Thomas A Vallim, Ph.D.

Laboratory Address:
675 Charles E Young Drive South
MRL Receiving
Room 3240
Los Angeles, CA 90095

Mailing Address:
650 Charles E. Young Drive South
A2-237 CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Assistant Professor, Cardiology, Biological Chemistry
Member, CTSI, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Molecular, Cellular & Integrative Physiology GPB Home Area
Biography:

Dr. Vallim is an Assistant Professor in the Department of Biological Chemistry and in the Department of Medicine, Division of Cardiology at UCLA. Dr. Vallim was born in Brazil and emigrated to England as a teenager. In England, Dr. Vallim received his M.Sci and Ph.D from the University of Nottingham. As an undergraduate Ph.D student, Dr. Vallim’s research focused was on the transcriptional regulation of genes in lipid metabolism by dietary factors. In 2008, Dr. Vallim came to UCLA for his post-doctoral studies in the laboratory of Peter Edwards. At UCLA, Dr. Vallim’s research was focused on identifying molecular mechanisms that underlie the regulation of bile acid metabolism, the major pathway of cholesterol excretion from the body. In 2013, Dr. Vallim was promoted to Assistant Professor in the Division of Cardiology at UCLA, and in 2016, Dr. Vallim also joined the Department of Biological Chemistry.

Publications
de Aguiar Vallim Thomas Q, Lee Elinor, Merriott David J, Goulbourne Christopher N, Cheng Joan, Cheng Angela, Gonen Ayelet, Allen Ryan M, Palladino Elisa N D, Ford David A, Wang Tisha, Baldán Ángel, Tarling Elizabeth J ABCG1 regulates pulmonary surfactant metabolism in mice and men. Journal of lipid research. 2017; 58(5): 941-954.
Rong Xin, Wang Bo, Palladino Elisa Nd, de Aguiar Vallim Thomas Q, Ford David A, Tontonoz Peter ER phospholipid composition modulates lipogenesis during feeding and in obesity. The Journal of clinical investigation. 2017; 127(10): 3640-3651.
Zhang Li, Rajbhandari Prashant, Priest Christina, Sandhu Jaspreet, Wu Xiaohui, Temel Ryan, Castrillo Antonio, de Aguiar Vallim Thomas Q, Sallam Tamer, Tontonoz Peter Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. eLife. 2017; 6(1): 1620.
Mack Julia J, Mosqueiro Thiago S, Archer Brian J, Jones William M, Sunshine Hannah, Faas Guido C, Briot Anais, Aragón Raquel L, Su Trent, Romay Milagros C, McDonald Austin I, Kuo Cheng-Hsiang, Lizama Carlos O, Lane Timothy F, Zovein Ann C, Fang Yun, Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Navab Mohamad, Fogelman Alan M, Bouchard Louis S, Iruela-Arispe M Luisa NOTCH1 is a mechanosensor in adult arteries. Nature communications. 2017; 8(1): 1620.
Tarling Elizabeth J, Clifford Bethan L, Cheng Joan, Morand Pauline, Cheng Angela, Lester Ellen, Sallam Tamer, Turner Martin, de Aguiar Vallim Thomas Q RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. The Journal of clinical investigation. 2017; 127(10): 3741-3754.
Sallam Tamer, Jones Marius C, Gilliland Thomas, Zhang Li, Wu Xiaohui, Eskin Ascia, Sandhu Jaspreet, Casero David, Vallim Thomas Q de Aguiar, Hong Cynthia, Katz Melanie, Lee Richard, Whitelegge Julian, Tontonoz Peter Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016; 534(7605): 124-8.
Wang Bo, Rong Xin, Duerr Mark A, Hermanson Daniel J, Hedde Per Niklas, Wong Jinny S, Vallim Thomas Q de Aguiar, Cravatt Benjamin F, Gratton Enrico, Ford David A, Tontonoz Peter Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell metabolism. 2016; 23(3): 492-504.
Vergnes Laurent, Chin Robert G, de Aguiar Vallim Thomas, Fong Loren G, Osborne Timothy F, Young Stephen G, Reue Karen SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. Journal of lipid research. 2016; 57(3): 410-21.
Ribas Vicent, Drew Brian G, Zhou Zhenqi, Phun Jennifer, Kalajian Nareg Y, Soleymani Teo, Daraei Pedram, Widjaja Kevin, Wanagat Jonathan, de Aguiar Vallim Thomas Q, Fluitt Amy H, Bensinger Steven, Le Thuc, Radu Caius, Whitelegge Julian P, Beaven Simon W, Tontonoz Peter, Lusis Aldons J, Parks Brian W, Vergnes Laurent, Reue Karen, Singh Harpreet, Bopassa Jean C, Toro Ligia, Stefani Enrico, Watt Matthew J, Schenk Simon, Akerstrom Thorbjorn, Kelly Meghan, Pedersen Bente K, Hewitt Sylvia C, Korach Kenneth S, Hevener Andrea L Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Science translational medicine. 2016; 8(334): 334ra54.
Lusis Aldons J, Seldin Marcus M, Allayee Hooman, Bennett Brian J, Civelek Mete, Davis Richard C, Eskin Eleazar, Farber Charles R, Hui Simon, Mehrabian Margarete, Norheim Frode, Pan Calvin, Parks Brian, Rau Christoph D, Smith Desmond J, Vallim Thomas, Wang Yibin, Wang Jessica The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. Journal of lipid research. 2016; 57(6): 925-42.
Zhang Hanrui, de Aguiar Vallim Thomas Q, Martel Catherine, Martel Catherine Translational and Therapeutic Approaches to the Understanding and Treatment of Dyslipidemia. Arteriosclerosis, thrombosis, and vascular biology. 2016; 36(7): e56-61.
Baldán Ángel, de Aguiar Vallim Thomas Q miRNAs and High-Density Lipoprotein metabolism. Biochimica et biophysica acta. 2016; 1861(12 Pt B): 2053-2061.
Shih Diana M, Wang Zeneng, Lee Richard, Meng Yonghong, Che Nam, Charugundla Sarada, Qi Hannah, Wu Judy, Pan Calvin, Brown J Mark, Vallim Thomas, Bennett Brian J, Graham Mark, Hazen Stanley L, Lusis Aldons J Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. Journal of lipid research. 2015; 56(1): 22-37.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Ahn Hannah, Hagey Lee R, Romanoski Casey E, Lee Richard G, Graham Mark J, Motohashi Hozumi, Yamamoto Masayuki, Edwards Peter A MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell metabolism. 2015; 21(2): 298-310.
Tarling Elizabeth J, Ahn Hannah, de Aguiar Vallim Thomas Q The Nuclear Receptor FXR Uncouples the Actions of miR-33 From SREBP-2. Arteriosclerosis, thrombosis, and vascular biology. 2015; .
Warrier Manya, Shih Diana M, Burrows Amy C, Ferguson Daniel, Gromovsky Anthony D, Brown Amanda L, Marshall Stephanie, McDaniel Allison, Schugar Rebecca C, Wang Zeneng, Sacks Jessica, Rong Xin, Vallim Thomas de Aguiar, Chou Jeff, Ivanova Pavlina T, Myers David S, Brown H Alex, Lee Richard G, Crooke Rosanne M, Graham Mark J, Liu Xiuli, Parini Paolo, Tontonoz Peter, Lusis Aldon J, Hazen Stanley L, Temel Ryan E, Brown J Mark The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell reports. 2015; .
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Kim Tammy, Civelek Mete, Baldan Angel, Esau Christine, Edwards Peter A MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circulation research. 2013; 112(12): 1602-12.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A Pleiotropic roles of bile acids in metabolism. Cell metabolism. 2013; 17(5): 657-69.
Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A Role of ABC transporters in lipid transport and human disease. Trends in endocrinology and metabolism: TEM. 2013; 24(7): 342-50.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell metabolism. 2013; 17(1): 49-60.
Foxler Daniel E, James Victoria, Shelton Samuel J, Vallim Thomas Q de A, Shaw Peter E, Sharp Tyson V PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1. FEBS letters. 2011; 585(7): 1089-96.
Lee Florence Ying, de Aguiar Vallim Thomas Quad, Chong Hansook Kim, Zhang Yanqiao, Liu Yaping, Jones Stacey A, Osborne Timothy F, Edwards Peter A Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Molecular endocrinology (Baltimore, Md.). 2010; 24(8): 1626-36.
Vallim Thomas Quad de Aguiar, Edwards Peter A Bile acids have the gall to function as hormones. Cell metabolism. 2009; 10(3): 162-4.
Sharp Tyson V, Al-Attar Ahmad, Foxler Daniel E, Ding Li, de A Vallim Thomas Q, Zhang Yining, Nijmeh Hala S, Webb Thomas M, Nicholson Andrew G, Zhang Qunyuan, Kraja Aldi, Spendlove Ian, Osborne John, Mardis Elaine, Longmore Gregory D The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(50): 19932-7.