|Associate Professor In-Residence, Cardiology|
|Member, Cell & Developmental Biology GPB Home Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area|
Reza Ardehali, MD, PhD, studies the molecular mechanisms of cardiovascular development. His goal is to apply an understanding of heart development to the creation of novel regenerative approaches to treat heart disease. Of particular interest to Dr. Ardehali is the intrinsic signaling that trigger cardiac regeneration early in life, molecular events that regulate developmental decisions instructing cardiac progenitor cells to adopt a specific cell fate, and delivery approaches of cardiovascular progenitors into an injured heart. Dr. Ardehali uses novel transgenic mouse models, as well as mostly human pluripotent stem cells (PSC) to address his research questions. Transgenic mouse models are instrumental for elucidating pathways that regulate cardiac development and regeneration. Additionally, PSCs - both embryonic stem cells and induced pluripotent stem cells - provide insights into the mechanisms involved in the differentiation and specification of heart cells. He and his team recently identified several novel surface markers that can highly enrich for early cardiovascular progenitors. When delivered into functioning human hearts that have been transplanted into animal models, the cardiovascular progenitors integrated structurally and functionally into the host myocardium. These studies have established the basis for future PSC-based cardiac therapy. Current projects in his lab include determining the extent of cardiomyocyte division during in utero and post-natal development at a clonal level; assessing the role of resident cardiac stem cells after cardiac injury and during development; using embryonic stem cells to lineage trace cardiomyocyte differentiation; and, using novel in vitro and in vivo models to identify pure populations of cardiovascular progenitors capable of engraftment into the host myocardium. An associate professor of cardiology, Dr. Ardehali completed his residency in internal medicine at Johns Hopkins, followed by clinical training in cardiology at Stanford University.
Fei Peng, Lee Juhyun, Packard RenÃ© R Sevag, Sereti Konstantina-Ioanna, Xu Hao, Ma Jianguo, Ding Yichen, Kang Hanul, Chen Harrison, Sung Kevin, Kulkarni Rajan, Ardehali Reza, Kuo C-C Jay, Xu Xiaolei, Ho Chih-Ming, Hsiai Tzung K Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Scientific reports. 2016; 6: 22489.
Skelton Rhys J P, Brady Bevin, Khoja Suhail, Sahoo Debashis, Engel James, Arasaratnam Deevina, Saleh Kholoud K, Abilez Oscar J, Zhao Peng, Stanley Edouard G, Elefanty Andrew G, Kwon Murray, Elliott David A, Ardehali Reza CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells. Stem cell reports. 2016; 6(1): 95-108.
Skelton Rhys J P, Khoja Suhail, Almeida Shone, Rapacchi Stanislas, Han Fei, Engel James, Zhao Peng, Hu Peng, Stanley Edouard G, Elefanty Andrew G, Kwon Murray, Elliott David A, Ardehali Reza Magnetic Resonance Imaging of Iron Oxide-Labeled Human Embryonic Stem Cell-Derived Cardiac Progenitors. Stem cells translational medicine. 2016; 5(1): 67-74.
Chen Cheng-Han, Sereti Konstantina-Ioanna, Wu Benjamin M, Ardehali Reza Translational aspects of cardiac cell therapy. Journal of cellular and molecular medicine. 2015; 19(8): 1757-72.
Almeida Shone O, Skelton Rhys J, Adigopula Sasikanth, Ardehali Reza Arrhythmia in stem cell transplantation. Cardiac electrophysiology clinics. 2015; 7(2): 357-70.
Jessup Mariell, Ardehali Reza, Konstam Marvin A, Manno Bruno V, Mathier Michael A, McPherson John A, Sweitzer Nancy K COCATS 4 Task Force 12: Training in Heart Failure. Journal of the American College of Cardiology. 2015; 65(17): 1866-76.
Milin Alexandra C, Vorobiof Gabriel, Aksoy Olcay, Ardehali Reza Insights into aortic sclerosis and its relationship with coronary artery disease. Journal of the American Heart Association. 2014; 3(5): e001111.
Ali Shah R, Ranjbarvaziri Sara, Talkhabi Mahmood, Zhao Peng, Subat Ali, Hojjat Armin, Kamran Paniz, MÃ¼ller Antonia M S, Volz Katharina S, Tang Zhaoyi, Red-Horse Kristy, Ardehali Reza Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation. Circulation research. 2014; 115(7): 625-35.
Skelton Rhys J P, Costa Magdaline, Anderson David J, Bruveris Freya, Finnin Ben W, Koutsis Katerina, Arasaratnam Deevina, White Anthony J, Rafii Arash, Ng Elizabeth S, Elefanty Andrew G, Stanley Edouard G, Pouton Colin W, Haynes John M, Ardehali Reza, Davis Richard P, Mummery Christine L, Elliott David A SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development. Stem cell research. 2014; 13(1): 172-9.
Ali Shah R, Hippenmeyer Simon, Saadat Lily V, Luo Liqun, Weissman Irving L, Ardehali Reza Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(24): 8850-5.
Kamran Paniz, Sereti Konstantina-Ioanna, Zhao Peng, Ali Shah R, Weissman Irving L, Ardehali Reza Parabiosis in mice: a detailed protocol. Journal of visualized experiments : JoVE. 2013; 27(80): .
Ueno Masaya, Lee Lydia K, Chhabra Akanksha, Kim Yeon Joo, Sasidharan Rajkumar, Van Handel Ben, Wang Ying, Kamata Masakazu, Kamran Paniz, Sereti Konstantina-Ioanna, Ardehali Reza, Jiang Meisheng, Mikkola Hanna K A c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface. Developmental cell. 2013; 27(4): 373-86.
Ardehali Reza, Ali Shah R, Inlay Matthew A, Abilez Oscar J, Chen Michael Q, Blauwkamp Timothy A, Yazawa Masayuki, Gong Yongquan, Nusse Roeland, Drukker Micha, Weissman Irving L Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(9): 3405-10.
Drukker Micha, Tang Chad, Ardehali Reza, Rinkevich Yuval, Seita Jun, Lee Andrew S, Mosley Adriane R, Weissman Irving L, Soen Yoav Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nature biotechnology. 2012; 30(6): 531-42.
Blauwkamp Timothy A, Nigam Shelly, Ardehali Reza, Weissman Irving L, Nusse Roel Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nature communications. 2012; 3(3): 1070.
Ardehali Reza, Leeper Nicholas J, Wilson Andrew M, Heidenreich Paul A The effect of angiotensin-converting enzyme inhibitors and statins on the progression of aortic sclerosis and mortality. The Journal of heart valve disease. 2012; 21(3): 337-43.
Tang Chad, Lee Andrew S, Volkmer Jens-Peter, Sahoo Debashis, Nag Divya, Mosley Adriane R, Inlay Matthew A, Ardehali Reza, Chavez Shawn L, Pera Renee Reijo, Behr Barry, Wu Joseph C, Weissman Irving L, Drukker Micha An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nature biotechnology. 2011; 29(9): 829-34.
Ardehali Reza, Ali Shah R, Inlay Matthew A, Mosley Adriane R, Weissman Irving L Enhanced survival of pluripotent stem cells under stressful conditions. Cell cycle (Georgetown, Tex.). 2011; 10(16): 2610-1.
Ardehali Reza, Inlay Matthew A, Ali Shah R, Tang Chad, Drukker Micha, Weissman Irving L Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(8): 3282-7.
Bravata Dena M, Gienger Allison L, McDonald Kathryn M, Sundaram Vandana, Perez Marco V, Varghese Robin, Kapoor John R, Ardehali Reza, Owens Douglas K, Hlatky Mark A Systematic review: the comparative effectiveness of percutaneous coronary interventions and coronary artery bypass graft surgery. Annals of internal medicine. 2007; 147(10): 703-16.
Leeper Nicholas J, Ardehali Reza, deGoma Emil M, Heidenreich Paul A Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival. Circulation. 2007; 116(6): 613-8.
Ardehali Reza, Nasir Khurram, Kolandaivelu Aravindan, Budoff Matthew J, Blumenthal Roger S Screening patients for subclinical atherosclerosis with non-contrast cardiac CT. Atherosclerosis. 2007; 192(2): 235-42.
Ardehali Reza, Brinton Todd J, Wilson Andrew M, Gradman Marc, Vagelos Randall H, Lee David P Recurrent spontaneous coronary artery dissection with transient left ventricular systolic dysfunction. International journal of cardiology. 2007; 116(2): e48-50.
Ardehali Reza, Reed Ann S, Owens Christopher, Meininger Glenn R, Conte John V, Hare Joshua M A long and bumpy road. The American journal of medicine. 2006; 119(11): 923-6.
Michos Erin D, Ardehali Reza, Blumenthal Roger S, Lange Richard A, Ardehali Hossein Aspirin and clopidogrel resistance. Mayo Clinic proceedings. 2006; 81(4): 518-26.