|Environmental Cardiology, UCLA|
|Member, Cardiology, Adult Cardiac Stress Testing and Echocardiographic Imaging Laboratory|
The main research interest of our lab are focused on two areas of investigation:
Environmental Cardiology: we are dissecting the mechanism by which exposure to air particulate matter promotes atherosclerosis and ischemic heart disease and studying gene-environment interactions of relevance in the development of cardiovascular disease. In recent years, we have found that air pollutant chemicals such as those present in diesel exhaust particlare are able to synergize with oxidized phospholipids generated within oxidated LDL, in the promtion of proatherogenic genees in vascular endothelial cells. We have also determined that inhalation of ambient ultrafine particle lead to systemic prooxidant and proinflammatory effects that result in the development of dysfunctional HDL and enhancement of atheroscleorotic leisons.
Biology of vascular oxidative stress: we are interested in genes and pathways of relevence in the oxidative stress generated in vascular inflammatory entities such as atherosclerosis and ischemia reperfusion. We have determined that heme oxygenase-1(HO-1) is an important antioxidant and anti-inflammatory protective gene and together with transcriptional regulator Nrf2, they may play a central role in orchestrating the antioxidant defense of vascular cells. However, while HO-1 is anti-atherogenic gene, NrF2 promotes atherosclerosis instead partly due to the regulation of genes involved in lipid metabolism and cholesterol transport. This underscores the complextiy of reactive oxygen species (ROS) signaling in vascular cells. We are currently studying how HO-1 expression modulates variosu inflammatory pathways via the use of genetic and biochemical approaches.