Office Phone Number:
CAMPUS - 173717
Biological Sciences Research Building
Los Angeles, CA 90095 Biological Sciences Research Building
Los Angeles, CA 90095
|Professor, Biological Chemistry|
|Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center, Cell & Developmental Biology GPB Home Area, JCCC Cancer and Stem Cell Biology Program Area, themes|
Dr. van der Bliek studied Biology as an undergraduate at the University of Amsterdam. In 1988 he obtained a Ph.D. for studies of multidrug resistance and gene amplification in mammalian cells. These studies were conducted at the Netherlands Cancer Institute under supervision of Dr. Piet Borst. Dr. van der Bliek then worked as a postdoctoral fellow in the lab of Dr. Elliot Meyerowitz at Cal Tech. While there, Dr. van der Bliek discovered the role of dynamin in endocytosis, first in Drosophila and then in mammalian cells (collaboration with Dr. Sandra Schmid at Scripps). In early 1993, Dr. van der Bliek joined the Department of Biological Chemistry at UCLA where his laboratory has maintained an interest in membrane biology with a focus on the cell biological functions of dynamin family members. The lab initially studied the roles of classic dynamins in C. elegans and mammalian cells. In 1999, the van der Bliek lab (and others) discovered the role of dynamin-related proteins in mitochondrial fission. In the following years, the lab has continued to look for novel proteins that are part of the fission machinery. This search recently led to the discovery of a novel mitochondrial fission factor called MFF. In parallel, the lab has investigated the roles of dynamin-related proteins in fusion between mitochondria. This second line of research led to the discovery of enhanced sensitivity to reactive oxygen species in cells lacking fusion proteins and the discovery of a proteolytic cascade controlling mitochondrial fusion in mammalian cells. These findings have relevance for a range of human diseases, including cancer (through apoptosis), eye disease, and Parkinson’s disease.
Head Brian P, Zulaika Miren, Ryazantsev Sergey, van der Bliek Alexander M A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Molecular biology of the cell. 2011; 22(6): 831-41.
van der Bliek Alexander M, Payne Gregory S Dynamin subunit interactions revealed. Developmental cell. 2010; 18(5): 687-8.
Van der Bliek, A. M. Fussy mitochondria fuse in response to stress. EMBO J 2009; 28: 1533-4.
Head, B., Griparic, L. Amiri, M. Gandre-Babbe, S. & van der Bliek, A. M. Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells. J. Cell Biol 2009; 187: 959-66.
Kanazawa, T., Zappaterra M.D., Hasegawa, A., Wright A.P., Newman-Smith, E.D., Buttle, K., McDonald K.L., Mannella, C.A. & van der Bliek A.M. The C. elegans Opa1 Homologue EAT-3 is Essential for Resistance to Free Radicals. PLoS Genetics 2008; 4: 4, e1000022.
Gandre-Babbe, S. & van der Bliek, A. M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 2008; 19: 2402-2412.
Hasegawa, A. & van der Bliek, A.M. Functions of C. elegans and mammalian Mdm38/LetM1 homologues. Hum. Molec. Genet 2007; 16: 2061-2071.
Gandre, S. & van der Bliek, A.M. Mitochondrial division in C. elegans. Methods in Molecular Biology 2007; 372: 485-501.
Griparic, L. Kanzawa , T. & van der Bliek, A.M. Regulation of the mitochondrial dynamin like protein Opa1 by proteolytic cleavage. J. Cell Biol 2007; 178: 757-764.
Griparic L, van der Wel NN, Orozco IJ, Peters PJ, van der Bliek AM Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria. The Journal of biological chemistry. . 2004; 279(18): 18792-8.
Griparic L, Head B & van der Bliek AM Mitochondrial division and fusion. Topics in Curr. Genet 2004; 8: 227-249.
Smirnova E, Griparic L, Shurland DL, van der Bliek AM Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. Molecular biology of the cell. . 2001; 12(8): 2245-56.
Smirnova E, D -L Shurland & AM van der Bliek Mapping Dynamin Interdomain Interactions with Yeast Two-Hybrid and GST-Pulldown Experiments. Methods in Enzymology 2001; 329: 468-477.
Griparic L, van der Bliek AM The many shapes of mitochondrial membranes. Traffic (Copenhagen, Denmark) . 2001; 2(4): 235-44.
Smirnova E, Shurland DL, Newman-Smith ED, Pishvaee B, van der Bliek AM A model for dynamin self-assembly based on binding between three different protein domains. The Journal of biological chemistry. . 1999; 274(21): 14942-7.
van der Bliek AM Functional diversity in the dynamin family. Trends in cell biology. . 1999; 9(3): 96-102.