Leonid Kruglyak, Ph.D.

Dr. Kruglyak received his A.B. degree in physics from Princeton University and his M.S. and Ph.D. degrees, also in physics, from the University of California at Berkeley. After postdoctoral fellowships at the Institute for Advanced Study in Princeton and at Oxford University, he joined the Whitehead Institute/MIT Center for Genome Research as a research scientist. Subsequently, Dr. Kruglyak held a faculty position in the Human Biology Division at the Fred Hutchinson Cancer Research Center in Seattle, where he was also an Investigator of the Howard Hughes Medical Institute and an Affiliate Professor of Genome Sciences at the University of Washington. In 2005, Dr. Kruglyak returned to Princeton University as a Professor in the Department of Ecology and Evolutionary Biology and the Lewis-Sigler Institute for Integrative Genomics. In 2008, he was again selected an Investigator of the Howard Hughes Medical Institute. In 2010, Dr. Kruglyak was named the inaugural William R. Harman ’63 and Mary-Love Harman Professor in Genomics. He also founded and chaired the Graduate Program in Quantitative and Computational Biology at Princeton. In 2013, Dr. Kruglyak moved to the David Geffen School of Medicine at UCLA, where he holds appointments in the Departments of Human Genetics and Biological Chemistry and continues to serve as an Investigator of the Howard Hughes Medical Institute. He is also a founding member of the Computational Biosciences Institute. Dr. Kruglyak is a recipient of many awards, including a James S. McDonnell Centennial Fellowship in Human Genetics, a Burroughs Wellcome Fund Innovation Award in Functional Genomics, a MERIT award from the National Institutes of Health, and an Agilent Thought Leader Award. In 2007 he was named a Highly Cited Researcher in Molecular Biology and Genetics by ISI Thomson Scientific and elected a Fellow of the American Association for the Advancement of Science “for distinguished contributions to the study of variation in the human genome and for pioneering genetic studies of gene expression variation.” His research interests focus on understanding the genetic basis of complex phenotypes. In 2020, Dr. Kruglyak was appointed the Diller-von-Furstenberg Endowed Chair in Human Genetics, UCLA.


A selected list of publications:

Albert Frank W, Treusch Sebastian, Shockley Arthur H, Bloom Joshua S, Kruglyak Leonid   Genetics of single-cell protein abundance variation in large yeast populations Nature, 2014; .
Bloom Joshua S, Ehrenreich Ian M, Loo Wesley T, Lite TL, Kruglyak Leonid   Finding the sources of missing heritability in a yeast cross Nature, 2013; 494(7436): 234-7.
Reaves Marshall Louis, Sinha Sunita, Rabinowitz Joshua D, Kruglyak Leonid, Redfield Rosemary J   Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells Science (New York, N.Y.), 2012; 337(6093): 470-3.
Andersen Erik C, Gerke Justin P, Shapiro Joshua A, Crissman Jonathan R, Ghosh Rajarshi, Bloom Joshua S, Felix Marie-Anne, Kruglyak Leonid   Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity Nature genetics, 2012; 44(3): 285-90.
Ehrenreich Ian M, Bloom Joshua, Torabi Noorossadat, Wang Xin, Jia Yue, Kruglyak Leonid   Genetic architecture of highly complex chemical resistance traits across four yeast strains PLoS genetics, 2012; 8(3): e1002570.
Torabi Noorossadat, Kruglyak Leonid   Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast PLoS genetics, 2012; 8(3): e1002546.
Bendesky Andres, Pitts Jason, Rockman Matthew V, Chen William C, Tan Man-Wah, Kruglyak Leonid, Bargmann Cornelia I   Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans PLoS genetics, 2012; 8(12): e1003157.
Ghosh Rajarshi, Mohammadi Aylia, Kruglyak Leonid, Ryu William S   Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans BMC biology, 2012; 10(4): 85.
Ghosh Rajarshi, Andersen Erik C, Shapiro Joshua A, Gerke Justin P, Kruglyak Leonid   Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans Science (New York, N.Y.), 2012; 335(6068): 574-8.
Khan Zia, Bloom Joshua S, Amini Sasan, Singh Mona, Perlman David H, Caudy Amy A, Kruglyak Leonid   Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS Molecular systems biology, 2012; 8(3): 602.
Seidel Hannah S, Ailion Michael, Li Jialing, van Oudenaarden Alexander, Rockman Matthew V, Kruglyak Leonid   A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans PLoS biology, 2011; 9(7): e1001115.
Khan Zia, Amini Sasan, Bloom Joshua S, Ruse Cristian, Caudy Amy A, Kruglyak Leonid, Singh Mona, Perlman David H, Tavazoie Saeed   Accurate proteome-wide protein quantification from high-resolution 15N mass spectra Genome biology, 2011; 12(12): R122.
Torabi Noorossadat, Kruglyak Leonid   Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae PLoS genetics, 2011; 7(7): e1002211.
Ehrenreich Ian M, Torabi Noorossadat, Jia Yue, Kent Jonathan, Martis Stephen, Shapiro Joshua A, Gresham David, Caudy Amy A, Kruglyak Leonid   Dissection of genetically complex traits with extremely large pools of yeast segregants Nature, 2010; 464(7291): 1039-42.
Gresham David, Curry Bo, Ward Alexandra, Gordon D Benjamin, Brizuela Leonardo, Kruglyak Leonid, Botstein David   Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(4): 1482-7.
Khan Zia, Bloom Joshua S, Kruglyak Leonid, Singh Mona   A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays Bioinformatics (Oxford, England), 2009; 25(13): 1609-16.
Kruglyak Leonid, Storey John D   Cause and express Nature biotechnology, 2009; 27(6): 544-5.
Schacherer Joseph, Shapiro Joshua A, Ruderfer Douglas M, Kruglyak Leonid   Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae Nature, 2009; 458(7236): 342-5.
Bloom Joshua S, Khan Zia, Kruglyak Leonid, Singh Mona, Caudy Amy A   Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays BMC genomics, 2009; 10(6): 221.
Khan Zia, Bloom Joshua S, Garcia Benjamin A, Singh Mona, Kruglyak Leonid   Protein quantification across hundreds of experimental conditions Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(37): 15544-8.
Rockman Matthew V, Kruglyak Leonid   Recombinational landscape and population genomics of Caenorhabditis elegans PLoS genetics, 2009; 5(3): e1000419.
Rockman Matthew V, Kruglyak Leonid   Breeding designs for recombinant inbred advanced intercross lines Genetics, 2008; 179(2): 1069-78.
Capra Emily J, Skrovanek Sonja M, Kruglyak Leonid   Comparative developmental expression profiling of two C. elegans isolates PloS one, 2008; 3(12): e4055.
Smith Erin N, Kruglyak Leonid   Gene-environment interaction in yeast gene expression PLoS biology, 2008; 6(4): e83.
Coller Hilary A, Kruglyak Leonid   Genetics. It's the sequence, stupid! Science (New York, N.Y.), 2008; 322(5900): 380-1.
Gresham David, Kruglyak Leonid   Rise of the machines PLoS genetics, 2008; 4(8): e1000134.
Kruglyak Leonid   The road to genome-wide association studies Nature reviews. Genetics, 2008; 9(4): 314-8.
Seidel Hannah S, Rockman Matthew V, Kruglyak Leonid   Widespread genetic incompatibility in C. elegans maintained by balancing selection Science (New York, N.Y.), 2008; 319(5863): 589-94.
Kruglyak Leonid, Stern David L   Evolution. An embarrassment of switches Science (New York, N.Y.), 2007; 317(5839): 758-9.
Perlstein Ethan O, Ruderfer Douglas M, Roberts David C, Schreiber Stuart L, Kruglyak Leonid   Genetic basis of individual differences in the response to small-molecule drugs in yeast Nature genetics, 2007; 39(4): 496-502.
Foss Eric J, Radulovic Dragan, Shaffer Scott A, Ruderfer Douglas M, Bedalov Antonio, Goodlett David R, Kruglyak Leonid   Genetic basis of proteome variation in yeast Nature genetics, 2007; 39(11): 1369-75.
Schacherer Joseph, Ruderfer Douglas M, Gresham David, Dolinski Kara, Botstein David, Kruglyak Leonid   Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains PloS one, 2007; 2(3): e322.
Eberle Michael A, Rieder Mark J, Kruglyak Leonid, Nickerson Deborah A   Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome PLoS genetics, 2006; 2(9): e142.
Rockman Matthew V, Kruglyak Leonid   Genetics of global gene expression Nature reviews. Genetics, 2006; 7(11): 862-72.
Gresham David, Ruderfer Douglas M, Pratt Stephen C, Schacherer Joseph, Dunham Maitreya J, Botstein David, Kruglyak Leonid   Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray Science (New York, N.Y.), 2006; 311(5769): 1932-6.
Parker Heidi G, Kruglyak Leonid, Ostrander Elaine A   Molecular genetics: DNA analysis of a putative dog clone Nature, 2006; 440(7081): E1-2.
Riehle Michelle M, Markianos Kyriacos, Niarè Oumou, Xu Jiannong, Li Jun, Tourè Abdoulaye M, Podiougou Belco, Oduol Frederick, Diawara Sory, Diallo Mouctar, Coulibaly Boubacar, Ouatara Ahmed, Kruglyak Leonid, Traorè Sèkou F, Vernick Kenneth D   Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region Science (New York, N.Y.), 2006; 312(5773): 577-9.
Ruderfer Douglas M, Pratt Stephen C, Seidel Hannah S, Kruglyak Leonid   Population genomic analysis of outcrossing and recombination in yeast Nature genetics, 2006; 38(9): 1077-81.
Perlstein Ethan O, Ruderfer Douglas M, Ramachandran Gopal, Haggarty Stephen J, Kruglyak Leonid, Schreiber Stuart L   Revealing complex traits with small molecules and naturally recombinant yeast strains Chemistry & biology, 2006; 13(3): 319-27.
Gatbonton Tonibelle, Imbesi Maria, Nelson Melisa, Akey Joshua M, Ruderfer Douglas M, Kruglyak Leonid, Simon Julian A, Bedalov Antonio   Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast PLoS genetics, 2006; 2(3): e35.
Carlson Christopher S, Reider Mark J, Nickerson Deborah A, Eberle Michael A, Kruglyak Leonid   Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns' Bioinformatics (Oxford, England), 2005; 21(2): 141-3.
Brem Rachel B, Storey John D, Whittle Jacqueline, Kruglyak Leonid   Genetic interactions between polymorphisms that affect gene expression in yeast Nature, 2005; 436(7051): 701-3.
Ronald James, Brem Rachel B, Whittle Jacqueline, Kruglyak Leonid   Local regulatory variation in Saccharomyces cerevisiae PLoS genetics, 2005; 1(2): e25.
Storey John D, Akey Joshua M, Kruglyak Leonid   Multiple locus linkage analysis of genomewide expression in yeast PLoS biology, 2005; 3(8): e267.
Kruglyak Leonid   Power tools for human genetics Nature genetics, 2005; 37(12): 1299-300.
Ronald James, Akey Joshua M, Whittle Jacqueline, Smith Erin N, Yvert Gael, Kruglyak Leonid   Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays Genome research, 2005; 15(2): 284-91.
Brem Rachel B, Kruglyak Leonid   The landscape of genetic complexity across 5,700 gene expression traits in yeast Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(5): 1572-7.
Sutter Nathan B, Eberle Michael A, Parker Heidi G, Pullar Barbara J, Kirkness Ewen F, Kruglyak Leonid, Ostrander Elaine A   Extensive and breed-specific linkage disequilibrium in Canis familiaris Genome research, 2004; 14(12): 2388-96.
Parker Heidi G, Kim Lisa V, Sutter Nathan B, Carlson Scott, Lorentzen Travis D, Malek Tiffany B, Johnson Gary S, DeFrance Hawkins B, Ostrander Elaine A, Kruglyak Leonid   Genetic structure of the purebred domestic dog Science (New York, N.Y.), 2004; 304(5674): 1160-4.
Crawford Dana C, Carlson Christopher S, Rieder Mark J, Carrington Dana P, Yi Qian, Smith Joshua D, Eberle Michael A, Kruglyak Leonid, Nickerson Deborah A   Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations American journal of human genetics, 2004; 74(4): 610-22.
Carlson Christopher S, Eberle Michael A, Kruglyak Leonid, Nickerson Deborah A   Mapping complex disease loci in whole-genome association studies Nature, 2004; 429(6990): 446-52.
Abecasis Goncalo, Cox Nancy, Daly Mark J, Kruglyak Leonid, Laird Nan, Markianos Kyriacos, Patterson Nick   No bias in linkage analysis American journal of human genetics, 2004; 75(4): 722-3; author reply 723-7.
Akey Joshua M, Eberle Michael A, Rieder Mark J, Carlson Christopher S, Shriver Mark D, Nickerson Deborah A, Kruglyak Leonid   Population history and natural selection shape patterns of genetic variation in 132 genes PLoS biology, 2004; 2(10): e286.
Carlson Christopher S, Eberle Michael A, Rieder Mark J, Yi Qian, Kruglyak Leonid, Nickerson Deborah A   Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium American journal of human genetics, 2004; 74(1): 106-20.
Furman Itay, Rieder Mark J, Da Ponte Suzanne, Carrington Dana P, Nickerson Deborah A, Kruglyak Leonid, Markianos Kyriacos   Sequence-based linkage analysis American journal of human genetics, 2004; 75(4): 647-53.
Matise Tara C, Sachidanandam Ravi, Clark Andrew G, Kruglyak Leonid, Wijsman Ellen, Kakol Jerzy, Buyske Steven, Chui Buena, Cohen Patrick, de Toma Claudia, Ehm Margaret, Glanowski Stephen, He Chunsheng, Heil Jeremy, Markianos Kyriacos, McMullen Ivy, Pericak-Vance Margaret A, Silbergleit Arkadiy, Stein Lincoln, Wagner Michael, Wilson Alexander F, Winick Jeffrey D, Winn-Deen Emily S, Yamashiro Carl T, Cann Howard M, Lai Eric, Holden Arthur L   A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set American journal of human genetics, 2003; 73(2): 271-84.
Carlson Christopher S, Eberle Michael A, Rieder Mark J, Smith Joshua D, Kruglyak Leonid, Nickerson Deborah A   Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans Nature genetics, 2003; 33(4): 518-21.
Yvert Gael, Brem Rachel B, Whittle Jacqueline, Akey Joshua M, Foss Eric, Smith Erin N, Mackelprang Rachel, Kruglyak Leonid   Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors Nature genetics, 2003; 35(1): 57-64.
Brem Rachel B, Yvert Gael, Clinton Rebecca, Kruglyak Leonid   Genetic dissection of transcriptional regulation in budding yeast Science (New York, N.Y.), 2002; 296(5568): 752-5.
Ardlie Kristin G, Kruglyak Leonid, Seielstad Mark   Patterns of linkage disequilibrium in the human genome Nature reviews. Genetics, 2002; 3(4): 299-309.