|Associate Professor, Medicine, Molecular, Cell, and Developmental Biology|
|Member, Cell & Developmental Biology GPB Home Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Cardiovascular Research Laboratory|
|Associate Member, Molecular Biology Institute|
Dr. Arjun Deb seeks to develop methods to activate heart stem cells that will generate new heart muscle cells instead of scar tissue that results from heart attack. More than half a million people are newly diagnosed with heart failure every year. The success of novel stem-cell based therapy for heart disease would dramatically improve the quality of life of patients, reduce an enormous burden on the health care system, and be an enormous benefit to society. Dr. Debs interest in stem cells began when he was studying how blood vessels form. He became fascinated with stem cell biology and decided to pursue a career in stem cell science after he isolated stem cells from his own blood (endothelial progenitor cells) and grew them into blood vessels in the laboratory. An associate professor in the Department of Medicine, Division of Cardiology at UCLAs David Geffen School of Medicine, Dr. Deb earned his medical degree at the University of Calcutta, India, and completed his residency in internal medicine at the Mayo Clinic College of Medicine in Minnesota where he also completed a fellowship in cardiovascular diseases. He then completed research fellowships at Mayo and at Duke University in Durham, North Carolina. Besides the UCLA Broad Stem Cell Research Center, he is a member of the Cardiovascular Research Laboratory, the Jonsson Comprehensive Cancer Center (Cancer and Stem Cell Biology Program), the Molecular Cellular and Integrative Physiology Program, and the Cell and Developmental Biology Program. He is also a member of the American Heart Association and the American College of Cardiology. Dr. Deb received the Louis N and Arnold M Katz Basic Science Research Prize awarded by the American Heart Association, the American College of Cardiology Foundation/Keating Career Development Award in Hypertension & Peripheral Vascular Disease, the Ellison Medical Foundation New Scholar in Aging Award, an NIH Pathway to Independence Award, a Glaxo Smith Kline Beecham Cardiovascular Research Foundation Young Investigator Award, the Medical Foundation of North Carolina Excellence Fund Award, and a Basic Science Young Investigator Award by the American College of Cardiology. His research is funded by the National Institutes of Health.
Yu Jingyi, Seldin Marcus M, Fu Kai, Li Shen, Lam Larry, Wang Ping, Wang Yijie, Huang Dian, Nguyen Thang L, Wei Bowen, Kulkarni Rajan P, Di Carlo Dino, Teitell Michael, Pellegrini Matteo, Lusis Aldons J, Deb Arjun Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circulation research. 2018; .
Foulquier Sébastien, Daskalopoulos Evangelos P, Lluri Gentian, Hermans Kevin C M, Deb Arjun, Blankesteijn W Matthijs WNT Signaling in Cardiac and Vascular Disease. Pharmacological reviews. 2018; 70(1): 68-141.
Lluri Gentian, Renella Pierangelo, Finn J Paul, Vorobiof Gabriel, Aboulhosn Jamil, Deb Arjun Prognostic Significance of Left Ventricular Fibrosis in Patients With Congenital Bicuspid Aortic Valve. The American journal of cardiology. 2017; .
Monaghan Michael, Holeiter Monika, Brauchle Eva, Layland Shannon, Lu Yan, Deb Arjun, Pandit Abhay, Nsair Ali, Schenke-Layland Katja Exogenous miR-29B delivery via a hyaluronan-based injectable system yields functional maintenance of the infarcted myocardium. Tissue engineering. Part A. 2017; .
Seldin Marcus M, Kim Eric D, Romay Milagros C, Li Shen, Rau Christoph D, Wang Jessica J, Krishnan Karthickeyan Chella, Wang Yibin, Deb Arjun, Lusis Aldons J A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. American journal of physiology. Heart and circulatory physiology. 2017; 312(4): H728-H741.
Murray Iain R, Baily James E, Chen William C W, Dar Ayelet, Gonzalez Zaniah N, Jensen Andrew R, Petrigliano Frank A, Deb Arjun, Henderson Neil C Skeletal and cardiac muscle pericytes: Functions and therapeutic potential. Pharmacology & therapeutics. 2017; 171: 65-74.
Pillai Indulekha C L, Li Shen, Romay Milagros, Lam Larry, Lu Yan, Huang Jie, Dillard Nathaniel, Zemanova Marketa, Rubbi Liudmilla, Wang Yibin, Lee Jason, Xia Ming, Liang Owen, Xie Ya-Hong, Pellegrini Matteo, Lusis Aldons J, Deb Arjun Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell stem cell. 2017; 20(2): 218-232.e5.
Wang Zhihua, Zhang Xiao-Jing, Ji Yan-Xiao, Zhang Peng, Deng Ke-Qiong, Gong Jun, Ren Shuxun, Wang Xinghua, Chen Iris, Wang He, Gao Chen, Yokota Tomohiro, Ang Yen Sin, Li Shen, Cass Ashley, Vondriska Thomas M, Li Guangping, Deb Arjun, Srivastava Deepak, Yang Huang-Tian, Xiao Xinshu, Li Hongliang, Wang Yibin The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nature medicine. 2016; 22(10): 1131-1139.
Brumm AJ, Nunez S, Doroudchi MM, Kawaguchi R, Duan J, Pellegrini M, Lam L, Carmichael ST, Deb A*, Hinman JD*. Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner. Molecular Neurobiology. 2016; Epub.
Arjun Deb, Yibin Wang Hypertrophic preconditioning: Short term tricks for long term gain. Circulation. 2015; .
Eric Ubil, Jinzhu Duan,Indulekha C. L. Pillai, Manuel Rosa-Garrido, Yong Wu, Francesca Bargiacchi, Yan Lu, Seta Stanbouly, Jie Huang, Mauricio Rojas, Thomas M. Vondriska, Enrico Stefani & Arjun Deb Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature. 2014; 514(7524): 585-590.
Deb Arjun, Ubil Eric Cardiac fibroblast in development and wound healing. Journal of molecular and cellular cardiology. 2014; 70(2): 47-55.
Deb Arjun Cell-cell interaction in the heart via Wnt/Î²-catenin pathway after cardiac injury. Cardiovascular research. 2014; 102(2): 214-23.
Duan JinZhu, Lee Yueh, Jania Corey, Gong Jucheng, Rojas Mauricio, Burk Laurel, Willis Monte, Homeister Jonathon, Tilley Stephen, Rubin Janet, Deb Arjun Rib fractures and death from deletion of osteoblast Î²catenin in adult mice is rescued by corticosteroids. PloS one. 2013; 8(2): e55757.
Duan Jinzhu, Gherghe Costin, Liu Dianxin, Hamlett Eric, Srikantha Luxman, Rodgers Laurel, Regan Jenna N, Rojas Mauricio, Willis Monte, Leask Andrew, Majesky Mark, Deb Arjun Wnt1/Î²catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. The EMBO journal. 2012; 31(2): 429-42.
Gherghe Costin M, Duan Jinzhu, Gong Jucheng, Rojas Mauricio, Klauber-Demore Nancy, Majesky Mark, Deb Arjun Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011; 25(6): 1836-43.
Deb Arjun, Patterson Cam Closer to fine: fewer steps to endothelial stemness. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(10): 1880-1.
Huang Jing, Zhang Zhiping, Guo Jian, Ni Aiguo, Deb Arjun, Zhang Lunan, Mirotsou Maria, Pratt Richard E, Dzau Victor J Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circulation research. 2010; 106(11): 1753-62.
Deb Arjun, Patterson Cam Hard luck stories: the reality of endothelial progenitor cells continues to fall short of the promise. Circulation. 2010; 121(7): 850-2.
Zhang Zhongyan, Deb Arjun, Zhang Zhiping, Pachori Alok, He Wei, Guo Jian, Pratt Richard, Dzau Victor J Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. Journal of molecular and cellular cardiology. 2009; 46(3): 370-7.
Deb Arjun, Davis Bryce H, Guo Jian, Ni Aiguo, Huang Jing, Zhang Zhiping, Mu Hui, Dzau Victor J SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a. Stem cells (Dayton, Ohio). 2008; 26(1): 35-44.
Noiseux Nicolas, Gnecchi Massimiliano, Lopez-Ilasaca Marco, Zhang Lunan, Solomon Scott D, Deb Arjun, Dzau Victor J, Pratt Richard E Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Molecular therapy : the journal of the American Society of Gene Therapy. 2006; 14(6): 840-50.
Friday Bret B, Deb Arjun Images in cardiovascular medicine. Systemic complications of infective endocarditis. Circulation. 2005; 112(20): e324.
Wolk Robert, Deb Arjun, Caplice Noel M, Somers Virend K Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis. 2005; 183(1): 131-9.
Miller Dylan V, Deb Arjun, Edwards William D, Zehr Kenton J, Oliveira Andre M Primary synovial sarcoma of the mitral valve. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2005; 14(6): 331-3.
Deb Arjun, Wang Shao Hua, Skelding Kimberly, Miller Dylan, Simper David, Caplice Noel Bone marrow-derived myofibroblasts are present in adult human heart valves. The Journal of heart valve disease. 2005; 14(5): 674-8.
Liu Chunsheng, Wang Shaohua, Deb Arjun, Nath Karl A, Katusic Zvonimir S, McConnell Joseph P, Caplice Noel M Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation. Circulation research. 2005; 97(2): 135-43.
Caplice Noel M, Deb Arjun Myocardial-cell replacement: the science, the clinic and the future. Nature clinical practice. Cardiovascular medicine. 2004; 1(2): 90-5.
Deb Arjun, Skelding Kimberly A, Wang Shaohua, Reeder Margo, Simper David, Caplice Noel M Integrin profile and in vivo homing of human smooth muscle progenitor cells. Circulation. 2004; 110(17): 2673-7.
Deb Arjun, Caplice Noel M Lipoprotein(a): new insights into mechanisms of atherogenesis and thrombosis. Clinical cardiology. 2004; 27(5): 258-64.
Deb Arjun, Tefferi Ayalew Images in clinical medicine. Systemic mastocytosis. The New England journal of medicine. 2003; 349(7): e7.
Simper David, Wang Shaohua, Deb Arjun, Holmes David, McGregor Christopher, Frantz Robert, Kushwaha Sudhir S, Caplice Noel M Endothelial progenitor cells are decreased in blood of cardiac allograft patients with vasculopathy and endothelial cells of noncardiac origin are enriched in transplant atherosclerosis. Circulation. 2003; 108(2): 143-9.
Deb Arjun, Wang Shaohua, Skelding Kimberly A, Miller Dylan, Simper David, Caplice Noel M Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation. 2003; 107(9): 1247-9.
Young Abbie L, Baysal Bora E, Deb Arjun, Young William F Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene. The Journal of clinical endocrinology and metabolism. 2002; 87(9): 4101-5.
Deb Arjun, Natt Neena 68-year-old man with generalized weakness. Mayo Clinic proceedings. 2002; 77(7): 705-8.