Office Phone Number:
650 Charles E. Young Drive
Los Angeles , CA 90095
700 Tiverton Ave.
Factor Bldg 12-272
Los Angeles, CA 90095
BOX 951732, Factor 12-272
Los Angeles, CA 90095
Dinesh S. Rao received a B.S. summa cum laude in Biochemistry and an M.D. from Case Western Reserve University, Cleveland, USA. During this time he developed a deep interest in the pathogenesis of cancer, completing several projects in cancer research during medical school, and went on to a research fellowship at the University of Michigan. There, he made a seminal discovery implicating clathrin mediated trafficking of growth factor receptor tyrosine kinases in the pathogenesis of oncogenic transformation. He then combined clinical training in the pathology of hematologic diseases with further research training in the laboratory of Nobel laureate David Baltimore at Caltech. His research came to focus on the involvement of microRNAs in hematologic development, particularly B-cell development and immunity, and cancer, and resulted in several high-impact publications in well-regarded journals. His research interests include how microRNAs and other non-coding RNAs regulate hematopoietic development and cancer. He combines running a vibrant research laboratory with a busy diagnostic service in leukemia and lymphoma pathology.
Rao Dinesh S, O'Connell Ryan M, Chaudhuri Aadel A, Garcia-Flores Yvette, Geiger Theresa L, Baltimore David MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity. 2010; 33(1): 48-59.
O'Connell Ryan M, Chaudhuri Aadel A, Rao Dinesh S, Gibson William S J, Balazs Alejandro B, Baltimore David MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proceedings of the National Academy of Sciences of the United States of America. 2010; .
O'Connell Ryan M, Rao Dinesh S, Chaudhuri Aadel A, Baltimore David Physiological and pathological roles for microRNAs in the immune system. Nature reviews. Immunology. 2010; 10(2): 111-22.
O'Connell Ryan M, Balazs Alejandro B, Rao Dinesh S, Kivork Christine, Yang Lili, Baltimore David Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PloS one. 2010; 5(8): .
O'Connell Ryan M, Chaudhuri Aadel A, Rao Dinesh S, Baltimore David Inositol phosphatase SHIP1 is a primary target of miR-155. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(17): 7113-8.
Baltimore David, Boldin Mark P, O'Connell Ryan M, Rao Dinesh S, Taganov Konstantin D MicroRNAs: new regulators of immune cell development and function. Nature immunology. 2008; 9(8): 839-45.
O'Connell Ryan M, Rao Dinesh S, Chaudhuri Aadel A, Boldin Mark P, Taganov Konstantin D, Nicoll John, Paquette Ronald L, Baltimore David Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. The Journal of experimental medicine. 2008; 205(3): 585-94.
Pullarkat Sheeja T, Vardiman James W, Slovak Marilyn L, Rao Dinesh S, Rao Nagesh P, Bedell Victoria, Said Jonathan W Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia. Leukemia research. 2008; 32(11): 1770-5.
Rao Dinesh S, Said Jonathan W Small lymphoid proliferations in extranodal locations. Archives of pathology & laboratory medicine. 2007; 131(3): 383-96.
Rao Dinesh S, Gui Dorina, Koski Michelle E, Popoviciu Laura M, Wang Hejing, Reiter Robert E, Said Jonathan W An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry. 2006; 14(4): 375-83.
Pham Peter H, Rao Dinesh S, Vasunilashorn Fah, Fishbein Michael C, Goldin Jonathan G Computed tomography calcium quantification as a measure of atherosclerotic plaque morphology and stability. Investigative radiology. 2006; 41(9): 674-80.
Kaluza Vesna, Rao Dinesh S, Said Jonathan W, de Vos Sven Primary extranodal nasal-type natural killer/T-cell lymphoma of the brain: a case report. Human pathology. 2006; 37(6): 769-72.
Rao Dinesh S, Infeld Michael D, Stern Robert C, Chelimsky Thomas C Cough-induced hemiplegic migraine with impaired consciousness in cystic fibrosis. Pediatric pulmonology. 2006; 41(2): 171-6.
Rao Dinesh S, Goldin Jonathan G, Fishbein Michael C Determinants of plaque instability in atherosclerotic vascular disease. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2006; 14(6): 285-93.
Hyun Teresa S, Rao Dinesh S, Saint-Dic Djenann, Michael L Evan, Kumar Priti D, Bradley Sarah V, Mizukami Ikuko F, Oravecz-Wilson Katherine I, Ross Theodora S HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. The Journal of biological chemistry. 2004; 279(14): 14294-306.
Oravecz-Wilson Katherine I, Kiel Mark J, Li Lina, Rao Dinesh S, Saint-Dic Djenann, Kumar Priti D, Provot Melissa M, Hankenson Kurt D, Reddy Venkat N, Lieberman Andrew P, Morrison Sean J, Ross Theodora S Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Human molecular genetics. 2004; 13(8): 851-67.
Rao Dinesh S, Bradley Sarah V, Kumar Priti D, Hyun Teresa S, Saint-Dic Djenann, Oravecz-Wilson Katherine, Kleer Celina G, Ross Theodora S Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer cell. 2003; 3(5): 471-82.
Rao Dinesh S, Hyun Teresa S, Kumar Priti D, Mizukami Ikuko F, Rubin Mark A, Lucas Peter C, Sanda Martin G, Ross Theodora S Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. The Journal of clinical investigation. 2002; 110(3): 351-60.
Rao, D. S. Chang, J. C. Kumar, P. D. Mizukami, I. Smithson, G. M. Bradley, S. V. Parlow, A. F. Ross, T. S. Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Molecular and Cellular Biology 2001; 21(22): 7796-806.
Balazs Alejandro B, Chen Joyce, Hong Christin M, Rao Dinesh S, Yang Lili, Baltimore David Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2011; .
O'Connell Ryan M, Zhao Jimmy L, Rao Dinesh S MicroRNA function in myeloid biology. Blood. 2011; 118(11): 2960-9.
Chaudhuri Aadel A, So Alex Yick-Lun, Mehta Arnav, Minisandram Aarathi, Sinha Nikita, Jonsson Vanessa D, Rao Dinesh S, O'Connell Ryan M, Baltimore David Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(11): 4233-8.
Fernando Thilini R, Rodriguez-Malave Norma I, Rao Dinesh S MicroRNAs in B cell development and malignancy. Journal of hematology & oncology. 2012; 5(11): 7.
Pigazzi Martina, Manara Elena, Bresolin Silvia, Tregnago Claudia, Beghin Alessandra, Baron Emma, Giarin Emanuela, Cho Er-Chieh, Masetti Riccardo, Rao Dinesh S, Sakamoto Kathleen M, Basso Giuseppe MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation. Haematologica. 2013; 98(4): 602-10.
O'Connell Ryan M, Rao Dinesh S, Baltimore David microRNA regulation of inflammatory responses. Annual review of immunology. 2012; 30(2): 295-312.
Hur Eun Mi, Patel Sonal N, Shimizu Saki, Rao Dinesh S, Gnanapragasam Priyanthi N P, An Dong Sung, Yang Lili, Baltimore David Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood. 2012; 120(23): 4571-82.
Zhao Jimmy L, Rao Dinesh S, O'Connell Ryan M, Garcia-Flores Yvette, Baltimore David MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. eLife. 2013; 2(7): e00537.
Tirado Carlos A, Shabsovich David, Denicola Matthew, Rao Dinesh, Yang Lynn, Garcia Rolando, Rao Nagesh A case of pediatric B-Lymphoblastic leukemia presenting with a t(9;12)(p24;q11.2) involving JAK2 and concomitant MLL rearrangement with apparent insertion at 6q27. Biomarker research. 2013; 1(1): 31.
Basak Saroj K, Veena Mysore S, Oh Scott, Lai Chi, Vangala Sitaram, Elashoff David, Fishbein Michael C, Sharma Sanjai, Rao Nagesh P, Rao Dinesh, Phan Ryan, Srivatsan Eri S, Batra Raj K The CD44(high) tumorigenic subsets in lung cancer biospecimens are enriched for low miR-34a expression. PloS one. 2013; 8(9): e73195.
Balazs Alejandro B, Bloom Jesse D, Hong Christin M, Rao Dinesh S, Baltimore David Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nature biotechnology. 2013; 31(7): 647-52.
Balazs Alejandro B, Ouyang Yong, Hong Christin M, Chen Joyce, Nguyen Steven M, Rao Dinesh S, An Dong Sung, Baltimore David Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nature medicine. 2014; 20(3): 296-300.
Palanichamy Jayanth Kumar, Rao Dinesh S miRNA dysregulation in cancer: towards a mechanistic understanding. Frontiers in genetics. 2014; 5(3): 54.
Hu Ruozhen, Kagele Dominique A, Huffaker Thomas B, Runtsch Marah C, Alexander Margaret, Liu Jin, Bake Erin, Su Wei, Williams Matthew A, Rao Dinesh S, MÃ¶ller Thomas, Garden Gwenn A, Round June L, O'Connell Ryan M miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014; 41(4): 605-19.
Fang Jing, Barker Brenden, Bolanos Lyndsey, Liu Xiaona, Jerez Andres, Makishima Hideki, Christie Susanne, Chen Xiaoting, Rao Dinesh S, Grimes H Leighton, Komurov Kakajan, Weirauch Matthew T, Cancelas Jose A, Maciejewski Jaroslaw P, Starczynowski Daniel T Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-ÎºB gene network. Cell reports. 2014; 8(5): 1328-38.
Fernando Thilini R, Rodriguez-Malave Norma I, Waters Ella V, Yan Weihong, Casero David, Basso Giuseppe, Pigazzi Martina, Rao Dinesh S LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia. Molecular cancer research : MCR. 2015; 13(5): 839-51.
Wallace Jared, Hu Ruozhen, Mosbruger Timothy L, Dahlem Timothy J, Stephens W Zac, Rao Dinesh S, Round June L, O'Connell Ryan M Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. PloS one. 2016; 11(4): e0153689.
Rodriguez-Malave Norma I, Fernando Thilini R, Patel Parth C, Contreras Jorge R, Palanichamy Jayanth Kumar, Tran Tiffany M, Anguiano Jaime, Davoren Michael J, Alberti Michael O, Pioli Kimanh T, Sandoval Salemiz, Crooks Gay M, Rao Dinesh S BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Molecular cancer. 2015; 14(4): 214.
Rodriguez-Malave Norma I, Rao Dinesh S Long noncoding RNAs in hematopoietic malignancies. Briefings in functional genomics. 2016; 15(3): 227-38.
Palanichamy Jayanth Kumar, Tran Tiffany M, Howard Jonathan M, Contreras Jorge R, Fernando Thilini R, Sterne-Weiler Timothy, Katzman Sol, Toloue Masoud, Yan Weihong, Basso Giuseppe, Pigazzi Martina, Sanford Jeremy R, Rao Dinesh S RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. The Journal of clinical investigation. 2016; 126(4): 1495-511.
Contreras Jorge R, Palanichamy Jayanth Kumar, Tran Tiffany M, Fernando Thilini R, Rodriguez-Malave Norma I, Goswami Neha, Arboleda Valerie A, Casero David, Rao Dinesh S MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1. Oncotarget. 2015; 6(13): 11023-37.
Wallace Jared A, Kagele Dominique A, Eiring Anna M, Kim Carissa N, Hu Ruozhen, Runtsch Marah C, Alexander Margaret, Huffaker Thomas B, Lee Soh-Hyun, Patel Ami B, Mosbruger Timothy L, Voth Warren P, Rao Dinesh S, Miles Rodney R, Round June L, Deininger Michael W, O'Connell Ryan M miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. Blood. 2017; 129(23): 3074-3086.
King Jennifer K, Ung Nolan M, Paing May H, Contreras Jorge R, Alberti Michael O, Fernando Thilini R, Zhang Kelvin, Pellegrini Matteo, Rao Dinesh S Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a. Frontiers in immunology. 2017; 7(23): 670.