Nicholas A Cacalano, Ph.D.

Work Address:
B3-109 CHS
Campus - 171415
CA

Affiliations
Affiliations
Assistant Professor, Radiation Oncology
Member, JCCC Signal Transduction and Therapeutics Program Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Publications
Paranjpe, A, Cacalano, NA, Hume, W, Jewett, A N-acetyl cysteine (NAC) mediates protection from 2-hydroxy methacrylate (HEMA) induced apoptosis via NF_B dependent and independent pathways: Potential involvement of JNK. Toxicological Sciences 2009; 108: 356-366.
Kim, K, Brush, JM, Watson, PA, Cacalano, NA, Iwamoto, KS, McBride, WH EGFRvIII expression in U87 glioboastoma cells alters their proteasome composition, function, and response to irradiation. Mol Cancer Res 2008; 6: 426-434.
Paranjpe A, Cacalano NA, Hume WR, Jewett A Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis. J Endod 2008; 34: 1191-1197.
Paranjpe, A, Sung, EC, Cacalano, NA, Hume, WR, Jewett, A N-acetyl cysteine protects pulp cells from resin toxins in vivo. J. Dental Research 2008; 87: 537-541.
Jewett, A. Teruel, A, Romero, M, Head, C, Cacalano, NA Rapid and potent induction of cell death and loss of NK cell cytotoxicity by F(ab’)2 fragment of anti-CD16 antibody. Cancer Immunology and Immunotherapy 2008; 57: 1053-1066.
Cacalano, NA, Wang, MY, Park, NH, Jewett, A Regulation of IgFbp6 and induction of cell death in HEp2 tumor cells is mediated by inverse expression and function of c-jun N- terminal Kinase (JNK) and NFkB. Apoptosis 2008; 13: 1439-1449.
Cacalano, NA, Wang, MY, Park, NH, Jewett, A. Regulation of IgFbp6 and induction of cell death in HEp2 tumor cells is mediated by inverse expression and function of c-jun N- terminal Kinase (JNK) and NFkB. Apoptosis 2008; 13: 1439-1449.
Sitko, J, Zhou, H, Takaesu, G, Yoshimura, A, McBride, WH, Jamieson, CAM, Jewett, A, Cacalano, NA SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cellular Signalling 2008; 20: 221-2230.
Paranjpe, A, Cacalano, NA, Hume, WR, Jewett , A N-acetylcysteine protects Dental Pulp Stromal Cells from HEMA-induced apoptosis by inducing differentiation of the cells. Free Radical Biology and Medicine 2007; 43: 1394-1408.
Romero-Reyes, M, Head, C, Cacalano NA, Jewett A Potent induction of TNF-_ during interaction of immune effectors with oral tumors is a potential mechanism for the loss of NK cell viability and function. Apoptosis 2007; 12: 2063-2075.
Teruel, A, Romero-Reyes, M, Head, C, Cacalano, NA, Jewett, A Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion. Cancer Immunology and Immunotherapy 2007; 57: 359-366.
Zhou, H, Miki, R, Eeva, M, Fike, FM, Seligson, D, Yang, L, Yoshimura, A, Teitell, MA, Christina A.M. Jamieson, CAM, Cacalano, NA Reciprocal regulation of SOCS1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme Clin. Cancer Res 2007; 13: 2344-2353.
Cui, X, Zhang, L, Luo, J, Rajasekaran, A, Hazra, S, Cacalano, NA, Dubinett, SM Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene 2007; 26: 4253-4260.
Jewett A, Cacalano NA, Head C, Teruel A. Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells. Clin Cancer Res 2006; 12: 1994-2003.
Qasimi P, Ming-Lum A, Ghanipour A, Ong CJ, Cox ME, Ihle J, Cacalano N, Yoshimura A, Mui AL Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumour necrosis factor alpha and nitric oxide production by macrophages. J Biol Chem 2006; 281: 6316-6324.
Jewett A, Head C, Cacalano NA Emerging mechanisms of immunosuppression in oral cancers. J Dent Res 2006; 85: 1061-1073.
Wang CC, Liao YP, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. Cancer Res 2006; 66(13): 6756-6762.
Jewett A, Cacalano NA, Teruel A, Romero M, Rashedi M, Wang M, Nakamura H Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation. Cancer Immunol Immunother 2006; 18: 1-12.
Dalwadi H, Krysan K, Heuze-Vourc'h N, Dohadwala M, Elashoff D, Sharma S, Cacalano N, Lichtenstein A, Dubinett S Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. Clin Cancer Res 2005; 11: 7674-7682.
Tannahill GM, Elliott J, Barry AC, Hibbert L, Cacalano NA, Johnston JA SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation. Mol Cell Biol 2005; 25: 9115-9126.
Sitko JC, Guevara CI, Cacalano NA Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation. The Journal of biological chemistry. . 2004; 279(36): 37662-9.
Sitko JC, Guevara CI and Cacalano NA Tyrosine-phosphorylated SOCS3 interacts with NcK and Crk-L adapter proteins and regulates Nck activation. Journal of Biological Chemistry 2004; 279: 37662-37669.
Haan S, Ferguson P, Sommer U, Hiremath M, McVicar DW, Heinrich PC, Johnston JA, Cacalano NA Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. The Journal of biological chemistry. . 2003; 278(34): 31972-9.
Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med. 2003; 9(8): 1047-54.
Seki, Y-I, Inoue, H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano NA, O’Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A and Kubo M SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses. Nature Medicine 2003; 9: 1047-1054.
Haan, S, Ferguson, P, Sommer, U, McVicar, D, Heinrich, PC, Johnston, JA, and Cacalano, NA Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. Journal of Biological Chemistry 2003; 278: 31972-31979.
Cacalano NA and Johnston JA Jak3-dependent pathways in hematopoiesis and SCID. In: The JAK-Stat Pathway in Hematopoiesis and Disease, AC Ward, A. ed. Plenum Publishers 2002; 10-50.
Cacalano, NA Role of Jak3 in Hematopoiesis and SCID. In: JAK-STAT Signaling in Hematopoiesis. Ward, A. ed. Eureka Press 2001; .
Cacalano, NA, Sanden, D, and Johnston, JA Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nature Cell Biology 2001; 3: 460-465.
Cacalano, NA, Migone, TS, Bazan, F, Hanson, EP, Chen, M, Candotti, F, OíShea, JJ, and Johnston, JA Autsosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3- receptor interaction domain. EMBO J 1999; 18(6): 1549-1558.
Cacalano, NA, and Johnston, JA Interleukin-2 signaling and inherited immunodeficiency. Am. J. Hum. Genet 1999; 65(2): 287-293.
Cohney, SJ, Sanden, D, Cacalano, NA, Yoshimura, A, Mui, A, Migone, TS, and Johnston, JA SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol 1999; 19(7): 4980-4988.