Leanne Jones
Affiliations
Affiliations
Professor, Molecular, Cell, and Developmental Biology
Member, Cell & Developmental Biology GPB Home Area, Center for Duchenne Muscular Dystrophy
Research Interests
Stem cells are the building blocks during development of organisms as varied as plants and humans. In addition, stem cells provide for the maintenance and regeneration of tissues, such as blood and skin, throughout the lifetime of an individual. The ability of stem cells to contribute to these processes depends on their ability to divide and generate both new stem cells (self-renewal) as well as specialized cell types (differentiation). The Jones lab uses the fruit fly Drosophila melanogaster and mammalian pluripotent stem cells as model systems to establish paradigms for how stem cell behavior is controlled.
Publications
Koehler Christopher L, Perkins Guy A, Ellisman Mark H, Jones D Leanne Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. The Journal of cell biology. 2017; 216(8): 2315-2327.
Resende Luís Pedro F, Truong Melissa E, Gomez Adam, Jones D Leanne Intestinal stem cell ablation reveals differential requirements for survival in response to chemical challenge. Developmental biology. 2017; 424(1): 10-17.
Resnik-Docampo Martin, Koehler Christopher L, Clark Rebecca I, Schinaman Joseph M, Sauer Vivien, Wong Daniel M, Lewis Sophia, D'Alterio Cecilia, Walker David W, Jones D Leanne Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nature cell biology. 2017; 19(1): 52-59.
Conway Anne E, Van Nostrand Eric L, Pratt Gabriel A, Aigner Stefan, Wilbert Melissa L, Sundararaman Balaji, Freese Peter, Lambert Nicole J, Sathe Shashank, Liang Tiffany Y, Essex Anthony, Landais Severine, Burge Christopher B, Jones D Leanne, Yeo Gene W Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival. Cell reports. 2016; 15(3): 666-79.
Artandi Steven E, Blau Helen M, de Haan Gerald, Geiger Hartmut, Goodell Margaret A, Jones Leanne, Levine Ross L, Muñoz-Cánoves Pura, Rodewald Hans-Reimer, Wagers Amy, Wang Zhao-Qi, Yamashita Yukiko Stem Cells and Aging: What's Next?. Cell stem cell. 2015; 16(6): 578-81.
Loza-Coll Mariano A, Southall Tony D, Sandall Sharsti L, Brand Andrea H, Jones D Leanne Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot. The EMBO journal. 2014; 33(24): 2983-96.
Voog Justin, Sandall Sharsti L, Hime Gary R, Resende Luís Pedro F, Loza-Coll Mariano, Aslanian Aaron, Yates John R, Hunter Tony, Fuller Margaret T, Jones D Leanne Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell reports. 2014; 7(3): 722-34.
Landais Severine, D'Alterio Cecilia, Jones D Leanne Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster. Cell reports. 2014; 7(3): 859-70.
Toledano Hila, D'Alterio Cecilia, Czech Benjamin, Levine Erel, Jones D Leanne The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature. 2012; 485(7400): 605-10.
Rera Michael, Bahadorani Sepehr, Cho Jaehyoung, Koehler Christopher L, Ulgherait Matthew, Hur Jae H, Ansari William S, Lo Thomas, Jones D Leanne, Walker David W Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell metabolism. 2011; 14(5): 623-34.
McLeod Catherine J, Wang Lei, Wong Chihunt, Jones D Leanne Stem cell dynamics in response to nutrient availability. Current biology : CB. 2010; 20(23): 2100-5.
Mair William, McLeod Catherine J, Wang Lei, Jones D Leanne Dietary restriction enhances germline stem cell maintenance. Aging cell. 2010; 9(5): 916-8.
Voog Justin, Jones D Leanne Stem cells and the niche: a dynamic duo. Cell stem cell. 2010; 6(2): 103-15.
Voog Justin, D'Alterio Cecilia, Jones D Leanne Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature. 2008; 454(7208): 1132-6.
Boyle Monica, Wong Chihunt, Rocha Michael, Jones D Leanne Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. Cell stem cell. 2007; 1(4): 470-8.
Yamashita Yukiko M, Jones D Leanne, Fuller Margaret T Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science (New York, N.Y.). 2003; 301(5639): 1547-50.