Hanna Katri Annikki Mikkola, M.D., Ph.D.

Mailing Address:
650 Charles E. Young Drive South
Los Angeles, CA 90095

Office Address:
BSRB 477A
477 A BSRB

Affiliations
Affiliations
Member, Cell & Developmental Biology GPB Home Area, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, Gene Regulation GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area, JCCC Gene Regulation Program Area
Biography

Hanna K.A. Mikkola is a new faculty member that joined the Department of Molecular, Cell and Developmental Biology/ Jonsson?s Comprehensive Cancer Center at UCLA in July 2005. Dr. Mikkola earned her MD PhD degrees in 1997 in University of Helsinki, Finland. Her doctorate thesis focused on molecular genetics of a congenital bleeding disorder, factor XIII deficiency. Dr. Mikkola has been interested in stem cell biology since 1998 when she started post-doctoral training in the Department of Gene Therapy and Molecular Medicine in Lund University, Sweden. She developed lentiviral vector based gene transfer protocols for stem cells and showed that these vectors are efficient tools to express transgenes in murine hematopoietic stem cells and ES-cells. In 2000 DR. Mikkola continued her post doctoral training and work with hematopoietic stem cells at Children?s Hospital/Dana-Farber Cancer Institute/Harvard Medical School, Boston. Her studies focused on resolving the role of leukemia related transcription factor SCL/tal1 in the development and maintenance of HSCs. Recent studies led by Dr. Mikkola have identified a novel hematopoietic site, the placenta, where HSCs are born and nurtured during early fetal life. At UCLA Dr. Mikkola will continue to pursue to define the molecular programs and microenvironmental cues that direct HSC formation, maturation, and expansion during fetal development.

Publications
Magnusson Mattias, Sierra Maria I, Sasidharan Rajkumar, Prashad Sacha L, Romero Melissa, Saarikoski Pamela, Van Handel Ben, Huang Andy, Li Xinmin, Mikkola Hanna K A Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability. PloS one. 2013; 8(1): e53912.
Nakano Haruko, Liu Xiaoqian, Arshi Armin, Nakashima Yasuhiro, van Handel Ben, Sasidharan Rajkumar, Harmon Andrew W, Shin Jae-Ho, Schwartz Robert J, Conway Simon J, Harvey Richard P, Pashmforoush Mohammad, Mikkola Hanna K A, Nakano Atsushi Haemogenic endocardium contributes to transient definitive haematopoiesis. Nature communications. 2013; 4(4): 1564.
Oh Philmo, Lobry Camille, Gao Jie, Tikhonova Anastasia, Loizou Evangelia, Manent Jan, van Handel Ben, Ibrahim Sherif, Greve Jeffrey, Mikkola Hanna, Artavanis-Tsakonas Spyros, Aifantis Iannis In Vivo mapping of notch pathway activity in normal and stress hematopoiesis. Cell stem cell. 2013; 13(2): 190-204.
Palomares Karina, Vigant Frederic, Van Handel Ben, Pernet Olivier, Chikere Kelechi, Hong Patrick, Sherman Sean P, Patterson Michaela, An Dong Sung, Lowry William E, Mikkola Hanna K A, Morizono Kouki, Pyle April D, Lee Benhur Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. Journal of virology. 2013; 87(4): 2094-108.
Goddard Lauren M, Ton Amy N, Org Tõnis, Mikkola Hanna K A, Iruela-Arispe M Luisa Selective suppression of endothelial cytokine production by progesterone receptor. Vascular pharmacology. 2013; 59(1-2): 36-43.
Montel-Hagen Amélie, Van Handel Ben, Mikkola Hanna [An unexpected repressive role for Scl in the embryonic endothelium]. Médecine sciences : M/S. 2013; 29(3): 257-9.
Hall-Glenn Faith, De Young R Andrea, Huang Bau-Lin, van Handel Ben, Hofmann Jennifer J, Chen Tom T, Choi Aaron, Ong Jessica R, Benya Paul D, Mikkola Hanna, Iruela-Arispe M Luisa, Lyons Karen M CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PloS one. 2012; 7(2): e30562.
Nsair Ali, Schenke-Layland Katja, Van Handel Ben, Evseenko Denis, Kahn Michael, Zhao Peng, Mendelis Joseph, Heydarkhan Sanaz, Awaji Obina, Vottler Miriam, Geist Susanne, Chyu Jennifer, Gago-Lopez Nuria, Crooks Gay M, Plath Kathrin, Goldhaber Josh, Mikkola Hanna K A, MacLellan W Robb Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PloS one. 2012; 7(10): e45603.
Xu Jian, Shao Zhen, Glass Kimberly, Bauer Daniel E, Pinello Luca, Van Handel Ben, Hou Serena, Stamatoyannopoulos John A, Mikkola Hanna K A, Yuan Guo-Cheng, Orkin Stuart H Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental cell. 2012; 23(4): 796-811.
Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. The Journal of clinical investigation. 2012; 122(1): 337-47.
Patterson Michaela, Chan David N, Ha Iris, Case Dana, Cui Yongyan, Van Handel Ben, Mikkola Hanna Ka, Lowry William E Defining the nature of human pluripotent stem cell progeny. Cell research. 2012; 22(1): 178-93.
Li Jing-Yu, Patterson Michaela, Mikkola Hanna K A, Lowry William E, Kurdistani Siavash K Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS genetics. 2012; 8(8): e1002879.
Kohn Lisa A, Hao Qian-Lin, Sasidharan Rajkumar, Parekh Chintan, Ge Shundi, Zhu Yuhua, Mikkola Hanna K A, Crooks Gay M Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nature immunology. 2012; 13(10): 963-71.
Van Handel Ben, Montel-Hagen Amélie, Sasidharan Rajkumar, Nakano Haruko, Ferrari Roberto, Boogerd Cornelis J, Schredelseker Johann, Wang Yanling, Hunter Sean, Org Tõnis, Zhou Jian, Li Xinmin, Pellegrini Matteo, Chen Jau-Nian, Orkin Stuart H, Kurdistani Siavash K, Evans Sylvia M, Nakano Atsushi, Mikkola Hanna K A Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012; 150(3): 590-605.
Chhabra Akanksha, Lechner Andrew J, Ueno Masaya, Acharya Asha, Van Handel Ben, Wang Yanling, Iruela-Arispe M Luisa, Tallquist Michelle D, Mikkola Hanna K A Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Developmental cell. 2012; 22(3): 651-9.
Schenke-Layland Katja, Nsair Ali, Van Handel Ben, Angelis Ekaterini, Gluck Jessica M, Votteler Miriam, Goldhaber Joshua I, Mikkola Hanna K, Kahn Michael, Maclellan William R Recapitulation of the embryonic cardiovascular progenitor cell niche. Biomaterials. 2011; 32(11): 2748-56.
Chhabra Akanksha, Mikkola Hanna K A Return to youth with Sox17. Genes & development. 2011; 25(15): 1557-62.
Gekas Christos, Rhodes Katrin E, Van Handel Ben, Chhabra Akanksha, Ueno Masaya, Mikkola Hanna K A Hematopoietic stem cell development in the placenta. The International journal of developmental biology. 2010; 54(6-7): 1089-98.
Lee Lydia K, Ueno Masaya, Van Handel Ben, Mikkola Hanna K A Placenta as a newly identified source of hematopoietic stem cells. Current opinion in hematology. 2010; 17(4): 313-8.
Huang Xinqiang, Gschweng Eric, Van Handel Ben, Cheng Donghui, Mikkola Hanna K A, Witte Owen N Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. Blood. 2010; .
Mikkola Hanna K A, Radu Caius G, Witte Owen N Targeting leukemia stem cells. Nature biotechnology. 2010; 28(3): 237-8.
Van Handel Ben, Prashad Sacha L, Hassanzadeh-Kiabi Nargess, Huang Andy, Magnusson Mattias, Atanassova Boriana, Chen Angela, Hamalainen Eija I, Mikkola Hanna K A The first trimester human placenta is a site for terminal maturation of primitive erythroid cells. Blood. 2010; 116(17): 3321-30.
Gereige Laurraine-Marcelle, Mikkola Hanna K A DNA methylation is a guardian of stem cell self-renewal and multipotency. Nature genetics. 2009; 41(11): 1164-6.
Park Tae Sub, Galic Zoran, Conway Anne E, Lindgren Anne, van Handel Benjamin J, Magnusson Mattias, Richter Laura, Teitell Michael A, Mikkola Hanna K A, Lowry William E, Plath Kathrin, Clark Amander T Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. Stem cells (Dayton, Ohio). 2009; 27(4): 783-95.
Mikkola Hanna ESAM: adding to the hematopoietic toolbox. Blood. 2009; 113(13): 2871-2.
Gekas Christos, Rhodes Katrin E, Gereige Laurraine M, Helgadottir Hildur, Ferrari Roberto, Kurdistani Siavash K, Montecino-Rodriguez Encarnación, Bassel-Duby Rhonda, Olson Eric, Krivtsov Andrei V, Armstrong Scott, Orkin Stuart H, Pellegrini Matteo, Mikkola Hanna K A Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009; 113(15): 3461-71.
Magnusson Mattias, Mikkola Hanna K A Hematopoietic stem cells in transit--where's the niche?. Cell stem cell. 2008; 2(4): 302-4.
Sankaran Vijay G, Menne Tobias F, Xu Jian, Akie Thomas E, Lettre Guillaume, Van Handel Ben, Mikkola Hanna K A, Hirschhorn Joel N, Cantor Alan B, Orkin Stuart H Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.). 2008; 322(5909): 1839-42.
Gekas Christos, Rhodes Katrin E, Mikkola Hanna K A Isolation and visualization of mouse placental hematopoietic stem cells. Current protocols in stem cell biology. 2008; Chapter 2(5909): Unit 2A.8.1-2A.8.14.
Schenke-Layland Katja, Rhodes Katrin E, Angelis Ekaterini, Butylkova Yekaterina, Heydarkhan-Hagvall Sepideh, Gekas Christos, Zhang Rui, Goldhaber Joshua I, Mikkola Hanna K, Plath Kathrin, MacLellan W Robb Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem cells (Dayton, Ohio). 2008; 26(6): 1537-46.
Rhodes Katrin E, Gekas Christos, Wang Yanling, Lux Christopher T, Francis Cameron S, Chan David N, Conway Simon, Orkin Stuart H, Yoder Mervin C, Mikkola Hanna K A The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell stem cell. 2008; 2(3): 252-63.
Elorza Alvaro, Hyde Brigham, Mikkola Hanna K, Collins Sheila, Shirihai Orian S UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. The Journal of biological chemistry. 2008; 283(45): 30461-70.
Schenke-Layland Katja, Angelis Ekaterini, Rhodes Katrin E, Heydarkhan-Hagvall Sepideh, Mikkola Hanna K, Maclellan W Robb Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells. Stem cells (Dayton, Ohio). 2007; 25(6): 1529-38.
Martinez-Agosto Julian A, Mikkola Hanna K A, Hartenstein Volker, Banerjee Utpal The hematopoietic stem cell and its niche: a comparative view. Genes & development. 2007; 21(23): 3044-60.
Mikkola Hanna K A, Orkin Stuart H The journey of developing hematopoietic stem cells. Development (Cambridge, England). 2006; 133(19): 3733-44.
Teitell Michael A, Mikkola Hanna K A Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development. Pediatric research. 2006; 59(4 Pt 2): 33R-9R.
Mikkola HK, Orkin SH Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in molecular medicine. . 2005; 105: 3-22.
Mikkola Hanna K A, Orkin Stuart H Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in molecular medicine. 2005; 105(3): 3-22.
Mikkola HKA, Gekas C, Orkin SH, Dieterlen-Lievre F Placenta as a site for hematopoietic stem cell development. Experimental Hematology 2005; 33: 1048-1054.
Mikkola Hanna K A, Gekas Christos, Orkin Stuart H, Dieterlen-Lievre Francoise Placenta as a site for hematopoietic stem cell development. Experimental hematology. 2005; 33(9): 1048-54.
Gekas C, Dieterlen-Lievre F, Orkin SH, Mikkola HK The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005; 8(3): 365-75.
Gekas Christos, Dieterlen-Lièvre Francoise, Orkin Stuart H, Mikkola Hanna K A The placenta is a niche for hematopoietic stem cells. Developmental cell. 2005; 8(3): 365-75.
Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. . 2005; 105(10): 3871-4.
Schlaeger Thorsten M, Mikkola Hanna K A, Gekas Christos, Helgadottir Hildur B, Orkin Stuart H Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 2005; 105(10): 3871-4.
Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol. 2004; 24(17): 7491-502.
Schlaeger Thorsten M, Schuh Anna, Flitter Simon, Fisher Andreas, Mikkola Hanna, Orkin Stuart H, Vyas Paresh, Porcher Catherine Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Molecular and cellular biology. 2004; 24(17): 7491-502.
Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. . 2003; 101(2): 508-16.
Mikkola Hanna K A, Fujiwara Yuko, Schlaeger Thorsten M, Traver David, Orkin Stuart H Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003; 101(2): 508-16.
Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003; 421(6922): 547-51.
Mikkola Hanna K A, Klintman Jenny, Yang Haidi, Hock Hanno, Schlaeger Thorsten M, Fujiwara Yuko, Orkin Stuart H Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003; 421(6922): 547-51.
Mikkola Hanna K A, Orkin Stuart H The search for the hemangioblast. Journal of hematotherapy & stem cell research. 2002; 11(1): 9-17.
Mikkola HK, Orkin SH The search for the hemangioblast. Journal of hematotherapy & stem cell research. . 2002; 11(1): 9-17.
Woods NB, Mikkola H, Nilsson E, Olsson K, Trono D, Karlsson S Lentiviral-mediated gene transfer into haematopoietic stem cells. Journal of internal medicine. . 2001; 249(4): 339-43.
Wartiovaara U, Mikkola H, Szoke G, Haramura G, Karpati L, Balogh I, Lassila R, Muszbek L, Palotie A Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A. Thromb Haemost. 2000; 84(4): 595-600.
Woods NB, Fahlman C, Mikkola H, Hamaguchi I, Olsson K, Zufferey R, Jacobsen SE, Trono D, Karlsson S Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood. . 2000; 96(12): 3725-33.
Mikkola H, Woods NB, Sjogren M, Helgadottir H, Hamaguchi I, Jacobsen SE, Trono D, Karlsson S Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells. J Virol. 2000; 74(24): 11911-8.
Hamaguchi I, Woods NB, Panagopoulos I, Andersson E, Mikkola H, Fahlman C, Zufferey R, Carlsson L, Trono D, Karlsson S Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. Journal of virology. . 2000; 74(22): 10778-84.
Loewy A, McDonagh J, Mikkola H, Teller DC, Yee VC Structure and Function of Factor XIII . Hemostasis and Thrombosis: Basic Principles and Clinical Practise 2000; 233-247.
Balogh I, Szoke G, Karpati L, Wartiovaara U, Katona E, Komaromi I, Haramura G, Pfliegler G, Mikkola H, Muszbek L Val34Leu polymorphism of plasma factor XIII: biochemistry and epidemiology in familial thrombophilia. Blood. 2000; 96(7): 2479-86.
Helio T, Wartiovaara U, Halme L, Turunen U, Mikkola H, Palotie A, Farkkila M, Kontula K Arg506Gln factor V mutation and Val34Leu factor XIII polymorphism in Finnish patients with inflammatory bowel disease. Scand J Gastroenterol. 1999; 34(2): 170-4.
Wartiovaara U, Perola M, Mikkola H, Totterman K, Savolainen V, Penttila A, Grant PJ, Tikkanen MJ, Vartiainen E, Karhunen PJ, Peltonen L, Palotie A Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males. Atherosclerosis. 1999; 142(2): 295-300.
Kohler HP, Stickland MH, Ossei-Gerning N, Carter A, Mikkola H, Grant PJ Association of a common polymorphism in the factor XIII gene with myocardial infarction. Thrombosis and haemostasis. . 1998; 79(1): 8-13.
Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation. Thrombosis and haemostasis. . 1998; 80(1): 171-5.
Mikkola H, Muszbek L, Laiho E, Syrjala M, Hamalainen E, Haramura G, Salmi T, Peltonen L, Palotie A Molecular mechanism of a mild phenotype in coagulation factor XIII (FXIII) deficiency: a splicing mutation permitting partial correct splicing of FXIII A-subunit mRNA. Blood. 1997; 89(4): 1279-87.
Mikkola H, Muszbek L, Haramura G, Hmlinen E, Jalanko A, Palotie A Molecular mechanisms of mutations in factor XIII A-subunit deficiency: in vitro expression in COS-cells demonstrates intracellular degradation of the mutant proteins. Thrombosis and haemostasis. . 1997; 77(6): 1068-72.
Laiho E, Ignatius J, Mikkola H, Yee VC, Teller DC, Niemi KM, Saarialho-Kere U, Kere J, Palotie A Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population. American journal of human genetics. . 1997; 61(3): 529-38.
Mikkola H, Yee VC, Syrjala M, Seitz R, Egbring R, Petrini P, Ljung R, Ingerslev J, Teller DC, Peltonen L, Palotie A Four novel mutations in deficiency of coagulation factor XIII: consequences to expression and structure of the A-subunit. Blood. 1996; 87(1): 141-51.
Mikkola H, Palotie A Gene defects in congenital factor XIII deficiency. Seminars in thrombosis and hemostasis. . 1996; 22(5): 393-8.
Muszbek L, Adany R, Mikkola H Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function. Crit Rev Clin Lab Sci. 1996; 33(5): 357-421.
Mikkola H, Syrjala M, Rasi V, Vahtera E, Hamalainen E, Peltonen L, Palotie A Deficiency in the A-subunit of coagulation factor XIII: two novel point mutations demonstrate different effects on transcript levels. Blood. 1994; 84(2): 517-25.