Elizabeth Tarling, Ph.D.
Assistant Professor, Cardiology
Research Interests

Lipids (particularly cholesterol and phospholipids) are essential components of cell membranes and are precursors to many signaling molecules, including steroid hormones, bile acids and oxysterols. As such, lipid synthesis pathways are among the most intensely regulated processes in biology. We are interested in understanding mechanisms that control celular, tissue and whole-body lipid homeostasis in healthy and disease states.

Ito Ayaka, Hong Cynthia, Rong Xin, Zhu Xuewei, Tarling Elizabeth J, Hedde Per Niklas, Gratton Enrico, Parks John, Tontonoz Peter LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. eLife. 2015; 4: .
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Ahn Hannah, Hagey Lee R, Romanoski Casey E, Lee Richard G, Graham Mark J, Motohashi Hozumi, Yamamoto Masayuki, Edwards Peter A MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell metabolism. 2015; 21(2): 298-310.
Baldan Angel, Gonen Ayelet, Choung Christina, Que Xuchu, Marquart Tyler J, Hernandez Irene, Bjorkhem Ingemar, Ford David A, Witztum Joseph L, Tarling Elizabeth J ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. Journal of immunology (Baltimore, Md. : 1950). 2014; 193(11): 5637-48.
Rong Xin, Albert Carolyn J, Hong Cynthia, Duerr Mark A, Chamberlain Brian T, Tarling Elizabeth J, Ito Ayaka, Gao Jie, Wang Bo, Edwards Peter A, Jung Michael E, Ford David A, Tontonoz Peter LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell metabolism. 2013; 18(5): 685-97.
Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A Role of ABC transporters in lipid transport and human disease. Trends in endocrinology and metabolism: TEM. 2013; 24(7): 342-50.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Kim Tammy, Civelek Mete, Baldán Ángel, Esau Christine, Edwards Peter A MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circulation research. 2013; 112(12): 1602-12.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A Pleiotropic roles of bile acids in metabolism. Cell metabolism. 2013; 17(5): 657-69.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J Response to Pomozi et al's research commentary. Circulation research. 2013; 112(11): e152-3.
Tarling Elizabeth J Expanding roles of ABCG1 and sterol transport. Current opinion in lipidology. 2013; 24(2): 138-46.