Dorthe Schaue
Affiliations
Affiliations
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Physics & Biology in Medicine GPB Home Area
Adjunct Assistant Professor, Radiation Oncology
Research Interests
Dr. Schaue current research focuses on tumor-specific immune responses following radiation therapy and the idea that radiation can be an immune adjuvant. It is based on previous work on a mouse model showing that irradiation of dendritic cells can drive antigen-cross presentation. She was also able to show that some patients with colorectal and prostate cancer increase their level of circulating tumor-specific T cells when treated with radiotherapy. This can be accompanied by a simultaneous rise in T regulatory (suppressor) cells perhaps indicating why the immune systems fails to execute an active anti-tumor response despite the recognition of tumor. Radiation appears to be able to shape the immune balance because of differences in intrinsic radiation sensitivity of T cells subsets, and by causing tumor and normal tissue damage and the release of danger signals. The importance of T regulatory cells and the adenosinergic pathway in radiation tissue damage is also part of an ongoing research effort to differentially modulate tissue and tumor responses following radiation exposure.
Biography:

Dr. Schaue received her Ph.D. at St Bartholomew's and the Royal London School of Medicine, Queen Mary College, University of London, United Kingdom in 2004. She was trained in several premier radiation research institutions in the United Kingdom and Germany, including the Gray Lab in London and the Paterson Institute in Manchester. As a PhD student, she was given the opportunity to work on radiation responses in inflammatory cells and, as a result, she developed an interest in the immunological aspects of radiation treatment. The prospect of being able to build on this knowledge in the Department of Radiation Oncology attracted her to UCLA, where she worked as a postdoctoral fellow from 2004 until 2009 under the supervision of Dr. McBride. In 2009 she was designated assistant researcher biologist at the UCLA Department of Radiation Oncology.

Publications

A selected list of publications:

Schaue Dörthe, Kachikwu Evelyn L, McBride William H   Cytokines in radiobiological responses: a review Radiation research, 2012; 178(6): 505-23.
Schaue Dörthe, Xie Michael W, Ratikan Josephine A, McBride William H   Regulatory T cells in radiotherapeutic responses Frontiers in oncology, 2012; 2(6): 90.
Schaue Dörthe, McBride William H   T lymphocytes and normal tissue responses to radiation Frontiers in oncology, 2012; 2(6): 119.
Schaue Dörthe, Ratikan Josephine A, Iwamoto Keisuke S, McBride William H   Maximizing tumor immunity with fractionated radiation International journal of radiation oncology, biology, physics, 2012; 83(4): 1306-10.
Hu David, Lau Ontario D, Wang Linda, Wang Guanyu, Schaue Dorthe, Zhu Li, Huang Min, Lin Yuan, Dennis Miranda, Abemayor Elliot, Elashoff David A, Dubinett Steven M, McBride William H, Sharma Sherven, Wu Ben, St John Maie A   A novel modular polymer platform for the treatment of head and neck squamous cell carcinoma in an animal model Archives of otolaryngology--head & neck surgery, 2012; 138(4): 412-7.
Schaue Dörthe, Ratikan Josephine A, Iwamoto Keisuke S   Cellular autofluorescence following ionizing radiation PloS one, 2012; 7(2): e32062.
Kachikwu Evelyn L, Iwamoto Keisuke S, Liao Yu-Pei, DeMarco John J, Agazaryan Nzhde, Economou James S, McBride William H, Schaue Dörthe   Radiation enhances regulatory T cell representation International journal of radiation oncology, biology, physics, 2011; 81(4): 1128-35.
Finkelstein Steven Eric, Timmerman Robert, McBride William H, Schaue Dörthe, Hoffe Sarah E, Mantz Constantine A, Wilson George D   The confluence of stereotactic ablative radiotherapy and tumor immunology Clinical & developmental immunology, 2011; 2011(4): 439752.
Baratelli Felicita, Lee Jay M, Hazra Saswati, Lin Ying, Walser Tonya C, Schaue Dorthe, Pak Peter S, Elashoff David, Reckamp Karen, Zhang Ling, Fishbein Michael C, Sharma Sherven, Dubinett Steven M   PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer American journal of translational research, 2010; 2(4): 356-67.
Schaue Dörthe, McBride William H   Links between innate immunity and normal tissue radiobiology Radiation research, 2010; 173(4): 406-17.
Schaue Dörthe, Koya Richard C, Liao Yu-Pei, Ribas Antoni, McBride William H   Immune rejection in a humanized model of murine prostate cancer Anticancer research, 2010; 30(2): 409-14.
Liao Yu-Pei, Wang Chun-Chieh, Schaue Dörthe, Iwamoto Keisuke S, McBride William H   Local irradiation of murine melanoma affects the development of tumour-specific immunity Immunology, 2009; 128(1 Suppl): e797-804.
Schaue Dörthe, Comin-Anduix Begonya, Ribas Antoni, Zhang Li, Goodglick Lee, Sayre James W, Debucquoy Annelies, Haustermans Karin, McBride William H   T-cell responses to survivin in cancer patients undergoing radiation therapy Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(15): 4883-90.
Liao Yu-Pei, Schaue Dorthe, McBride William H   Modification of the tumor microenvironment to enhance immunity Frontiers in bioscience : a journal and virtual library, 2007; 12(15): 3576-600.
Schaue Dörthe, McBride William H   Counteracting tumor radioresistance by targeting DNA repair Molecular cancer therapeutics, 2005; 4(10): 1548-50.
Schaue Dörthe, Jahns Jutta, Hildebrandt Guido, Trott Klaus-Rüdiger   Radiation treatment of acute inflammation in mice International journal of radiation biology, 2005; 81(9): 657-67.