A selected list of publications:
Ribas Vicent, Drew Brian G, Zhou Zhenqi, Phun Jennifer, Kalajian Nareg Y, Soleymani Teo, Daraei Pedram, Widjaja Kevin, Wanagat Jonathan, de Aguiar Vallim Thomas Q, Fluitt Amy H, Bensinger Steven, Le Thuc, Radu Caius, Whitelegge Julian P, Beaven Simon W, Tontonoz Peter, Lusis Aldons J, Parks Brian W, Vergnes Laurent, Reue Karen, Singh Harpreet, Bopassa Jean C, Toro Ligia, Stefani Enrico, Watt Matthew J, Schenk Simon, Akerstrom Thorbjorn, Kelly Meghan, Pedersen Bente K, Hewitt Sylvia C, Korach Kenneth S, Hevener Andrea L
Skeletal muscle action of estrogen receptor α is critical for the
maintenance of mitochondrial function and metabolic homeostasis in
females
Science translational medicine,
2016; 8(334):
334ra54.
Meriwether David, Sulaiman Dawoud, Wagner Alan, Grijalva Victor, Kaji Izumi, Williams Kevin J, Yu Liqing, Fogelman Spencer, Volpe Carmen, Bensinger Steven J, Anantharamaiah G M, Shechter Ishaiahu, Fogelman Alan M, Reddy Srinivasa T
Transintestinal transport of the anti-inflammatory drug 4F and the
modulation of transintestinal cholesterol efflux
Journal of lipid research,
2016; 57(7):
1175-93.
Cunningham Cameron R, Champhekar Ameya, Tullius Michael V, Dillon Barbara Jane, Zhen Anjie, de la Fuente Justin Rafael, Herskovitz Jonathan, Elsaesser Heidi, Snell Laura M, Wilson Elizabeth B, de la Torre Juan Carlos, Kitchen Scott G, Horwitz Marcus A, Bensinger Steven J, Smale Stephen T, Brooks David G
Type I and Type II Interferon Coordinately Regulate Suppressive
Dendritic Cell Fate and Function during Viral Persistence
PLoS pathogens,
2016; 12(1):
e1005356.
York Autumn G, Williams Kevin J, Argus Joseph P, Zhou Quan D, Brar Gurpreet, Vergnes Laurent, Gray Elizabeth E, Zhen Anjie, Wu Nicholas C, Yamada Douglas H, Cunningham Cameron R, Tarling Elizabeth J, Wilks Moses Q, Casero David, Gray David H, Yu Amy K, Wang Eric S, Brooks David G, Sun Ren, Kitchen Scott G, Wu Ting-Ting, Reue Karen, Stetson Daniel B, Bensinger Steven J
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I
IFN Signaling
Cell,
2015; 163(7):
1716-29.
Xie Letian X, Williams Kevin J, He Cuiwen H, Weng Emily, Khong San, Rose Tristan E, Kwon Ohyun, Bensinger Steven J, Marbois Beth N, Clarke Catherine F
Resveratrol and para-coumarate serve as ring precursors for coenzyme Q
biosynthesis
Journal of lipid research,
2015; 56(4):
909-19.
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J
An essential requirement for the SCAP/SREBP signaling axis to protect
cancer cells from lipotoxicity
Cancer research,
2013; 73(9):
2850-62.
Akhavan David, Pourzia Alexandra L, Nourian Alex A, Williams Kevin J, Nathanson David, Babic Ivan, Villa Genaro R, Tanaka Kazuhiro, Nael Ali, Yang Huijun, Dang Julie, Vinters Harry V, Yong William H, Flagg Mitchell, Tamanoi Fuyuhiko, Sasayama Takashi, James C David, Kornblum Harley I, Cloughesy Tim F, Cavenee Webster K, Bensinger Steven J, Mischel Paul S
De-repression of PDGFRβ transcription promotes acquired resistance to
EGFR tyrosine kinase inhibitors in glioblastoma patients
Cancer discovery,
2013; 3(5):
534-47.
Schjerven Hilde, McLaughlin Jami, Arenzana Teresita L, Frietze Seth, Cheng Donghui, Wadsworth Sarah E, Lawson Gregory W, Bensinger Steven J, Farnham Peggy J, Witte Owen N, Smale Stephen T
Selective regulation of lymphopoiesis and leukemogenesis by individual
zinc fingers of Ikaros
Nature immunology,
2013; 14(10):
1073-83.
Kidani Yoko, Elsaesser Heidi, Hock M Benjamin, Vergnes Laurent, Williams Kevin J, Argus Joseph P, Marbois Beth N, Komisopoulou Evangelia, Wilson Elizabeth B, Osborne Timothy F, Graeber Thomas G, Reue Karen, Brooks David G, Bensinger Steven J
Sterol regulatory element-binding proteins are essential for the
metabolic programming of effector T cells and adaptive immunity
Nature immunology,
2013; 14(5):
489-99.
Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J
Coordinate regulation of neutrophil homeostasis by liver X receptors
in mice
The Journal of clinical investigation,
2012; 122(1):
337-47.
Ribas Vicent, Drew Brian G, Le Jamie A, Soleymani Teo, Daraei Pedram, Sitz Daniel, Mohammad Laila, Henstridge Darren C, Febbraio Mark A, Hewitt Sylvia C, Korach Kenneth S, Bensinger Steven J, Hevener Andrea L
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic
homeostasis and accelerates atherosclerotic lesion development
Proceedings of the National Academy of Sciences of the United States of America,
2011; 108(39):
16457-62.
A. Gonzalez N Bensinger, S. J. Hong, C. Beceiro, S. Bradley, M. N. Zelcer, N. Deniz, J. Ramirez, C. Diaz, M. Gallardo, G. de Galarreta, C. R. Salazar, J. Lopez, F. Edwards, P. Parks, J. Andujar, M. Tontonoz, P. Castrillo, A.
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR
Immunity,
2009; 31(2):
245-58.
A-Gonzalez Noelia, Bensinger Steven J, Hong Cynthia, Beceiro Susana, Bradley Michelle N, Zelcer Noam, Deniz Jose, Ramirez Cristina, DÃaz Mercedes, Gallardo German, de Galarreta Carlos Ruiz, Salazar Jon, Lopez Felix, Edwards Peter, Parks John, Andujar Miguel, Tontonoz Peter, Castrillo Antonio
Apoptotic cells promote their own clearance and immune tolerance
through activation of the nuclear receptor LXR
Immunity,
2009; 31(2):
245-58.
Frank, M. J. Dawson, D. W. Bensinger, S. J. Hong, J. S. Knosp, W. M. Xu, L. Balatoni, C. E. Allen, E. L. Shen, R. R. Bar-Sagi, D. Martin, G. R. Teitell, M. A.
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas
Blood,
2009; 113(11):
2478-87.
Bensinger, S. J. Bradley, M. N. Joseph, S. B. Zelcer, N. Janssen, E. M. Hausner, M. A. Shih, R. Parks, J. S. Edwards, P. A. Jamieson, B. D. Tontonoz, P.
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Cell,
2008; 134(1):
97-111.
Saleh, M. Mathison, J. C. Wolinski, M. K. Bensinger, S. J. Fitzgerald, P. Droin, N. Ulevitch, R. J. Green, D. R. Nicholson, D. W.
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
Nature,
2006; 440(7087):
1064-8.
Walsh, P. T. Buckler, J. L. Zhang, J. Gelman, A. E. Dalton, N. M. Taylor, D. K. Bensinger, S. J. Hancock, W. W. Turka, L. A.
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs
J Clin Invest,
2006; 116(9):
2521-31.
Janssen, E. M. Droin, N. M. Lemmens, E. E. Pinkoski, M. J. Bensinger, S. J. Ehst, B. D. Griffith, T. S. Green, D. R. Schoenberger, S. P.
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
Nature,
2005; 434(7029):
88-93.
Bensinger, S. J. Walsh, P. T. Zhang, J. Carroll, M. Parsons, R. Rathmell, J. C. Thompson, C. B. Burchill, M. A. Farrar, M. A. Turka, L. A.
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells
J Immunol,
2004; 172(9):
5287-96.
Wu, Z. Bensinger, S. J. Zhang, J. Chen, C. Yuan, X. Huang, X. Markmann, J. F. Kassaee, A. Rosengard, B. R. Hancock, W. W. Sayegh, M. H. Turka, L. A.
Homeostatic proliferation is a barrier to transplantation tolerance
Nat Med,
2004; 10(1):
87-92.
Burchill, M. A. Goetz, C. A. Prlic, M. O'Neil, J. J. Harmon, I. R. Bensinger, S. J. Turka, L. A. Brennan, P. Jameson, S. C. Farrar, M. A.
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells
J Immunol,
2003; 171(11):
5853-64.
Wekerle, T. Kurtz, J. Sayegh, M. Ito, H. Wells, A. Bensinger, S. Shaffer, J. Turka, L. Sykes, M.
Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
J Immunol,
2001; 166(4):
2311-6.
Ito Ayaka, Hong Cynthia, Oka Kazuhiro, Salazar Jon V, Diehl Cody, Witztum Joseph L, Diaz Mercedes, Castrillo Antonio, Bensinger Steven J, Chan Lawrence, Tontonoz Peter
Cholesterol Accumulation in CD11c
Immunity,
2016; 45(6):
1311-1326.
Zhou Quan D, Chi Xun, Lee Min Sub, Hsieh Wei Yuan, Mkrtchyan Jonathan J, Feng An-Chieh, He Cuiwen, York Autumn G, Bui Viet L, Kronenberger Eliza B, Ferrari Alessandra, Xiao Xu, Daly Allison E, Tarling Elizabeth J, Damoiseaux Robert, Scumpia Philip O, Smale Stephen T, Williams Kevin J, Tontonoz Peter, Bensinger Steven J
Interferon-mediated reprogramming of membrane cholesterol to evade
bacterial toxins
Nature immunology,
2020;
.
Hsieh Wei-Yuan, Zhou Quan D, York Autumn G, Williams Kevin J, Scumpia Philip O, Kronenberger Eliza B, Hoi Xen Ping, Su Baolong, Chi Xun, Bui Viet L, Khialeeva Elvira, Kaplan Amber, Son Young Min, Divakaruni Ajit S, Sun Jie, Smale Stephen T, Flavell Richard A, Bensinger Steven J
Toll-Like Receptors Induce Signal-Specific Reprogramming of the
Macrophage Lipidome
Cell metabolism,
2020;
.
Argus Joseph P, Wilks Moses Q, Zhou Quan D, Hsieh Wei Yuan, Khialeeva Elvira, Hoi Xen Ping, Bui Viet, Xu Shili, Yu Amy K, Wang Eric S, Herschman Harvey R, Williams Kevin J, Bensinger Steven J
Development and Application of FASA, a Model for Quantifying Fatty
Acid Metabolism Using Stable Isotope Labeling
Cell reports,
2018; 25(10):
2919-2934.e8.
Raud Brenda, Roy Dominic G, Divakaruni Ajit S, Tarasenko Tatyana N, Franke Raimo, Ma Eric H, Samborska Bozena, Hsieh Wei Yuan, Wong Alison H, Stüve Philipp, Arnold-Schrauf Catharina, Guderian Melanie, Lochner Matthias, Rampertaap Shakuntala, Romito Kimberly, Monsale Joseph, Brönstrup Mark, Bensinger Steven J, Murphy Anne N, McGuire Peter J, Jones Russell G, Sparwasser Tim, Berod Luciana
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of
Cpt1a-Mediated Fatty Acid Oxidation
Cell metabolism,
2018; 28(3):
504-515.e7.
Divakaruni Ajit S, Hsieh Wei Yuan, Minarrieta Lucía, Duong Tin N, Kim Kristen K O, Desousa Brandon R, Andreyev Alexander Y, Bowman Caitlyn E, Caradonna Kacey, Dranka Brian P, Ferrick David A, Liesa Marc, Stiles Linsey, Rogers George W, Braas Daniel, Ciaraldi Theodore P, Wolfgang Michael J, Sparwasser Tim, Berod Luciana, Bensinger Steven J, Murphy Anne N
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA
Homeostasis
Cell metabolism,
2018; 28(3):
490-503.e7.
He Cuiwen, Hu Xuchen, Weston Thomas A, Jung Rachel S, Sandhu Jaspreet, Huang Song, Heizer Patrick, Kim Jason, Ellison Rochelle, Xu Jiake, Kilburn Matthew, Bensinger Steven J, Riezman Howard, Tontonoz Peter, Fong Loren G, Jiang Haibo, Young Stephen G
Macrophages release plasma membrane-derived particles rich in
accessible cholesterol
Proceedings of the National Academy of Sciences of the United States of America,
2018; 115(36):
E8499-E8508.
Erbilgin Ayca, Seldin Marcus M, Wu Xiuju, Mehrabian Margarete, Zhou Zhiqiang, Qi Hongxiu, Dabirian Keeyon S, Sevag Packard René R, Hsieh Wei, Bensinger Steven J, Sinha Satyesh, Lusis Aldons J
Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and
Promotes Macrophage Apoptosis in Mice
Arteriosclerosis, thrombosis, and vascular biology,
2018; 38(9):
2016-2027.
Newton Ryan H, Shrestha Sharad, Sullivan Jenna M, Yates Kathleen B, Compeer Ewoud B, Ron-Harel Noga, Blazar Bruce R, Bensinger Steven J, Haining W Nicholas, Dustin Michael L, Campbell Daniel J, Chi Hongbo, Turka Laurence A
Maintenance of CD4 T cell fitness through regulation of Foxo1
Nature immunology,
2018; 19(8):
838-848.
Mai Wilson X, Gosa Laura, Daniels Veerle W, Ta Lisa, Tsang Jonathan E, Higgins Brian, Gilmore W Blake, Bayley Nicholas A, Harati Mitra Dehghan, Lee Jason T, Yong William H, Kornblum Harley I, Bensinger Steven J, Mischel Paul S, Rao P Nagesh, Clark Peter M, Cloughesy Timothy F, Letai Anthony, Nathanson David A
Cytoplasmic p53 couples oncogene-driven glucose metabolism to
apoptosis and is a therapeutic target in glioblastoma
Nature medicine,
2017; 23(11):
1342-1351.
Mukherjee Pallavi, Hough Greg, Chattopadhyay Arnab, Navab Mohamad, Fogelman Hannah R, Meriwether David, Williams Kevin, Bensinger Steven, Moller Travis, Faull Kym F, Lusis Aldons J, Iruela-Arispe M Luisa, Bostrom Kristina I, Tontonoz Peter, Reddy Srinivasa T, Fogelman Alan M
Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent
diet-induced increases of IFN-β and cholesterol 25-hydroxylase in
jejunum
Journal of lipid research,
2017; 58(8):
1636-1647.