Work Phone Number:
Los Angeles, CA 90095
|Professor, Ecology and Evolutionary Biology|
Evolution/Development of Invertebrate Body Plans, Paleobiology and Marine Speciation Our laboratory brings an evolutionary perspective to the study of developmental genetics. In particular, we are investigating the role played by developmental genes in the early, geologically rapid Cambrian evolution of animal morphology. Comparison of developmental gene expression between morphologically distinct kinds of organisms is the primary focus in the laboratory. To this end, we have retrieved the engrailed gene via PCR from all the major classes of molluscs. We are now in the process of comparing the expression pattern of this gene through in situ hybridization studies in clams, snails, and chitons. In addition, we are reconstructing histories of gene duplication events using phylogenetic methods. The phylogenies produced permit a better understanding of the evolution of the genes, as well as shed light on the sequence of events in the evolution of animal development. Evolutionary hypotheses generated by examination of these developmental gene trees are then tested against the fossil and phylogenetic record of animal evolution. Gene sequences are also useful in reconstructing the relationships between organisms. We are especially motivated to explore such branching histories of organisms when they relate to paleontology, historical aspects of marine biology or climatic process. For example, a new project in the lab involves the use of molecular markers to study gene flow associated with the transport of planktonic larvae in marine organisms. Another molecular study investigates the geologic and climatic isolation of populations of jellyfish in salt water lakes, separated from the sea. In the lab we have ongoing interests in several non-molecular questions in invertebrate paleontology and paleoclimatology. Previous studies have explored the functional morphology of fossil cephalopods. Other studies pertain to the effects of milankovitch-driven climate change on sea level in non-glacial times, mans ongoing contribution to sea-level change, and climatic influences on the evolution of wetland faunas.
Ramachandra, N. B., R. D. Gates, P. D. Ladurner, D. K. Jacobs & V. Hartenstein. Neurogenesis in the Primitive Bilaterian Neochildia fusca I. Normal Development and Isolation of Genes Controlling Neural Fate. . Developmental Genes & Evolution ; .
Jacobs, D. K. & Gates, R. D. Developmental Genes and the Reconstruction of Metazoan Evolution ? Implications of Evolutionary Loss, Limits on Inference of Ancestry and Type 2 Errors. Integrative & Comparative Biology 2003; 43: 619-646.
Lee, SE Gates, RD Jacobs, DK Gene fishing: the use of a simple protocol to isolate multiple homeodomain classes from diverse invertebrate taxa. Journal of molecular evolution. . 2003; 56(4): 509-16.
Holland, ND Venkatesh, TV Holland, LZ Jacobs, DK Bodmer, R AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart. Developmental biology. . 2003; 255(1): 128-37.
Gates, R.D., T. Hadrys, Arenas-Mena, C. & D. K. Jacobs. Determining spatial and temporal patterns of developmental gene expression in vertebrates and invertebrates using in situ hybridization techniques. . In: Methods and Tools in Biosciences and Medicine: Techniques in Molecular Systematics and Evolution. (R. DeSalle ed.) 2002; 365-399.
Dawson, MN Louie, KD Barlow, M Jacobs, DK Swift, CC Comparative phylogeography of sympatric sister species, Clevelandia ios and Eucyclogobius newberryi (Teleostei, Gobiidae), across the California Transition Zone. Molecular ecology. . 2002; 11(6): 1065-75.
Ramachandra, NB Gates, RD Ladurner, P Jacobs, DK Hartenstein, V Embryonic development in the primitive bilaterian Neochildia fusca: normal morphogenesis and isolation of POU genes Brn-1 and Brn-3. Development genes and evolution. . 2002; 212(2): 55-69.
Lee, SE Gates, RD Jacobs, DK The isolation of a Distal-less gene fragment from two molluscs. Development genes and evolution. . 2001; 211(10): 506-8.
Jacobs, D. K. Buoyancy, Hydrodynamics and Structure in Chambered Cephalopods. Paleobiology II 2001; 2: 397-401.
Alroy, J, et al. Effects of sample standardization on estimates of Phanerozoic marine diversification. Proc. Nat. Acad.Sci. USA 2001; 98: 6261-6266.
Dawson, MN Staton, JL Jacobs, DK Phylogeography of the tidewater goby, Eucyclogobius newberryi (Teleostei, Gobiidae), in coastal California. Evolution; international journal of organic evolution. . 2001; 55(6): 1167-79.
Dawson, MN Jacobs, DK Molecular evidence for cryptic species of Aurelia aurita (Cnidaria, Scyphozoa). The Biological bulletin. . 2001; 200(1): 92-6.
Schubert, M Holland, LZ Holland, ND Jacobs, DK A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus. Molecular biology and evolution. . 2000; 17(12): 1896-903.
Seki, K., K. Tanabe, N. H. Landman, & D. K. Jacobs Hydrodynamic analysis of some Late Cretaceous desmoceratine ammonites. Revue de Paleobiologie, Geneve 2000; 8: 172-179.
Jacobs, DK Wray, CG Wedeen, CJ Kostriken, R DeSalle, R Staton, JL Gates, RD Lindberg, DR Molluscan engrailed expression, serial organization, and shell evolution. Evolution & development. . 2000; 2(6): 340-7.
Lee, SE Jacobs, DK Expression of Distal-less in molluscan eggs, embryos, and larvae. Evolution & development. . 1999; 1(3): 172-9.
Jacobs, DK Lindberg, DR Oxygen and evolutionary patterns in the sea: onshore/offshore trends and recent recruitment of deep-sea faunas. Proceedings of the National Academy of Sciences of the United States of America. . 1998; 95: 9396-401.
Dawson, MN Raskoff, KA Jacobs, DK Field preservation of marine invertebrate tissue for DNA analyses. Molecular marine biology and biotechnology. . 1998; 7(2): 145-52.
Jacobs, David K Chambered, Cephalopod Shells, Buoyancy, Structure and Decoupling: History and Red Herrings. Palaios 1996; 11: 610-614.
Jacobs, D. K. and J. A. Chamberlain, Jr. Hydrostatic and Hydrodynamic Issues in Ammonoid Functional Morphology. Ammonoid Paleobiology 1996; 169-224.
Agosti, D Jacobs, D DeSalle, R On combining protein sequences and nucleic acid sequences in phylogenetic analysis: the homeobox protein case. Cladistics : the international journal of the Willi Hennig Society. . 1996; 12: 65-82.
Jacobs, D. K., & D. L. Sahagian Milankovitch fluctuations in sea level and recent trends in sea level change: Ice may not always be the answer. Sequence Stratigraphy and Sea-Level Change 1995; 329-366 .
Wray, CG Jacobs, DK Kostriken, R Vogler, AP Baker, R DeSalle, R Homologues of the engrailed gene from five molluscan classes. FEBS letters. . 1995; 365(1): 71-4.
Jacobs, D. K, N. H. Landman & J. A. Chamberlain, Jr. Ammmonite shell shape varies with facies and hydrodynamics. Geology 1994; 22: 905-908..
Jacobs, DK Developmental genes and the origin and evolution of Metazoa. EXS. . 1994; 69: 537-49.
Sahagian, D. L., F. W. Schwartz & D. K. Jacobs Direct anthropogenic contributions to 20th century sea level rise. Nature 1994; 367: 54-57..
Jacobs D. K. & N. H. Landman Nautilus - model or muddle. Lethaia 1994; 27: 95-96..
Jacobs, D. K., & D. L. Sahagian. Climate-induced fluctuations in sea level during non-glacial times. Nature 1993; 361: 710-712..
Jacobs, D.K., & N. H. Landman. Is Nautilus a good model for the function and behavior of ammonoids ?. Lethaia 1993; 26: 101-110..
Jones, D. S., & D. K. Jacobs. Photosymbiosis in Clinocardium nuttalli: Implications for tests of photosymbiosis in fossil molluscs. Palaios 1992; 7: 86-95..
Jacobs, D. K. Shape, drag and power, in ammonoid swimming. Paleobiology 1992; 18: 203-220..
Miller, A. I., G. Llewellyn, K. M. Parsons, H. Cummins, B. J. Greenstein, M. R. Boardman, & D. K. Jacobs. The effect of Hurricane Hugo on molluscan skeletal distributions, Salt River Bay, St. Croix, U. S. Virgin Islands. 20 1992; 20: 23-26..
Jacobs, D. K. The support of hydrostatic load in cephalopod shells: A history of adaptive and ontogenetic explanations in morphology and evolution. Evolutionary Biology 1992; 26: 287-349..
Jacobs, D. K. Sutural pattern and shell stress in Baculites with implications for other cephalopod shell morphologies. Paleobiology 1990; 16: 336-348..
Jacobs, DK Selector genes and the Cambrian radiation of Bilateria. Proceedings of the National Academy of Sciences of the United States of America. . 1990; 87(11): 4406-10.