Frank Pajonk, M.D., Ph.D.

Mailing Address:
UCLA Rad Onc
BOX 951714
B3-109 CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Radiation Oncology
Member, Cell & Developmental Biology GPB Home Area, JCCC Signal Transduction and Therapeutics Program Area, Physics & Biology in Medicine GPB Home Area
Publications

A selected list of publications:

Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank   Metabolic state of glioma stem cells and nontumorigenic cells Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(38): 16062-7.
Donna Lorenza Della, Lagadec Chann, Pajonk Frank   Radioresistance of prostate cancer cells with low proteasome activity The Prostate, 2011; 108(38): .
Vlashi Erina, Mattes Malcom, Lagadec Chann, Donna Lorenza Della, Phillips Tiffany M, Nikolay Polin, McBride William H, Pajonk Frank   Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells Translational oncology, 2010; 3(1): 50-5.
Evers Patrick, Lee Percy P, DeMarco John, Agazaryan Nzhde, Sayre James W, Selch Michael, Pajonk Frank   Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma BMC cancer, 2010; 10(38): 384.
Pajonk Frank, Vlashi Erina, McBride William H   Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited Stem cells (Dayton, Ohio), 2010; 28(4): 639-48.
Lagadec Chann, Vlashi Erina, Della Donna Lorenza, Meng Yonghong, Dekmezian Carmen, Kim Kwanghee, Pajonk Frank   Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment Breast cancer research : BCR, 2010; 12(1): R13.
Vlashi Erina, Pajonk Frank   Targeted cancer stem cell therapies start with proper identification of the target Molecular cancer research : MCR, 2010; 8(2): 291; author reply 291.
Vlashi, E. Kim, K. Dealla Donna, L. Lagadec, C. McDonald, T Eghbali, M. Sayre, JW. Stefani, E. McBride, WH. Pajonk, F.   In-vivo imaging, tracking, and targeting of cancer stem cells J Natl Cancer Inst, 2009; 101(5): 350-359.
Woodward, W. A. Bristow, R. G. Clarke, M. F. Coppes, R. P. Cristofanilli, M. Duda, D. G. Fike, J. R. Hambardzumyan, D. Hill, R. P. Jordan, C. T. Milas, L. Pajonk, F. Curran, W. J. Dicker, A. P. Chen, Y.   Radiation Therapy Oncology Group Translational Research Program Stem Cell Symposium: Incorporating Stem Cell Hypotheses into Clinical Trials Int J Radiat Oncol Biol Phys, 2009; volume(number): pages.
Vlashi Erina, McBride William H, Pajonk Frank   Radiation responses of cancer stem cells Journal of cellular biochemistry, 2009; 108(2): 339-42.
Phillips, T. M. Kim, K. Vlashi, E. McBride, W. H. Pajonk, F.   Effects of recombinant erythropoietin on breast cancer-initiating cells Neoplasia, 2007; 9(12): 1122-9.
Henke, M. Mattern, D. Pepe, M. Bezay, C. Weissenberger, C. Werner, M. Pajonk, F.   Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol, 2006; 24(29): 4708-13.
Henke, M. Mattern, D. Pepe, M. Bezay, C. Weissenberger, C. Werner, M. Pajonk, F.   Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol, 2006; 24(29): 4708-13.
Pajonk, F. Riedisser, A. Henke, M. McBride, W.H. Fiebich, B.   The Effects Of Tea Extracts On Proinflammatory Signaling BMC Medicine, 2006; 4(28): pages.
Pajonk, F. Grumann, T. McBride, W. H.   The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation Neoplasia, 2006; 8(12): 1037-41.
Phillips, T. M. McBride, W. H. Pajonk, F.   The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation J Natl Cancer Inst, 2006; 98(24): 1777-85.
Fekete, M. R. McBride, W. H. Pajonk, F.   Anthracyclines, proteasome activity and mult-drug-resistance BMC Cancer, 2005; 5(1): 114.
Pajonk, F. Scholber, J. Fiebich, B.   Hypericin-an inhibitor of proteasome function Cancer Chemother Pharmacol, 2005; 55(5): 439-46.
Pajonk, F. van Ophoven, A. McBride, W. H.   Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells Cancer Res, 2005; 65(11): 4836-43.
Pajonk, F. van Ophoven, A. Weissenberger, C. McBride, W. H.   The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism BMC Cancer, 2005; 5(1): 76.
McBride, W. H. Chiang, C. S. Olson, J. L. Wang, C. C. Hong, J. H. Pajonk, F. Dougherty, G. J. Iwamoto, K. S. Pervan, M. Liao, Y. P.   A sense of danger from radiation Radiat Res, 2004; 162(1): 1-19.
Henke, M. Pajonk, F.   Erythropoietin to treat anaemia in patients with head and neck cancer. The Lancet, 2004; 363(9413): 993.
Pajonk, F. Weil, A. Sommer, A. Suwinski, R. Henke, M.   The erythropoietin-receptor pathway modulates survival of cancer cells Oncogene, 2004; 23(55): 8987-91.
McBride, W. H. Iwamoto, K. S. Syljuasen, R. Pervan, M. Pajonk, F.   The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene, 2003; 22(37): 5755-73.
Pajonk, F. Riess, K. Sommer, A. McBride, W. H.   N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation Free Radic Biol Med, 2002; 32(6): 536-43.
McBride, W. H. Pajonk, F. Chiang, C. S. Sun, J. R.   NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure Mil Med, 2002; 167(2 Suppl): 66-7.
Pajonk, F. McBride, W. H.   Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy Aids, 2002; 16(8): 1195-6.
Pajonk, F. Himmelsbach, J. Riess, K. Sommer, A. McBride, W. H.   The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer Res, 2002; 62(18): 5230-5.
Pajonk, F. Weissenberger, C. Witucki, G. Henke, M.   Vitiligo at the sites of irradiation in a patient with Hodgkin's disease Strahlenther Onkol, 2002; 178(3): 159-62.
Pajonk, F. Schlessmann, S. Guttenberger, R. Henke, M.   Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significance Radiother Oncol, 2001; 59(2): 213-7..
Pajonk, F. McBride, W. H.   Ionizing radiation affects 26s proteasome function and associated molecular responses, even at low doses Radiother Oncol, 2001; 59(2): 203-12..
Pervan, M. Pajonk, F. Sun, J. R. Withers, H. R. McBride, W. H.   Molecular pathways that modify tumor radiation response Am J Clin Oncol, 2001; 24(5): 481-5.
Pajonk, F. McBride, W. H.   The Proteasome in Cancer Biology and Treatment Radiat Res, 2001; 156(5): 447-459.
Pervan, Milena Pajonk, Frank Sun, Ji-Rong Withers, Rodney H. McBride, William H.   The proteasome inhibitor PS-341 is a potential radiosensitizer Proceedings of the American Association for Cancer Research Annual Meeting, 2001; 42(number): 666-667.
Pajonk, F. Pajonk, K. McBride, W. H.   Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition International Journal of Radiation Oncology, Biology, Physics, 2000; 47(4): 1025-32.
Pajonk, F. McBride, W. H.   Comment on double-strand break repair and rapamycin treatment Int J Radiat Biol, 2000; 76(12): 1691-3..
Henke, M. Guttenberger, R. Barke, A. Pajonk, F. Potter, R. Frommhold, H.   Erythropoietin for patients undergoing radiotherapy: a pilot study Radiother Oncol, 1999; 50(2): 185-90..
Pajonk, F. Pajonk, K. McBride, W. H.   Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells Journal of the National Cancer Institute, 1999; 91(22): 1956-60.
Pajonk, F. Flick, H. Mittelviefhaus, H. Slanina, J.   Postoperative pterygium prevention by radiotherapy with strontium-90 beta-rays Frontiers of Radiation Therapy and Oncology, 1997; 30(7): 259-64.
Henke Michael, Mattern Dominik, Pepe Margaret, Bézay Christina, Weissenberger Christian, Werner Martin, Pajonk Frank   Do erythropoietin receptors on cancer cells explain unexpected clinical findings? Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006; 24(29): 4708-13.
Lagadec Chann, Vlashi Erina, Bhuta Sunita, Lai Chi, Mischel Paul, Werner Martin, Henke Michael, Pajonk Frank   Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients BMC cancer, 2014; 14: 152.
Fekete Mirela R, McBride William H, Pajonk Frank   Anthracyclines, proteasome activity and multi-drug-resistance BMC cancer, 2005; 5(4 Pt 1): 114.
van Ophoven Arndt, Rossbach Gordon, Pajonk Frank, Hertle Lothar   Safety and efficacy of hyperbaric oxygen therapy for the treatment of interstitial cystitis: a randomized, sham controlled, double-blind trial The Journal of urology, 2006; 176(4 Pt 1): 1442-6.
Lagadec Chann, Vlashi Erina, Frohnen Patricia, Alhiyari Yazeed, Chan Mabel, Pajonk Frank   The RNA-binding protein Musashi-1 regulates proteasome subunit expression in breast cancer- and glioma-initiating cells Stem cells (Dayton, Ohio), 2014; 32(1): 135-44.
Pajonk Frank, van Ophoven Arndt, Weissenberger Christian, McBride William H   The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism BMC cancer, 2005; 5(4 Pt 1): 76.
Lagadec Chann, Vlashi Erina, Alhiyari Yazeed, Phillips Tiffany M, Bochkur Dratver Milana, Pajonk Frank   Radiation-induced Notch signaling in breast cancer stem cells International journal of radiation oncology, biology, physics, 2013; 87(3): 609-18.
Pajonk Frank, van Ophoven Arndt, McBride William H   Hyperthermia-induced proteasome inhibition and loss of androgen receptor expression in human prostate cancer cells Cancer research, 2005; 65(11): 4836-43.
Pajonk Frank, Vlashi Erina   Characterization of the stem cell niche and its importance in radiobiological response Seminars in radiation oncology, 2013; 23(4): 237-41.
Pajonk Frank, Weil Antonia, Sommer Alfred, Suwinski Rafal, Henke Michael   The erythropoietin-receptor pathway modulates survival of cancer cells Oncogene, 2004; 23(55): 8987-91.
Vlashi Erina, Lagadec Chann, Chan Mabel, Frohnen Patricia, McDonald Alexandra Jean, Pajonk Frank   Targeted elimination of breast cancer cells with low proteasome activity is sufficient for tumor regression Breast cancer research and treatment, 2013; 141(2): 197-203.
McBride William H, Chiang Chi-Shiun, Olson Jennifer L, Wang Chun-Chieh, Hong Ji-Hong, Pajonk Frank, Dougherty Graeme J, Iwamoto Keisuke S, Pervan Milena, Liao Yu-Pei   A sense of danger from radiation Radiation research, 2004; 162(1): 1-19.
Steinberg Michael, McBride William H, Vlashi Erina, Pajonk Frank   National Institutes of Health funding in radiation oncology: a snapshot International journal of radiation oncology, biology, physics, 2013; 86(2): 234-40.
McBride William H, Iwamoto Keisuke S, Syljuasen Randi, Pervan Milena, Pajonk Frank   The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene, 2003; 22(37): 5755-73.
Lagadec Chann, Pajonk Frank   Catch-22: does breast cancer radiotherapy have negative impacts too? Future oncology (London, England), 2012; 8(6): 643-5.
Pajonk Frank, Himmelsbach Judith, Riess Katrin, Sommer Alfred, McBride William H   The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer research, 2002; 62(18): 5230-5.
Lagadec Chann, Vlashi Erina, Della Donna Lorenza, Dekmezian Carmen, Pajonk Frank   Radiation-induced reprogramming of breast cancer cells Stem cells (Dayton, Ohio), 2012; 30(5): 833-44.
Pajonk Frank, McBride William H   Survival of AIDS patients with primary central nervous system lymphoma may be improved by the radiosensitizing effects of highly active antiretroviral therapy AIDS (London, England), 2002; 16(8): 1195-6.
Lagadec Chann, Dekmezian Carmen, Bauché Lucile, Pajonk Frank   Oxygen levels do not determine radiation survival of breast cancer stem cells PloS one, 2012; 7(3): e34545.
Woodward Wendy A, Bristow Robert G, Clarke Michael F, Coppes Robert P, Cristofanilli Massimo, Duda Dan G, Fike John R, Hambardzumyan Dolores, Hill Richard P, Jordan Craig T, Milas Luka, Pajonk Frank, Curran Walter J, Dicker Adam P, Chen Yuhchyau   Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials International journal of radiation oncology, biology, physics, 2009; 74(5): 1580-91.
Pajonk Frank, Riess Katrin, Sommer Alfred, McBride William H   N-acetyl-L-cysteine inhibits 26S proteasome function: implications for effects on NF-kappaB activation Free radical biology & medicine, 2002; 32(6): 536-43.
Vlashi Erina, Kim Kwanghee, Lagadec Chann, Donna Lorenza Della, McDonald John Tyson, Eghbali Mansoureh, Sayre James W, Stefani Encrico, McBride William, Pajonk Frank   In vivo imaging, tracking, and targeting of cancer stem cells Journal of the National Cancer Institute, 2009; 101(5): 350-9.
McBride William H, Pajonk Frank, Chiang Chi-Shuin, Sun Ji-Rong   NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure Military medicine, 2002; 167(2 Suppl): 66-7.
Pajonk Frank, Weissenberger Christian, Witucki Gerlo, Henke Michael   Vitiligo at the sites of irradiation in a patient with Hodgkin's disease Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al], 2002; 178(3): 159-62.
Phillips Tiffany M, Kim Kwanghee, Vlashi Erina, McBride William H, Pajonk Frank   Effects of recombinant erythropoietin on breast cancer-initiating cells Neoplasia (New York, N.Y.), 2007; 9(12): 1122-9.
Phillips Tiffany M, McBride William H, Pajonk Frank   The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation Journal of the National Cancer Institute, 2006; 98(24): 1777-85.
Pajonk Frank, Riedisser Anja, Henke Michael, McBride William H, Fiebich Bernd   The effects of tea extracts on proinflammatory signaling BMC medicine, 2006; 4(24): 28.
Pajonk Frank, Grumann Thorsten, McBride William H   The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinoma cells after cyclic hypoxia/reoxygenation from ionizing radiation Neoplasia (New York, N.Y.), 2006; 8(12): 1037-41.
Vlashi Erina, Lagadec Chann, Vergnes Laurent, Reue Karen, Frohnen Patricia, Chan Mabel, Alhiyari Yazeed, Dratver Milana Bochkur, Pajonk Frank   Metabolic differences in breast cancer stem cells and differentiated progeny Breast cancer research and treatment, 2014; 146(3): 525-34.
Vlashi Erina, Pajonk Frank   Cancer stem cells, cancer cell plasticity and radiation therapy Seminars in cancer biology, 2015; 31: 28-35.
Yu Victoria Y, Nguyen Dan, Pajonk Frank, Kupelian Patrick, Kaprealian Tania, Selch Michael, Low Daniel A, Sheng Ke   Incorporating cancer stem cells in radiation therapy treatment response modeling and the implication in glioblastoma multiforme treatment resistance International journal of radiation oncology, biology, physics, 2015; 91(4): 866-75.
Vlashi Erina, Pajonk Frank   The metabolic state of cancer stem cells-a valid target for cancer therapy? Free radical biology & medicine, 2015; 79(4): 264-8.