Simon William Beaven, M.D., Ph.D.

Work Address:
200 UCLA Medical Plaza
#214
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Digestive Diseases/Gastroenterology
Member, CTSI, Hepatology, Molecular, Cellular & Integrative Physiology GPB Home Area, Pfleger Liver Institute, themes
Biography:

Dr. Beaven attended Stanford University where he majored in mathematics with honors in humanities. He went on to receive his MD from the University of California, San Francisco, and received the Dean’s Research Prize for work he performed in the laboratory of Dr. Scott Friedman under a Howard Hughes Medical Student Research Fellowship. Dr. Beaven completed internal medicine residency training at the Brigham & Women’s Hospital and Harvard Medical School in Boston. He came to UCLA in 2003 as a fellow in digestive diseases where he completed his gastroenterology fellowship. During this period, Dr. Beaven continued his research training and received a PhD with Dr. Peter Tontonoz in the Howard Hughes Medical Institute and Department of Pathology. His doctoral work focused on cholesterol and lipid metabolism as it pertains to an important clinical problem: the metabolic syndrome. His major research interests include the genetics of liver fibrosis, especially in relation to fatty liver and the metabolic syndrome, the study of rare GI diseases (porphyrias and familial Mediterranean fever), and quality improvement projects in gastroenterology and liver disease at Olive View – UCLA Medical Center.

Dr. Beaven joined the digestive diseases faculty at UCLA as an assistant professor in 2010. He is a research director for the Center for Obesity and Metabolic Health (COMET), which studies how metabolic pathways influence liver and gastrointestinal diseases. He has been studying the biology of the hepatic stellate cell, the key scar-forming cell in all forms of liver disease (e.g. fatty liver, viral hepatitis, alcoholic liver disease). This work is aimed at better understanding the genetics of liver fibrosis and the development of better tools to detect and predict outcomes from liver disease. He is a member of the American Porphyria Foundation and has joined the NIH-funded Porphyria Research Consortium. More recently, he is spearheading an effort to focus on rare liver and GI diseases such as the porphyrias and familial Mediterranean fever (FMF).  Dr. Beaven and his trainees have received awards from the UCLA Department of Medicine Research Day, UCLA CURE, and the American Association for the Study of Liver Diseases (AASLD). He is an active peer reviewer for several scientific journals, including Diabetes, Molecular & Cellular Biology, Hepatology, Gastroenterology, and the Journal of Lipid Research. Dr. Beaven teaches in the medical school at all levels and lectures to medical residents and fellows on issues related to liver and gastrointestinal disease. He primarily sees patients with liver diseases at the Pfleger Liver Institute (UCLA) and patients with liver disease and general GI conditions at Olive View – UCLA Medical Center.

Publications

A selected list of publications:

Hui ST, Kurt Z, Tuominen I, Norheim F, Davis RC, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ   The Genetic Architecture of Diet-induced Hepatic Fibrosis in Mice Hepatology, 2018; .
O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW   Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein Hepatology, 2015; .
Clark PM, Flores G, Evdokimov NM, McCracken MN, Chai T, Nair-Gill E, O'Mahony F, Beaven SW, Faull KF, Phelps ME, Jung ME, Witte ON   Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver Proc Natl Acad Sci U S A, 2014; .
Beaven Simon W, Matveyenko Aleksey, Wroblewski Kevin, Chao Lily, Wilpitz Damien, Hsu Tu Wen, Lentz Jacob, Drew Brian, Hevener Andrea L, Tontonoz Peter   Reciprocal regulation of hepatic and adipose lipogenesis by liver x receptors in obesity and insulin resistance Cell metabolism, 2013; 18(1): 106-17.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C   Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits Mammalian genome : official journal of the International Mammalian Genome Society, 2012; 23(9-10): 680-92.
Chen Xuqi, McClusky Rebecca, Chen Jenny, Beaven Simon W, Tontonoz Peter, Arnold Arthur P, Reue Karen   The number of x chromosomes causes sex differences in adiposity in mice PLoS genetics, 2012; 8(5): e1002709.
Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J   Coordinate regulation of neutrophil homeostasis by liver X receptors in mice The Journal of clinical investigation, 2012; 122(1): 337-47.
Beaven Simon W, Wroblewski Kevin, Wang Jiaohong, Hong Cynthia, Bensinger Steven, Tsukamoto Hide, Tontonoz Peter   Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease Gastroenterology, 2011; 140(3): 1052-62.
Ribas Vicent, Nguyen M T Audrey, Henstridge Darren C, Nguyen Anh-Khoi, Beaven Simon W, Watt Matthew J, Hevener Andrea L   Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice American journal of physiology. Endocrinology and metabolism, 2010; 298(2): E304-19.
Dean Jason T, Tran Linh, Beaven Simon, Tontonoz Peter, Reue Karen, Dipple Katrina M, Liao James C   Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt Cell metabolism, 2009; 9(6): 525-36.
Bansal Meena B, Beaven Simon W, Rockey Don C   Scott L. Friedman, 59th President, AASLD Hepatology (Baltimore, Md.), 2008; 48(5): 1357-8.
Banck Michaela S, Beaven Simon W, Narla Goutham, Walsh Martin J, Friedman Scott L, Beutler Andreas S   KLF6 degradation after apoptotic DNA damage FEBS letters, 2006; 580(30): 6981-6.
Beaven Simon W, Tontonoz Peter   Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia Annual review of medicine, 2006; 57(20): 313-29.
Chen Mingyi, Bradley Michelle N, Beaven Simon W, Tontonoz Peter   Phosphorylation of the liver X receptors FEBS letters, 2006; 580(20): 4835-41.
Chen Mingyi, Beaven Simon, Tontonoz Peter   Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha Journal of lipid research, 2005; 46(12): 2570-9.
Beaven Simon W, Martín Martín G   Tales from the crypt: beta-catenin in the development of juvenile polyps: commentary on the article by Iwamoto et al. on page 4 Pediatric research, 2005; 57(1): 1-3.
Beaven Simon W, Abreu Maria T   Biomarkers in inflammatory bowel disease Current opinion in gastroenterology, 2004; 20(4): 318-27.