Christopher Scott Colwell, Ph.D.

Work Address:
760 Westwood Plaza
Los Angeles, CA 90095 760 Westwood Plaza
Los Angeles, CA 90024

Affiliations
Affiliations
Professor, Psychiatry and Biobehavioral Sciences
Member, Brain Research Institute, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Neuroscience GPB Home Area
Research Interests
Most organisms, including humans, exhibit daily rhythms in their behavior and physiology. In most cases, these rhythms are generated by endogenous processes referred to as circadian oscillators. These oscillators provide temporal structure to an organism?s physiological processes. Nearly all functions of the body show significant daily variations including arousal, cognition, learning, memory, motor performance and perception. This temporal variation obviously plays an important role in the body?s homeostatic mechanisms and has a major impact on the function of the nervous system. Mammals have evolved a set of anatomically discrete cell populations that function as a physiological system to provide temporal organization on a circadian time scale. These structures are commonly referred to as the circadian system and can be localized to a pair of structures in the hypothalamus known as the suprachiasmatic nucleus or SCN. Importantly, when SCN cells are removed from the organism and maintained in a brain slice preparation, they continue to generate 24-hour rhythms in electrical activity, secretion, and gene expression. Previous studies suggest that the basic mechanism responsible for the generation of these rhythms is intrinsic to individual cells in the SCN. In order to function adaptively, these cells must be synchronized to the exact 24 hr cycle of the physical world. The daily cycle of light and dark is the dominant cue used by organisms, including humans, to synchronize their biological clocks to the environment. Therefore, in the simplest case, a circadian system can be modeled as having three components: 1) input pathways by which the environment and other components of the nervous system provide information to the SCN, 2) an oscillator or clock within the SCN responsible for the generation of the daily rhythm, and 3) output pathways by which the SCN provides temporal information to a wide range of physiological and behavioral control centers. The long-term goal of our research program is to understand each of these three components at different levels of organization from systems to molecular. My laboratory uses two strategies to approach this goal. In one, a systems-level analysis is carried out on the effects of genetic and pharmacological manipulations on behavioral rhythms driven by the circadian system. The other strategy examines the effects of these manipulations on the cellular/molecular activity of neural populations that make up this system. http://www.mrrc.npi.ucla.edu/CColwell/Colwell_Lab_WebPage/page1.htm
Biography

Christopher S. Colwell is a Neuroscientist who has served on the UCLA School of Medicine faculty since he joined the Department of Psychiatry and Biobehavioral Sciences in 1997. He became a Professor in 2008. Dr. Colwell earned his B.S. in Neuroscience from Vanderbilt University in 1985. During this time, he started his research in circadian rhythms under the mentorship of Dr. T. Page. Dr. Colwell earned his Ph.D. in Biology at the University of Virginia in 1991. His thesis work explored the neural mechanisms by which light regulates circadian rhythms. Dr. Colwell continued this line of research during a postdoctoral fellowship at the University of Virginia with Dr. G. Block. A second postdoctoral fellowship was carried out on the topics of motor control and excitotoxicity in the laboratory of Dr. M. Levine at UCLA. Dr. Colwell learned how to utilize imaging techniques to measure calcium levels inside neurons while a visiting scientist in the laboratory of Dr. Konnerth at the University of Saarland, Germany. Since Dr. Colwell's faculty appointment at UCLA, his laboratory's research has focused on understanding the mechanisms underlying circadian rhythms in mammals. Dysfunction in the timing these daily cycles is a key symptom in a number of neurological and psychiatric disorders. Better understanding the basic biology of this timing system should result in new therapies to improve the quality of life of these patients and the people who care for them.

Publications
Nakamura Takahiro J, Nakamura Wataru, Yamazaki Shin, Kudo Takashi, Cutler Tamara, Colwell Christopher S, Block Gene D Age-related decline in circadian output. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(28): 10201-5.
Schroeder Analyne, Loh Dawn H, Jordan Maria C, Roos Kenneth P, Colwell Christopher S Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide. American journal of physiology. Heart and circulatory physiology. 2011; 300(1): H241-50.
Mengatto Cristiane Machado, Mussano Federico, Honda Yoshitomo, Colwell Christopher S, Nishimura Ichiro Circadian rhythm and cartilage extracellular matrix genes in osseointegration: a genome-wide screening of implant failure by vitamin D deficiency. PloS one. 2011; 6(1): e15848.
Atkinson Susan E, Maywood Elizabeth S, Chesham Johanna E, Wozny Christian, Colwell Christopher S, Hastings Michael H, Williams Stephen R Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus. Journal of biological rhythms. 2011; 26(3): 210-20.
Hu Wang-Ping, Li Jia-Da, Colwell Christopher S, Zhou Qun-Yong Decreased REM sleep and altered circadian sleep regulation in mice lacking vasoactive intestinal polypeptide. Sleep. 2011; 34(1): 49-56.
Kudo Takashi, Schroeder Analyne, Loh Dawn H, Kuljis Dika, Jordan Maria C, Roos Kenneth P, Colwell Christopher S Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease. Experimental neurology. 2011; 228(1): 80-90.
Loh Dawn H, Dragich Joanna M, Kudo Takashi, Schroeder Analyne M, Nakamura Takahiro J, Waschek James A, Block Gene D, Colwell Christopher S Effects of vasoactive intestinal peptide genotype on circadian gene expression in the suprachiasmatic nucleus and peripheral organs. Journal of biological rhythms. 2011; 26(3): 200-9.
Kudo Takashi, Loh Dawn H, Kuljis Dika, Constance Cara, Colwell Christopher S Fast delayed rectifier potassium current: critical for input and output of the circadian system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(8): 2746-55.
Gamble Karen L, Kudo Takashi, Colwell Christopher S, McMahon Douglas G Gastrin-releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons. Journal of biological rhythms. 2011; 26(2): 99-106.
Colwell Christopher S Neuroscience: Sleepy neurons?. Nature. 2011; 472(7344): 427-8.
Itri JN, Vosko AM, Schroeder A, Dragich JM, Michel S, and Colwell CS Circadian Regulation of A-type Potassium Currents in the Suprachiasmatic Nucleus. J Neurophysiol 2009; 103: 632-640.
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Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS and Block GD Estrous Variations of Circadian Clock Gene Expression in Reproductive Tissues. Steriods 2010; 75: 203-212.
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Christopher S. Colwell Preventing dehydration during sleep. Nature Neuroscience 2010; 13(4): 1-2.
Loh Dawn H, Navarro Juliana, Hagopian Arkady, Wang Louisa M, Deboer Tom, Colwell Christopher S Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice. PloS one. 2010; 5(9): .
Fulton Daniel, Paez Pablo M, Fisher Robin, Handley Vance, Colwell Christopher S, Campagnoni Anthony T Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins. Glia. 2010; 58(11): 1292-303.
Dragich JM, Loh DH, Wang LM, Vosko AM, Kudo T, Nakamura TJ, Odom IH, Tateyama S, Hagopian A, Waschek JA and Colwell CS The Role of the Neuropeptides PACAP and VIP in the Photic Regulation of Gene Expression in the Suprachiasmatic Nucleus. . Eur. J. Neurosci 2009; 31: 864-875.
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Dragich Joanna M, Loh Dawn H, Wang Louisa M, Vosko Andrew M, Kudo Takashi, Nakamura Takahiro J, Odom Irene H, Tateyama Sei, Hagopian Arkady, Waschek James A, Colwell Christopher S The role of the neuropeptides PACAP and VIP in the photic regulation of gene expression in the suprachiasmatic nucleus. The European journal of neuroscience. 2010; 31(5): 864-75.
Wang LMC, Dragich JM, Kudo T, Odom IH, Welsh DK, O’Dell TJ, Colwell CS Expression of the circadian clock gene Period2 in the hippocampus: Possible implications for synaptic plasticity and learned behavior. ASN_Neuro 2009; 1(3): 139-152.
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Paez P, Fulton D, Spreuer V, Handley V, Campagnoni C, Macklin W, Colwell CS, and Campagnoni AT Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. . J. Neuroscience 2009; 29(20): 6663-6676.
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Ciarleglio CM, Gamble KL, Axley JC, Strauss BR, Cohen JY, CS Colwell, and DG McMahon Population Encoding by Circadian Clock Neurons Organizes Circadian Behavior. J. Neuroscience 2009; 29(6): 1670-1676.
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Choi HJ, Lee CJ, Schroeder A, Kim YS, Jung SH, JS Kim JS, Kim DY, Sohn EJ, Han HC, Hong SK, Colwell CS, Kim YI Excitatory Actions of GABA in the Suprachiasmatic Nucleus. J. Neuroscience 2008; 28(21): 5450-9.
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Wang LM, Schroeder A, Loh D, Smith D, Lin K, Han JH, Michel S, Hummer DL, Ehlen JC, Albers HE, Colwell CS Role for the NR2B Subunit of the NMDA Receptor in Mediating Light Input to the Circadian System. Eur. J. Neurosci 2008; 27(7): 1771-9.
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Chaudhury D, Loh DH, Dragich J, Hagopian A, Colwell CS Select cognitive deficits in Vasoactive Intestinal Peptide deficient mice. BMC_Neuroscience 2008; 9: 63.
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Loh DH, Abad C, Colwell CS, Waschek JA Vasoactive Intestinal Peptide is Critical for Circadian Regulation of Glucocorticoids. Neuroendocrinology 2008; 88(4): 246-255.
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Paez P, Fulton D, Colwell CS, Campagnoni AT Voltage-operated Ca2+ and Na+ channels in the oligodendrocyte linage. J. Neuroscience Res 2008; .
Brown T, Colwell CS, Waschek J, Piggins H Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice. J. Neurophysiol 2007; 97 : 2553-2558.
C.S. Colwell Soporific signaling: how flies sleep through the night. Nature Neuroscience 2007; 10(9): 1079-1080.
Vosko AM, Schroeder A, Loh DH, Colwell CS Vasoactive intestinal peptide and the mammalian circadian system. Gen Comp Endocrinol 2007; 152(2-3): 165-175.
Kim YI, Choi H-J, Colwell CS BDNF Regulation of NMDA Receptor-Mediated Synaptic Currents in Suprachiasmatic Nucleus Neurons. J. Neurosci. Res 2006; 84(7): 1512-20.
Michel S, Clark JP, Ding JM, Colwell CS BDNF and Neurotrophin Receptors Modulate Glutamate-Induced Phase Shifts of the Suprachiasmatic Nucleus. Eur. J. Neuroscience 2006; 24(4): 1109-16.
Colwell CS BK channels and circadian output. Nature Neuroscience 2006; 9(8): 985-6.
Feng JM, Hu YK, Xie LH, Colwell CS, Shao XM, Sun XP, Chen B, Tang H, Campagnoni AT Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity 2006; 24(6): 717-727.
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Michel S, Itri J, Han JH, Gniotczynski K, Colwell CS Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. BMC_Neuroscience 2006; 7: 15.
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Colwell, CS Bridging the gap: coupling single-cell oscillators in the suprachiasmatic nucleus. Nature neuroscience. . 2005; 8(1): 10-2.
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Chaudhury, D Wang, LM Colwell, CS Circadian regulation of hippocampal long-term potentiation. Journal of biological rhythms. . 2005; 20(3): 225-36.
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Itri, JN Michel, S Vansteensel, MJ Meijer, JH Colwell, CS Fast delayed rectifier potassium current is required for circadian neural activity. Nature neuroscience. . 2005; 8(5): 650-6.
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Wang, LM Suthana, NA Chaudhury, D Weaver, DR Colwell, CS Melatonin inhibits hippocampal long-term potentiation. The European journal of neuroscience. 2005; 22(9): 2231-7.
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Jacobs, EC Pribyl, TM Kampf, K Campagnoni, C Colwell, CS Reyes, SD Martin, M Handley, V Hiltner, TD Readhead, C Jacobs, RE Messing, A Fisher, RS Campagnoni, AT Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2005; 25(30): 7004-13.
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Aton SJ, Colwell CS, Harmar AJ, Waschek J, and Herzog ED Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in distinct subsets of mammalian clock neurons. Nature Neurosci 2005; 8(4): 476-483.
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Itri, J Michel, S Waschek, JA Colwell, CS Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus. Journal of neurophysiology. . 2004; 92(1): 311-9.
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Colwell, CS Michel, S Itri, J Rodriguez, W Tam, J Lelièvre, V Hu, Z Waschek, JA Selective deficits in the circadian light response in mice lacking PACAP. American journal of physiology. Regulatory, integrative and comparative physiology. . 2004; 287(5): R1194-201.
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Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X and Waschek JA Disrupted Circadian Rhythms and Synaptic Communication in Vasoactive Intestinal Peptide-Deficient Mice. Am. J. Physiol 2003; 285(5): R939-R949.
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Itri J, Colwell CS Presynaptic regulation of gamma-aminobutyric acid (GABA) release by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus. J. Neurophysiol 2003; 90(3): 1589-1597.
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Colwell, CS Michel, S Sleep and circadian rhythms: do sleep centers talk back to the clock?. Nature neuroscience. . 2003; 6(10): 1005-6.
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Chaudhury D, Colwell CS Circadian Modulation of Learning and Memory in Fear-Conditioned Mice. Behavioral Brain Research 2002; 133: 95-108.
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Michel, S Itri, J Colwell, CS Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors. Journal of neurophysiology. . 2002; 88(2): 817-28.
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Miche, S Colwell, CS Cellular communication and coupling within the suprachiasmatic nucleus. Chronobiology international. . 2001; 18(4): 579-600.
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Colwell, CS NMDA-evoked calcium transients and currents in the suprachiasmatic nucleus: gating by the circadian system. The European journal of neuroscience. . 2001; 13(7): 1420-8.
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Colwell, CS Circadian modulation of calcium levels in cells in the suprachiasmatic nucleus. The European journal of neuroscience. . 2000; 12(2): 571-6.
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Colwell, CS Rhythmic coupling among cells in the suprachiasmatic nucleus. Journal of neurobiology. . 2000; 43(4): 379-88.
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Colwell, CS Levine, MS Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels. Brain research. . 1999; 833(2): 234-41.
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Flett, J Colwell, CS Serotonin modulation of calcium transients in cells in the suprachiasmatic nucleus. Journal of biological rhythms. . 1999; 14(5): 354-63.
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Colwell CS. Circadian Rhythms. Psychopharmacology: the fourth generation of progress. CD/ROM 1998; .
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Cepeda, C Colwell, CS Itri, JN Chandler, SH Levine, MS Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances. Journal of neurophysiology. . 1998; 79(1): 82-94.
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Cepeda, C Colwell, CS Itri, JN Gruen, E Levine, MS Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons. The European journal of neuroscience. . 1998; 10(11): 3491-7.
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Levine MS, Cepeda C, Colwell CS, Yu Q, Chandler SH Infrared video microscopy: visualization and manipulation of neurons in neostriatal slices. Receptor Localization: Laboratory Methods and Procedures 1998; .
Colwell CS, Cepeda C, Crawford C, Levine MS Postnatal Development of NMDA Evoked Responses in the Neostriatum. J. Dev. Neurobiology 1998; 20: 154-163..
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Colwell, CS Circadian rhythms. Time to get excited by GABA. Nature. . 1997; 387(6633): 554-5.
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Colwell CS, Levine MS Histamine modulates NMDA-dependent swelling in the developing neostriatum. Brain Research 1997; 766: 205-212.
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Colwell, CS Levine, MS Glutamate receptor-induced toxicity in neostriatal cells. Brain research. . 1996; 724(2): 205-12.
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Colwell, CS Altemus, KL Levine, MS Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum. Brain research. . 1996; 726(1-2): 223-6.
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Colwell CS, Altemus KL, Cepeda C, Levine MS Regulation of NMDA-induced toxicity in the neostriatum: a new role for metabotropic glutamate receptors?. Proc. Natl. Acad. Science 1996; 93(3): 1200-1204.
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Colwell, CS Levine, MS Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1995; 15(3 Pt 1): 1704-13.
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Colwell CS Regulation of Photic Input to Circadian Systems: a role for serotonin. Nervous systems and Behaviour. 1995; 131.
Colwell CS, Menaker M. Regulation of circadian rhythms by excitatory amino acids. Excitatory amino acids: Their Role in Neuroendocrine Function 1995; 223-252.
Colwell, CS Whitmore, D Michel, S Block, GD Calcium plays a central role in phase shifting the ocular circadian pacemaker of Aplysia. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. . 1994; 175(4): 415-23.
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Colwell, CS Levine, MS Metabotropic glutamate receptors modulate N-methyl-D-aspartate receptor function in neostriatal neurons. Neuroscience. . 1994; 61(3): 497-507.
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Rea MA, Glass JD, Colwell CS Serotonin modulates the photic response of the circadian oscillator in the hamster suprachiasmatic nucleus. J. Neuroscience 1994; 14: 3635-3642.
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Colwell, CS Kaufman, CM Menaker, M Ralph, MR Light-induced phase shifts and Fos expression in the hamster circadian system: the effects of anesthetics. Journal of biological rhythms. . 1993; 8(3): 179-88.
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Colwell, CS Kaufman, CM Menaker, M Phase-shifting mechanisms in the mammalian circadian system: new light on the carbachol paradox. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1993; 13(4): 1454-9.
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Colwell CS, Kaufman CM, Menaker M Photic induction of Fos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicucullin. Neuroscience Lett 1993; 163: 177-181.
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Foster, RG Argamaso, S Coleman, S Colwell, CS Lederman, A Provencio, I Photoreceptors regulating circadian behavior: a mouse model. Journal of biological rhythms. . 1993; 8 Suppl: S17-23.
Colwell CS, Khalsa SBS, Block GD Cellular mechanisms of entrainment. Chronobiol. International 1992; 9: 163-179.
Colwell, CS Michel, S Block, GD Evidence that potassium channels mediate the effects of serotonin on the ocular circadian pacemaker of Aplysia. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. . 1992; 171(5): 651-6.
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Colwell CS, Khalsa SBS, Block GD FMRFamide antagonizes the actions of 5-HT and light on a circadian rhythm recorded from the eye of Aplysia. J. Comp. Physiology 1992; 170: 211-215.
Colwell, CS Menaker, M NMDA as well as non-NMDA receptor antagonists can prevent the phase-shifting effects of light on the circadian system of the golden hamster. Journal of biological rhythms. . 1992; 7(2): 125-36.
Colwell, CS Foster, RG Photic regulation of Fos-like immunoreactivity in the suprachiasmatic nucleus of the mouse. The Journal of comparative neurology. . 1992; 324(2): 135-42.
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Colwell, CS Max, M Hudson, D Menaker, M Excitatory amino acid receptors may mediate the effects of light on the reproductive system of the golden hamster. Biology of reproduction. . 1991; 44(4): 604-8.
Colwell, CS Foster, RG Menaker, M NMDA receptor antagonists block the effects of light on circadian behavior in the mouse. Brain research. . 1991; 554(1-2): 105-10.
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Colwell CS, Page TL Circadian rhythms in spontaneous neural activity recorded in vivo and in vitro from cockroach's central nervous system. J. Comp. Physiology 1990; 166: 643-649.
Colwell CS, Ralph M, Menaker M Do NMDA receptors mediate the effects of light on circadian behavior in the golden hamster. Brain Research 1990; 523: 117-120.
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Colwell CS Interactive effects of serotonin and light on the circadian rhythm of neural activity recorded from the eye of Aplysia. J. Comp. Physiology 1990; 167: 841-845.
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Colwell, CS Page, TL The electroretinogram of the cockroach Leucophaea maderae. Comparative biochemistry and physiology. A, Comparative physiology. . 1989; 92(1): 117-23.
Wills, SA Page, TL Colwell, CS Circadian rhythms in the electroretinogram of the cockroach. Journal of biological rhythms. . 1985; 1(1): 25-37.
Itri Jason N, Vosko Andrew M, Schroeder Analyne, Dragich Joanna M, Michel Stephan, Colwell Christopher S Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus. Journal of neurophysiology. 2010; 103(2): 632-40.
Jacobs Erin C, Pribyl Thomas M, Feng Ji-Ming, Kampf Kathy, Spreur Vilma, Campagnoni Celia, Colwell Christopher S, Reyes Samuel D, Martin Melanie, Handley Vance, Hiltner Timothy D, Readhead Carol, Jacobs Russell E, Messing Albee, Fisher Robin S, Campagnoni Anthony T Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(30): 7004-13.
Lucassen Eliane A, van Diepen Hester C, Houben Thijs, Michel Stephan, Colwell Christopher S, Meijer Johanna H Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock. The European journal of neuroscience. 2012; 35(9): 1466-74.
Wang Louisa M-C, Dragich Joanna M, Kudo Takashi, Odom Irene H, Welsh David K, O'Dell Thomas J, Colwell Christopher S Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour. ASN neuro. 2009; 1(3): .
Chaudhury Dipesh, Wang Louisa M, Colwell Christopher S Circadian regulation of hippocampal long-term potentiation. Journal of biological rhythms. 2005; 20(3): 225-36.
Itri Jason N, Michel Stephan, Vansteensel Mariska J, Meijer Johanna H, Colwell Christopher S Fast delayed rectifier potassium current is required for circadian neural activity. Nature neuroscience. 2005; 8(5): 650-6.
Ciarleglio Christopher M, Gamble Karen L, Axley John C, Strauss Benjamin R, Cohen Jeremiah Y, Colwell Christopher S, McMahon Douglas G Population encoding by circadian clock neurons organizes circadian behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(6): 1670-6.
Schroeder Analyne M, Loh Dawn H, Jordan Maria C, Roos Kenneth P, Colwell Christopher S Baroreceptor reflex dysfunction in the BACHD mouse model of Huntington's disease. PLoS currents. 2011; 3(1): RRN1266.
Aton Sara J, Colwell Christopher S, Harmar Anthony J, Waschek James, Herzog Erik D Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nature neuroscience. 2005; 8(4): 476-83.
Chaudhury Dipesh, Loh Dawn H, Dragich Joanna M, Hagopian Arkady, Colwell Christopher S Select cognitive deficits in vasoactive intestinal peptide deficient mice. BMC neuroscience. 2008; 9(6): 63.
Kudo Takashi, Loh Dawn H, Truong Danny, Wu Yingfei, Colwell Christopher S Circadian dysfunction in a mouse model of Parkinson's disease. Experimental neurology. 2011; 232(1): 66-75.
Colwell Christopher S Bridging the gap: coupling single-cell oscillators in the suprachiasmatic nucleus. Nature neuroscience. 2005; 8(1): 10-2.
Choi Hee Joo, Lee C Justin, Schroeder Analyne, Kim Yoon Sik, Jung Seung Hoon, Kim Jeong Sook, Kim Do Young, Son Eun Ju, Han Hee Chul, Hong Seung Kil, Colwell Christopher S, Kim Yang In Excitatory actions of GABA in the suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(21): 5450-9.
Gale John E, Cox Heather I, Qian Jingyi, Block Gene D, Colwell Christopher S, Matveyenko Aleksey V Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. Journal of biological rhythms. 2011; 26(5): 423-33.
Loh Dawn H, Abad Catalina, Colwell Christopher S, Waschek James A Vasoactive intestinal peptide is critical for circadian regulation of glucocorticoids. Neuroendocrinology. 2008; 88(4): 246-55.
Kim Jeong Sook, Kim Woong Bin, Kim Young-Beom, Lee Yeon, Kim Yoon Sik, Shen Feng-Yan, Lee Seung Won, Park Dawon, Choi Hee-Joo, Hur Jinyoung, Park Joong Jean, Han Hee Chul, Colwell Christopher S, Cho Young-Wuk, Kim Yang In Chronic hyperosmotic stress converts GABAergic inhibition into excitation in vasopressin and oxytocin neurons in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(37): 13312-22.
Colwell Christopher S Soporific signaling: how flies sleep through the night. Nature neuroscience. 2007; 10(9): 1079-80.
Colwell Christopher S Linking neural activity and molecular oscillations in the SCN. Nature reviews. Neuroscience. 2011; 12(10): 553-69.
Itri Jason, Michel Stephan, Waschek James A, Colwell Christopher S Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus. Journal of neurophysiology. 2004; 92(1): 311-9.
Colwell Christopher S, Michel Stephan, Itri Jason, Rodriguez Williams, Tam J, Lelievre Vincent, Hu Zhou, Liu X, Waschek James A Disrupted circadian rhythms in VIP- and PHI-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology. 2003; 285(5): R939-49.
Vosko Andrew M, Schroeder Analyne, Loh Dawn H, Colwell Christopher S Vasoactive intestinal peptide and the mammalian circadian system. General and comparative endocrinology. 2007; 152(2-3): 165-75.
Fulton Daniel, Paez Pablo, Spreur Vilma, Handley Vance, Colwell Christopher S, Campagnoni Anthony, Fisher Robin Developmental activation of the proteolipid protein promoter transgene in neuronal and oligodendroglial cells of neostriatum in mice. Developmental neuroscience. 2011; 33(2): 170-84.
Colwell Christopher S BK channels and circadian output. Nature neuroscience. 2006; 9(8): 985-6.
Colwell Christopher S, Michel Stephan Sleep and circadian rhythms: do sleep centers talk back to the clock?. Nature neuroscience. 2003; 6(10): 1005-6.
Michel Stephan, Itri Jason, Colwell Christopher S Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors. Journal of neurophysiology. 2002; 88(2): 817-28.
Itri Jason, Colwell Christopher S Regulation of inhibitory synaptic transmission by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus. Journal of neurophysiology. 2003; 90(3): 1589-97.
Feng Ji-Ming, Hu Yanhong K, Xie Lai-Hua, Colwell Christopher S, Shao Xuesi M, Sun Xiao-Ping, Chen Boming, Tang Hezhen, Campagnoni Anthony T Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 2006; 24(6): 717-27.
Chaudhury Dipesh, Colwell Christopher S Circadian modulation of learning and memory in fear-conditioned mice. Behavioural brain research. 2002; 133(1): 95-108.
Michel Stephan, Itri Jason, Han Jung H, Gniotczynski Kathryn, Colwell Christopher S Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus. BMC neuroscience. 2006; 7(6): 15.
Colwell Christopher S Preventing dehydration during sleep. Nature neuroscience. 2010; 13(4): 403-4.
Wang Louisa M, Suthana Nanthia A, Chaudhury Dipesh, Weaver David R, Colwell Christopher S Melatonin inhibits hippocampal long-term potentiation. The European journal of neuroscience. 2005; 22(9): 2231-7.
Nakamura Takahiro J, Sellix Michael T, Kudo Takashi, Nakao Nobuhiro, Yoshimura Takashi, Ebihara Shizufumi, Colwell Christopher S, Block Gene D Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels. Steroids. 2010; 75(3): 203-12.
Kuljis Dika, Schroeder Analyne M, Kudo Takashi, Loh Dawn H, Willison David L, Colwell Christopher S Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's disease. Minerva pneumologica. 2012; 51(3): 93-106.
Meijer Johanna H, Colwell Christopher S, Rohling Jos H T, Houben Thijs, Michel Stephan Dynamic neuronal network organization of the circadian clock and possible deterioration in disease. Progress in brain research. 2012; 199(3): 143-62.
Colwell Christopher S, Matveyenko Aleksey V Timing is everything: implications for metabolic consequences of sleep restriction. Diabetes. 2014; 63(6): 1826-8.
Kudo Takashi, Loh Dawn H, Tahara Yu, Truong Danny, Hernández-Echeagaray Elizabeth, Colwell Christopher S Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid. ASN neuro. 2014; 6(1): e00133.
Kim Young-Beom, Kim Yoon Sik, Kim Woong Bin, Shen Feng-Yan, Lee Seung Won, Chung Hyun Joo, Kim Jeong Sook, Han Hee Chul, Colwell Christopher S, Kim Yang In GABAergic excitation of vasopressin neurons: possible mechanism underlying sodium-dependent hypertension. Circulation research. 2013; 113(12): 1296-307.
Schroeder Analyne M, Colwell Christopher S How to fix a broken clock. Trends in pharmacological sciences. 2013; 34(11): 605-19.
Qian Jingyi, Block Gene D, Colwell Christopher S, Matveyenko Aleksey V Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes. 2013; 62(10): 3469-78.
Kudo Takashi, Tahara Yu, Gamble Karen L, McMahon Douglas G, Block Gene D, Colwell Christopher S Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus. Journal of neurophysiology. 2013; 110(5): 1097-106.
Loh Dawn H, Kudo Takashi, Truong Danny, Wu Yingfei, Colwell Christopher S The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep. PloS one. 2013; 8(7): e69993.
Willison L David, Kudo Takashi, Loh Dawn H, Kuljis Dika, Colwell Christopher S Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: insights from a transgenic mouse model. Experimental neurology. 2013; 243(5): 57-66.
Kuljis Dika A, Loh Dawn H, Truong Danny, Vosko Andrew M, Ong Margaret L, McClusky Rebecca, Arnold Arthur P, Colwell Christopher S Gonadal- and sex-chromosome-dependent sex differences in the circadian system. Endocrinology. 2013; 154(4): 1501-12.
Michel Stephan, Marek Roger, Vanderleest Henk T, Vansteensel Mariska J, Schwartz William J, Colwell Christopher S, Meijer Johanna H Mechanism of bilateral communication in the suprachiasmatic nucleus. The European journal of neuroscience. 2013; 37(6): 964-71.
Schroeder Analyne M, Truong Danny, Loh Dawn H, Jordan Maria C, Roos Kenneth P, Colwell Christopher S Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild-type and vasoactive intestinal peptide-deficient mice. The Journal of physiology. 2012; 590(Pt 23): 6213-26.
Li Quan, Loh Dawn H, Kudo Takashi, Truong Danny, Derakhshesh Matthew, Kaswan Zoë MacDowell, Ghiani Cristina A, Tsoa Rosemarie, Cheng Yin, Sun Yi E, Colwell Christopher S Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT. Neurobiology of disease. 2015; 77(12): 155-64.
Loh Dawn H, Kudo Takashi, Colwell Christopher S Short circuiting the circadian system with a new generation of precision tools. Neuron. 2015; 85(5): 895-8.
Vosko Andrew, van Diepen Hester C, Kuljis Dika, Chiu Andrew M, Heyer Djai, Terra Huub, Carpenter Ellen, Michel Stephan, Meijer Johanna H, Colwell Christopher S Role of vasoactive intestinal peptide in the light input to the circadian system. The European journal of neuroscience. 2015; 42(2): 1839-48.
Qian Jingyi, Yeh Bonnie, Rakshit Kuntol, Colwell Christopher S, Matveyenko Aleksey V Circadian disruption and diet-induced obesity synergize to promote development of beta cell failure and diabetes in male rats. Endocrinology. 2015; en20151516.
Ago Yukio, Condro Michael C, Tan Yossan-Var, Ghiani Cristina A, Colwell Christopher S, Cushman Jesse D, Fanselow Michael S, Hashimoto Hitoshi, Waschek James A Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist. Psychopharmacology. 2015; 232(12): 2181-9.
Chen Xuqi, Wang Lixin, Loh Dawn H, Colwell Christopher S, Taché Yvette, Reue Karen, Arnold Arthur P Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes. Hormones and behavior. 2015; 75: 55-63.
Lee Seung Won, Kim Young-Beom, Kim Jeong Sook, Kim Woong Bin, Kim Yoon Sik, Han Hee Chul, Colwell Christopher S, Cho Young-Wuk, In Kim Yang GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat. Molecular brain. 2015; 8(12): 34.
Kim Yoon Sik, Kim Young-Beom, Kim Woong Bin, Yoon Bo-Eun, Shen Feng-Yan, Lee Seung Won, Soong Tuck-Wah, Han Hee-Chul, Colwell Christopher S, Lee C Justin, Kim Yang In Histamine resets the circadian clock in the suprachiasmatic nucleus through the H1R-CaV 1.3-RyR pathway in the mouse. The European journal of neuroscience. 2015; 75: .
Loh D H, Kuljis D A, Azuma L, Wu Y, Truong D, Wang H B, Colwell C S Disrupted reproduction, estrous cycle, and circadian rhythms in female mice deficient in vasoactive intestinal peptide. Journal of biological rhythms. 2014; 29(5): 355-69.
Ricketts Emily J, Rozenman Michelle, Choy Caitlin, Goldberg Hannah B, Kim Jessica S, Colwell Christopher S, McCracken James T, Piacentini John Sleep Sufficiency in Pediatric and Adolescent Tourette's Disorder: National Survey of Children's Health. Journal of developmental and behavioral pediatrics : JDBP. 2017; .
Whittaker Daniel S, Wang Huei-Bin, Loh Dawn H, Cachope Roger, Colwell Christopher S Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease. Pharmacology research & perspectives. 2017; 5(5): .
Hassan Nathaniel, McCarville Kirstin, Morinaga Kenzo, Mengatto Cristiane M, Langfelder Peter, Hokugo Akishige, Tahara Yu, Colwell Christopher S, Nishimura Ichiro Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PloS one. 2017; 12(8): e0183359.
Qian Jingyi, Thomas Anthony P, Schroeder Analyne M, Rakshit Kuntol, Colwell Christopher S, Matveyenko Aleksey V Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus. American journal of physiology. Endocrinology and metabolism. 2017; 313(2): E213-E221.
Cutler Tamara S, Park Saemi, Loh Dawn H, Jordan Maria C, Yokota Tomohiro, Roos Kenneth P, Ghiani Cristina A, Colwell Christopher S Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease. Physiological reports. 2017; 5(11): E213-E221.
Allen Charles N, Nitabach Michael N, Colwell Christopher S Membrane Currents, Gene Expression, and Circadian Clocks. Cold Spring Harbor perspectives in biology. 2017; 9(5): E213-E221.
Colwell Christopher S Circadian Rhythms: Does Burning the Midnight Oil Leave You Weak?. Current biology : CB. 2016; 26(14): R669-71.
Kim Yoon Sik, Kim Young-Beom, Kim Woong Bin, Lee Seung Won, Oh Seog Bae, Han Hee-Chul, Lee C Justin, Colwell Christopher S, Kim Yang In Histamine 1 receptor-Gβγ-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock. Molecular brain. 2016; 9(1): 49.
Kuljis Dika A, Gad Laura, Loh Dawn H, MacDowell Kaswan Zoë, Hitchcock Olivia N, Ghiani Cristina A, Colwell Christopher S Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease. PloS one. 2016; 11(2): e0147583.
Schroeder Analyne M, Wang Huei Bin, Park Saemi, Jordan Maria C, Gao Fuying, Coppola Giovanni, Fishbein Michael C, Roos Kenneth P, Ghiani Cristina A, Colwell Christopher S Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease. PloS one. 2016; 11(1): e0147269.
Loh Dawn H, Jami Shekib A, Flores Richard E, Truong Danny, Ghiani Cristina A, O'Dell Thomas J, Colwell Christopher S Misaligned feeding impairs memories. eLife. 2015; 4(1): 73-82.
Kudo Takashi, Block Gene D, Colwell Christopher S The Circadian Clock Gene Period1 Connects the Molecular Clock to Neural Activity in the Suprachiasmatic Nucleus. ASN neuro. 2015; 7(6): 73-82.
Nakamura Takahiro J, Nakamura Wataru, Tokuda Isao T, Ishikawa Takahiro, Kudo Takashi, Colwell Christopher S, Block Gene D Age-Related Changes in the Circadian System Unmasked by Constant Conditions(1,2,3). eNeuro. 2015; 2(4): 1440-4.
Rakshit Kuntol, Qian Jingyi, Gaonkar Krutika Satish, Dhawan Sangeeta, Colwell Christopher S, Matveyenko Aleksey V Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in β-Cell Maturation Process. Diabetes. 2018; 67(5): 911-922.
Kim Young-Beom, Kim Woong Bin, Jung Won Woo, Jin Xiangyan, Kim Yoon Sik, Kim Byoungjae, Han Hee Chul, Block Gene D, Colwell Christopher S, Kim Yang In Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018; 67(3): 486-495.
Whittaker Daniel S, Loh Dawn H, Wang Huei-Bin, Tahara Yu, Kuljis Dika, Cutler Tamara, Ghiani Cristina A, Shibata Shigenobu, Block Gene D, Colwell Christopher S Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington's Disease. Journal of biological rhythms. 2018; 33(5): 535-554.
Wang Huei-Bin, Loh Dawn H, Whittaker Daniel S, Cutler Tamara, Howland David, Colwell Christopher S Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. eNeuro. 2018; 5(1): 486-495.
Kuljis Dika, Kudo Takashi, Tahara Yu, Ghiani Cristina A, Colwell Christopher S Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease. Journal of neuroscience research. 2018; 33(5): 535-554.