Office Phone Number:
Los Angeles, CA 90095 CHS
Los Angeles, CA 90095
|Professor, Microbiology, Immunology & Molecular Genetics|
|Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area|
The laboratory is investigating the molecular aspects of Herpes simplex virus latency in a mouse and rabbit model. In the mouse model, the promoter for the LAT (latency associated) transcript has been identified, and efforts to map the transcription factor sites for neuronal transcription in the mouse are in progress. They are currently investigating the role of the TAATGARAT sequences on the viral DNA as sites of repression to allow latency to occur. Another aspect of the research is cDNAs and PCR products for open reading frames in the LAT region. Finally, the laboratory is attempting to use HSV-I as a viral vector to specifically deliver and express gene products in neurons.