Kirk E. Lohmueller
Affiliations
Affiliations
Member, Bioinformatics GPB Home Area, Genetics & Genomics GPB Home Area
Biography:

Lohmuller's research focuses on human population genetics and genomics. I develop and implement computational approaches to interpret genetic variation data to learn about evolution and disease. Here you can find more information about my work.

Publications

A selected list of publications:

Lohmueller Kirk E, Rudin Norah   Calculating the weight of evidence in low-template forensic DNA casework Journal of forensic sciences, 2013; 58 Suppl 1: S243-9.
Rasmussen Morten, Guo Xiaosen, Wang Yong, Lohmueller Kirk E, Rasmussen Simon, Albrechtsen Anders, Skotte Line, Lindgreen Stinus, Metspalu Mait, Jombart Thibaut, Kivisild Toomas, Zhai Weiwei, Eriksson Anders, Manica Andrea, Orlando Ludovic, De La Vega Francisco M, Tridico Silvana, Metspalu Ene, Nielsen Kasper, Ávila-Arcos María C, Moreno-Mayar J Víctor, Muller Craig, Dortch Joe, Gilbert M Thomas P, Lund Ole, Wesolowska Agata, Karmin Monika, Weinert Lucy A, Wang Bo, Li Jun, Tai Shuaishuai, Xiao Fei, Hanihara Tsunehiko, van Driem George, Jha Aashish R, Ricaut François-Xavier, de Knijff Peter, Migliano Andrea B, Gallego Romero Irene, Kristiansen Karsten, Lambert David M, Brunak Søren, Forster Peter, Brinkmann Bernd, Nehlich Olaf, Bunce Michael, Richards Michael, Gupta Ramneek, Bustamante Carlos D, Krogh Anders, Foley Robert A, Lahr Marta M, Balloux Francois, Sicheritz-Pontén Thomas, Villems Richard, Nielsen Rasmus, Wang Jun, Willerslev Eske   An Aboriginal Australian genome reveals separate human dispersals into Asia Science (New York, N.Y.), 2011; 334(6052): 94-8.
Kim Su Yeon, Lohmueller Kirk E, Albrechtsen Anders, Li Yingrui, Korneliussen Thorfinn, Tian Geng, Grarup Niels, Jiang Tao, Andersen Gitte, Witte Daniel, Jorgensen Torben, Hansen Torben, Pedersen Oluf, Wang Jun, Nielsen Rasmus   Estimation of allele frequency and association mapping using next-generation sequencing data BMC bioinformatics, 2011; 12(10): 231.
Lohmueller Kirk E, Albrechtsen Anders, Li Yingrui, Kim Su Yeon, Korneliussen Thorfinn, Vinckenbosch Nicolas, Tian Geng, Huerta-Sanchez Emilia, Feder Alison F, Grarup Niels, Jørgensen Torben, Jiang Tao, Witte Daniel R, Sandbæk Annelli, Hellmann Ines, Lauritzen Torsten, Hansen Torben, Pedersen Oluf, Wang Jun, Nielsen Rasmus   Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome PLoS genetics, 2011; 7(10): e1002326.
Lohmueller Kirk E, Bustamante Carlos D, Clark Andrew G   Detecting directional selection in the presence of recent admixture in African-Americans Genetics, 2011; 187(3): 823-35.
Lohmueller Kirk E   Graydon et al. provide no new evidence that forensic STR loci are functional Forensic science international. Genetics, 2010; 4(4): 273-4.
Lohmueller Kirk E, Degenhardt Jeremiah D, Keinan Alon   Sex-averaged recombination and mutation rates on the X chromosome: a comment on Labuda et al American journal of human genetics, 2010; 86(6): 978-80; author reply 980-1.
Lohmueller Kirk E, Bustamante Carlos D, Clark Andrew G   The effect of recent admixture on inference of ancient human population history Genetics, 2010; 185(2): 611-22.
Vonholdt Bridgett M, Pollinger John P, Lohmueller Kirk E, Han Eunjung, Parker Heidi G, Quignon Pascale, Degenhardt Jeremiah D, Boyko Adam R, Earl Dent A, Auton Adam, Reynolds Andy, Bryc Kasia, Brisbin Abra, Knowles James C, Mosher Dana S, Spady Tyrone C, Elkahloun Abdel, Geffen Eli, Pilot Malgorzata, Jedrzejewski Wlodzimierz, Greco Claudia, Randi Ettore, Bannasch Danika, Wilton Alan, Shearman Jeremy, Musiani Marco, Cargill Michelle, Jones Paul G, Qian Zuwei, Huang Wei, Ding Zhao-Li, Zhang Ya-Ping, Bustamante Carlos D, Ostrander Elaine A, Novembre John, Wayne Robert K   Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication Nature, 2010; 464(7290): 898-902.
Boyko Adam R, Quignon Pascale, Li Lin, Schoenebeck Jeffrey J, Degenhardt Jeremiah D, Lohmueller Kirk E, Zhao Keyan, Brisbin Abra, Parker Heidi G, vonHoldt Bridgett M, Cargill Michele, Auton Adam, Reynolds Andy, Elkahloun Abdel G, Castelhano Marta, Mosher Dana S, Sutter Nathan B, Johnson Gary S, Novembre John, Hubisz Melissa J, Siepel Adam, Wayne Robert K, Bustamante Carlos D, Ostrander Elaine A   A simple genetic architecture underlies morphological variation in dogs PLoS biology, 2010; 8(8): e1000451.
Wall Jeffrey D, Lohmueller Kirk E, Plagnol Vincent   Detecting ancient admixture and estimating demographic parameters in multiple human populations Molecular biology and evolution, 2009; 26(8): 1823-7.
Auton Adam, Bryc Katarzyna, Boyko Adam R, Lohmueller Kirk E, Novembre John, Reynolds Andy, Indap Amit, Wright Mark H, Degenhardt Jeremiah D, Gutenkunst Ryan N, King Karen S, Nelson Matthew R, Bustamante Carlos D   Global distribution of genomic diversity underscores rich complex history of continental human populations Genome research, 2009; 19(5): 795-803.
Lohmueller Kirk E, Bustamante Carlos D, Clark Andrew G   Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data Genetics, 2009; 182(1): 217-31.
Boyko Adam R, Williamson Scott H, Indap Amit R, Degenhardt Jeremiah D, Hernandez Ryan D, Lohmueller Kirk E, Adams Mark D, Schmidt Steffen, Sninsky John J, Sunyaev Shamil R, White Thomas J, Nielsen Rasmus, Clark Andrew G, Bustamante Carlos D   Assessing the evolutionary impact of amino acid mutations in the human genome PLoS genetics, 2008; 4(5): e1000083.
Olshen Adam B, Gold Bert, Lohmueller Kirk E, Struewing Jeffery P, Satagopan Jaya, Stefanov Stefan A, Eskin Eleazar, Kirchhoff Tomas, Lautenberger James A, Klein Robert J, Friedman Eitan, Norton Larry, Ellis Nathan A, Viale Agnes, Lee Catherine S, Borgen Patrick I, Clark Andrew G, Offit Kenneth, Boyd Jeff   Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping BMC genetics, 2008; 9(7181): 14.
Lohmueller Kirk E, Indap Amit R, Schmidt Steffen, Boyko Adam R, Hernandez Ryan D, Hubisz Melissa J, Sninsky John J, White Thomas J, Sunyaev Shamil R, Nielsen Rasmus, Clark Andrew G, Bustamante Carlos D   Proportionally more deleterious genetic variation in European than in African populations Nature, 2008; 451(7181): 994-7.
Lohmueller Kirk E, Mauney Matthew M, Reich David, Braverman John M   Variants associated with common disease are not unusually differentiated in frequency across populations American journal of human genetics, 2006; 78(1): 130-6.
Hirschhorn Joel N, Lohmueller Kirk, Byrne Edward, Hirschhorn Kurt   A comprehensive review of genetic association studies Genetics in medicine : official journal of the American College of Medical Genetics, 2003; 4(2): 45-61.
Lohmueller Kirk E, Pearce Celeste L, Pike Malcolm, Lander Eric S, Hirschhorn Joel N   Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nature genetics, 2003; 33(2): 177-82.