Elizabeta Nemeth, Ph.D.

Office Address:
10833 Le Conte Ave.
Los Angeles, CA 90095

Affiliations
Biography:

Elizabeta Nemeth is a Professor of Medicine at the David Geffen School of Medicine at UCLA, and Director of the UCLA Center for Iron Disorders. Dr. Nemeth received her BS in Molecular Biology at the University of Belgrade, Yugoslavia, and a PhD in Cell, Molecular and Neurosciences at the University of Hawaii. Dr. Nemeth came to UCLA for a postdoctoral fellowship in 2002, and has been studying the pathobiology of the iron-regulatory peptide hepcidin ever since. She has made major contributions to the understanding of iron homeostasis and of its dysregulation in many diseases. She characterized the regulation of hepcidin production by inflammation and iron, and elucidated the mechanism of action of hepcidin in regulating the absorption of dietary iron and its release from stores. Dr. Nemeth also described the role of hepcidin in various iron disorders including hereditary hemochromatosis, iron-loading anemias (e.g. β-thalassemia), and iron-restricted anemias associated with inflammation and chronic kidney disease. In 2007, Dr. Nemeth received the Grace Goldsmith Award from the American College of Nutrition for "significant achievements in the field of nutrition by a scientist under the age of 50 years". Dr. Nemeth’s laboratory has been continuously funded by the National Institute of Health and grants from biotechnology sector. Dr. Nemeth is currently serving as a standing member of the Molecular and Cellular Hematology Study Section of the National Institutes of Health, a member of the Board of Directors of the International Bioiron Society, and a member of the Editorial Board of Blood. She helped start three biotechnology companies: Intrinsic LifeSciences, focused on developing iron diagnostics, Merganser Biotech, focused on developing hepcidin peptide therapeutics, and Silarus Therapeutics, focused on developing erythroferrone-targeted therapeutics.

Publications

A selected list of publications:

Kim Airie, Fung Eileen, Parikh Sona G, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas   Isocitrate treatment of acute anemia of inflammation in a mouse model Blood cells, molecules & diseases, 2016; 56(1): 31-6.
Drakesmith Hal, Nemeth Elizabeta, Ganz Tomas   Ironing out Ferroportin Cell metabolism, 2015; 22(5): 777-87.
Chua Kristine, Fung Eileen, Micewicz Ewa D, Ganz Tomas, Nemeth Elizabeta, Ruchala Piotr   Small cyclic agonists of iron regulatory hormone hepcidin Bioorganic & medicinal chemistry letters, 2015; 25(21): 4961-9.
Kautz Léon, Jung Grace, Du Xin, Gabayan Victoria, Chapman Justin, Nasoff Marc, Nemeth Elizabeta, Ganz Tomas   Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia Blood, 2015; 126(17): 2031-7.
Michels Kathryn, Nemeth Elizabeta, Ganz Tomas, Mehrad Borna   Hepcidin and Host Defense against Infectious Diseases PLoS pathogens, 2015; 11(8): e1004998.
Ganz Tomas, Nemeth Elizabeta   Iron homeostasis in host defence and inflammation Nature reviews. Immunology, 2015; 15(8): 500-10.
Keel Siobán B, Doty Raymond, Liu Li, Nemeth Elizabeta, Cherian Sindhu, Ganz Tomas, Abkowitz Janis L   Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver Experimental hematology, 2015; 43(6): 469-78.e6.
Kim Airie, Nemeth Elizabeta   New insights into iron regulation and erythropoiesis Current opinion in hematology, 2015; 22(3): 199-205.
Gutschow Patrick, Schmidt Paul J, Han Huiling, Ostland Vaughn, Bartnikas Thomas B, Pettiglio Michael A, Herrera Carolina, Butler James S, Nemeth Elizabeta, Ganz Tomas, Fleming Mark D, Westerman Mark   A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis Haematologica, 2015; 100(2): 167-77.
Fung Eileen, Chua Kristine, Ganz Tomas, Nemeth Elizabeta, Ruchala Piotr   Thiol-derivatized minihepcidins retain biological activity Bioorganic & medicinal chemistry letters, 2015; 25(4): 763-6.
Arezes João, Jung Grace, Gabayan Victoria, Valore Erika, Ruchala Piotr, Gulig Paul A, Ganz Tomas, Nemeth Elizabeta, Bulut Yonca   Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus Cell host & microbe, 2015; 17(1): 47-57.
Zhang Shuping, Chen Yue, Guo Wenli, Yuan Lin, Zhang Daoqiang, Xu Yong, Nemeth Elizabeta, Ganz Tomas, Liu Sijin   Disordered hepcidin-ferroportin signaling promotes breast cancer growth Cellular signalling, 2014; 26(11): 2539-50.
Kautz Léon, Jung Grace, Nemeth Elizabeta, Ganz Tomas   Erythroferrone contributes to recovery from anemia of inflammation Blood, 2014; 124(16): 2569-74.
Nemeth Elizabeta, Ganz Tomas   Anemia of inflammation Hematology/oncology clinics of North America, 2014; 28(4): 671-81, vi.
Koenig Mary Dawn, Tussing-Humphreys Lisa, Day Jessica, Cadwell Brooke, Nemeth Elizabeta   Hepcidin and iron homeostasis during pregnancy Nutrients, 2014; 6(8): 3062-83.
Kautz Léon, Jung Grace, Valore Erika V, Rivella Stefano, Nemeth Elizabeta, Ganz Tomas   Identification of erythroferrone as an erythroid regulator of iron metabolism Nature genetics, 2014; 46(7): 678-84.
Kautz Leon, Nemeth Elizabeta   Molecular liaisons between erythropoiesis and iron metabolism Blood, 2014; 124(4): 479-82.
Mitchell Colin J, Shawki Ali, Ganz Tomas, Nemeth Elizabeta, Mackenzie Bryan   Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc American journal of physiology. Cell physiology, 2014; 306(5): C450-9.
Ruchala Piotr, Nemeth Elizabeta   The pathophysiology and pharmacology of hepcidin Trends in pharmacological sciences, 2014; 35(3): 155-61.
Dekan Zoltan, Mobli Mehdi, Pennington Michael W, Fung Eileen, Nemeth Elizabeta, Alewood Paul F   Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl Angewandte Chemie (International ed. in English), 2014; 53(11): 2931-4.
Kim Airie, Fung Eileen, Parikh Sona G, Valore Erika V, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas   A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin Blood, 2014; 123(8): 1129-36.
Rodriguez Richard, Jung Chun-Ling, Gabayan Victoria, Deng Jane C, Ganz Tomas, Nemeth Elizabeta, Bulut Yonca   Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6 Infection and immunity, 2014; 82(2): 745-52.
Kim Airie, Rivera Seth, Shprung Dana, Limbrick Donald, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas   Mouse models of anemia of cancer PloS one, 2014; 9(3): e93283.
Pusatcioglu Cenk K, Nemeth Elizabeta, Fantuzzi Giamila, Llor Xavier, Freels Sally, Tussing-Humphreys Lisa, Cabay Robert J, Linzmeier Rose, Ng Damond, Clark Julia, Braunschweig Carol   Systemic and tumor level iron regulation in men with colorectal cancer: a case control study Nutrition & metabolism, 2014; 11(2): 21.