A selected list of publications:
Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D, Sun H.
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. ,
Science,
; 315(5813):
820-5.
Radu RA, Yuan Q, Hu J, Peng JH, Lloyd M, Nusinowitz S, Bok D, Travis GH.
Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation,
Invest Ophthalmol Vis. Sci,
2008; 49(9):
3821-9.
Radu RA, Hu J, Peng J, Bok D, Mata NL, Travis GH.
Retinal pigment epithelium-retinal G protein receptor-opsin mediates light-dependent translocation of all-trans-retinyl esters for synthesis of visual chromophore in retinal pigment epithelial cells,
J Biol Chem,
2008; 283(28):
19730-8.
Brill E, Malanson KM, Radu RA, Boukharov NV, Wang Z, Chung HY, Lloyd MB, Bok D, Travis GH, Obin M, Lem J
A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin,
Invest Ophthalmol Vis. Sci,
2007; 48(12):
5445-53.
Bok D.
Contributions of genetics to our understanding of inherited monogenic retinal diseases and age-related macular degeneration,
Arch Oppthalmol,
2007; 125(2):
160-4.
Rhee KD, Ruiz A, Duncan JL, Hauswirth WW, Lavail MM, Bok D, Yang XJ.
Molecular and cellular alterations induced by sustained expression of ciliary neurotrophic factor in a mouse model of retinitis pigmentosa,
Invest Ophthalmol Vis. Sci,
2007; 48(3):
1389-400.
Mukherjee PK, Marcheselli VL, Barreiro S, Hu J, Bok D, Bazan NG.
Neurotrophins enhance retinal pigment epithelial cell survival though neuroprotectin D1 signaling,
Proc Natl Acad Sci U S A,
2007; 104(32):
13152-7.
Mukherjee PK, Marcheselli VL, Barreiro S, Hu J, Bok D, Bazan NG.
Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling,
Proc Natl Acad Sci U S A,
2007; 104(32):
13152-7.
Ruiz A, Ghyselinck NB, Mata N, Nusinowitz S, Lloyd M, Dennefeld C, Chambon P, Bok D.
Somatic ablation of the Lrat gene in the mouse retinal pgiment epithelium drastically reduces its retinoid storage,
Invest Ophthalmol Vis. Sci,
2007; 48(12):
5377-87.
Senanayake P, Calabro A, Hu JG, Bonilha VL, Darr A, Bok D, Hollyfield JG.
Glucose utilization by the retinal pgment epithelium: evidence for rapid uptake and storage in glycogen, followed by glycogen utilization,
Exp Eye Res,
2006; 83(2):
235-46.
Sheren-Manoff M, Shin SJ, Su D, Bok D, Rando RR, Gudas LJ.
Reduced lecithin: retinol acyltransferase expression in human breast cancer,
Int J Oncol,
2006; 29(5):
1193-9.
Mora RC, Bonilha VL, Shin BC, Hu J, Cohen-Gould L, Bok D, Rodriguez-Boulan E.
Bipolar assembly of caveolae in retinal pigment epithelium,
Am J Physiol Cell Physiol,
2005; 290(3):
C832-43.
Bok D.
Cellular mechanisms of retinal degenerations: RPE65, ABCA4, RDS, and bicarbonate transporter genes are examples,
Retina,
2005; 25(8):
S18-S20.
Bok D.
Ciliary neurotrophic factor therapy for inherited retinal diseases: pros and cons,
Retina,
2005; 25(8):
S27-S28.
Bok D.
Evidence for an inflammatory process in age-related macular degeneration gains new support,
Proc Natl Acad Sci U S A,
2005; 102(20):
7053-4.
Deora AA, Philp N, Hu J, Bok D, Rodriguez-Boulan E.
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia,
Proc Natl Acad Sci U S A,
2005; 102(45):
16245-50.
Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL.
Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases,
Invest Ophthalmol Vis Sci,
2005; 46(12):
4393-401.
Bok D.
Retinal researchers have reasons to be optimistic,
Retina,
2005; 25(8):
S43.
Bok D.
The role of RPE65 in inherited retinal diseases,
Retina,
2005; 25(8):
S61-S62.
Lopez IA, Acuna D, Galbraith G, Bok D, Ishiyama A, Liu W, Kurtz I.
Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7),
Brain Res Dev Brain Res,
2005; 160(1):
63-77.
Rohrer B, Blanco R, Marc RE, Lloyd MB, Bok D, Schneeweis DM, Reichardt LF.
Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina,
Vis Neurosci,
2004; 21(5):
703-13.
Bok D.
Gene therapy of retinal dystrophies: achievements, challenges and prospects,
Novartis Found Symp,
2004; 255:
4-12.
Boorjian S, Tickoo SK, Mongan NP, Yu H, Bok D, Rando RR, Nanus DM, Scherr DS, Gudas LJ.
Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer,
Clin Cancer Res,
2004; 10(10):
3429-3.
Deora AA, Gravotta D, Kreitzer G, Hu J, Bok D, Rodriguez-Boulum E.
The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium,
Mol Biol Cell,
2004; 15(9):
4148-65.
Zhan HC, Gudas LJ, Bok D, Rando R, Nanus DM, Tickoo SK.
Differential expression of the enzyme that esterifies retinol, lecithin: retinol acyltransferase, in subtypes of human renal cancer and normal kidney,
Clin Cancer Res,
2003; 9(13):
4897-905.
Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV, Zolutukhin S, Hauswirth W and LaVail MM.
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation,
Exp Eye Res,
2002; 74:
719-735.
Ruiz A, Kuehn MH, Andorf J, Stone E, Hageman GS and Bok D.
Organization of the lecithin retinol acyltransferase gene and mutation screening in various human hereditary retinal degenerations,
Invest. Ophthalmol. Vis. Sci,
2001; 42:
31-37.
Mondal, MS, Ruiz A, Bok D and Rando RR
Lecithin retinol acyltransferse contains cysteine residues essential for catalysis,
Biochemistry,
2000; 39:
5215-5220.
Kedzierski, W., Bok D. and Travis, G.H.
Non cell-autonomous photoreceptor degeneration in rds mutant mice mosaic for expression of a rescue transgene,
J. Neurosci,
1998; 18:
4076-4082.
Ruiz A., Bhat S.P. and Bok D.
Expression and synthesis of the Na,K-ATPase b2 subunit in human retinal pigment epithelium,
Gene,
1996; 176:
237-242.
Ruiz, A., Bhat, S.P. and Bok, D.
Characterization and quantification of full-length and truncated Na,K-ATPase a1 and b1 transcripts expressed in human retinal pigment epithelium,
Gene,
1995; 155:
179-184.