|Assistant Professor, Urology, Molecular, Cell, and Developmental Biology|
|Faculty, Cell & Developmental Biology GPB Home Area|
Dr. Goldstein is an Assistant Professor-In-Residence in the departments of Urology and Molecular, Cell & Developmental Biology, and a member of the Broad Stem Cell Research Center and Jonsson Comprehensive Cancer Center at UCLA. Dr. Goldstein attended Dartmouth College in Hanover, New Hampshire where he majored in Biochemistry and Molecular Biology and was a two-time NCAA Division 1 All-American lacrosse player. Dr. Goldstein moved to UCLA where he completed his Ph.D. in the laboratory of Dr. Owen Witte, isolating epithelial progenitor cells from mouse and human prostate tissue and demonstrating the capacity of progenitor cells to respond to oncogenic transformation. This work included the first demonstration of a cell of origin for human prostate cancer reported in Science Magazine. In 2011, Dr. Goldstein became the Inaugural fellow of the Broad Stem Cell Research Center and received a Prostate Cancer Foundation Young Investigator Award and a Department of Defense Prostate Cancer Research Program Idea Development Award to elucidate the cellular and molecular mechanisms promoting epithelial cancer initiation, progression and resistance to treatment.
His laboratory is interested in functionally defining mechanisms that drive the initiation and progression of human prostate cancer. Recent advances in sequencing technology have enabled the identification of numerous mutations, amplifications and deletions that may contribute to the pathogenesis of prostate cancer. However, few of these alterations have been functionally characterized to distinguish drivers from passengers. Dr. Goldstein’s group utilizes an innovative approach to engineer over-expression of known and candidate oncogenic drivers and determine which alterations can directly convert benign human prostate epithelium into cancer in mice. Dr. Goldstein has published his group’s results in PNAS (2013) and Cell Reports (2016), demonstrating the capacity of distinct genetic alterations to drive cancer from distinct cells of origin. In addition to support from the Prostate Cancer Foundation and Department of Defense, Dr. Goldstein has recently received funding from an American Cancer Society Research Scholar Grant.