Otoniel Martinez-Maza, Ph.D.

Laboratory Address:
UCLA AIDS Institute
615 Charles E. Young Drive South
BSRB 157
Los Angeles, CA 90095

Mailing Address:
UCLA OB & GYN
BOX 951740, 153 BSRB
Los Angeles, CA 90095

Office Address:
615 Charles F. Young Drive South
BSRB 173
mail code: 736322
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Obstetrics and Gynecology, Epidemiology, Microbiology, Immunology & Molecular Genetics
Member, CTSI, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC) , Microbiology, Immunology & Molecular Genetics
Research Interests
We are interested in better understanding the role of immune dysfunction in the genesis and growth of human cancer. Current work is focusing on better defining the role of HIV infection-associated immune dysfunction in the development and growth of AIDS-associated cancers. Currently, much of our work is directed at determining how immune system factors associated with B cell hyperactivation, including the up-regulation of the expression of activation-induced cytidine deaminase (AID), and virus (EBV, HIV) infection, contribute to the molecular lesions that result in the genesis of B cell lymphoma.
Biography

Dr. Martinez-Maza received his Ph.D. in Microbiology and Immunology from UCLA in 1981, going on to do postdoctoral work at the Karolinska Institute (Stockholm), Pasteur Institute (Paris), and at UCLA. He has been a faculty member at UCLA since 1988, most recently serving as Professor of Obstetrics & Gynecology (Vice Chair for Basic Research) and Microbiology, Immunology & Molecular Genetics in the David Geffen School of Medicine at UCLA, as well as in Epidemiology in the UCLA Fielding School of Public Health. Martinez-Maza also is a member of the UCLA AIDS Institute, where his laboratory is physically located, as well as the Jonsson Comprehensive Cancer Center. He is actively involved in several national and international multi-center studies, serving on the Executive Committees of the Multicenter AIDS Cohort Study and the AIDS Malignancies Consortium, and participating in Interlymph, an international consortium of researchers with an interest in the epidemiology and pathogenesis of lymphoma. In addition to this, he is on the external steering committee for the AIDS Cancer Specimen Resource, is a member of the advisory council for the California HIV Research Program and of the Human Stem Cell Research Advisory Committee, California Department of Health Services.

Publications

A selected list of publications:

Thapa Dharma R, Bhatia Kishor, Bream Jay H, DʼSouza Gypsyamber, Rinaldo Charles R, Wolinsky Steven, Detels Roger, Martínez-Maza Otoniel   B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas AIDS (London, England), 2012; 26(9): 1177-80.
Vendrame Elena, Martínez-Maza Otoniel   Assessment of pre-diagnosis biomarkers of immune activation and inflammation: insights on the etiology of lymphoma Journal of proteome research, 2011; 10(1): 113-9.
Thapa Dharma R, Li Xinmin, Jamieson Beth D, Martínez-Maza Otoniel   Overexpression of microRNAs from the miR-17-92 paralog clusters in AIDS-related non-Hodgkin's lymphomas PloS one, 2011; 6(6): e20781.
Epeldegui Marta, Thapa Dharma R, De la Cruz Justin, Kitchen Scott, Zack Jerome A, Martínez-Maza Otoniel   CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes PloS one, 2010; 5(7): e11448.
Lithgow Diana, Nyamathi Adeline, Elashoff David, Martinez-Maza Otoniel, Covington Chandice   C-reactive protein in nipple aspirate fluid: relation to women's health factors Nursing research, 2007; 55(6): 418-25.
Epeldegui Marta, Widney Daniel P, Martínez-Maza Otoniel   Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions Current opinion in oncology, 2006; 18(5): 444-8.
Breen Elizabeth Crabb, Fatahi Sepi, Epeldegui Marta, Boscardin W John, Detels Roger, Martínez-Maza Otoniel   Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2006; 27(4): 187-94.
Widney Daniel P, Breen Elizabeth C, Boscardin W John, Kitchen Scott G, Alcantar Juan M, Smith Jeffrey B, Zack Jerome A, Detels Roger, Martínez-Maza Otoniel   Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2005; 25(11): 702-6.
Breen Elizabeth Crabb, Epeldegui Marta, Boscardin W John, Widney Daniel P, Detels Roger, Martínez-Maza Otoniel   Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma AIDS (London, England), 2005; 19(15): 1711-2.
Souter Irene, Janzen Carla, Martinez-Maza Otoniel, Breen Elizabeth Crabb, Stanczyk Frank, Chaudhuri Gautam, Nathan Lauren   Serum levels of soluble vascular cell adhesion molecule-1 are decreased in women receiving oral contraceptives compared with normally menstruating women: implications in atherosclerosis Fertility and sterility, 2005; 83(5): 1480-8.
Nicol Alcina Frederica, Fernandes Ana Teresa Gomes, Grinsztejn Beatriz, Russomano Fabio, E Silva José Roberto Lapa, Tristão Aparecida, Pérez Mauricio de Andrade, Nuovo Gerard J, Martínez-Maza Otoniel, Bonecini-Almeida Maria da Gloria   Distribution of immune cell subsets and cytokine-producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection Diagnostic molecular pathology : the American journal of surgical pathology, part B, 2005; 14(1): 39-47.
Kogevinas Manolis, Zock Jan-Paul, Alvaro Tomas, Garcia-Villanueva Mercedes, Domingo-Domenech Eva, Kennedy Susan, Martínez-Maza Otoniel, de Sanjose Silvia   Occupational exposure to immunologically active agents and risk for lymphoma Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004; 13(11 Pt 1): 1814-8.
Vredevoe Donna L, Widawski Mel, Fonarow Gregg C, Hamilton Michele, Martínez-Maza Otoniel, Gage Julia R   Interleukin-6 (IL-6) expression and natural killer (NK) cell dysfunction and anergy in heart failure The American journal of cardiology, 2004; 93(8): 1007-11.
Cozen Wendy, Gill Parkash S, Ingles Sue Ann, Masood Rizwan, Martínez-Maza Otoniel, Cockburn Myles G, Gauderman W James, Pike Malcolm C, Bernstein Leslie, Nathwani Bharat N, Salam Muhammad T, Danley Kathleen Lackerdas, Wang Wei, Gage Julia, Gundell-Miller Susan, Mack Thomas M   IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Blood, 2004; 103(8): 3216-21.
Gage Julia R, Fonarow Gregg, Hamilton Michele, Widawski Mel, Martínez-Maza Otoniel, Vredevoe Donna L   Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure Neuroimmunomodulation, 2004; 11(3): 173-80.
Breen Elizabeth Crabb, Boscardin W John, Detels Roger, Jacobson Lisa P, Smith Michael W, O'Brien Stephen J, Chmiel Joan S, Rinaldo Charles R, Lai Shenghan, Martínez-Maza Otoniel   Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype Clinical immunology (Orlando, Fla.), 2003; 109(2): 119-29.
Widney Daniel, Boscardin W John, Kasravi Arjang, Martínez-Maza Otoniel   Expression and function of CD28 on Epstein-Barr virus-positive B cell lines and AIDS-associated non-Hodgkin's lymphoma cell lines Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2003; 24(2): 82-93.
Deng Hongyu, Chu Julia T, Rettig Matthew B, Martinez-Maza Otoniel, Sun Ren   Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression Blood, 2002; 100(5): 1919-21.
Martínez-Maza Otoniel, Breen Elizabeth Crabb   B-cell activation and lymphoma in patients with HIV Current opinion in oncology, 2002; 14(5): 528-32.
Chao Chun, Silverberg Michael J, Martínez-Maza Otoniel, Chi Margaret, Abrams Donald I, Haque Reina, Zha Hongbin D, McGuire Michelle, Xu Lanfang, Said Jonathan   Epstein-Barr virus infection and expression of B-cell oncogenic markers in HIV-related diffuse large B-cell Lymphoma Clinical cancer research : an official journal of the American Association for Cancer Research, 2012; 18(17): 4702-12.
Daniels Tracy R, Leuchter Richard K, Quintero Rafaela, Helguera Gustavo, Rodríguez José A, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L   Targeting HER2/neu with a fully human IgE to harness the allergic reaction against cancer cells Cancer immunology, immunotherapy : CII, 2012; 61(7): 991-1003.
Schneider Michael F, Margolick Joseph B, Jacobson Lisa P, Reddy Susheel, Martinez-Maza Otoniel, Muñoz Alvaro   Improved estimation of the distribution of suppressed plasma HIV-1 RNA in men receiving effective antiretroviral therapy Journal of acquired immune deficiency syndromes (1999), 2012; 59(4): 389-92.
Mizwicki Mathew T, Fiala Milan, Magpantay Larry, Aziz Najib, Sayre James, Liu Guanghao, Siani Avi, Chan Derrick, Martinez-Maza Otoniel, Chattopadhyay Madhuri, La Cava Antonio   Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling American journal of neurodegenerative disease, 2012; 1(3): 305-15.
Zheng Dasheng, Wan Jun, Cho Yong Gu, Wang Leyao, Chiou Chuang-Jiun, Pai Shweta, Woodard Crystal, Zhu Jian, Liao Gangling, Martinez-Maza Otoniel, Qian Jiang, Zhu Heng, Hayward Gary S, Ambinder Richard F, Hayward S Diane   Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray The Journal of infectious diseases, 2011; 204(11): 1683-91.
Rodríguez José A, Luria-Pérez Rosendo, López-Valdés Héctor E, Casero David, Daniels Tracy R, Patel Shabnum, Avila David, Leuchter Richard, So Sokuntheavy, Ortiz-Sánchez Elizabeth, Bonavida Benjamin, Martínez-Maza Otoniel, Charles Andrew C, Pellegrini Matteo, Helguera Gustavo, Penichet Manuel L   Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells Leukemia & lymphoma, 2011; 52(11): 2169-78.
Breen Elizabeth Crabb, Reynolds Sandra M, Cox Christopher, Jacobson Lisa P, Magpantay Larry, Mulder Candice B, Dibben Oliver, Margolick Joseph B, Bream Jay H, Sambrano Elise, Martínez-Maza Otoniel, Sinclair Elizabeth, Borrow Persephone, Landay Alan L, Rinaldo Charles R, Norris Philip J   Multisite comparison of high-sensitivity multiplex cytokine assays Clinical and vaccine immunology : CVI, 2011; 18(8): 1229-42.
Daniels Tracy R, Ortiz-Sánchez Elizabeth, Luria-Pérez Rosendo, Quintero Rafaela, Helguera Gustavo, Bonavida Benjamin, Martínez-Maza Otoniel, Penichet Manuel L   An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies Journal of immunotherapy (Hagerstown, Md. : 1997), 2011; 34(6): 500-8.
Daniels-Wells Tracy R, Helguera Gustavo, Leuchter Richard K, Quintero Rafaela, Kozman Maggie, Rodríguez José A, Ortiz-Sánchez Elizabeth, Martínez-Maza Otoniel, Schultes Birgit C, Nicodemus Christopher F, Penichet Manuel L   A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy BMC cancer, 2013; 13: 195.
Helguera Gustavo, Rodríguez José A, Luria-Pérez Rosendo, Henery Shannon, Catterton Paul, Bregni Carlos, George Thaddeus C, Martínez-Maza Otoniel, Penichet Manuel L   Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry Journal of immunological methods, 2011; 368(1-2): 54-63.
Wiley Dorothy Joann, Hsu Hilary, Bolan Robert, Voskanian Alen, Elashoff David, Young Stephen, Dayrit Ruvy, Barman Provaboti, Deazambuja Katherine, Masongsong Emmanuel V, Martínez-Maza Otoniel, Detels Roger   Comparison of 2 Anal Cytology Protocols to Predict High-Grade Anal Intraepithelial Neoplasia Journal of lower genital tract disease, 2013; 13: .
Fiala Milan, Chattopadhay Madhuri, La Cava Antonio, Tse Eric, Liu Guanghao, Lourenco Elaine, Eskin Ascia, Liu Philip T, Magpantay Larry, Tse Stephen, Mahanian Michelle, Weitzman Rachel, Tong Jason, Nguyen Caroline, Cho Tiffany, Koo Patrick, Sayre James, Martinez-Maza Otoniel, Rosenthal Mark J, Wiedau-Pazos Martina   IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients Journal of neuroinflammation, 2010; 7(1-2): 76.
Grulich Andrew E, Vajdic Claire M, Falster Michael O, Kane Eleanor, Smedby Karin Ekstrom, Bracci Paige M, de Sanjose Silvia, Becker Nikolaus, Turner Jenny, Martinez-Maza Otoniel, Melbye Mads, Engels Eric A, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C H, Franceschi Silvia, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard K, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy   Birth order and risk of non-hodgkin lymphoma--true association or bias? American journal of epidemiology, 2010; 172(6): 621-30.
Miller Pamela S, Evangelista Lorraine S, Giger Joyce Newman, Martinez-Maza Otoniel, Corvera-Tindel Teresita, Magpantay Larry, Pena Guadalupe, Doering Lynn V   Exhaustion, immuno-inflammation, and pathogen burden after cardiac surgery: An exploratory study European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2013; 13: .
Vajdic Claire M, Falster Michael O, de Sanjose Silvia, Martínez-Maza Otoniel, Becker Nikolaus, Bracci Paige M, Melbye Mads, Smedby Karin Ekström, Engels Eric A, Turner Jennifer, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Kane Eleanor, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C-H, Dal Maso Luigino, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy, Grulich Andrew E   Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis Cancer research, 2009; 69(16): 6482-9.
Hussain Shehnaz K, Zhu Weiming, Chang Shen-Chih, Breen Elizabeth Crabb, Vendrame Elena, Magpantay Larry, Widney Dan, Conn Daniel, Sehl Mary, Jacobson Lisa P, Bream Jay H, Wolinsky Steven, Rinaldo Charles R, Ambinder Richard F, Detels Roger, Zhang Zuo-Feng, Martínez-Maza Otoniel   Serum levels of the chemokine CXCL13, genetic variation in CXCL13 and its receptor CXCR5, and HIV-associated non-hodgkin B-cell lymphoma risk Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013; 22(2): 295-307.
Chao Chun, Jacobson Lisa P, Jenkins Frank J, Tashkin Donald, Martínez-Maza Otoniel, Roth Michael D, Ng Leslie, Margolick Joseph B, Chmiel Joan S, Zhang Zuo-Feng, Detels Roger   Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual men AIDS research and human retroviruses, 2009; 25(2): 149-56.
Daniels-Wells Tracy R, Helguera Gustavo, Rodríguez José A, Leoh Lai Sum, Erb Michael A, Diamante Graciel, Casero David, Pellegrini Matteo, Martínez-Maza Otoniel, Penichet Manuel L   Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 Toxicology in vitro : an international journal published in association with BIBRA, 2013; 27(1): 220-31.
Birmann Brenda M, Breen Elizabeth C, Stuver Sherri, Cranston Beverly, Martínez-Maza Otoniel, Falk Kerstin I, Okayama Akihiko, Hanchard Barrie, Mueller Nancy, Hisada Michie   Population differences in immune marker profiles associated with human T-lymphotropic virus type I infection in Japan and Jamaica International journal of cancer. Journal international du cancer, 2009; 124(3): 614-21.
Becker Nikolaus, Falster Michael O, Vajdic Claire M, de Sanjose Silvia, Martínez-Maza Otoniel, Bracci Paige M, Melbye Mads, Smedby Karin Ekström, Engels Eric A, Turner Jennifer, Vineis Paolo, Costantini Adele Seniori, Holly Elizabeth A, Spinelli John J, La Vecchia Carlo, Zheng Tongzhang, Chiu Brian C-H, Montella Maurizio, Cocco Pierluigi, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Davis Scott, Severson Richard, Cerhan James R, Breen Elizabeth C, Birmann Brenda, Cozen Wendy, Grulich Andrew E, Newton Robert   Self-reported history of infections and the risk of non-Hodgkin lymphoma: an InterLymph pooled analysis International journal of cancer. Journal international du cancer, 2012; 131(10): 2342-8.
Vega Mario I, Martinez-Paniagua Melissa, Jazirehi Ali R, Huerta-Yepez Sara, Umezawa Kazuo, Martinez-Maza Otoniel, Bonavida Benjamin   The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs Leukemia & lymphoma, 2008; 49(10): 1982-94.
Schultze-Florey Christian R, Martínez-Maza Otoniel, Magpantay Larry, Breen Elizabeth Crabb, Irwin Michael R, Gündel Harald, O'Connor Mary-Frances   When grief makes you sick: bereavement induced systemic inflammation is a question of genotype Brain, behavior, and immunity, 2012; 26(7): 1066-71.
Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve   Sleep loss activates cellular inflammatory signaling Biological psychiatry, 2008; 64(6): 538-40.
De Roos Anneclaire J, Mirick Dana K, Edlefsen Kerstin L, LaCroix Andrea Z, Kopecky Kenneth J, Madeleine Margaret M, Magpantay Larry, Martínez-Maza Otoniel   Markers of B-cell activation in relation to risk of non-Hodgkin lymphoma Cancer research, 2012; 72(18): 4733-43.
Shiels Meredith S, Cole Stephen R, Wegner Scott, Armenian Haroutune, Chmiel Joan S, Ganesan Anuradha, Marconi Vincent C, Martinez-Maza Otoniel, Martinson Jeremy, Weintrob Amy, Jacobson Lisa P, Crum-Cianflone Nancy F   Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters Journal of acquired immune deficiency syndromes (1999), 2008; 48(4): 485-90.
Daniels Tracy R, Martínez-Maza Otoniel, Penichet Manuel L   Animal models for IgE-meditated cancer immunotherapy Cancer immunology, immunotherapy : CII, 2012; 61(9): 1535-46.
Cozen Wendy, Gill Parkash S, Salam Muhammad T, Nieters Alexandra, Masood Rizwan, Cockburn Myles G, Gauderman W James, Martínez-Maza Otoniel, Nathwani Bharat N, Pike Malcolm C, Van Den Berg David J, Hamilton Ann S, Deapen Dennis M, Mack Thomas M   Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood, 2008; 111(7): 3377-82.
Chao Chun, Jacobson Lisa P, Tashkin Donald, Martínez-Maza Otoniel, Roth Michael D, Margolick Joseph B, Chmiel Joan S, Rinaldo Charles, Zhang Zuo-Feng, Detels Roger   Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men Drug and alcohol dependence, 2008; 94(1-3): 165-71.
Doering Lynn V, Martínez-Maza Otoniel, Vredevoe Donna L, Cowan Marie J   Relation of depression, natural killer cell function, and infections after coronary artery bypass in women European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2008; 7(1): 52-8.
Epeldegui Marta, Breen Elizabeth Crabb, Hung Yee Ping, Boscardin W John, Detels Roger, Martínez-Maza Otoniel   Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis AIDS (London, England), 2007; 21(17): 2265-70.
Lithgow Diana, Nyamathi Adeline, Elashoff David, Martinez-Maza Otoniel, Covington Chandice   C-reactive protein in nipple aspirate fluid associated with Gail model factors Biological research for nursing, 2007; 9(2): 108-16.
Doering Lynn V, Cross Rebecca, Vredevoe Donna, Martinez-Maza Otoniel, Cowan Marie J   Infection, depression, and immunity in women after coronary artery bypass: a pilot study of cognitive behavioral therapy Alternative therapies in health and medicine, 2007; 13(3): 18-21.
Epeldegui Marta, Hung Yee Ping, McQuay Amy, Ambinder Richard F, Martínez-Maza Otoniel   Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations Molecular immunology, 2007; 44(5): 934-42.
Griffis Charles A, Irwin Michael R, Martinez-Maza Otoniel, Doering Lynn, Nyamathi Adeline, Kaufman Robert, Elashoff David, Aziz Najib, Compton Peggy   Pain-related activation of leukocyte cellular adhesion molecules: preliminary findings Neuroimmunomodulation, 2007; 14(5): 224-8.