Joseph Distefano III, Ph.D.

Mailing Address:
4711 Boelter Hall
Los Angeles, CA 90095

Work Address:
Boelter hall, 159610
Los Angeles, CA 90095

Distinguished Professor, Computer Science
Professor, Medicine, Endocrinology, Diabetes and Hypertension
Member, Bioinformatics GPB Home Area, Brain Research Institute, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroengineering Training Program

Professor DiStefano was born in New York in 1938, graduated from Stuyvesant High School in 1956, received the BEE in Electrical Engineering from CCNY in 1961, and MS and PhD degrees from UCLA in 1964 & 1966, in the fields of Control Systems (MS) and Biocybernetics, Computer Methodology and Applied Mathematics (PhD), with minor field studies in Physiology. He joined the UCLA Engineering faculty in 1966, Medicine faculty in 1970, Computer Science faculty in 1982 and Cybernetics Inderdepartmental Program (IDP), as Chair, in 1981. He received a Distinguished Teaching Award in Engineering in 1971, was a Senior Fulbright-Hays Scholar in Italy in 1979, was awarded the UCLA Distinguished Teaching Award in 2003 and the Lockeed-Martin Award for Teaching Excellence in 2004. Currently, he Chairs the Cybernetics IDP, the Computational Systems Biology graduate program in Computer Science, Co-Chairs the Biocybernetics Subfield in the Biomedical Engineering IDP and is the Director of the Biocybernetics Research Laboratory. His research areas include systems biology, biocybernetics, PK/PD, multicompartmental and other dynamic systems modeling and optimization methodology, expert systems applications in life sciences research, endocrine system physiology and control, optimal experiment design, thyroid hormone regulation & metabolism in mammals and fishes, and disease (cancer, HCV, diabetes) process dynamics and optimal therapies.


A selected list of publications:

Meshkat Nicolette, Anderson Chris, DiStefano Joseph J   Alternative to Ritt's pseudodivision for finding the input-output equations of multi-output models Mathematical biosciences, 2012; 239(1): 117-23.
Ben-Shachar Rotem, Eisenberg Marisa, Huang Stephen A, DiStefano Joseph J   Simulation of post-thyroidectomy treatment alternatives for triiodothyronine or thyroxine replacement in pediatric thyroid cancer patients Thyroid : official journal of the American Thyroid Association, 2012; 22(6): 595-603.
Ben-Shachar Rotem, Eisenberg Marisa, Huang Stephen, Distefano Joseph J   Simulation of Post-thyroidectomy Treatment Alternatives for T3 or T4 Replacement in Pediatric Thyroid Cancer Patients Thyroid : official journal of the American Thyroid Association, 2011; 22(6): .
Meshkat Nicolette, Anderson Chris, Distefano Joseph J   Finding identifiable parameter combinations in nonlinear ODE models and the rational reparameterization of their input-output equations Mathematical biosciences, 2011; 233(1): 19-31.
Nichols John W, Breen Miyuki, Denver Robert J, Distefano Joseph J, Edwards Jeremy S, Hoke Robert A, Volz David C, Zhang Xiaowei   Predicting chemical impacts on vertebrate endocrine systems Environmental toxicology and chemistry / SETAC, 2011; 30(1): 39-51.
Eisenberg Marisa C, Santini Ferruccio, Marsili Alessandro, Pinchera Aldo, DiStefano Joseph J   TSH regulation dynamics in central and extreme primary hypothyroidism Thyroid : official journal of the American Thyroid Association, 2010; 20(11): 1215-28.
Meshkat Nicolette, Eisenberg Marisa, Distefano Joseph J   An algorithm for finding globally identifiable parameter combinations of nonlinear ODE models using Gröbner Bases Mathematical biosciences, 2009; 222(2): 61-72.
Eisenberg Marisa, Distefano Joseph J   TSH-based protocol, tablet instability, and absorption effects on L-T4 bioequivalence Thyroid : official journal of the American Thyroid Association, 2009; 19(2): 103-10.
Eisenberg Marisa, Samuels Mary, DiStefano Joseph J   Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis Thyroid : official journal of the American Thyroid Association, 2008; 18(10): 1071-85.
Eisenberg Marisa, Samuels Mary, DiStefano Joseph J   L-T4 bioequivalence and hormone replacement studies via feedback control simulations Thyroid : official journal of the American Thyroid Association, 2006; 16(12): 1279-92.
Russell Solomon, Distefano Joseph J   W3MAMCAT: a world wide web based tool for mammillary and catenary compartmental modeling and expert system distinguishability Computer methods and programs in biomedicine, 2006; 83(1): 34-42.
Ferl Gregory Z, Kenanova Vania, Wu Anna M, DiStefano Joseph J   A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments Molecular cancer therapeutics, 2006; 5(6): 1550-8.
Hori Sharon S, Kurland Irwin J, DiStefano Joseph J   Role of endosomal trafficking dynamics on the regulation of hepatic insulin receptor activity: models for Fao cells Annals of biomedical engineering, 2006; 34(5): 879-92.
Ferl Gregory Z, Wu Anna M, DiStefano Joseph J   A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) Annals of biomedical engineering, 2005; 33(11): 1640-52.
Harless Charles, Distefano Joseph J   Automated expert multiexponential biomodeling interactively over the Internet Computer methods and programs in biomedicine, 2005; 79(2): 169-78.
Bulis Kirk D, DiStefano Joseph J   W3MCSim: an online and reconfigurable Monte Carlo simulator for interactive probabilistic/statistical modeling Computer methods and programs in biomedicine, 2005; 77(1): 71-9.
Tee Daniel, DiStefano Joseph   Simulation of tumor-induced angiogenesis and its response to anti-angiogenic drug treatment: mode of drug delivery and clearance rate dependencies Journal of cancer research and clinical oncology, 2004; 130(1): 15-24.
Nguyen Thuvan T, Mol Koen A, DiStefano Joseph J   Thyroid hormone production rates in rat liver and intestine in vivo: a novel graph theory and experimental solution American journal of physiology. Endocrinology and metabolism, 2003; 285(1): E171-81.