, S. S. Lee, J. Lim, K. B. Sharpless, and J. R. Heath.   Iterative In Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1 J Am Chem Soc, 2011; 133(45): 18280-18288.
S. S. Lee, J. Lim, S. Tan, J. Cha, S. Y. Yeo, H. D. Agnew, and J. R. Heath.   Accurate MALDI-TOF/TOF Sequencing of One-Bead-One-Compound Peptide Libraries with Application to the Identification of Multiligand Protein Affinity Agents Using in situ Click Chemistry Screening Anal Chem, 2010; 82(2): 672-679.
H. D. Agnew, R. D. Rohde, S. W. Millward, A. Nag, W.-S. Yeo, J. E. Hein, S. M. Pitram, A. A. Tariq, V. M. Burns, R. J. Krom, V. V. Fokin, K. B. Sharpless, and J. R. Heath.   Iterative in situ Click Chemistry Creates Antibody-like Protein Capture Agents Angew Chem Int Ed, 2009; 48(27): 4944-4948.
M. C. McAlpine, H. D. Agnew, R. D. Rohde, M. Blanco, H. Ahmad, A. D. Stuparu, W. A. Goddard III, and J. R. Heath.   Peptide-Nanowire Hybrid Materials for Selective Sensing of Small Molecules J Am Chem Soc, 2008; 130(29): 9583-9589.
O. S. Miljanic, W. R. Dichtel, I. Aprahamian, R. D. Rohde, H. D. Agnew, J. R. Heath, and J. F. Stoddart.   Rotaxanes and Catenanes by Click Chemistry QSAR Comb Sci, 2007; 26(11-12): 1165-1174.
R. D. Rohde, H. D. Agnew, W.-S. Yeo, R. C. Bailey, and J. R. Heath.   A Non-Oxidative Approach toward Chemically and Electrochemically Functionalizing Si(111) J Am Chem Soc, 2006; 128(29): 9518-9525.
J. J. Lichty, J. L. Malecki, H. D. Agnew, D. J. Michelson-Horowitz, and S. Tan.   Comparison of Affinity Tags for Protein Purification Prot Expr Purif, 2005; 41(1): 98-105.
B. Farrow, M. Wong, J. Malette, B. Lai, K. M. Deyle, S. Das, A. Nag, H. D. Agnew, and J. R. Heath.   Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin Angew Chem Int Ed, 2015; 54(24): 7114-7119.
S. Das, A. Nag, J. Liang, D. N. Bunck, A. Umeda, B. Farrow, M. B. Coppock, D. A. Sarkes, A. S. Finch, H. D. Agnew, S. Pitram, B. Lai, M. B. Yu, A. K. Museth, K. M. Deyle, B. Lepe, F. P. Rodriguez-Rivera, A. McCarthy, B. Alvarez-Villalonga, A. Chen, J. Heath, D. N. Stratis-Cullum, and J. R. Heath.   A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands Angew Chem Int Ed, 2015; 54(45): 13219-13224.
M. B. Coppock, C. R. Warner, B. Dorsey, J. A. Orlicki, D. A. Sarkes, B. T. Lai, S. M. Pitram, R. D. Rohde, J. Malette, J. A. Wilson, P. Kearney, K. C. Fang, S. M. Law, S. L. Candelario, B. Farrow, A. S. Finch, H. D. Agnew, J. R. Heath, and D. N. Stratis-Cullum.   Protein Catalyzed Capture Agents with Tailored Performance for In Vitro and In Vivo Applications Biopolymers (Pept Sci), 2017; 108(2): e22934.
B. T. Lai, J. A. Wilson, J. M. Loredo, S. M. Pitram, N. A. LaBerge, J. R. Heath, and H. D. Agnew.   Epitope Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin-17F Chem Eur J, 2018; 24(15): 3760-3767.
H. D. Agnew, M. B. Coppock, M. N. Idso, B. T. Lai, J. Liang, A. M. McCarthy-Torrens, C. M. Warren, and J. R. Heath.   Protein-Catalyzed Capture Agents Chem Rev, 2019; 119(17): 9950-9970.