Timothy Donahue, M.D.

Mailing Address:
UCLA Surg-Surg Onc
BOX 956904
72-215
Los Angeles, CA 90095

Office Address:
10833 Le Conte Ave.
72-256 CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Surgery, General Surgery, Molecular & Medical Pharmacology
Member, CTSI, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area, Molecular Pharmacology GPB Home Area, themes
Biography

Dr. Timothy Donahue is a Professor of Surgery at the David Geffen School of Medicine at UCLA. He also serves as the Chief of the Division of Surgical Oncology, and Vice Chair for Clinical Cancer Care. Dr. Donahue oversees the UCLA pancreatic cancer program which is one of the largest in the nation. He also has a joint appointment in the Department of Molecular and Medical Pharmacology to facilitate his research program.

Dr. Donahue is a very busy pancreatic surgeon. He performs three to four pancreatic surgeries per week. He is genuinely interested in caring for patients with pancreatic cancer. His clinical research is focused on improving the care of patients with borderline resectable or locally advanced disease. Dr. Donahue is a strong advocate of prolonged preoperative chemo- or radiation therapy for this group of patients to optimally select for those who will benefit from a surgical resection. As a result of this approach, Dr. Donahue and his team have among the best reported survival rates reported in the world.

In addition to his clinical work, Dr. Donahue is the Principal Investigator of a National Institutes of Health funded research laboratory. His scientific research focuses on developing improved treatment strategies and earlier diagnostic markers for patients with pancreatic cancer. He collaborates closely with other scientists across the UCLA campus, including faculty in the Ahmanson Translational Imaging Division and California Nanosystems Institute. He is optimistic that therapy for pancreatic cancer will markedly improve during his career.

After graduating from college and medical school at Northwestern University, Dr. Donahue completed his surgical and research training at UCLA. He has been on the faculty and in his current role since 2009. He resides in the Pacific Palisades with his wife and three children.

Publications

A selected list of publications:

Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Calvopina Joseph Hargan, Garcia Alejandro, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong   Cell intrinsic role of COX-2 in pancreatic cancer development Molecular cancer therapeutics, 2012; 11(10): 2127-37.
Donahue Timothy R, Tran Linh M, Hill Reginald, Li Yunfeng, Kovochich Anne, Hargan Calvopina Joseph, Patel Sanjeet G, Wu Nanping, Hindoyan Antreas, Farrell James J, Li Xinmin, Dawson David W, Wu Hong   Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2012; .
Donahue Timothy R, Dawson David W   Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy Cell stem cell, 2011; 9(5): 383-4.
Sherman Mara H, Yu Ruth T, Engle Dannielle D, Ding Ning, Atkins Annette R, Tiriac Herve, Collisson Eric A, Connor Frances, Van Dyke Terry, Kozlov Serguei, Martin Philip, Tseng Tiffany W, Dawson David W, Donahue Timothy R, Masamune Atsushi, Shimosegawa Tooru, Apte Minoti V, Wilson Jeremy S, Ng Beverly, Lau Sue Lynn, Gunton Jenny E, Wahl Geoffrey M, Hunter Tony, Drebin Jeffrey A, O'Dwyer Peter J, Liddle Christopher, Tuveson David A, Downes Michael, Evans Ronald M   Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy Cell, 2014; 159(1): 80-93.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G   [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(15): 4027-32.
Le Thuc M, Poddar Soumya, Capri Joseph R, Abt Evan R, Kim Woosuk, Wei Liu, Uong Nhu T, Cheng Chloe M, Braas Daniel, Nikanjam Mina, Rix Peter, Merkurjev Daria, Zaretsky Jesse, Kornblum Harley I, Ribas Antoni, Herschman Harvey R, Whitelegge Julian, Faull Kym F, Donahue Timothy R, Czernin Johannes, Radu Caius G   ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways Nature communications, 2017; 8(1): 241.
Liu Xiangsheng, Situ Allen, Kang Yanan, Villabroza Katie Rose, Liao Yupei, Chang Chong Hyun, Donahue Timothy, Nel Andre E, Meng Huan   Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer ACS nano, 2016; 10(2): 2702-15.
Liu Xiangsheng, Lin Paulina, Perrett Ian, Lin Joshua, Liao Yu-Pei, Chang Chong Hyun, Jiang Jinhong, Wu Nanping, Donahue Timothy, Wainberg Zev, Nel Andre E, Meng Huan   Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer The Journal of clinical investigation, 2017; 127(5): 2007-2018.
Elliott Irmina A, Dann Amanda M, Ghukasyan Razmik, Damato Lauren, Girgis Mark D, King Jonathan C, Hines O J, Reber Howard A, Donahue Timothy R   Pasireotide does not prevent postoperative pancreatic fistula: a prospective study HPB : the official journal of the International Hepato Pancreato Biliary Association, 2018; 20(5): 418-422.
Toste Paul A, Nguyen Andrew H, Kadera Brian E, Duong Mindy, Wu Nanping, Gawlas Irmina, Tran Linh M, Bikhchandani Mihir, Li Luyi, Patel Sanjeet G, Dawson David W, Donahue Timothy R   Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK Molecular cancer research : MCR, 2016; 14(5): 437-47.
Nguyen Andrew H, Elliott Irmina A, Wu Nanping, Matsumura Cynthia, Vogelauer Maria, Attar Narsis, Dann Amanda, Ghukasyan Razmik, Toste Paul A, Patel Sanjeet G, Williams Jennifer L, Li Luyi, Dawson David W, Radu Caius, Kurdistani Siavash K, Donahue Timothy R   Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts Oncotarget, 2017; 8(12): 19074-19088.