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Department of Psychiatry & Biobehavioral Sciences
760 Westwood Plaza
Los Angeles, CA 90024
Department of Psychiatry & Biobehavioral Sciences
760 Westwood Plaza
Los Angeles, CA 90024
|Director, Pasarow Mass Spectrometry Laboratory|
|Professor, Psychiatry and Biobehavioral Sciences|
|Affiliate, Cotsen Institute of Archaeology|
|Professor In-Residence, Semel Institute for Neuroscience and Human Behavior|
|Member, Brain Research Institute, Molecular Biology Institute, Biochemistry, Biophysics & Structural Biology GPB Home Area, JCCC Signal Transduction and Therapeutics Program Area, Molecular Pharmacology GPB Home Area, Neuroscience GPB Home Area|
Kym Francis Faull was born, raised and educated at The University of Adelaide, South Australia. He completed a Bachelor of Agricultural Science degree in 1968, an Honours degree in Agricultural Biochemistry (nitrogen metabolism of soil-borne bacteria) in 1969 and a Ph.D. degree in Plant Physiology in 1974 (gibberellin biosynthesis). After a post-doctoral fellowship (74-76) at the University of Wollongong, New South Wales (human metabolic diseases), he joined the research staff at Stanford University School of Medicine Department of Psychiatry and Behavioral Sciences (76-90) where he rose through the ranks of staff and senior staff scientific officers. He joined the faculty at UCLA in 1990 as an Assistant Professor in the Department of Psychiatry & Biobehavioral Sciences and the Neuropsychiatric Institute. With an unusual combination of interests and experience encompassing biochemistry, and in particular brain biochemistry, and with expertise in mass spectrometry, his objective was to develop a multifaceted program in analytical neurochemistry addressing the biochemical substrates of psychiatric diseases. As a consequence of his extensive research collaborations, the scope of Dr. Faull's responsibilities expanded in 1992 to embrace teaching and research missions across Departments within the Medical School and the College of Letters and Sciences. This change came with his appointment as Director of the newly-created Center for Molecular and Medical Sciences Mass Spectrometry, subsequently re-named The Pasarow Mass Spectrometry Laboratory. Originally located in the then recently completed Molecular Life Sciences Building, the facility has since moved to the Center for Health Sciences, rooms 68-146,, 155 and 162. The mission of this interdepartmental facility was to broadly develop a mass spectrometry research and service facility for the entire campus.
Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human Î±-synuclein. PloS one. 2013; 8(5): e63557.
Lam Maggie P Y, Lau Edward, Scruggs Sarah B, Wang Ding, Kim Tae-Young, Liem David A, Zhang Jun, Ryan Christopher M, Faull Kym F, Ping Peipei Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation. Journal of proteomics. 2013; 81(5): 15-23.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, CalvopiÃ±a Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell stem cell. 2013; 12(4): 470-8.
Dawlaty Meelad M, Breiling Achim, Le Thuc, Raddatz GÃ¼nter, Barrasa M Inmaculada, Cheng Albert W, Gao Qing, Powell Benjamin E, Li Zhe, Xu Mingjiang, Faull Kym F, Lyko Frank, Jaenisch Rudolf Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Developmental cell. 2013; 24(3): 310-23.
Li Sichen, Chou Arthur P, Chen Weidong, Chen Ruihuan, Deng Yuzhong, Phillips Heidi S, Selfridge Julia, Zurayk Mira, Lou Jerry J, Everson Richard G, Wu Kuan-Chung, Faull Kym F, Cloughesy Timothy, Liau Linda M, Lai Albert Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro-oncology. 2013; 15(1): 57-68.
Tsirulnikov Kirill, Abuladze Natalia, Vahi Ritu, Hasnain Huma, Phillips Martin, Ryan Christopher M, Atanasov Ivo, Faull Kym F, Kurtz Ira, Pushkin Alexander Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein. FEBS letters. 2012; 586(21): 3799-804.
Lam Maggie P Y, Scruggs Sarah B, Kim Tae-Young, Zong Chenggong, Lau Edward, Wang Ding, Ryan Christopher M, Faull Kym F, Ping Peipei An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue. Journal of proteomics. 2012; .
Xu Hongbin, Kongmanas Kessiri, Kadunganattil Suraj, Smith Charles E, Rupar Tony, Goto-Inoue Naoko, Hermo Louis, Faull Kym F, Tanphaichitr Nongnuj Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells. Journal of lipid research. 2011; 52(12): 2187-97.
Landau Meytal, Sawaya Michael R, Faull Kym F, Laganowsky Arthur, Jiang Lin, Sievers Stuart A, Liu Jie, Barrio Jorge R, Eisenberg David Towards a pharmacophore for amyloid. PLoS biology. 2011; 9(6): e1001080.
Le Thuc, Kim Kee-Pyo, Fan Guoping, Faull Kym F A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples. Analytical biochemistry. 2011; 412(2): 203-9.
He Jianbo, Whelan Stephen A, Lu Ming, Shen Dejun, Chung Debra U, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response. International journal of proteomics. 2011; 2011(2): 896476.
Keire David A, Whitelegge Julian P, Souda Puneet, Faull Kym F, Bassilian Sara, Reidelberger Roger D, Haver Alvin C, Reeve Joseph R PYY(1-36) is the major form of PYY in rat distal small intestine: quantification using high-resolution mass spectrometry. Regulatory peptides. 2010; 165(2-3): 151-7.
Webb Kristofor J, Zurita-Lopez Cecilia I, Al-Hadid Qais, Laganowsky Arthur, Young Brian D, Lipson Rebecca S, Souda Puneet, Faull Kym F, Whitelegge Julian P, Clarke Steven G A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. The Journal of biological chemistry. 2010; 285(48): 37598-606.
Duarte Victor M, Han Eugene, Veena Mysore S, Salvado Amanda, Suh Jeffrey D, Liang Li-Jung, Faull Kym F, Srivatsan Eri S, Wang Marilene B Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKÎ² protein of the NFÎºB pathway. Molecular cancer therapeutics. 2010; 9(10): 2665-75.
Thangaraj Balakumar, Ryan Christopher M, Souda Puneet, Krause Kirsten, Faull Kym F, Weber Andreas P M, Fromme Petra, Whitelegge Julian P Data-directed top-down Fourier-transform mass spectrometry of a large integral membrane protein complex: photosystem II from Galdieria sulphuraria. Proteomics. 2010; 10(20): 3644-56.
Lu Ming, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer. Clinical proteomics. 2010; 6(3): 93-103.
Jansen Michael A, Kiwata Jacqueline, Arceo Jennifer, Faull Kym F, Hanrahan Grady, Porter Edith Evolving neural network optimization of cholesteryl ester separation by reversed-phase HPLC. Analytical and bioanalytical chemistry. 2010; 397(6): 2367-74.
Ryan Christopher M, Souda Puneet, Halgand Frederic, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry. 2010; 21(6): 908-17.
Halgand FrÃ©dÃ©ric, Zabrouskov Vlad, Bassilian Sara, Souda Puneet, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. Journal of the American Society for Mass Spectrometry. 2010; 21(5): 868-77.
Ryan Christopher M, Souda Puneet, Bassilian Sara, Ujwal Rachna, Zhang Jun, Abramson Jeff, Ping Peipei, Durazo Armando, Bowie James U, Hasan S Saif, Baniulis Danas, Cramer William A, Faull Kym F, Whitelegge Julian P Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation. Molecular & cellular proteomics : MCP. 2010; 9(5): 791-803.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur A broad-spectrum antiviral targeting entry of enveloped viruses. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(7): 3157-62.
Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors. PloS one. 2010; 5(2): e9121.
Lu Ming, Whitelegge Julian P, Whelan Stephen A, He Jianbo, Saxton Romaine E, Faull Kym F, Chang Helena R Hydrophobic Fractionation Enhances Novel Protein Detection by Mass Spectrometry in Triple Negative Breast Cancer. Journal of proteomics & bioinformatics. 2010; 3(2): 1-10.
Shaw Bryan F, Moustakas Demetri T, Whitelegge Julian P, Faull Kym F Taking charge of proteins from neurodegeneration to industrial biotechnology. Advances in protein chemistry and structural biology. 2010; 79(2): 127-64.
Oliveira DÃ©bora L, Nimrichter Leonardo, Miranda Kildare, Frases Susana, Faull Kym F, Casadevall Arturo, Rodrigues Marcio L Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan. Fungal genetics and biology : FG & B. 2009; 46(12): 956-63.
Durazo Armando, Shaw Bryan F, Chattopadhyay Madhuri, Faull Kym F, Nersissian Aram M, Valentine Joan Selverstone, Whitelegge Julian P Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature. The Journal of biological chemistry. 2009; 284(49): 34382-9.
Budzik Jonathan M, Poor Catherine B, Faull Kym F, Whitelegge Julian P, He Chuan, Schneewind Olaf Intramolecular amide bonds stabilize pili on the surface of bacilli. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(47): 19992-7.
He Jianbo, Shen Dejun, Chung Debra U, Saxton Romaine E, Whitelegge Julian P, Faull Kym F, Chang Helena R Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy. International journal of oncology. 2009; 35(4): 683-92.
Wang Yanju, Lin Wei-Yu, Liu Kan, Lin Rachel J, Selke Matthias, Kolb Hartmuth C, Zhang Nangang, Zhao Xing-Zhong, Phelps Michael E, Shen Clifton K F, Faull Kym F, Tseng Hsian-Rong An integrated microfluidic device for large-scale in situ click chemistry screening. Lab on a chip. 2009; 9(16): 2281-5.
Whelan Stephen A, Lu Ming, He Jianbo, Yan Weihong, Saxton Romaine E, Faull Kym F, Whitelegge Julian P, Chang Helena R Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers. Journal of proteome research. 2009; 8(8): 4151-60.
Bulkacz Jaime, Faull Kym F Multiple extracellular phospholipase activities from Prevotella intermedia. Anaerobe. 2009; 15(3): 91-4.
Keire David A, Whitelegge Julian P, Bassilian Sara, Faull Kym F, Wiggins Brian W, Mehdizadeh Omid B, Reidelberger Roger D, Haver Alvin C, Sayegh Ayman I, Reeve Joseph R A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36). Regulatory peptides. 2008; 151(1-3): 61-70.
Lanigan-Gerdes Sara, Briceno Geraldine, Dooley Alek N, Faull Kym F, Lazazzera Beth A Identification of residues important for cleavage of the extracellular signaling peptide CSF of Bacillus subtilis from its precursor protein. Journal of bacteriology. 2008; 190(20): 6668-75.
Wang Dorothy, Veena Mysore S, Stevenson Kerry, Tang Christopher, Ho Baran, Suh Jeffrey D, Duarte Victor M, Faull Kym F, Mehta Kapil, Srivatsan Eri S, Wang Marilene B Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008; 14(19): 6228-36.
Do Thai Q, Moshkani Safiehkhatoon, Castillo Patricia, Anunta Suda, Pogosyan Adelina, Cheung Annie, Marbois Beth, Faull Kym F, Ernst William, Chiang Su Ming, Fujii Gary, Clarke Catherine F, Foster Krishna, Porter Edith Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid. Journal of immunology (Baltimore, Md. : 1950). 2008; 181(6): 4177-87.
Anupriwan Araya, Schenk Matthias, Kongmanas Kessiri, Vanichviriyakit Rapeepun, Santos Daniela Costa, Yaghoubian Arman, Liu Fang, Wu Alexander, Berger Trish, Faull Kym F, Saitongdee Porncharn, Sretarugsa Prapee, Tanphaichitr Nongnuj Presence of arylsulfatase A and sulfogalactosylglycerolipid in mouse ovaries: localization to the corpus luteum. Endocrinology. 2008; 149(8): 3942-51.
Budzik Jonathan M, Marraffini Luciano A, Souda Puneet, Whitelegge Julian P, Faull Kym F, Schneewind Olaf Amide bonds assemble pili on the surface of bacilli. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(29): 10215-20.
Begum Aynun N, Jones Mychica R, Lim Giselle P, Morihara Takashi, Kim Peter, Heath Dennis D, Rock Cheryl L, Pruitt Mila A, Yang Fusheng, Hudspeth Beverly, Hu Shuxin, Faull Kym F, Teter Bruce, Cole Greg M, Frautschy Sally A Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. The Journal of pharmacology and experimental therapeutics. 2008; 326(1): 196-208.
Denny Paul, Hagen Fred K, Hardt Markus, Liao Lujian, Yan Weihong, Arellanno Martha, Bassilian Sara, Bedi Gurrinder S, Boontheung Pinmannee, Cociorva Daniel, Delahunty Claire M, Denny Trish, Dunsmore Jason, Faull Kym F, Gilligan Joyce, Gonzalez-Begne Mireya, Halgand FrÃ©dÃ©ric, Hall Steven C, Han Xuemei, Henson Bradley, Hewel Johannes, Hu Shen, Jeffrey Sherry, Jiang Jiang, Loo Joseph A, Ogorzalek Loo Rachel R, Malamud Daniel, Melvin James E, Miroshnychenko Olga, Navazesh Mahvash, Niles Richard, Park Sung Kyu, Prakobphol Akraporn, Ramachandran Prasanna, Richert Megan, Robinson Sarah, Sondej Melissa, Souda Puneet, Sullivan Mark A, Takashima Jona, Than Shawn, Wang Jianghua, Whitelegge Julian P, Witkowska H Ewa, Wolinsky Lawrence, Xie Yongming, Xu Tao, Yu Weixia, Ytterberg Jimmy, Wong David T, Yates John R, Fisher Susan J The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. Journal of proteome research. 2008; 7(5): 1994-2006.
Franchini Laura, Panza Luigi, Kongmanas Kessiri, Tanphaichitr Nongnuj, Faull Kym F, Ronchetti Fiamma An efficient and convenient synthesis of deuterium-labelled seminolipid isotopomers and their ESI-MS characterization. Chemistry and physics of lipids. 2008; 152(2): 78-85.
Grintsevich Elena E, Benchaar Sabrina A, Warshaviak Dora, Boontheung Pinmanee, Halgand FrÃ©dÃ©ric, Whitelegge Julian P, Faull Kym F, Loo Rachel R Ogorzalek, Sept David, Loo Joseph A, Reisler Emil Mapping the cofilin binding site on yeast G-actin by chemical cross-linking. Journal of molecular biology. 2008; 377(2): 395-409.
Fujishige Nancy A, Lum Michelle R, De Hoff Peter L, Whitelegge Julian P, Faull Kym F, Hirsch Ann M Rhizobium common nod genes are required for biofilm formation. Molecular microbiology. 2008; 67(3): 504-15.
Whitelegge Julian P, Zabrouskov Vlad, Halgand Frederic, Souda Puneet, Bassilian Sara, Yan Weihong, Wolinsky Larry, Loo Joseph A, Wong David T W, Faull Kym F Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry. International journal of mass spectrometry. 2007; 268(2-3): 190-197.
Lu Ming, Faull Kym F, Whitelegge Julian P, He Jianbo, Shen Dejun, Saxton Romaine E, Chang Helena R Proteomics and mass spectrometry for cancer biomarker discovery. Biomarker insights. 2007; 2(2-3): 347-60.
Lanigan-Gerdes Sara, Dooley Alek N, Faull Kym F, Lazazzera Beth A Identification of subtilisin, Epr and Vpr as enzymes that produce CSF, an extracellular signalling peptide of Bacillus subtilis. Molecular microbiology. 2007; 65(5): 1321-33.
Mitrirattanakul Somsak, LÃ³pez-ValdÃ©s HÃ©ctor E, Liang Jing, Matsuka Yoshizo, Mackie Ken, Faull Kym F, Spigelman Igor Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence. Alcoholism, clinical and experimental research. 2007; 31(5): 855-67.
Waldron Richard T, Whitelegge Julian P, Faull Kym F, Rozengurt Enrique Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D. Biochemical and biophysical research communications. 2007; 356(2): 361-7.
Potter Soshanna Zittin, Zhu Haining, Shaw Bryan Francis, Rodriguez Jorge A, Doucette Peter A, Sohn Se Hui, Durazo Armando, Faull Kym F, Gralla Edith Butler, Nersissian Aram M, Valentine Joan Selverstone Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein. Journal of the American Chemical Society. 2007; 129(15): 4575-83.
He Jianbo, Gornbein Jeffrey, Shen Dejun, Lu Ming, Rovai Leonor E, Shau Hungyi, Katz John, Whitelegge Julian P, Faull Kym F, Chang Helena R Detection of breast cancer biomarkers in nipple aspirate fluid by SELDI-TOF and their identification by combined liquid chromatography-tandem mass spectrometry. International journal of oncology. 2007; 30(1): 145-54.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain. 2006; 126(1-3): 102-14.
Shaw Bryan Francis, Durazo Armando, Nersissian Aram M, Whitelegge Julian P, Faull Kym F, Valentine Joan Selverstone Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry. The Journal of biological chemistry. 2006; 281(26): 18167-76.
Kim Danny H, Hee Shane Que, Norris Andrew J, Faull Kym F, Eckhert Curtis D Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively. Journal of chromatography. A. 2006; 1115(1-2): 246-52.
Norris Andrew J, Whitelegge Julian P, Yaghoubian Arman, Alattia Jean-Rene, PrivÃ© Gilbert G, Toyokuni Tatsushi, Sun Hubert, Brooks Mai N, Panza Luigi, Matto Pamela, Compostella Federica, Remmel Natascha, Klingenstein Ralf, Sandhoff Konrad, Fluharty Claire, Fluharty Arvan, Faull Kym F A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A. Journal of lipid research. 2005; 46(10): 2254-64.
Kang Mo K, Kim Reuben H, Shin Ki-Hyuk, Zhong Weiguong, Faull Kym F, Park No-Hee Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo. Experimental cell research. 2005; 310(1): 186-95.
Eugene Pekary A, Faull Kym F, Paulson Mark, Lloyd Robert L, Sattin Albert TRH-like antidepressant peptide, pyroglutamyltyroslyprolineamide, occurs in rat brain. Journal of mass spectrometry : JMS. 2005; 40(9): 1232-6.
Rodriguez Jorge A, Shaw Bryan Francis, Durazo Armando, Sohn Se Hui, Doucette Peter A, Nersissian Aram M, Faull Kym F, Eggers Daryl K, Tiwari Ashutosh, Hayward Lawrence J, Valentine Joan Selverstone Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(30): 10516-21.
Marbois Beth, Gin Peter, Faull Kym F, Poon Wayne W, Lee Peter T, Strahan Jeff, Shepherd Jennifer N, Clarke Catherine F Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. The Journal of biological chemistry. 2005; 280(21): 20231-8.
Weinglass Adam B, Soskine Misha, Vazquez-Ibar Jose-Luis, Whitelegge Julian P, Faull Kym F, Kaback H Ronald, Schuldiner Shimon Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry. The Journal of biological chemistry. 2005; 280(9): 7487-92.
Weinglass Adam, Whitelegge Julian P, Faull Kym F, Kaback H Ronald Monitoring conformational rearrangements in the substrate-binding site of a membrane transport protein by mass spectrometry. The Journal of biological chemistry. 2004; 279(40): 41858-65.
Kim Danny H, Faull Kym F, Norris Andrew J, Eckhert Curtis D Borate-nucleotide complex formation depends on charge and phosphorylation state. Journal of mass spectrometry : JMS. 2004; 39(7): 743-51.
Whitelegge Julian P, Katz Jonathan E, Pihakari Katianna A, Hale Rebecca, Aguilera Rodrigo, GÃ³mez Stephen M, Faull Kym F, Vavilin Dmitrii, Vermaas Willem Subtle modification of isotope ratio proteomics; an integrated strategy for expression proteomics. Phytochemistry. 2004; 65(11): 1507-15.
Katz Jonathan E, Dumlao Darren S, Wasserman Jacob I, Lansdown Michael G, Jung Michael E, Faull Kym F, Clarke Steven 3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase. Biochemistry. 2004; 43(20): 5976-86.
Norris Andrew J, Whitelegge Julian P, Strouse M Jane, Faull Kym F, Toyokuni Tatsushi Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism. Bioorganic & medicinal chemistry letters. 2004; 14(3): 571-3.
Chen Fayu, Ng Pei-San, Faull Kym F, Lee Rehwa H Cone photoreceptor betagamma-transducin: posttranslational modification and interaction with phosducin. Investigative ophthalmology & visual science. 2003; 44(11): 4622-9.
Woo Ho-Hyung, Faull Kym F, Hirsch Ann M, Hawes Martha C Altered life cycle in Arabidopsis plants expressing PsUGT1, a UDP-glucuronosyltransferase-encoding gene from pea. Plant physiology. 2003; 133(2): 538-48.
GÃ³mez Stephen M, Bil' Karl Y, Aguilera Rodrigo, Nishio John N, Faull Kym F, Whitelegge Julian P Transit peptide cleavage sites of integral thylakoid membrane proteins. Molecular & cellular proteomics : MCP. 2003; 2(10): 1068-85.
Shau Hungyi, Chandler G Scott, Whitelegge Julian P, Gornbein Jeffrey A, Faull Kym F, Chang Helena R Proteomic profiling of cancer biomarkers. Briefings in functional genomics & proteomics. 2003; 2(2): 147-58.
Kim Danny H, Marbois Beth N, Faull Kym F, Eckhert Curtis D Esterification of borate with NAD+ and NADH as studied by electrospray ionization mass spectrometry and 11B NMR spectroscopy. Journal of mass spectrometry : JMS. 2003; 38(6): 632-40.
Weinglass Adam B, Whitelegge Julian P, Hu Yonglin, Verner Gillian E, Faull Kym F, Kaback H Ronald Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry. The EMBO journal. 2003; 22(7): 1467-77.
Ahn, V. E. Faull, K. F. Whitelegge, J. P. Fluharty, A. L. Prive, G. G. Crystal structure of saposin B reveals a dimeric shell for lipid binding. Proc Natl Acad Sci U S A. 2003; 100(1): 38-43.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Fluharty Arvan L, PrivÃ© Gilbert G Crystal structure of saposin B reveals a dimeric shell for lipid binding. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(1): 38-43.
Ahn Victoria E, Faull Kym F, Whitelegge Julian P, Higginson Jason, Fluharty Arvan L, PrivÃ© Gilbert G Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B. Protein expression and purification. 2003; 27(1): 186-93.
Whitelegge Julian P, GÃ³mez Stephen M, Faull Kym F Proteomics of membrane proteins. Advances in protein chemistry. 2003; 65(1): 271-307.
Jonassen Tanya, Marbois Beth N, Faull Kym F, Clarke Catherine F, Larsen Pamela L Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria. The Journal of biological chemistry. 2002; 277(47): 45020-7.
Glasgow Ben J, Abduragimov Adil R, Gassymov Oktay K, Faull Kym F, Yusifov Taleh N, Lehrer Robert I Characterization of a lipophilin in rabbit tears. Advances in experimental medicine and biology. 2002; 506(Pt A): 573-80.
Subbanagounder Ganesamoorthy, Wong Jason W, Lee Hans, Faull Kym F, Miller Elizabeth, Witztum Joseph L, Berliner Judith A Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. The Journal of biological chemistry. 2002; 277(9): 7271-81.
Glasgow Ben J, Abduragimov Adil R, Gassymov Oktay K, Yusifov Taleh N, Ruth Edward C, Faull Kym F Vitamin E associated with the lipocalin fraction of human tears. Advances in experimental medicine and biology. 2002; 506(Pt A): 567-72.
GÃ³mez Stephen M, Nishio John N, Faull Kym F, Whitelegge Julian P The chloroplast grana proteome defined by intact mass measurements from liquid chromatography mass spectrometry. Molecular & cellular proteomics : MCP. 2002; 1(1): 46-59.
Rudenko Andrii, Dawlaty Meelad M, Seo Jinsoo, Cheng Albert W, Meng Jia, Le Thuc, Faull Kym F, Jaenisch Rudolf, Tsai Li-Huei Tet1 is critical for neuronal activity-regulated gene expression and memory extinction. Neuron. 2013; 79(6): 1109-22.
Cole Stephanie J, Yoon Alexander J, Faull Kym F, Diener Andrew C Host perception of jasmonates promotes infection by Fusarium oxysporum formae speciales that produce isoleucine- and leucine-conjugated jasmonates. Molecular plant pathology. 2014; 15(6): 589-600.
Kern Justin, Ryan Christopher, Faull Kym, Schneewind Olaf Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO. Journal of molecular biology. 2010; 401(5): 757-75.
Tsirulnikov Kirill, Abuladze Natalia, Koag Myong-Chul, Newman Debra, Scholz Karoline, Bondar Galyna, Zhu Quansheng, Avliyakulov Nuraly K, Dekant Wolfgang, Faull Kym, Kurtz Ira, Pushkin Alexander Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2). Toxicology and applied pharmacology. 2010; 244(2): 218-25.
Babiec Walter E, Faull Kym F, Feldman Jack L Cyclothiazide-induced persistent increase in respiratory-related activity in vitro. The Journal of physiology. 2012; 590(Pt 19): 4897-915.
Thomer Lena, Becker Samuel, Emolo Carla, Quach Austin, Kim Hwan Keun, Rauch Sabine, Anderson Mark, Leblanc James F, Schneewind Olaf, Faull Kym F, Missiakas Dominique N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection. The Journal of biological chemistry. 2014; 289(6): 3478-86.
Leuchter Andrew F, Cook Ian A, Hamilton Steven P, Narr Katherine L, Toga Arthur, Hunter Aimee M, Faull Kym, Whitelegge Julian, Andrews Anne M, Loo Joseph, Way Baldwin, Nelson Stanley F, Horvath Steven, Lebowitz Barry D Biomarkers to predict antidepressant response. Current psychiatry reports. 2010; 12(6): 553-62.
Tsirulnikov Kirill, Abuladze Natalia, Bragin Anatol, Faull Kym, Cascio Duilio, Damoiseaux Robert, Schibler Matthew J, Pushkin Alexander Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal. Toxicology and applied pharmacology. 2012; 263(3): 303-14.
Janzen Deanna M, Paik Daniel Y, Rosales Miguel A, Yep Brian, Cheng Donghui, Witte Owen N, Kayadibi Huseyin, Ryan Christopher M, Jung Michael E, Faull Kym, Memarzadeh Sanaz Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo. Molecular cancer therapeutics. 2013; 12(12): 2917-28.
Kongmanas, Kessiri, Hongbin Xu, Arman Yaghoubian, Laura Franchini, Luigi Panza, Fiamma Ronchetti, Kym Faull, Nongnuj Tanphaichitr Seminolipid quantification by colorimetric assay and ESI-LC-MS/MS-multiple reaction monitoring: compensation of seminolipid expression in Cgt+/- mice. Journal of Lipid Research. 2010; 51(12): 3548-58.
Barnard H., A.N. Dooley, G. Areshian, B. Gasparyan and K.F. Faull Chemical evidence for wine production around 4000 BCE in the Late Chalcolithic Near Eastern highlands. Journal of Archaeological Science 2011; 38(5): 977-984.
Halgand FJ, Zabrouskov V, Bassilian S, Souda P, Loo JA, Faull KF, Wong DT, Whitelegge JP Defining intact protein primary structures from saliva: a step toward the human proteome project. Analytical Chemistry 2012; 84: 4383-95.
Nathanson, David A.,Amanda L. Armijo, Michelle Tom, Zheng Li, Wayne R. Austin, Julian Nomme, Dean O. Campbell, Elizabeth Dimitrova, Lisa Ta, Thuc Le, Jason T. Lee, Ryan Darvish, Ari Gordin, Liu Wei, Hsiang-I Liao, Moses Wilks, Colette Martin, Saman Sadeghi, Jennifer M. Murphy, Nidal Boulos, Michael E. Phelps, Kym F. Faull, Harvey R. Herschman, Michael E. Jung, Johannes Czernin, Arnon Lavie, and Caius G. Radu Co-Targeting of Convergent, Switchable Nucleotide Biosynthetic Pathways Induces Synthetic Lethality in Leukemia. Journal of Experimental Medicine 2014; 211(3): 473-86.
Dawlaty, Meelad, M., Achim Breiling, Thuc Le, M. Inmaculada Barrasa, Günter Raddatz, Qing Gao, Benjamin E. Powell1, Albert W. Cheng, Kym F. Faull, Frank Lyko, and Rudolf Jaenisch Loss of Tet enzymes compromises normal differentiation of embryonic stem cells. Developmental Cell 2014; .
Sun, D., M. Luo, M. Jeong, B. Rodriguez, Z. Xia, R. Hanna, H. Wang, T. Le, K. Faull, R. Chen, H. Gu, C. Bock, A. Meissner, B. Gottgens, G. Darlington, W. Li, and M.A. Goodell Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 2014; .
Randall C., Xudong Fu, Melody Pai, Laurent Vergnes, Simon Diep, Brett Lomenick, Gang Deng, Vijaykumar Meli, Gabriela C. Monsalve, Heejun Hwang, Eileen Hu, Gwanghyun Jung, Stephen A. Whelan, Farbod Fazlollahi, Chitrada Kaweeteerawat, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Meisheng Jiang, Catherine F. Clarke, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand, and Jing Huang Alpha-ketoglutarate extends lifespan in Caenorhabditis elegans by a novel mechanism mediated by the ATP synthase and TOR. Nature 2014; .
Bullwinkle, Tammy, Noah Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym Faull, Beth Lazazzera and Michael Ibba Oxidation of cellular amino acid pools leads to context-dependent cytotoxic mistranslation of the genetic code. eLife 2014; .
Clark, Peter M., Graciela Flores, Nikolai M. Evdokimov, Melissa N. McCracken, Timothy Chai, Evan Nair-Gill, Fiona OMahony, Simon W. Beaven, Kym F. Faull Michael E. Phelps, Michael E. Jung, Owen N. Witte A novel positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver. Proc. Natl, Acad. Sci 2014; .
Kongmanas, Kessiri, Hathairat Kruevaisayawan, Arpornrad Saewu, Clarissa Sugeng, Jason Fernandes, Puneet Souda, Jonathan Angel, Kym F. Faull, R. John Aitken, Julian Whitelegge, Dan Hardy, Trish Berger, Mark Baker, Nongnuj Tanphaichitr Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Vesicles Reveals Roles of Acrosomal Proteins in ZP3 Binding. Journal of Cellular Physiology 2015; 230: 449463.
Huang, Kevin, Zhourui Wu, Zhenshan Liu, Ganlu Hu, Juehua Yu, Kai H. Chang, Kee-Pyo Kim, Thuc Le, Kym F. Faull, Nagesh Rao, Andrew Gennery, Zhigang Xue, Cun-yu Wang, Matteo Pellegrini, Guoping Fan Selective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells. Human Molecular Genetics 2014; .
Calkins, Kara L., Lauren A. Sanchez, Chi-Hong Tseng, Kym F. Faull, Alexander J. Yoon, Christopher M. Ryan, Thuc Le, Stephen B. Shew High-Dose Cysteine Supplementation and Erythrocyte Glutathione Concentrations: a Double-Blinded, Randomized Controlled in Critically Ill Neonates. Journal of Parenteral and Enteral Nutrition 2014; .
Fazlollahi F, Kongmanas K, Tanphaichitr N, Clair JM, Gopen Q, Faull KF, Suh JD Lipidomic Profiling of Sinus Mucosa from Patients with Chronic Rhinosinusitis. Clin Transl Sci 2015; .
Fazlollahi, Farbod, Kessiri Kongmanas, Nongnuj Tanphaichitr, Jeffrey Suh, Kym Faull, Quinton Gopen Lipidomic Profiling of Mastoid Bone and Tissue from Patients with Chronic Otomastoiditis. International Archives of Otorhinolaryngology 2014; .
Jian Feng, Ningyi Shao, Keith E. Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E. Cahill, Yujing Li, JaWook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M. Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F. Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin, and Eric J. Nestler Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nature Neuroscience 2015; .
Tanphaichitr N, Kongmanas K, Kruevaisayawan K, Saewu A, Sugeng C, Fernandes J, Souda P, Angel JB, Faull KF, Aitken RJ, Whitelegge J, Hardy D, Berger T and Baker M Remodelling of the plasma membrane in preparation for sperm-egg recognition: Roles of acrosomal membranes. Asian Journal of Andrology (a special issue for the proceedings of the 12th International Symposium of Spermatology) 2015; .
Ma, Daniel, Alexander Yoon, Kym F. Faull, Robert Desharnais, Edith T. Zemanick and Edith Porter Antimicrobial cholesteryl esters are elevated in bronchial lavage fluid collected from pediatric cystic fibrosis patients and may serve as novel biomarker for disease. PLOS ONE 2015; .
Tanphaichitr, Nongnuj, Kessiri Kongmanas, Hathairat Kruevaisayawan, Arpornrad Saewu, Clarissa Sugeng, Jason Fernandes, Puneet Souda, Jonathan B Angel, Kym F Faull, R John Aitken, Julian Whitelegge, Daniel Hardy, Trish Berger, Mark Baker Remodeling of the plasma membrane in preparation for spermegg recognition: roles of acrosomal proteins. Asian Journal of Andrology 2015; 17(4): 574582.
Chattopadhyay, Arnab, Victor Grijalva, Greg Hough, Feng Su, Pallavi Mukherjee, Robin Farias-Eisner, G.M. Anantharamahiah, Kym F. Faull, Lin H. Hwang, Mohamad Navab, Alan M. Fogelman, and Srinivasa T. Reddy Efficacy of Tomato Concentrates in Mouse Models of Dyslipidemia and Cancer. Pharmacology Research & Perspectives 2015; 3(4): e00154.
Sen, Suvajiy, Kawahara, Brian. Divya Gupta, Rebecca Tsai, Sinchita Roy Chowdhuri, Shikha Bose, Marine Khachatryan, Alexander Yoon, Kym Faull, Robin Farias-Eisner, Gautam Chaudhuri Role of Cystathionine β-Synthase in Human Breast Cancer. Free Radical Biology & Medicine 2015; .
Rajkovic, Andrei, Sarah Tyler, Annie Kalinoski, Owen E Branson, Jin Seo, Philip R. Gafken, Michael Frietas, Julian Whittelegge, Kym Faull, William Navarre, Andrew Darwin5and Michael Ibba Cyclic rhamnosylated EF-P establishes antibiotic resistance in Pseudomonas PAK. mBio 2015; .
Lesage, Denis, Gabriella Barozzino-Consiglio, Romain Duwald, Catherine Fressigné, Anne Harrison-Marchand, Kym F. Faull, Jacques Maddaluno, and Yves Gimbert A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl. J. Organic Chemistry 2015; .
Xudong Fu, Xudong, Randall M. Chin, Laurent Vergnes, Heejun Hwang, Gang Deng, Yanpeng Xing, Melody Y. Pai2, Sichen Li, Lisa Ta1, Farbod Fazlollahi, Chuo Chen, Robert M. Prins, Michael A. Teitell, David A. Nathanson, Albert Lai, Kym F. Faull, Meisheng Jiang, Steven G. Clarke, Timothy F. Cloughesy, Thomas Graeber, Daniel Braas, Heather R. Christofk, Michael E. Jung, Karen Reue, Jing Huang 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metabolism 2015; 22: 345-532.
Evdokimov, Nicolai, M., Peter M. Clark, Graciela Flores, Timothy Chai, Kym F. Faull, Michael E. Phelps, Owen N. Witte, and Michael E. Jung Development of 2‑Deoxy-2‑[18F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo. Journal of Medicinal Chemistry 2015; .
Porter, Edith, Daniel C Ma, Sandy Alvarez, and Kym F Faull Invited manuscript: Antimicrobial Lipids: Emerging Effector Molecules of Innate Host Defense. World Journal of Immunology 2015; 5: 51-61.
Maymon, Maskit, Pilar Martínez-Hidalgo, Stephen S. Tran, Tyler Ice, Karena Craemer, Teni Anbarchian, Tiffany Sung, Lin H. Hwang, Minxia Chou, Nancy A. Fujishige, William Villella, Jerome Ventosa, Johannes Sikorski, Erin R. Sanders, Kym F. Faull, Ann M. Hirsch Mining the phytomicrobiome to understand how bacterial coinoculations enhance plant growth. Frontiers in Plant Science 2015; 6(784): .
Shaw, Bryan F., Demetri T. Moustakas, Julian P. Whitelegge, and Kym F. Faull Taking charge of proteins: from neurodegeneration to industrial biotechnology. Advances in Protein Chemistry and Structural Biology 2010; 79: 128-158.
Nigra, Benjamin T., Kym F. Faull and Hans Barnard Analytical Chemistry in Archaeological Research. Analytical Chemistry (invited review) 2015; 87: 3−18 .
Meytal Landau, Meytal, Michael R. Sawaya, Kym F. Faull, Arthur Laganowsky, Lin Jiang, Stuart Sievers1, Jie Liu, Jorge Barrio and David Eisenberg The amyloid pharmacophore. PLoS Biol 2011; 9: e1001080.