Jennifer Murphy, Ph.D.

Laboratory Address:
CNSI 4310, Crump Institute for Molecular Imaging
Los Angeles, CA 90095

Office Address:
CNSI 4321, Crump Institute for Molecular Imaging
570 Westwood Plaza
Los Angeles, CA 90095

Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Faculty, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology

Dr. Murphy’s lab is focused on developing new [18F]-fluorination methods for the synthesis of small-molecule imaging probes that are useful for performing in vivo assays of biochemical and biological processes using the molecular imaging technique of positron emission tomography (PET).  In addition to small molecule PET probes, research includes developing novel approaches for the site-specific and rapid [18F]-radiolabeling of biologics like peptides, proteins and antibodies.  The aim is to simplify and facilitate general access to promising PET imaging probes for examining the biology of disease, enhancing molecular diagnostic tools and advancing therapeutic developments. 


A selected list of publications:

Tao, H.; Liu, F.; Zheng, R.; Shao, Z.; Zou, L.; Cao, Y.; Murphy, J.M.; Houk, K.N.; Liang, Y.   Origins of halogen effects in bioorthogonal sydnone cycloadditions, Chem. Commun, 2018; 54: 5082-5085.
Levandowski, B.J.; Gamache, R.F.; Murphy, J.M.*; Houk, K.N.*   Readily accessible ambiphilic cyclopentadienes for bioorthogonal labeling, J. Am. Chem. Soc, 2018; 140: 6426-6431.
Collins, J.; Waldmann, C.M.; Drake, C.; Slavik, R.; Ha, N.S.; Sergeev, M.; Lazari, M.; Shen, B.; Chin, F.T.; Moore, M.; Sadeghi, S.; Phelps, M.E.; Murphy, J.M.; van Dam, R.M.   Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer, Proc. Natl. Acad. Sci. U.S.A. , 2017; 114: 11309-11314.
Narayanam, M.K.; Ma, G.; Champagne, P.A.; Houk, K.N.; Murphy, J.M.   Synthesis of [18F]fluorarenes via nucleophilic radiofluorination of N-arylsydnones, Angew. Chem. Int. Ed. , 2017; 56: 13006-13010.
Hoover, A.J.; Lazari, M.; Ren, H.; Narayanam, M.K.; Murphy, J.M.; van Dam, R.M.; Hooker, J.M.; Ritter, T.   A transmetalation reaction enables the synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging, Organometallics , 2016; 35: 1008-1014.
Gamache, R.F; Waldmann, C.; Murphy, J.M.   Copper-mediated oxidative fluorination of aryl stannanes with fluoride, Org. Lett. , 2016; 18: 4522-4525.
Narayanam, M.K.; Liang, Y.; Houk, K.N.; Murphy, J.M.   Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening, Chem. Sci. , 2016; 7: 1257-1261.
Lazari, M.; Lyashchenko, S.K.; Burnazi, E.M.; Lewis, J.S.; van Dam, R.M.; Murphy, J.M.   Fully-automated synthesis of 16β-18F-Fluoro-5α-dihydrotestosterone (18F-FDHT) on the ELIXYS radiosynthesizer, Appl. Radiat. Isot. , 2015; 103: 9-14.
David A. Nathanson; Amanda L. Armijo; Michelle Tom; Zheng Li; Elizabeth Dimitrova; Wayne R. Austin; Julian Nomme; Dean O. Campbell; Lisa Ta; Thuc M. Le; Jason T. Lee; Ryan Darvish; Ari Gordin; Liu Wei; Hsiang-I Liao; Moses Wilks; Colette Martin; Saman Sadeghi; Jennifer M. Murphy; Nidal Boulos; Michael E. Phelps; Johannes Czernin; Arnon Lavie; Caius G. Radu   Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication, J. Exp. Med, 2014; 211: 473-486.
Julian Nomme; Jennifer M. Murphy; Ying Su; Natasha D. Sansone; Amanda L. Armijo; Steven T. Olson; Caius G. Radu; Arnon Lavie   Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity determining moieties of the molecules, Acta Cryst, 2014; D70: 68-78.
Jennifer M. Murphy; Amanda L. Armijo; Julian Nomme; Chi Hang Lee; Quentin A. Smith; Zheng Li; Dean O. Campbell; Hsiang-I Liao; David A. Nathanson; Wayne R. Austin; Jason T. Lee; Ryan Darvish; Liu Wei; Jue Wang; Ying Su; Robert Damoiseaux; Saman Sadeghi; Michael E. Phelps; Harvey R. Herschman; Johannes Czernin; Anastassia N. Alexandrova; Michael E. Jung; Arnon Lavie; Caius G. Radu   Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography, Journal of Medicinal Chemistry, 2013; 56(17): 6696-6708.
Anthony R. Mazzotti, Michael G. Campbell, Pingping Tang, Jennifer M. Murphy, Tobias Ritter   Palladium(III)-catalyzed fluorination of arylboronic acid derivatives, Journal of the American Chemical Society, 2013; 135(38): 14012-14015.
Michael E. Jung, Jennifer M. Murphy   Functional group selectivity in reactions of epoxides with tungsten hexachloride, Tetrahedron Letters, 2007; 48(47): 8388-8391.