Work Address:
695 Charles E. Young Drive South, Gonda Room 6554A
Los Angeles, CA 90095
Neurogenetics
Genomics of Neurological Disease
Genetic Diagnostics
Neurodevelopment
Regulation of gene expression
Gene therapy
Bioinformatics
Systems biology
Molecular genetics
Brent L. Fogel MD, PhD is a Professor in the Departments of Neurology and Human Genetics at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr. Fogel’s research uses genomics, bioinformatics, and systems biology to understand how genetic mutations and associated impairment of genetic pathways leads to neurodegenerative disorders such as spinocerebellar ataxia or neurodevelopmental conditions. Dr. Fogel also specifically studies the molecular pathogenesis of ataxia with oculomotor apraxia (AOA) and is developing gene therapy approaches to treat this disorder. Clinically, Dr. Fogel directs the UCLA Clinical Neurogenomics Research Center, a department-wide program in Neurology designed to promote and facilitate access to genomic and other cellular and molecular research studies for all UCLA Neurology patients. He also directs the UCLA Neurogenetics Clinic where his work focuses on the use of genomic sequencing to identify rare and novel causes of neurological disease. Dr. Fogel also runs a clinic devoted to patients with AOA and diagnoses and treats various disorders of balance and coordination in the UCLA Ataxia Center. He has authored multiple research and clinical articles, reviews, and book chapters on spinocerebellar ataxia, clinical neurogenetics, and neurodevelopmental disease. Dr. Fogel’s work has been funded, in part, by the American Academy of Neurology / American Brain Foundation, the National Institutes of Health, and the National Ataxia Foundation.