Lawrence Thomas Feldman

Work Address:
CHS
Los Angeles, CA 90095 CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Professor, Microbiology, Immunology & Molecular Genetics
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area
Research Interests
The laboratory is investigating the molecular aspects of Herpes simplex virus latency in a mouse and rabbit model. In the mouse model, the promoter for the LAT (latency associated) transcript has been identified, and efforts to map the transcription factor sites for neuronal transcription in the mouse are in progress. They are currently investigating the role of the TAATGARAT sequences on the viral DNA as sites of repression to allow latency to occur. Another aspect of the research is cDNAs and PCR products for open reading frames in the LAT region. Finally, the laboratory is attempting to use HSV-I as a viral vector to specifically deliver and express gene products in neurons.
Biography

The laboratory is investigating the molecular aspects of Herpes simplex virus latency in a mouse and rabbit model. In the mouse model, the promoter for the LAT (latency associated) transcript has been identified, and efforts to map the transcription factor sites for neuronal transcription in the mouse are in progress. They are currently investigating the role of the TAATGARAT sequences on the viral DNA as sites of repression to allow latency to occur. Another aspect of the research is cDNAs and PCR products for open reading frames in the LAT region. Finally, the laboratory is attempting to use HSV-I as a viral vector to specifically deliver and express gene products in neurons.

Publications
Feldman, LT Ellison, AR Voytek, CC Yang, L Krause, P Margolis, TP Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proceedings of the National Academy of Sciences of the United States of America. . 2002; 99(2): 978-83.
Berthomme, H Lokensgard, J Yang, L Margolis, T Feldman, LT Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latency. Journal of virology. . 2000; 74(8): 3613-22.
Daheshia, M., Feldman, L.T., Rouse, B.T. Herpes simplex virus latency and the immune response. Current Topics in Microbiology 1998; 1: 430-435.
Lokensgard, JR Berthomme, H Feldman, LT The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency. Journal of virology. . 1997; 71(9): 6714-9.
Turner, EE Rhee, JM Feldman, LT The POU-domain factor Brn-3.0 recognizes characteristic sites in the herpes simplex virus genome. Nucleic acids research. . 1997; 25(13): 2589-94.