Janet Sinsheimer, Ph.D.

Work Address:
5-357C Gonda / 5213 LSB
Los Angeles, CA 90095 Gonda Center
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Biomathematics, Human Genetics
Member, Bioinformatics GPB Home Area, CTSI, Genetics & Genomics GPB Home Area, JCCC Healthy and At-Risk Populations Program Area, JCCC Molecular Epidemiology Program Area
Research Interests
Dr. Sinsheimer's research is focused on developing mathematical models of evolution and genetics. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, her group have been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility and models to disentangle maternal genetic effects from environment. She has also developed methods for realistic inference of evolutionary relationships in a Bayesian context and applied these methods to HIV evolution. Her research in HIV evolution has been geared towards understanding the mechanisms by which HIV evades the immune system.
Biography

Janet Sinsheimer is a Professor in the Departments of Human Genetics, Biomathematics and Biostatistics at UCLA. She has a PhD in Biomathematics (UCLA), an MA in Biochemistry (Brandeis) and an ScB in Chemistry (Brown U). Dr. Sinsheimer's research is focused on developing mathematical models of evolution and genetics. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, her group have been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility and models to disentangle maternal genetic effects from environment. She has also developed methods for realistic inference of evolutionary relationships in a Bayesian context.

Publications

A selected list of publications:

Palmer Christina G S, Boudreault Patrick, Baldwin Erin E, Fox Michelle, Deignan Joshua L, Kobayashi Yoko, Sininger Yvonne, Grody Wayne, Sinsheimer Janet S   Deaf genetic testing and psychological well-being in deaf adults Journal of genetic counseling, 2013; 22(4): 492-507.
Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S, Sripracha Ram, Zhou Hua, Sobel Eric M   Mendel: the Swiss army knife of genetic analysis programs Bioinformatics (Oxford, England), 2013; 29(12): 1568-70.
Lee Pei-Chen, Rhodes Shannon L, Sinsheimer Janet S, Bronstein Jeff, Ritz Beate   Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure Environment international, 2013; 56(12): 42-7.
Weissglas-Volkov Daphna, Aguilar-Salinas Carlos A, Nikkola Elina, Deere Kerry A, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernandez Linda Liliana, Gomez-Munguia Lizeth, Ordoñez-Sánchez Maria Luisa, Reddy Prasad M V Linga, Lusis Aldons J, Matikainen Niina, Taskinen Marja-Riitta, Riba Laura, Cantor Rita M, Sinsheimer Janet S, Tusie-Luna Teresa, Pajukanta Päivi   Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci Journal of medical genetics, 2013; 50(5): 298-308.
Cybis Gabriela B, Sinsheimer Janet S, Lemey Philippe, Suchard Marc A   Graph hierarchies for phylogeography Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013; 368(1614): 20120206.
Clark Michelle M, Blangero John, Dyer Thomas D, Sobel Eric M, Sinsheimer Janet S   The Quantitative-MFG Test: A Linear Mixed Effect Model to Detect Maternal-Offspring Gene Interactions Annals of human genetics, 2016; 80(1): 63-80.
Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S, Sobel Eric M   Next Generation Statistical Genetics: Modeling, Penalization, and Optimization in High-Dimensional Data Annual review of statistics and its application, 2014; 1(1): 279-300.
Clark Michelle M, Chazara Olympe, Sobel Eric M, Gjessing Håkon K, Magnus Per, Moffett Ashley, Sinsheimer Janet S   Human Birth Weight and Reproductive Immunology: Testing for Interactions between Maternal and Offspring KIR and HLA-C Genes Human heredity, 2016; 81(4): 181-193.
Cybis Gabriela B, Sinsheimer Janet S, Bedford Trevor, Rambaut Andrew, Lemey Philippe, Suchard Marc A   Bayesian nonparametric clustering in phylogenetics: modeling antigenic evolution in influenza Statistics in medicine, 2018; 37(2): 195-206.
Lake James A, Larsen Joseph, Sarna Brooke, de la Haba Rafael R, Pu Yiyi, Koo HyunMin, Zhao Jun, Sinsheimer Janet S   Rings Reconcile Genotypic and Phenotypic Evolution within the Proteobacteria Genome biology and evolution, 2015; 7(12): 3434-42.
Chuang Yu-Hsuan, Lill Christina M, Lee Pei-Chen, Hansen Johnni, Lassen Christina F, Bertram Lars, Greene Naomi, Sinsheimer Janet S, Ritz Beate   Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2 Neuroepidemiology, 2016; 47(3-4): 192-200.
Boudreault Patrick, Wolfson Alicia, Berman Barbara, Venne Vickie L, Sinsheimer Janet S, Palmer Christina   Bilingual Cancer Genetic Education Modules for the Deaf Community: Development and Evaluation of the Online Video Material Journal of genetic counseling, 2017; 37(2): 195-206.
Narayan Shilpa, Sinsheimer Janet S, Paul Kimberly C, Liew Zeyan, Cockburn Myles, Bronstein Jeff M, Ritz Beate   Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease Environmental research, 2015; 143(Pt A): 98-106.
Kusters Cynthia D J, Paul Kimberly C, Guella Ilaria, Bronstein Jeff M, Sinsheimer Janet S, Farrer Matt J, Ritz Beate R   Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease Parkinsonism & related disorders, 2017; 37(2): 195-206.
Gilbert Princess S, Chang Jonathan, Pan Calvin, Sobel Eric M, Sinsheimer Janet S, Faircloth Brant C, Alfaro Michael E   Genome-wide ultraconserved elements exhibit higher phylogenetic informativeness than traditional gene markers in percomorph fishes Molecular phylogenetics and evolution, 2015; 92(Pt A): 140-6.
Paul Kimberly C, Sinsheimer Janet S, Cockburn Myles, Bronstein Jeff M, Bordelon Yvette, Ritz Beate   Organophosphate pesticides and PON1 L55M in Parkinson's disease progression Environment international, 2017; 107(2): 75-81.
Cybis Gabriela B, Sinsheimer Janet S, Bedford Trevor, Mather Alison E, Lemey Philippe, Suchard Marc A   ASSESSING PHENOTYPIC CORRELATION THROUGH THE MULTIVARIATE PHYLOGENETIC LATENT LIABILITY MODEL The annals of applied statistics, 2015; 9(2): 969-991.
vonHoldt Bridgett M, Shuldiner Emily, Koch Ilana Janowitz, Kartzinel Rebecca Y, Hogan Andrew, Brubaker Lauren, Wanser Shelby, Stahler Daniel, Wynne Clive D L, Ostrander Elaine A, Sinsheimer Janet S, Udell Monique A R   Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs Science advances, 2017; 3(7): e1700398.
Huertas-Vazquez Adriana, Nelson Christopher P, Sinsheimer Janet S, Reinier Kyndaron, Uy-Evanado Audrey, Teodorescu Carmen, Ayala Jo, Hall Alistair S, Gunson Karen, Jui Jonathan, Samani Nilesh J, Chugh Sumeet S   Cumulative effects of common genetic variants on risk of sudden cardiac death International journal of cardiology. Heart & vasculature, 2015; 7(2): 88-91.
Lorenzo Bermejo Justo, Boekstegers Felix, González Silos Rosa, Marcelain Katherine, Baez Benavides Pablo, Barahona Ponce Carol, Müller Bettina, Ferreccio Catterina, Koshiol Jill, Fischer Christine, Peil Barbara, Sinsheimer Janet, Fuentes Guajardo Macarena, Barajas Olga, Gonzalez-Jose Rolando, Bedoya Gabriel, Cátira Bortolini Maria, Canizales-Quinteros Samuel, Gallo Carla, Ruiz Linares Andres, Rothhammer Francisco   Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile PLoS genetics, 2017; 13(5): e1006756.
Gatto Nicole M, Sinsheimer Janet S, Cockburn Myles, Escobedo Loraine A, Bordelon Yvette, Ritz Beate   Vitamin D receptor gene polymorphisms and Parkinson's disease in a population with high ultraviolet radiation exposure Journal of the neurological sciences, 2015; 352(1-2): 88-93.
Crandall Carolyn J, Manson JoAnn E, Hohensee Chancellor, Horvath Steve, Wactawski-Wende Jean, LeBlanc Erin S, Vitolins Mara Z, Nassir Rami, Sinsheimer Janet S   Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study Menopause (New York, N.Y.), 2017; 24(3): 252-261.
Rickabaugh Tammy M, Baxter Ruth M, Sehl Mary, Sinsheimer Janet S, Hultin Patricia M, Hultin Lance E, Quach Austin, Martínez-Maza Otoniel, Horvath Steve, Vilain Eric, Jamieson Beth D   Acceleration of age-associated methylation patterns in HIV-1-infected adults PloS one, 2015; 10(3): e0119201.
Han Eunjung, Sinsheimer Janet S, Novembre John   Fast and accurate site frequency spectrum estimation from low coverage sequence data Bioinformatics (Oxford, England), 2015; 31(5): 720-7.
Palmer Christina G S, Boudreault Patrick, Berman Barbara A, Wolfson Alicia, Duarte Lionel, Venne Vickie L, Sinsheimer Janet S   Bilingual approach to online cancer genetics education for Deaf American Sign Language users produces greater knowledge and confidence than English text only: A randomized study Disability and health journal, 2017; 10(1): 23-32.
Gatto Nicole M, Paul Kimberly C, Sinsheimer Janet S, Bronstein Jeff M, Bordelon Yvette, Rausch Rebecca, Ritz Beate   Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease Journal of the neurological sciences, 2016; 370(1): 100-106.
Palmer Christina G S, Boudreault Patrick, Baldwin Erin E, Sinsheimer Janet S   Impact of genetic counseling and Connexin-26 and Connexin-30 testing on deaf identity and comprehension of genetic test results in a sample of deaf adults: a prospective, longitudinal study PloS one, 2014; 9(11): e111512.
Lee Pei-Chen, Raaschou-Nielsen Ole, Lill Christina M, Bertram Lars, Sinsheimer Janet S, Hansen Johnni, Ritz Beate   Gene-environment interactions linking air pollution and inflammation in Parkinson's disease Environmental research, 2016; 151(1): 713-720.
Arboleda Valerie A, Fleming Alice, Barseghyan Hayk, Délot Emmanuèle, Sinsheimer Janet S, Vilain Eric   Regulation of sex determination in mice by a non-coding genomic region Genetics, 2014; 197(3): 885-97.
Ngun Tuck C, Ghahramani Negar M, Creek Michelle M, Williams-Burris Shayna M, Barseghyan Hayk, Itoh Yuichiro, Sánchez Francisco J, McClusky Rebecca, Sinsheimer Janet S, Arnold Arthur P, Vilain Eric   Feminized behavior and brain gene expression in a novel mouse model of Klinefelter Syndrome Archives of sexual behavior, 2014; 43(6): 1043-57.
Levine Andrew J, Soontornniyomkij Virawudh, Achim Cristian L, Masliah Eliezer, Gelman Benjamin B, Sinsheimer Janet S, Singer Elyse J, Moore David J   Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV Journal of neurovirology, 2016; 22(4): 431-41.
Anastasopoulos Eleftherios, Coleman Anne L, Wilson M Roy, Sinsheimer Janet S, Yu Fei, Katafigiotis Sokratis, Founti Panayiota, Salonikiou Angeliki, Pappas Theofanis, Koskosas Archimidis, Katopodi Theodora, Lambropoulos Alexandros, Topouzis Fotis   Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study Investigative ophthalmology & visual science, 2014; 55(7): 4238-43.
Paul Kimberly C, Sinsheimer Janet S, Rhodes Shannon L, Cockburn Myles, Bronstein Jeff, Ritz Beate   Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene-Pesticide Interactions in a Case-Control Study of Parkinson's Disease, California (USA) Environmental health perspectives, 2016; 124(5): 570-7.
Ko Arthur, Cantor Rita M, Weissglas-Volkov Daphna, Nikkola Elina, Reddy Prasad M V Linga, Sinsheimer Janet S, Pasaniuc Bogdan, Brown Robert, Alvarez Marcus, Rodriguez Alejandra, Rodriguez-Guillen Rosario, Bautista Ivette C, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Salomaa Veikko, Kaprio Jaakko, Jula Antti, Jauhiainen Matti, Heliövaara Markku, Raitakari Olli, Lehtimäki Terho, Eriksson Johan G, Perola Markus, Lohmueller Kirk E, Matikainen Niina, Taskinen Marja-Riitta, Rodriguez-Torres Maribel, Riba Laura, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi   Amerindian-specific regions under positive selection harbour new lipid variants in Latinos Nature communications, 2014; 5(7): 3983.
Paul Kimberly C, Rausch Rebecca, Creek Michelle M, Sinsheimer Janet S, Bronstein Jeff M, Bordelon Yvette, Ritz Beate   APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression Journal of Parkinson's disease, 2016; 6(2): 349-59.
Levine Andrew J, Reynolds Sandra, Cox Christopher, Miller Eric N, Sinsheimer Janet S, Becker James T, Martin Eileen, Sacktor Ned, Sacktor Ned   The longitudinal and interactive effects of HIV status, stimulant use, and host genotype upon neurocognitive functioning Journal of neurovirology, 2014; 20(3): 243-57.
Janowitz Koch Ilana, Clark Michelle M, Thompson Michael J, Deere-Machemer Kerry A, Wang Jun, Duarte Lionel, Gnanadesikan Gitanjali E, McCoy Eskender L, Rubbi Liudmilla, Stahler Daniel R, Pellegrini Matteo, Ostrander Elaine A, Wayne Robert K, Sinsheimer Janet S, vonHoldt Bridgett M   The concerted impact of domestication and transposon insertions on methylation patterns between dogs and grey wolves Molecular ecology, 2016; 25(8): 1838-55.
Han Eunjung, Sinsheimer Janet S, Novembre John   Characterizing bias in population genetic inferences from low-coverage sequencing data Molecular biology and evolution, 2014; 31(3): 723-35.
Lake James A, Larsen Joseph, Sarna Brooke, de la Haba Rafael R, Pu Yiyi, Koo HyunMin, Zhao Jun, Sinsheimer Janet S   Rings Reconcile Genotypic and Phenotypic Evolution within the Proteobacteria Genome biology and evolution, 2016; 8(3): 578.