Tomas Ganz, M.D., Ph.D.

Office Address:
CHS 52-243, Department of Medicine
David Geffen School of Medicine
Los Angeles, CA 90095

Work Address:
37-131 - CHS
Campus -169017
CA

Affiliations
Affiliations
Professor, Medicine, Pathology and Laboratory Medicine
Member, CTSI, JCCC Cancer and Stem Cell Biology Program Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Faculty, Cellular and Molecular Pathology PhD Program
Research Interests
Iron is an essential trace element whose plasma concentrations must be maintained in a narrow range. Prolonged decrease in plasma iron concentration causes cellular iron deficiency and anemia, and prolonged increase causes iron toxicity leading to organ failure and death. Our group discovered the iron-regulatory hormone hepcidin and, together with others, characterized its effects, regulation and mechanism of action. Hepcidin binds to the cellular iron channel/receptor ferroportin and induces its internalization and degradation. We are studying the molecular pathways involved in hepcidin and ferroportin regulation, and developing lead candidates for the treatment of iron disorders, including hereditary hemochromatosis and various anemias. Experimental approaches range from molecular analysis of gene and protein regulation in cell lines and transgenic mice, synthetic production and testing of natural and modified peptides, to histopathologic studies and assays of samples from human patients and experimental animals.
Biography

Dr. Tomas Ganz received his Ph.D. in Applied Physics from Caltech in 1976 and M.D. from UCLA in 1978. After training in Internal Medicine and Pulmonary Medicine at UCLA, he joined the faculty in 1983. He has a joint appointment in the Departments of Medicine and Pathology and is involved in the graduate program in Molecular and Cellular Pathology.

Publications
Vos Josephine M, Tsakmaklis Nickolas, Patterson Christopher J, Meid Kirsten, Castillo Jorge J, Brodsky Philip, Ganz Tomas, Pals Steven T, Kersten Marie José, Xu Lian, Yang Guang, Treon Steven P, Hunter Zachary R CXCL13 levels are elevated in patients with Waldenström macroglobulinemia, and are predictive of major response to ibrutinib. Haematologica. 2017; 102(11): e452-e455.
Ganz Tomas Correction to: Iron and infection. International journal of hematology. 2017; .
Ganz Tomas Does Pathological Iron Overload Impair the Function of Human Lungs?. EBioMedicine. 2017; 20(3): 13-14.
Stefanova Deborah, Raychev Antoan, Arezes Joao, Ruchala Piotr, Gabayan Victoria, Skurnik Mikael, Dillon Barbara J, Horwitz Marcus A, Ganz Tomas, Bulut Yonca, Nemeth Elizabeta Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. Blood. 2017; 130(3): 245-257.
Aschemeyer Sharraya, Gabayan Victoria, Ganz Tomas, Nemeth Elizabeta, Kautz Léon Erythroferrone and matriptase-2 independently regulate hepcidin expression. American journal of hematology. 2017; 92(5): E61-E63.
Latour Chloé, Wlodarczyk Myriam F, Jung Grace, Gineste Aurélie, Blanchard Nicolas, Ganz Tomas, Roth Marie-Paule, Coppin Hélène, Kautz Léon Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia. Haematologica. 2017; 102(1): 60-68.
Clinkenbeard Erica L, Hanudel Mark R, Stayrook Keith R, Appaiah Hitesh Nidumanda, Farrow Emily G, Cass Taryn A, Summers Lelia J, Ip Colin S, Hum Julia M, Thomas Joseph C, Ivan Mircea, Richine Briana M, Chan Rebecca J, Clemens Thomas L, Schipani Ernestina, Sabbagh Yves, Xu Linlin, Srour Edward F, Alvarez Marta B, Kacena Melissa A, Salusky Isidro B, Ganz Tomas, Nemeth Elizabeta, White Kenneth E Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. 2017; 102(11): e427-e430.
McLachlan Stela, Page Kathryn E, Lee Seung-Min, Loguinov Alex, Valore Erika, Hui Simon T, Jung Grace, Zhou Jie, Lusis Aldons J, Fuqua Brie, Ganz Tomas, Nemeth Elizabeta, Vulpe Chris D Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice. American journal of physiology. Gastrointestinal and liver physiology. 2017; 313(5): G511-G523.
Michels Kathryn R, Zhang Zhimin, Bettina Alexandra M, Cagnina R Elaine, Stefanova Debora, Burdick Marie D, Vaulont Sophie, Nemeth Elizabeta, Ganz Tomas, Mehrad Borna Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. JCI insight. 2017; 2(6): e92002.
Ganz Tomas, Jung Grace, Naeim Arash, Ginzburg Yelena, Pakbaz Zahra, Walter Patrick B, Kautz Léon, Nemeth Elizabeta Immunoassay for human serum erythroferrone. Blood. 2017; 130(10): 1243-1246.
Khorramian Eeman, Fung Eileen, Chua Kristine, Gabayan Victoria, Ganz Tomas, Nemeth Elizabeta, Kim Airie In a Mouse Model of Sepsis, Hepcidin Ablation Ameliorates Anemia More Effectively than Iron and Erythropoietin Treatment. Shock (Augusta, Ga.). 2017; 48(4): 490-497.
Hanudel Mark R, Rappaport Maxime, Gabayan Victoria, Jung Grace, Salusky Isidro B, Nemeth Elizabeta, Ganz Tomas, Zaritsky Joshua Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. Haematologica. 2017; 102(3): e85-e88.
Ganz Tomas Iron and infection. International journal of hematology. 2017; 23(12): 1541-1552.
Coffey Richard, Ganz Tomas Iron homeostasis: An anthropocentric perspective. The Journal of biological chemistry. 2017; 292(31): 12727-12734.
Chow Jennifer K L, Ganz Tomas, Ruthazer Robin, Simpson Mary Ann, Pomfret Elizabeth A, Gordon Fredric D, Westerman Mark E, Snydman David R Iron-related markers are associated with infection after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2017; 23(12): 1541-1552.
Preziosi Morgan E, Singh Sucha, Valore Erika V, Jung Grace, Popovic Branimir, Poddar Minakshi, Nagarajan Shanmugam, Ganz Tomas, Monga Satdarshan P Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. Journal of hepatology. 2017; 67(2): 360-369.
Antman Elliott M, Di Corleto Paul E, Freeman Mason W, Ganz Tomas, Golan David E, Kitterman Roger, Loscalzo Joseph, Low Mark, McKenna Erin, O'Connor Alan C, Palazzolo Michael, Parrish John, Reizes Ofer, Ross Robert S, Vaughan Cheryl, Vince D Geoffrey, Watts Lesley, Watts Lesley NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nature reviews. Drug discovery. 2017; 16(10): 663-664.
Aschemeyer Sharraya, Qiao Bo, Stefanova Deborah, Valore Erika V, Sek Albert C, Ruwe T Alex, Vieth Kyle R, Jung Grace, Casu Carla, Rivella Stefano, Jormakka Mika, Mackenzie Bryan, Ganz Tomas, Nemeth Elizabeta Structure-function analysis of ferroportin defines the binding site and an alternative mechanism of action of hepcidin. Blood. 2017; .
Hanudel Mark R, Chua Kristine, Rappaport Maxime, Gabayan Victoria, Valore Erika, Goltzman David, Ganz Tomas, Nemeth Elizabeta, Salusky Isidro B Effects of dietary iron intake and chronic kidney disease on fibroblast growth factor 23 metabolism in wild-type and hepcidin knockout mice. American journal of physiology. Renal physiology. 2016; 311(6): F1369-F1377.
Ganz Tomas Hepcidin. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2016; 57(10): 1913-1917.
Ganz Tomas, Nemeth Elizabeta Iron Balance and the Role of Hepcidin in Chronic Kidney Disease. Seminars in nephrology. 2016; 36(2): 87-93.
Kim Airie, Fung Eileen, Parikh Sona G, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood cells, molecules & diseases. 2016; 56(1): 31-6.
Ganz Tomas Macrophages and Iron Metabolism. Microbiology spectrum. 2016; 4(5): F1369-F1377.
Casu Carla, Oikonomidou Paraskevi Rea, Chen Huiyong, Nandi Vijay, Ginzburg Yelena, Prasad Princy, Fleming Robert E, Shah Yatrik M, Valore Erika V, Nemeth Elizabeta, Ganz Tomas, MacDonald Brian, Rivella Stefano Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera. Blood. 2016; 128(2): 265-76.
Kalinowski Danuta S, Stefani Christian, Toyokuni Shinya, Ganz Tomas, Anderson Gregory J, Subramaniam Nathan V, Trinder Debbie, Olynyk John K, Chua Anita, Jansson Patric J, Sahni Sumit, Lane Darius J R, Merlot Angelica M, Kovacevic Zaklina, Huang Michael L H, Lee C Soon, Richardson Des R Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et biophysica acta. 2016; 1863(4): 727-48.
Gutschow Patrick, Schmidt Paul J, Han Huiling, Ostland Vaughn, Bartnikas Thomas B, Pettiglio Michael A, Herrera Carolina, Butler James S, Nemeth Elizabeta, Ganz Tomas, Fleming Mark D, Westerman Mark A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. Haematologica. 2015; 100(2): 167-77.
Kautz Léon, Jung Grace, Du Xin, Gabayan Victoria, Chapman Justin, Nasoff Marc, Nemeth Elizabeta, Ganz Tomas Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia. Blood. 2015; 126(17): 2031-7.
Keel Siobán B, Doty Raymond, Liu Li, Nemeth Elizabeta, Cherian Sindhu, Ganz Tomas, Abkowitz Janis L Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver. Experimental hematology. 2015; 43(6): 469-78.e6.
Michels Kathryn, Nemeth Elizabeta, Ganz Tomas, Mehrad Borna Hepcidin and Host Defense against Infectious Diseases. PLoS pathogens. 2015; 11(8): e1004998.
Ganz Tomas Hepcidin and the global burden of iron deficiency. Clinical chemistry. 2015; 61(4): 577-8.
Arezes Joao, Jung Grace, Gabayan Victoria, Valore Erika, Ruchala Piotr, Gulig Paul A, Ganz Tomas, Nemeth Elizabeta, Bulut Yonca Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus. Cell host & microbe. 2015; 17(1): 47-57.
Ganz Tomas, Nemeth Elizabeta Iron homeostasis in host defence and inflammation. Nature reviews. Immunology. 2015; 15(8): 500-10.
Drakesmith Hal, Nemeth Elizabeta, Ganz Tomas Ironing out Ferroportin. Cell metabolism. 2015; 22(5): 777-87.
Chua Kristine, Fung Eileen, Micewicz Ewa D, Ganz Tomas, Nemeth Elizabeta, Ruchala Piotr Small cyclic agonists of iron regulatory hormone hepcidin. Bioorganic & medicinal chemistry letters. 2015; 61(4): .
Maccia Antonio, Madeddu Clelia, Gramignano Giulia, Mulas Carlo, Tanca Luciana, Cherchi Maria Cristina, Floris Carlo, Omoto Itaru, Barracca Antonio, Ganz Tomas The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study. Haematologica. 2015; 100(1): 124-32.
Fung Eileen, Chua Kristine, Ganz Tomas, Nemeth Elizabeta, Ruchala Piotr Thiol-derivatized minihepcidins retain biological activity. Bioorganic & medicinal chemistry letters. 2015; 25(4): 763-6.
Kim Airie, Fung Eileen, Parikh Sona G, Valore Erika V, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin. Blood. 2014; 123(8): 1129-36.
Nemeth Elizabeta, Ganz Tomas Anemia of inflammation. Hematology/oncology clinics of North America. 2014; 28(4): 671-81, vi.
Zhang Shuping, Chen Yue, Guo Wenli, Yuan Lin, Zhang Daoqiang, Xu Yong, Nemeth Elizabeta, Ganz Tomas, Liu Sijin Disordered hepcidin-ferroportin signaling promotes breast cancer growth. Cellular signalling. 2014; 26(11): 2539-50.
Kautz Leon, Jung Grace, Nemeth Elizabeta, Ganz Tomas Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014; 124(16): 2569-74.
Mitchell Colin J, Shawki Ali, Ganz Tomas, Nemeth Elizabeta, Mackenzie Bryan Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc. American journal of physiology. Cell physiology. 2014; 306(5): C450-9.
Rodriguez Richard, Jung Chun-Ling, Gabayan Victoria, Deng Jane C, Ganz Tomas, Nemeth Elizabeta, Bulut Yonca Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infection and immunity. 2014; 82(2): 745-52.
Kautz Leon, Jung Grace, Valore Erika V, Rivella Stefano, Nemeth Elizabeta, Ganz Tomas Identification of erythroferrone as an erythroid regulator of iron metabolism. Nature genetics. 2014; 46(7): 678-84.
Kim Airie, Rivera Seth, Shprung Dana, Limbrick Donald, Gabayan Victoria, Nemeth Elizabeta, Ganz Tomas Mouse models of anemia of cancer. PloS one. 2014; 9(3): e93283.
Latour Chloe, Kautz Leon, Besson-Fournier Celine, Island Marie-Laure, Canonne-Hergaux Francois, Loreal Olivier, Ganz Tomas, Coppin Helene, Roth Marie-Paule Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology (Baltimore, Md.). 2014; 59(2): 683-94.
Preza Gloria Cuevas, Pinon Rogelio, Ganz Tomas, Nemeth Elizabeta Cellular catabolism of the iron-regulatory peptide hormone hepcidin. PloS one. 2013; 8(3): e58934.
Clark Richard J, Preza Gloria C, Tan Chia Chia, van Dijk Johannes W A, Fung Eileen, Nemeth Elizabeta, Ganz Tomas, Craik David J Design, synthesis, and characterization of cyclic analogues of the iron regulatory peptide hormone hepcidin. Biopolymers. 2013; 100(5): 519-26.
Mast Alan E, Schlumpf Karen S, Wright David J, Johnson Bryce, Glynn Simone A, Busch Michael P, Olbina Gordana, Westerman Mark, Nemeth Elizabeta, Ganz Tomas Hepcidin predicts hemoglobin in individuals experiencing repeated phlebotomy. Haematologica. 2013; 83(3): .
Fung Eileen, Sugianto Priscilla, Hsu Jason, Damoiseaux Robert, Ganz Tomas, Nemeth Elizabeta High-throughput screening of small molecules identifies hepcidin antagonists. Molecular pharmacology. 2013; 83(3): 681-90.
McCranor Bryan J, Langdon Jacqueline M, Prince Olivier D, Femnou Laurette K, Berger Alan E, Cheadle Chris, Civin Curt I, Kim Airie, Rivera Seth, Ganz Tomas, Vaulont Sophie, Xue Qian-Li, Walston Jeremy D, Roy Cindy N Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013; 98(10): 1633-40.
Ganz Tomas Preface: iron and cancer. Critical reviews in oncogenesis. 2013; 18(5): preceding 391.
Ganz Tomas Systemic iron homeostasis. Physiological reviews. 2013; 93(4): 1721-41.
Kautz Leon, Gabayan Victoria, Wang Xuping, Wu Judy, Onwuzurike James, Jung Grace, Qiao Bo, Lusis Aldons J, Ganz Tomas, Nemeth Elizabeta Testing the iron hypothesis in a mouse model of atherosclerosis. Cell reports. 2013; 5(5): 1436-42.
Ganz Tomas, Nemeth Elizabeta Hepcidin and iron homeostasis. Biochimica et Biophysica Acta. 2012; 2(5): .
Ravasi Giulia, Pelucchi Sara, Trombini Paola, Mariani Raffaella, Tomosugi Naohisa, Modignani Giulia Litta, Pozzi Matteo, Nemeth Elizabeth, Ganz Tomas, Hayashi Hisao, Barisani Donatella, Piperno Alberto Hepcidin expression in iron overload diseases is variably modulated by circulating factors. PloS one. 2012; 7(5): e36425.
Qiao Bo, Sugianto Priscilla, Fung Eileen, Del-Castillo-Rueda Alejandro, Moran-Jimenez Maria-Josefa, Ganz Tomas, Nemeth Elizabeta Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Cell Metabolism. 2012; 15(6): 918-24.
Ganz Tomas, Goff Jesse, Klasing Kirk, Nemeth Elizabeta, Roth Terri IOD in rhinos--immunity group report: report from the Immunity, Genetics and Toxicology Working Group of the International Workshop on Iron Overload Disorder in Browsing Rhinoceros (February 2011). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2012; 43(3 Suppl): S117-9.
Besson-Fournier Céline, Latour Chloé, Kautz Léon, Bertrand Jessica, Ganz Tomas, Roth Marie-Paule, Coppin Hélène Induction of activin B by inflammatory stimuliupregulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood. 2012; 15(6): .
Goodnough Julia B, Ramos Emilio, Nemeth Elizabeta, Ganz Tomas Inhibition of hepcidin transcription by growth factors. Hepatology (Baltimore, Md.). 2012; 2(5): .
Ganz Tomas, Nemeth Elizabeta Iron homeostasis and its disorders in mice and men: potential lessons for rhinos. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2012; 43(3 Suppl): S19-26.
Ganz Tomas, Nemeth Elizabeta Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harbor perspectives in medicine. 2012; 2(5): a011668.
Ganz Tomas Macrophages and Systemic Iron Homeostasis. Journal of Innate Immunity. 2012; 2(5): .
Ramos Emilio, Ruchala Piotr, Goodnough Julia B, Kautz Léon, Preza Gloria C, Nemeth Elizabeta, Ganz Tomas Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012; 120(18): 3829-36.
Ross Sandra L, Tran Lynn, Winters Aaron, Lee Ki-Jeong, Plewa Cherylene, Foltz Ian, King Chadwick, Miranda Les P, Allen Jennifer, Beckman Holger, Cooke Keegan S, Moody Gordon, Sasu Barbra J, Nemeth Elizabeta, Ganz Tomas, Molineux Graham, Arvedson Tara L Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT. Cell Metabolism. 2012; 15(6): 905-17.
Girelli Domenico, Trombini Paola, Busti Fabiana, Campostrini Natascia, Sandri Marco, Pelucchi Sara, Westerman Mark, Ganz Tomas, Nemeth Elizabeta, Piperno Alberto, Camaschella Clara A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica. 2011; 96(4): 500-6.
Gordeuk Victor R, Miasnikova Galina Y, Sergueeva Adelina I, Niu Xiaomei, Nouraie Mehdi, Okhotin Daniel J, Polyakova Lydia A, Ammosova Tatiana, Nekhai Sergei, Ganz Tomas, Prchal Josef T Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood. 2011; 118(19): 5278-82.
Ramos Emilio, Kautz Leon, Rodriguez Richard, Hansen Michael, Gabayan Victoria, Ginzburg Yelena, Roth Marie-Paule, Nemeth Elizabeta, Ganz Tomas Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (Baltimore, Md.). 2011; 53(4): 1333-41.
Ganz Tomas, Nemeth Elizabeta Hepcidin and disorders of iron metabolism. Annual Review of Medicine. 2011; 62(10): 347-60.
Ganz Tomas Hepcidin and iron regulation, 10 years later. Blood. 2011; 117(17): 4425-33.
Trombini Paola, Paolini Valentina, Pelucchi Sara, Mariani Raffaella, Nemeth Elizabeta, Ganz Tomas, Piperno Alberto Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. Liver international : official journal of the International Association for the Study of the Liver. 2011; 31(7): 994-1000.
Ghoti Hussam, Fibach Eitan, Westerman Mark, Gordana Olbina, Ganz Tomas, Rachmilewitz Eliezer A Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. British journal of haematology. 2011; 153(1): 118-20.
Preza Gloria C, Ruchala Piotr, Pinon Rogelio, Ramos Emilio, Qiao Bo, Peralta Michael A, Sharma Shantanu, Waring Alan, Ganz Tomas, Nemeth Elizabeta Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload. The Journal of Clinical Investigation. 2011; 121(12): 4880-8.
Piperno Alberto, Galimberti Stefania, Mariani Raffaella, Pelucchi Sara, Ravasi Giulia, Lombardi Carolina, Bilo Grzegorz, Revera Miriam, Giuliano Andrea, Faini Andrea, Mainini Veronica, Westerman Mark, Ganz Tomas, Valsecchi Maria Grazia, Mancia Giuseppe, Parati Gianfranco, Parati Gianfranco Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood. 2011; 117(10): 2953-9.
Pasricha Sant-Rayn, McQuilten Zoe, Westerman Mark, Keller Anthony, Nemeth Elizabeta, Ganz Tomas, Wood Erica Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors. Haematologica. 2011; 96(8): 1099-105.
Ganz Tomas, Nemeth Elizabeta The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2011; 2011(10): 538-42.
Miasnikova Galina Y, Sergueeva Adelina I, Nouraie Mehdi, Niu Xiaomei, Okhotin Daniel J, Polyakova Lydia A, Ganz Tomas, Prchal Josef T, Gordeuk Victor R The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica. 2011; 96(9): 1371-4.
Clark Richard J, Tan Chia Chia, Preza Gloria C, Nemeth Elizabeta, Ganz Tomas, Craik David J Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry & Biology. 2011; 18(3): 336-43.
Ayoya Mohamed A, Spiekermann-Brouwer Gerburg M, Stoltzfus Rebecca J, Nemeth Elizabeta, Habicht Jean-Pierre, Ganz Tomas, Rawat Rahul, Traoré Abdel K, Garza Cutberto Alpha 1-acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. The American journal of clinical nutrition. 2010; 91(6): 1784-90.
Goodnough Lawrence Tim, Nemeth Elizabeta, Ganz Tomas Detection, evaluation, and management of iron-restricted erythropoiesis. Blood. 2010; 116(23): 4754-61.
Maes Ken, Nemeth Elizabeta, Roodman G David, Huston Alissa, Esteve Flavia, Freytes Cesar, Callander Natalie, Katodritou Eirini, Tussing-Humphreys Lisa, Rivera Seth, Vanderkerken Karin, Lichtenstein Alan, Ganz Tomas In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood. 2010; 116(18): 3635-44.
Chen QiXing, Hakimi Matthew, Wu ShuiJing, Jin Yue, Cheng BaoLi, Wang HaiHong, Xie GuoHao, Ganz Tomas, Linzmeier Rose M, Fang XiangMing Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology. 2010; 112(6): 1428-34.
Bdeir Khalil, Higazi Abd Al-Roof, Kulikovskaya Irina, Christofidou-Solomidou Melpo, Vinogradov Sergei A, Allen Timothy C, Idell Steven, Linzmeier Rose, Ganz Tomas, Cines Douglas B Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. American journal of respiratory and critical care medicine. 2010; 181(9): 935-46.
Ferrucci Luigi, Semba Richard D, Guralnik Jack M, Ershler William B, Bandinelli Stefania, Patel Kushang V, Sun Kai, Woodman Richard C, Andrews Nancy C, Cotter Robert J, Ganz Tomas, Nemeth Elizabeta, Longo Dan L Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010; 115(18): 3810-6.
Zaritsky Joshua, Young Brian, Gales Barbara, Wang He-Jing, Rastogi Anjay, Westerman Mark, Nemeth Elizabeta, Ganz Tomas, Salusky Isidro B Reduction of serum hepcidin by hemodialysis in pediatric and adult patients. Clinical Journal of the American Society of Nephrology : CJASN. 2010; 5(6): 1010-4.
Bachman Eric, Feng Rui, Travison Thomas, Li Michelle, Olbina Gordana, Ostland Vaughn, Ulloor Jagadish, Zhang Anqi, Basaria Shehzad, Ganz Tomas, Westerman Mark, Bhasin Shalender Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. The Journal of clinical endocrinology and metabolism. 2010; 95(10): 4743-7.
Rivera Seth, Ganz Tomas Animal models of anemia of inflammation. Seminars in Hematology. 2009; 46(4): 351-7.
Troadec Marie-Bérengère, Lainé Fabrice, Daniel Vincent, Rochcongar Pierre, Ropert Martine, Cabillic Florian, Perrin Michèle, Morcet Jeff, Loréal Olivier, Olbina Gordana, Westerman Mark, Nemeth Elizabeta, Ganz Tomas, Brissot Pierre Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism. European journal of applied physiology. 2009; 106(3): 435-43.
Wilson Carole L, Schmidt Amy P, Pirilä Emma, Valore Erika V, Ferri Nicola, Sorsa Timo, Ganz Tomas, Parks William C Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7). The Journal of biological chemistry. 2009; 284(13): 8301-11.
Zaritsky Joshua, Young Brian, Wang He-Jing, Westerman Mark, Olbina Gordana, Nemeth Elizabeta, Ganz Tomas, Rivera Seth, Nissenson Allen R, Salusky Isidro B Hepcidin--a potential novel biomarker for iron status in chronic kidney disease. Clinical Journal of the American Society of Nephrology : CJASN. 2009; 4(6): 1051-6.
Sham Ronald L, Phatak Pradyumna D, Nemeth Elizabeta, Ganz Tomas Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation. Blood. 2009; 114(2): 493-4.
Tanno Toshihiko, Porayette Prashanth, Sripichai Orapan, Noh Seung-Jae, Byrnes Colleen, Bhupatiraju Ajoy, Lee Y Terry, Goodnough Julia B, Harandi Omid, Ganz Tomas, Paulson Robert F, Miller Jeffery L Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood. 2009; 114(1): 181-6.
Ruivard Marc, Lainé Fabrice, Ganz Tomas, Olbina Gordana, Westerman Mark, Nemeth Elizabeta, Rambeau Mathieu, Mazur André, Gerbaud Laurent, Tournilhac Valérie, Abergel Armand, Philippe Pierre, Deugnier Yves, Coudray Charles Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. Journal of hepatology. 2009; 50(6): 1219-25.
Ganz Tomas Iron in innate immunity: starve the invaders. Current Opinion in Immunology. 2009; 21(1): 63-7.
Ganz Tomas, Nemeth Elizabeta Iron sequestration and anemia of inflammation. Seminars in Hematology. 2009; 46(4): 387-93.
Girelli Domenico, Pasino Michela, Goodnough Julia B, Nemeth Elizabeta, Guido Maria, Castagna Annalisa, Busti Fabiana, Campostrini Natascia, Martinelli Nicola, Vantini Italo, Corrocher Roberto, Ganz Tomas, Fattovich Giovanna Reduced serum hepcidin levels in patients with chronic hepatitis C. Journal of hepatology. 2009; 51(5): 845-52.
Kroot Joyce J C, Kemna Erwin H J M, Bansal Sukhvinder S, Busbridge Mark, Campostrini Natascia, Girelli Domenico, Hider Robert C, Koliaraki Vasiliki, Mamalaki Avgi, Olbina Gordana, Tomosugi Naohisa, Tselepis Chris, Ward Douglas G, Ganz Tomas, Hendriks Jan C M, Swinkels Dorine W Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica. 2009; 94(12): 1748-52.
Katodritou Eirini, Ganz Tomas, Terpos Evangelos, Verrou Evgenia, Olbina Gordana, Gastari Vassiliki, Hadjiaggelidou Christina, Varthaliti Maria, Georgiadou Sofia, Westerman Mark, Zervas Konstantinos Sequential evaluation of serum hepcidin in anemic myeloma patients: study of correlations with myeloma treatment, disease variables, and anemia response. American journal of hematology. 2009; 84(8): 524-6.
Fernandes Augustine, Preza Gloria C, Phung Yen, De Domenico Ivana, Kaplan Jerry, Ganz Tomas, Nemeth Elizabeta The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 2009; 114(2): 437-43.
Nemeth Elizabeta, Ganz Tomas The role of hepcidin in iron metabolism. Acta haematologica. 2009; 122(2-3): 78-86.
Aberg Karin M, Man Mao-Qiang, Gallo Richard L, Ganz Tomas, Crumrine Debra, Brown Barbara E, Choi Eung-Ho, Kim Dong-Kun, Schröder Jens M, Feingold Kenneth R, Elias Peter M Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. The Journal of investigative dermatology. 2008; 128(4): 917-25.
Bullard Rebecca S, Gibson Willietta, Bose Sudeep K, Belgrave Jamila K, Eaddy Andre C, Wright Corey J, Hazen-Martin Debra J, Lage Janice M, Keane Thomas E, Ganz Tomas A, Donald Carlton D Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer. Molecular immunology. 2008; 45(3): 839-48.
Barisani Donatella, Pelucchi Sara, Mariani Raffaella, Galimberti Stefania, Trombini Paola, Fumagalli Daniela, Meneveri Raffaella, Nemeth Elizabeta, Ganz Tomas, Piperno Alberto Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. Journal of hepatology. 2008; 49(1): 123-33.
Ganz Tomas, Olbina Gordana, Girelli Domenico, Nemeth Elizabeta, Westerman Mark Immunoassay for human serum hepcidin. Blood. 2008; 112(10): 4292-7.
Sharma Sanjai, Nemeth Elizabeta, Chen Yi-Hsiang, Goodnough Julia, Huston Alissa, Roodman G D, Ganz Tomas, Lichtenstein Alan Involvement of hepcidin in the anemia of multiple myeloma. Clinical Cancer Research : an official journal of the American Association for Cancer Research. 2008; 14(11): 3262-7.
Ganz Tomas Iron homeostasis: fitting the puzzle pieces together. Cell Metabolism. 2008; 7(4): 288-90.
Bozzini Claudia, Campostrini Natascia, Trombini Paola, Nemeth Elizabeta, Castagna Annalisa, Tenuti Ilaria, Corrocher Roberto, Camaschella Clara, Ganz Tomas, Olivieri Oliviero, Piperno Alberto, Girelli Domenico Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood cells, molecules & diseases. 2008; 40(3): 347-52.
Valore Erika V, Ganz Tomas Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells, Molecules & Diseases. 2008; 40(1): 132-8.
Lin Lan, Nemeth Elizabeta, Goodnough Julia B, Thapa Dharma R, Gabayan Victoria, Ganz Tomas Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood cells, molecules & diseases. 2008; 40(1): 122-31.
De Domenico Ivana, Nemeth Elizabeta, Nelson Jenifer M, Phillips John D, Ajioka Richard S, Kay Michael S, Kushner James P, Ganz Tomas, Ward Diane M, Kaplan Jerry The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell metabolism. 2008; 8(2): 146-56.
Winder Asher, Lefkowitz Rafi, Ghoti Hussam, Leiba Merav, Ganz Tomas, Nemeth Elizabeta, Rachmilewitz Eliezer A Urinary hepcidin excretion in patients with myelodysplastic syndrome and myelofibrosis. British journal of haematology. 2008; 142(4): 669-71.
Piperno Alberto, Girelli Domenico, Nemeth Elizabeta, Trombini Paola, Bozzini Claudia, Poggiali Erika, Phung Yen, Ganz Tomas, Camaschella Clara Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood. 2007; 110(12): 4096-100.
Trombini Paola, Coliva Tiziana, Nemeth Elizabeta, Mariani Raffaella, Ganz Tomas, Biondi Andrea, Piperno Alberto Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica. 2007; 92(10): 1407-10.
Tanno Toshihiko, Bhanu Natarajan V, Oneal Patricia A, Goh Sung-Ho, Staker Pamela, Lee Y Terry, Moroney John W, Reed Christopher H, Luban Naomi L C, Wang Rui-Hong, Eling Thomas E, Childs Richard, Ganz Tomas, Leitman Susan F, Fucharoen Suthat, Miller Jeffery L High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature medicine. 2007; 13(9): 1096-101.
Lin Lan, Valore Erika V, Nemeth Elizabeta, Goodnough Julia B, Gabayan Victoria, Ganz Tomas Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007; 110(6): 2182-9.
Origa Raffaella, Galanello Renzo, Ganz Tomas, Giagu Nicolina, Maccioni Liliana, Faa Gavino, Nemeth Elizabeta Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica. 2007; 92(5): 583-8.
Ganz Tomas Molecular control of iron transport. Journal of the American Society of Nephrology : JASN. 2007; 18(2): 394-400.
Aberg Karin M, Radek Katherine A, Choi Eung-Ho, Kim Dong-Kun, Demerjian Marianne, Hupe Melanie, Kerbleski Joseph, Gallo Richard L, Ganz Tomas, Mauro Theodora, Feingold Kenneth R, Elias Peter M Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. The Journal of clinical investigation. 2007; 117(11): 3339-49.
De Domenico Ivana, Ward Diane McVey, Langelier Charles, Vaughn Michael B, Nemeth Elizabeta, Sundquist Wesley I, Ganz Tomas, Musci Giovanni, Kaplan Jerry The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Molecular biology of the cell. 2007; 18(7): 2569-78.
Kearney Susan L, Nemeth Elizabeta, Neufeld Ellis J, Thapa Dharma, Ganz Tomas, Weinstein David A, Cunningham Melody J Urinary hepcidin in congenital chronic anemias. Pediatric blood & cancer. 2007; 48(1): 57-63.
Linzmeier Rose M, Ganz Tomas Copy number polymorphisms are not a common feature of innate immune genes. Genomics. 2006; 88(1): 122-6.
Pospisilova Dagmar, Mims Martha P, Nemeth Elizabeta, Ganz Tomas, Prchal Josef T DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006; 108(1): 404-5.
Nemeth Elizabeta, Ganz Tomas Hepcidin and iron-loading anemias. Haematologica. 2006; 91(6): 727-32.
Ganz Tomas Hepcidin and its role in regulating systemic iron metabolism. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2006; 107(1): 29-35, 507.
Sørensen Ole E, Thapa Dharma R, Roupé K Markus, Valore Erika V, Sjöbring Ulf, Roberts Alice A, Schmidtchen Artur, Ganz Tomas Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. The Journal of clinical investigation. 2006; 116(7): 1878-85.
Ganz Tomas, Nemeth Elizabeta Iron imports. IV. Hepcidin and regulation of body iron metabolism. American journal of physiology. Gastrointestinal and liver physiology. 2006; 290(2): G199-203.
Tan Belinda H, Meinken Christoph, Bastian Max, Bruns Heiko, Legaspi Annaliza, Ochoa Maria Teresa, Krutzik Stephan R, Bloom Barry R, Ganz Tomas, Modlin Robert L, Stenger Steffen Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. Journal of Immunology (Baltimore, Md. : 1950). 2006; 177(3): 1864-71.
De Domenico Ivana, McVey Ward Diane, Nemeth Elizabeta, Ganz Tomas, Corradini Elena, Ferrara Francesca, Musci Giovanni, Pietrangelo Antonello, Kaplan Jerry Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006; 91(8): 1092-5.
Ganz Tomas Molecular pathogenesis of anemia of chronic disease. Pediatric blood & cancer. 2006; 46(5): 554-7.
Ganz Tomas, Nemeth Elizabeta Regulation of iron acquisition and iron distribution in mammals. Biochimica et Biophysica Acta. 2006; 1763(7): 690-9.
Nemeth Elizabeta, Ganz Tomas Regulation of iron metabolism by hepcidin. Annual review of nutrition. 2006; 26(2): 323-42.
Valore Erika V, Wiley Dorothy J, Ganz Tomas Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infection and immunity. 2006; 74(10): 5693-702.
Pak Mihwa, Lopez Miguel A, Gabayan Victroia, Ganz Tomas, Rivera Seth Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006; 108(12): 3730-5.
Nemeth Elizabeta, Preza Gloria C, Jung Chun-Ling, Kaplan Jerry, Waring Alan J, Ganz Tomas The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood. 2006; 107(1): 328-33.
Porto Graça, Roetto Antonella, Daraio Filomena, Pinto Jorge Pereira, Almeida Susana, Bacelar Conceição, Nemeth Elizabeth, Ganz Tomas, Camaschella Clara A Portuguese patient homozygous for the -25G>A mutation of the HAMP promoter shows evidence of steady-state transcription but fails to up-regulate hepcidin levels by iron. Blood. 2005; 106(8): 2922-3.
Ganz Tomas Cellular iron: ferroportin is the only way out. Cell Metabolism. 2005; 1(3): 155-7.
Lin Lan, Goldberg Y Paul, Ganz Tomas Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 2005; 106(8): 2884-9.
Cole Alexander M, Thapa Dharma R, Gabayan Victoria, Liao Hsiang-I, Liu Lide, Ganz Tomas Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M. Journal of leukocyte biology. 2005; 78(5): 1081-5.
Ganz Tomas Defensins and other antimicrobial peptides: a historical perspective and an update. Combinatorial chemistry & high throughput screening. 2005; 8(3): 209-17.
Sørensen Ole E, Thapa Dharma R, Rosenthal Adam, Liu Lide, Roberts Alice A, Ganz Tomas Differential regulation of beta-defensin expression in human skin by microbial stimuli. Journal of immunology (Baltimore, Md. : 1950). 2005; 174(8): 4870-9.
Porter Edith, Yang Huixia, Yavagal Sujata, Preza Gloria C, Murillo Omar, Lima Heriberto, Greene Sheila, Mahoozi Laily, Klein-Patel Marcia, Diamond Gill, Gulati Sunita, Ganz Tomas, Rice Peter A, Quayle Alison J Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infection and immunity. 2005; 73(8): 4823-33.
Rivera Seth, Liu Lide, Nemeth Elizabeta, Gabayan Victoria, Sorensen Ole E, Ganz Tomas Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood. 2005; 105(4): 1797-802.
Papanikolaou George, Tzilianos Michalis, Christakis John I, Bogdanos Dionisios, Tsimirika Konstantina, MacFarlane Julie, Goldberg Y Paul, Sakellaropoulos Nikos, Ganz Tomas, Nemeth Elizabeta Hepcidin in iron overload disorders. Blood. 2005; 105(10): 4103-5.
Nemeth Elizabeta, Roetto Antonella, Garozzo Giovanni, Ganz Tomas, Camaschella Clara Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005; 105(4): 1803-6.
Détivaud Lénaïck, Nemeth Elizabeta, Boudjema Karim, Turlin Bruno, Troadec Marie-Bérengère, Leroyer Patricia, Ropert Martine, Jacquelinet Sylvie, Courselaud Brice, Ganz Tomas, Brissot Pierre, Loréal Olivier Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood. 2005; 106(2): 746-8.
Ganz Tomas Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. Best practice & research. Clinical haematology. 2005; 18(2): 171-82.
Linzmeier Rose M, Ganz Tomas Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. Genomics. 2005; 86(4): 423-30.
Liuzzi Juan P, Lichten Louis A, Rivera Seth, Blanchard Raymond K, Aydemir Tolunay Beker, Knutson Mitchell D, Ganz Tomas, Cousins Robert J Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(19): 6843-8.
Zoller Heinz, McFarlane Ian, Theurl Igor, Stadlmann Sylvia, Nemeth Elizabeta, Oxley David, Ganz Tomas, Halsall David J, Cox Timothy M, Vogel Wolfgang Primary iron overload with inappropriate hepcidin expression in V162del ferroportin disease. Hepatology (Baltimore, Md.). 2005; 42(2): 466-72.
Wehkamp Jan, Salzman Nita H, Porter Edith, Nuding Sabine, Weichenthal Michael, Petras Robert E, Shen Bo, Schaeffeler Elke, Schwab Matthias, Linzmeier Rose, Feathers Ryan W, Chu Hiutung, Lima Heriberto, Fellermann Klaus, Ganz Tomas, Stange Eduard F, Bevins Charles L Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(50): 18129-34.
Rivera Seth, Nemeth Elizabeta, Gabayan Victoria, Lopez Miguel A, Farshidi Dina, Ganz Tomas Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005; 106(6): 2196-9.
Miller Lloyd S, Sørensen Ole E, Liu Philip T, Jalian H Ray, Eshtiaghpour Deborah, Behmanesh Behnaz E, Chung Woosin, Starner Timothy D, Kim Jenny, Sieling Peter A, Ganz Tomas, Modlin Robert L TGF-alpha regulates TLR expression and function on epidermal keratinocytes. Journal of immunology (Baltimore, Md. : 1950). 2005; 174(10): 6137-43.
De Domenico Ivana, Ward Diane McVey, Nemeth Elizabeta, Vaughn Michael B, Musci Giovanni, Ganz Tomas, Kaplan Jerry The molecular basis of ferroportin-linked hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(25): 8955-60.
Ganz Tomas Defensins: antimicrobial peptides of vertebrates. Comptes rendus biologies. 2004; 327(6): 539-49.
Ganz Tomas Hepcidin in iron metabolism. Current opinion in hematology. 2004; 11(4): 251-4.
Nemeth Elizabeta, Tuttle Marie S, Powelson Julie, Vaughn Michael B, Donovan Adriana, Ward Diane McVey, Ganz Tomas, Kaplan Jerry Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (New York, N.Y.). 2004; 306(5704): 2090-3.
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of clinical investigation. . 2004; 113(9): 1271-6.
Ross David J, Cole Alexander M, Yoshioka Dawn, Park Albert K, Belperio John A, Laks Hillel, Strieter Robert M, Lynch Joseph P, Kubak Bernard, Ardehali Abbas, Ganz Tomas Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004; 78(8): 1222-4.
Kalfa V Cuneyt, Spector Sheldon L, Ganz Tomas, Cole Alexander M Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2004; 93(3): 288-92.
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004; 36(1): 77-82.
Ganz T Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. . 2003; 102(3): 783-8.
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein (Plenary Article). Blood. 2003; 101: 2461-2463.
Park CH, Valore EV, Waring AJ, Ganz T Hepcidin, a urinary antimicrobial peptide synthesized in the liver. The Journal of Biological Chemistry. . 2001; 276(11): 7806-10.