Karen Gylys, Ph.D.

Work Address:
Factor Building 6-266
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, School of Nursing
Member, Brain Research Institute, Molecular Pharmacology GPB Home Area, Neuroscience GPB Home Area
Biography

Karen Hoppens Gylys is a neuroscientist who joined the faculty of the School of Nursing and the Brain Research Institute in 1998. Dr. Gylys earned a B.S. degree in Nursing and a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance in the NPI. Since joining the faculty of the School of Nursing, she has taught pharmacology and research in the School of Nursing and is actively involved in the BRI. Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer's disease, which is thought to underlie the earliest cognitive impairments.

Publications

A selected list of publications:

Bilousova Tina, Elias Chris, Miyoshi Emily, Alam Mohammad Parvez, Zhu Chunni, Campagna Jesus, Vadivel Kanagasabai, Jagodzinska Barbara, Gylys Karen Hoppens, John Varghese   Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2 Biochemical and biophysical research communications, 2018; 499(4): 751-757.
Ma Qiu-Lan, Teng Edmond, Zuo Xiaohong, Jones Mychica, Teter Bruce, Zhao Evan Y, Zhu Cansheng, Bilousova Tina, Gylys Karen H, Apostolova Liana G, LaDu Mary Jo, Hossain Mir Ahamed, Frautschy Sally A, Cole Gregory M   Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease Neurobiology of disease, 2018; 114(2): 120-128.
Gylys Karen Hoppens, Bilousova Tina   Flow Cytometry Analysis and Quantitative Characterization of Tau in Synaptosomes from Alzheimer's Disease Brains Methods in molecular biology (Clifton, N.J.), 2017; 1523(3): 273-284.
Gonzalez Bianca, Abud Edsel M, Abud Abigail M, Poon Wayne W, Gylys Karen H   Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease Neurologic clinics, 2017; 35(2): 175-190.
Abud Edsel M, Ramirez Ricardo N, Martinez Eric S, Healy Luke M, Nguyen Cecilia H H, Newman Sean A, Yeromin Andriy V, Scarfone Vanessa M, Marsh Samuel E, Fimbres Cristhian, Caraway Chad A, Fote Gianna M, Madany Abdullah M, Agrawal Anshu, Kayed Rakez, Gylys Karen H, Cahalan Michael D, Cummings Brian J, Antel Jack P, Mortazavi Ali, Carson Monica J, Poon Wayne W, Blurton-Jones Mathew   iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases Neuron, 2017; 94(2): 278-293.e9.
Prieto G Aleph, Trieu Brian H, Dang Cindy T, Bilousova Tina, Gylys Karen H, Berchtold Nicole C, Lynch Gary, Cotman Carl W   Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017; 37(5): 1197-1212.
Zhang Liang, Trushin Sergey, Christensen Trace A, Bachmeier Benjamin V, Gateno Benjamin, Schroeder Andreas, Yao Jia, Itoh Kie, Sesaki Hiromi, Poon Wayne W, Gylys Karen H, Patterson Emily R, Parisi Joseph E, Diaz Brinton Roberta, Salisbury Jeffrey L, Trushina Eugenia   Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease Scientific reports, 2016; 6(4): 18725.
Bilousova Tina, Miller Carol A, Poon Wayne W, Vinters Harry V, Corrada Maria, Kawas Claudia, Hayden Eric Y, Teplow David B, Glabe Charles, Albay Ricardo, Cole Gregory M, Teng Edmond, Gylys Karen H   Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases The American journal of pathology, 2016; 186(1): 185-98.
Lazaris Andreas, Hwang Kristy S, Goukasian Naira, Ramirez Leslie M, Eastman Jennifer, Blanken Anna E, Teng Edmond, Gylys Karen, Cole Greg, Saykin Andrew J, Shaw Leslie M, Trojanowski John Q, Jagust William J, Weiner Michael W, Apostolova Liana G, Apostolova Liana G   Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding Neurology. Genetics, 2015; 1(3): e22.
Wang David B, Kinoshita Yoshito, Kinoshita Chizuru, Uo Takuma, Sopher Bryce L, Cudaback Eiron, Keene C Dirk, Bilousova Tina, Gylys Karen, Case Amanda, Jayadev Suman, Wang Hong-Gang, Garden Gwenn A, Morrison Richard S   Loss of endophilin-B1 exacerbates Alzheimer's disease pathology Brain : a journal of neurology, 2015; 138(Pt 7): 2005-19.
Hwang Kristy S, Lazaris Andreas S, Eastman Jennifer A, Teng Edmond, Thompson Paul M, Gylys Karen H, Cole Gregory M, Apostolova Liana G, Apostolova Liana G   Plasma BDNF levels associate with Pittsburgh compound B binding in the brain Alzheimer's & dementia (Amsterdam, Netherlands), 2015; 1(2): 187-193.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Gonzalez Bianca, Vinters Harry V, Miller Carol A, Cornwell Lindsey, Poon Wayne W, Gylys Karen H   Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease Journal of neurochemistry, 2015; 133(3): 368-79.
Teng Edmond, Chow Nicole, Hwang Kristy S, Thompson Paul M, Gylys Karen H, Cole Gregory M, Jack Clifford R, Shaw Leslie M, Trojanowski John Q, Soares Holly D, Weiner Michael W, Apostolova Liana G, Apostolova Liana G   Low plasma ApoE levels are associated with smaller hippocampal size in the Alzheimer's disease neuroimaging initiative cohort Dementia and geriatric cognitive disorders, 2015; 39(3-4): 154-66.
Meyer Dawn M, Eastwood Jo-Ann, Compton M Peggy, Gylys Karen, Zivin Justin A   rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome Biology of sex differences, 2014; 5(2): 9.
Meyer Dawn M, Compton Peggy, Eastwood Jo-Ann, Gylys Karen, Zivin Justin A   Antiplatelet loading improves behavioral outcome in a rabbit model of stroke Stroke, 2013; 44(11): 3246-8.
Tai Leon M, Bilousova Tina, Jungbauer Lisa, Roeske Stephen K, Youmans Katherine L, Yu Chunjiang, Poon Wayne W, Cornwell Lindsey B, Miller Carol A, Vinters Harry V, Van Eldik Linda J, Fardo David W, Estus Steve, Bu Guojun, Gylys Karen Hoppens, Ladu Mary Jo   Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples The Journal of biological chemistry, 2013; 288(8): 5914-26.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens   Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses Brain pathology (Zurich, Switzerland), 2012; 22(6): 826-33.
Ringman John M, Frautschy Sally A, Teng Edmond, Begum Aynun N, Bardens Jenny, Beigi Maryam, Gylys Karen H, Badmaev Vladimir, Heath Dennis D, Apostolova Liana G, Porter Verna, Vanek Zeba, Marshall Gad A, Hellemann Gerhard, Sugar Catherine, Masterman Donna L, Montine Thomas J, Cummings Jeffrey L, Cole Greg M   Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study Alzheimer's research & therapy, 2012; 4(5): 43.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens   AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly Neurobiology of aging, 2012; 33(8): 1545-55.
Ringman John M, Elashoff David, Geschwind Daniel H, Welsh Brian T, Gylys Karen H, Lee Cathy, Cummings Jeffrey L, Cole Greg M   Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype Archives of neurology, 2012; 69(6): 757-64.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H   Isolation of synaptic terminals from Alzheimer's disease cortex Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2012; 81(3): 248-54.
Arold Stephen, Sullivan Patrick, Bilousova Tina, Teng Edmond, Miller Carol A, Poon Wayne W, Vinters Harry V, Cornwell Lindsey B, Saing Tommy, Cole Gregory M, Gylys Karen Hoppens   Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex Acta neuropathologica, 2012; 123(1): 39-52.
Ringman John M, Tomic Jennifer L, Coppola Giovanni, Elashoff David, Gylys Karen H, Glabe Charles G   Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers Dementia and geriatric cognitive disorders extra, 2012; 2(1): 652-7.
Ringman John M, Fithian Andrew T, Gylys Karen, Cummings Jeffrey L, Coppola Giovanni, Elashoff David, Pratico Domenico, Moskovitz Jackob, Bitan Gal   Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations Dementia and geriatric cognitive disorders, 2012; 33(4): 219-25.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I   Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations Archives of neurology, 2012; 69(1): 96-104.
Wiley Dorothy J, Elashoff David, Masongsong Emmanuel V, Harper Diane M, Gylys Karen H, Silverberg Michael J, Cook Robert L, Johnson-Hill Lisette M   Smoking enhances risk for new external genital warts in men International journal of environmental research and public health, 2009; 6(3): 1215-34.
Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geshwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL.   Biochemical markers in persons with preclinical familial Alzheimer disease, Neurology, 2008; 71(1): 85-92.
Fein Jeffrey A, Sokolow Sophie, Miller Carol A, Vinters Harry V, Yang Fusheng, Cole Gregory M, Gylys Karen Hoppens   Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes The American journal of pathology, 2008; 172(6): 1683-92.
Gylys Karen Hoppens, Fein Jeffrey A, Yang Fusheng, Miller Carol A, Cole Gregory M   Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex Neurobiology of aging, 2007; 28(1): 8-17.
Wiley Dorothy J, Wiesmeier Edward, Masongsong Emmanuel, Gylys Karen H, Koutsky Laura A, Ferris Daron G, Barr Eliav, Yu Rao Jian, Yu Rao Jian   Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006; 15(5): 915-20.
Gylys Karen Hoppens, Fein Jeffrey A, Yang Fusheng, Wiley Dorothy J, Miller Carol A, Cole Gregory M   Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence The American journal of pathology, 2004; 165(5): 1809-17.