Shimon S. Weiss, D.Sc.

Laboratory Address:
Young Hal 2002 & 2041
Mail Code: 156905

Office Address:
Young Hall 2021

Work Address:
Young Hall 2037A
Mail Code: 156905

Affiliations
Affiliations
Dean M. Willard Chair, Chemistry and Biochemistry
Director, Advanced Light Microscopy/Spectroscopy Lab, Macro-Scale Imaging Lab
Lab Director, S. Weiss Lab
Professor, Chemistry and Biochemistry, Physical Chemistry, Physiology
Member, Biochemistry, Biophysics & Structural Biology GPB Home Area, California NanoSystems Institute, Cell & Developmental Biology GPB Home Area, Molecular Biology Institute, Molecular, Cellular & Integrative Physiology GPB Home Area
Researcher, Biophysics and Structural Biology, Nanoscience and Materials, Physical
Research Interests
Identifying and cataloging all gene sequences and their corresponding protein high-resolution static 3-dimensional structures is only a prelude to the real challenges of future biological inquiries. We need to understand the dynamic structural changes of isolated macromolecules undergoing biochemical reactions. We need to identify transient interactions between macromolecules. We need to decipher the cell circuitry and its detailed time-dependent responses to various stimuli. We need to decode intracellular and extracellular communication signals and the corresponding molecular-level responses of live cells, tissues and whole organs. Analytical tools will need to be developed in order to identify and measure these molecular conformations and interactions. High-sensitivity fluorescence methods will play a vital role in this endeavor because they offer many advantages for probing isolated molecules and molecules in live cells, tissues and organs. Fluorescence is non-invasive; it provides imaging and sectioning capabilities in three dimensions; it has high sensitivity, down to the single molecule level, and it allows the observation of molecular- and organelle-specific signals. Our group develops and applies ultrahigh-resolution, ultrahigh-sensitivity fluorescence imaging and spectroscopy tools to solving outstanding problems in biology. CONFORMATIONAL DYNAMICS OF BIOMOLECULES: Many of the molecular machines that are essential for cell function and survival (transcription, replication, translation, recombination, splicing, protein folding etc.) are asynchronous, have multiple kinetic pathways and intermediates, and are comprised of several interacting components. The ability to watch one molecule at a time helps us obtain unique information on distribution functions of relevant observables, resolve subpopulations in heterogeneous samples, and record asynchronous time trajectories of observables that would otherwise be hidden. For example, dynamic distance changes between two sites on a macromolecule (or between two different molecules) can be measured via single-pair fluorescence resonance energy transfer (spFRET) by following spectral changes in the emission of a single donor-acceptor pair. Orientational changes can be detected via single-molecule fluorescence polarization anisotropy (smFPA) by following changes in the dipole orientation of a rigidly-attached or tethered probe. Our group developed such tools and uses them to study protein folding and transcription on the single-molecule level. We study the folding reaction energy landscape, pathways, conformational distributions and folding intermediates. The same tools are used to answer 25-years-old outstanding questions about the mechanisms of DNA transcription by the enzyme RNA polymerase. We are studying the relative motions between the enzyme and its DNA "molecular track", the conformational motions in the enzyme itself, and conformational transitions in the DNA during the various steps of the transcription reaction. DEVELOPMENT OF SEMICONDUCTOR NANOCRYSTALS AS BIOLOGICAL PROBES: Single-molecule experiments are currently performed predominantly in in-vitro environments. The ultimate challenge is to image cellular substructures, determine the relationships and dynamics of vesicles and organelles, describe existing conformational dynamics and biomolecular interactions, and localization all of the above in-vivo with single molecule sensitivity and nanometer-accuracy. This will allow the study of enzymes and multi-component molecular machines in their natural environment, with the signaling and regulation circuitry all wired-up. Towards the accomplishment of this tremendously complex task, we are developing colloidal fluorescent semiconductor nanocrystals (a class of quantum dots) for biological labeling. Nanocrystals posses several properties that make them very attractive as fluorescent probes for in-vivo single-molecule experiments: broad excitation spectra, narrow emission spectra, precise-tunable emission peaks, long fluorescence lifetimes, and negligible photobleaching. We are developing organic coatings, bioconjugation schemes, targeting strategies, and unique instrumentation that take advantage of nanocrystals?\225 spectral properties. Recently, we have shown how these distinctive properties increase the resolution of fluorescence microscopy measurements down to the nanometer level using far-field optics. We have also shown that their long fluorescence lifetime can be used to observe molecules and organelles in live cells without interference from autofluorescence background (a pre-requisite for single molecule detectability). We are currently pursuing applications in genomics (physical mapping, genome rearrangement), vesicle trafficking, cargo selection and in-vivo motility assays of molecular motors. BIOMOLECULAR INTERACTIONS BY COINCIDENCE DETECTION: Understanding the intricate network of protein interactions that take place within the cell of an organism a llows the understanding of the mechanisms that control its growth, maintenance, and disease. Protein-protein interactions are most commonly identified using the yeast two-hybrid (Y2H) assay. However, Y2H has several limitations including complications associated with the use of protein fusions, incorrect protein folding, incorrect post-translational modification, potential for toxicity and incompatibility with DNA binding proteins. We are developing a new method for detecting static and transient macromolecular interactions with ultrahigh sensitivity, ba sed on two-color coincident detection of single molecules in a confocal detection volume. Towards this end, we are developing unique fluorescent reagents, site- directed labeling schemes and novel single-molecule detection and analysis tools for monitoring protein-protein and protein-DNA interactions initially in-vitro and at a later stage in-vivo. We envision applications in cellular signaling and bio-sensing.
Biography:

Shimon got his PhD in Electrical Engineering from the Technion, Israel in 1989. After a year of postdoctoral research in AT&T Bell Laboratories, he was hired by Lawrence Berkeley National Laboratory as a staff Scientist. In 2001 he joined the departments of Chemistry & Biochemistry and Physiology at UCLA

Publications
Kim S, Streets AM, Lin RR, Quake SR, Weiss S, Majumdar DS High-throughput single-molecule optofluidic analysis. Nat Methods. 2011; 8(3): 242-5.
Dertinger T, Colyer R, Vogel R, Enderlein J, Weiss S Achieving increased resolution and more pixels with Superresolution Optical Fluctuation Imaging (SOFI). Opt Express. 2010; 18(18): 18875-85.
Colyer RA, Scalia G, Rech I, Gulinatti A, Ghioni M, Cova S, Weiss S, Michalet X High-throughput FCS using an LCOS spatial light modulator and an 8 × 1 SPAD array. Biomed Opt Express. 2010; 1(5): 1408-31.
Dertinger T, Heilemann M, Vogel R, Sauer M, Weiss S Superresolution optical fluctuation imaging with organic dyes. Angew Chem Int Ed Engl. 2010; 49(49): 9441-3.
Iyer G, Michalet X, Chang YP, Weiss S Tracking single proteins in live cells using single-chain antibody fragment-fluorescent quantum dot affinity pair. Methods Enzymol. 2010; 475: 61-79.
Liu C, Chung SY, Lee S, Weiss S, Neuhauser D Adsorbate-induced absorption redshift in an organic-inorganic cluster conjugate: Electronic effects of surfactants and organic adsorbates on the lowest excited states of a methanethiol-CdSe conjugate. J Chem Phys. 2009; 131(17): 174705.
Ebenstein, Y. Gassman, N. Kim, S. Weiss, S. Combining atomic force and fluorescence microscopy for analysis of quantum-dot labeled protein-DNA complexes. J Mol Recognit. 2009; 22(5): 397-402.
Barat B, Sirk SJ, McCabe KE, Li J, Lepin EJ, Remenyi R, Koh AL, Olafsen T, Gambhir SS, Weiss S, Wu AM Cys-diabody Quantum Dot Conjugates (ImmunoQdots) for Cancer Marker Detection. Bioconjug Chem. 2009; 20(8): 1474–1481.
Tremsin AS, Siegmund OH, Vallerga JV, Raffanti R, Weiss S, Michalet X High Speed Multichannel Charge Sensitive Data Acquisition System with Self-Triggered Event Timing. IEEE Trans Nucl Sci. 2009; 56(3): 1148-52.
Gassman, N. R. Ho, S. O. Korlann, Y. Chiang, J. Wu, Y. Perry, L. J. Kim, Y. Weiss, S. In vivo assembly and single-molecule characterization of the transcription machinery from Shewanella oneidensis MR-1. Protein Expr Purif. 2009; 65(1): 66-76.
Ebenstein, Y. Gassman, N. Kim, S. Antelman, J. Kim, Y. Ho, S. Samuel, R. Michalet, X. Weiss, S. Lighting up individual DNA binding proteins with quantum dots. Nano Lett. 2009; 9(4): 1598-603.
Antelman, J. Wilking-Chang, C. Weiss, S. Michalet, X. Nanometer distance measurements between multicolor quantum dots. Nano Lett. 2009; 9(5): 2199-205.
Bentolila, L. A. Ebenstein, Y. Weiss, S. Quantum dots for in vivo small-animal imaging. J Nucl Med. 2009; 50(4): 493-6.
Kapanidis, A.N.; Weiss, S Single-molecule FRET analysis of the path from transcription initiation to elongation. RNA Polymerases as Molecular Motors. 2009; Buc, H.; Strick, T.; Eds., : 115-156.
Antelman J, Ebenstein Y, Dertinger T, Michalet X, Weiss S Suppression of quantum dot blinking in DTT-doped polymer films. J Phys Chem C Nanomater Interfaces. 2009; 113(27): 11541-5.
Pinaud, F. Michalet, X. Iyer, G. Margeat, E. Moore, H. P. Weiss, S. Dynamic Partitioning of a Glycosyl-Phosphatidylinositol-Anchored Protein in Glycosphingolipid-Rich Microdomains Imaged by Single-Quantum Dot Tracking. Traffic. 2009; 10(6): 691-712.
Korlann, Y. Dertinger, T. Michalet, X. Weiss, S. Enderlein, J. Measuring diffusion with polarization-modulation dual-focus fluorescence correlation spectroscopy. Opt Express. 2008; 16(19): 14609-16.
Kim, Y. Ho, S. O. Gassman, N. R. Korlann, Y. Landorf, E. V. Collart, F. R. Weiss, S. Efficient site-specific labeling of proteins via cysteines. Bioconjug Chem. 2008; 19(3): 786-91.
Iyer, G. Michalet, X. Chang, Y. P. Pinaud, F. F. Matyas, S. E. Payne, G. Weiss, S. High affinity scFv-hapten pair as a tool for quantum dot labeling and tracking of single proteins in live cells. Nano Lett. 2008; 8(12): 4618-23.
Hamadani, K. M. Weiss, S. Nonequilibrium single molecule protein folding in a coaxial mixer. Biophys J. 2008; 95(1): 352-65.
Schipper, M.L.; Iyer, G.; Koh, A.L.; Cheng, Z.; Ebenstein, Y.; Aharoni, A.; Keren, S.; Bentolila, L.A.; Li, J.; Rao, J.; Chen, X.; Banin, U.; Wu, A.M.; Sinclair, R.; Weiss, S.; Gambhir, S.S. Particle Size, Surface Coating, and Pegylation Influence the Biodistribution of Quantum Dots in Living Mice. Small. 2008; 5(1): 126-34.
Bentolila, L.A.; Michalet, X.; and Weiss, S Quantum Optics: Colloidal Fluorescent Semiconductor Nanocrystals (Quantum dots) in Single-Molecule Detection and Imaging . Springer Series in Biophysics: Single Molecules and Nanotechnology. 2008; 12(Edited by Rudolf Rigler and Horst Vogel): 53-81.
Waldauer SA, Bakajin O, Ball T, Chen Y, Decamp SJ, Kopka M, Jäger M, Singh VR, Wedemeyer WJ, Weiss S, Yao S, Lapidus LJ Ruggedness in the folding landscape of protein L. HFSP J. 2008; 2(6): 388-95.
Chang, Y. P.; Pinaud, F.; Antelman, J.; Weiss, S. Tracking bio-molecules in live cells using quantum dots. J Biophotonics. 2008; 1(4): 287-98.
Nir, E.; Jäger, M.; and Weiss, S Alternating Laser Excitation Spectroscopy of freely diffusing single molecules: Application to biomolecular structure, dynamics and interactions. Handai Nanophotonics. 2007; 3(Masuhara, H.; Kawata, S.; and Tokunaga, F. Eds.): 23-42.
Kapanidis, A.N.; Heilemann, M.; Margeat, E.; Kong, X.; Nir, E.; Weiss, S. Alternating-Laser Excitation of Single Molecules. Single-Molecule Techniques: A Laboratory Manual. 2007; Selvin, P.; Ha, T.; Eds.(Chapter 6): .
Michalet, X.; Siegmund, O.H.W.,; Vallerga, J.V.; Jelinsky, P.; Millaud, J.E.; Arisaka, K.; Weiss, S. Detectors for Microscopy: Next-generation 3-D detector improves single-molecule imaging. Laser Focus World. 2007; 43: 97-101.
Schipper, M.L.; Cheng, Z.; Lee, S.W.; Keren, S.; Bentolila, L.A.; Sundaresan, G.; Iyer, G.; Gheysens,O.; Ebenstein, Y.; Li, J.; Rao, J.; Chen, X.; Wu, A.M.; Weiss, S.; Gambhir, S.S. MicroPET-Based Biodistribution of Quantum Dots in Living Mice. J. of Nuclear Medicine. 2007; 48(9): 1511-8.
Doose, S.; Heilemann, M.; Michalet, X.; Weiss, S.; and Kapanidis A.N. Periodic Acceptor Excitation Spectroscopy of Single Molecules. European Biophysical J. 2007; 36(6): 669-74.
Laurence, T.A.; Michalet, X.; Jäger, M.; and Weiss, S. Protein Dynamics and Interactions. Single Molecule Dynamics. 2007; Yanagida, T.; Ishii, Y. Eds., : .
Majumdar, D.S.; Smirnova, I.; Kasho, V.; Nir, E.; Kong, X.; Weiss, S.; Kaback, H.R. Single-molecule FRET Reveals a Sugar-Induced Conformational Dynamics in LacY. Proc Natl Acad Sci USA. 2007; 104(31): 12640-12645.
Tsay, J.M.; Trzoss, M.; Shi, L.; Komg, X.; Selke, M.; Jung, M.E.; Weiss, S. Singlet Oxygen Production by Peptide-coated Quantum Dot-Photosensitizer Conjugates. J. Am. Chem. Soc. 2007; 129(21): 6865-6871.
Iyer, G. Pinaud, F. Tsay, J. Weiss, S. Solubilization of quantum dots with a recombinant peptide from Escherichia coli. Small. 2007; 3(5): 793-8.
Lee, N.K.; Kapanidis, A.N.; Koh, H.R.; Korlann, Y.; Ho, S.O.; Kim; Y.;Gassman, N.; Kim, S.K.; and Weiss, S. Three-color alternating-laser excitation of single molecules: simultaneous monitoring of multiple interactions and distances. Biophysical Journal. 2007; 92(1): 303-12.
Kong, X. Nir, E. Hamadani, K. Weiss, S. Photobleaching pathways in single-molecule FRET experiments. J Am Chem Soc. 2007; 129(15): 4643-54.
Kapanidis, A. N.; Margeat, E.; Ho, S. O.; Kortkhonjia, E.; Weiss, S.; Ebright, R. H. Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism. Science. 2006; 314(5802): 1144-7.
Nir, E. Michalet, X. Hamadani, K. M. Laurence, T. A. Neuhauser, D. Kovchegov, Y. Weiss, S. Shot-noise limited single-molecule FRET histograms: comparison between theory and experiments. J Phys Chem B. 2006; 110(44): 22103-24.
Michalet, X.; Siegmund, O.H.W.; Vallerga, J.V.; Jelinsky, P.; Millaud, J.E.;Weiss,S A space and time –resolved single-photon counting detector for fluorescence microscopy and spectroscopy. Proceedings of SPIE, 2006. 2006; 6092M: .
Pinaud, F. Michalet, X. Bentolila, L. A. Tsay, J. M. Doose, S. Li, J. J. Iyer, G. Weiss, S. Advances in fluorescence imaging with quantum dot bio-probes. Biomaterials. 2006; 27(9): 1679-87.
Margeat E, Kapanidis AN, Tinnefeld P, Wang Y, Mukhopadhyay J, Ebright RH and Weiss S Direct observation of abortive initiation and promoter escape within single immoblized transcription complexes. Biophys J. 2006; 90(4): 1419-1431.
Michalet, X.; Siegmund, O.H.W.; Vallerga, J.V.; Jelinsky, P.; Pinaud, F.; Millaud, J.E.; Weiss, S. Fluorescence lifetime microscopy with a time- and space-resolved single-photon counting detector. Proceedings of the SPIE. 2006; 6372(63720E): .
Iyer, G.; Li, J.J.; Pinaud, F.; Tsay, J.M.; Bentolila, L.A.; Michalet, X.; Weiss, S. Near-infrared peptide-coated quantum dots for small animal imaging. Proceedings of the SPIE. 2006; 6096(6096B): .
Iyer, G. Pinaud, F. Tsay, J. Li, J. J. Bentolila, L. A. Michalet, X. Weiss, S. Peptide coated quantum dots for biological applications. IEEE Trans Nanobioscience. 2006; 5(4): 231-8.
Michalet X, Siegmund OHW, Vallerga JV, Jelinsky P, Millaud JE, Weiss S Photon-Counting H33D Detector for Biological Fluorescence Imaging. Nuclear Instruments and Methods in Physics Research. 2006; 567(1): 133.
Michalet, X. Weiss, S. Jager, M. Single-molecule fluorescence studies of protein folding and conformational dynamics. Chem Rev. 2006; 106(5): 1785-813.
Bentolila LA, Weiss S Single-step multicolor fluorescence In situ hybridization using semiconductor quantum dot-DNA conjugates. Cell Biochemistry and Biophysics. 2006; 45((1) Editor-in-Chief: Edward J. Massaro): 59-70.
Bentolila, L. A. Weiss, S. Single-step multicolor fluorescence in situ hybridization using semiconductor quantum dot-DNA conjugates. Cell Biochem Biophys. 2006; 45(1): 59-70.
Jager, M. Nir, E. Weiss, S. Site-specific labeling of proteins for single-molecule FRET by combining chemical and enzymatic modification. Protein Sci. 2006; 15(3): 640-6.
Michalet, X. Weiss, S. Using photon statistics to boost microscopy resolution. Proc Natl Acad Sci U S A. 2006; 103(13): 4797-8.
Margeat, E. Kapanidis, A. N. Tinnefeld, P. Wang, Y. Mukhopadhyay, J. Ebright, R. H. Weiss, S. Direct observation of abortive initiation and promoter escape within single immobilized transcription complexes. Biophys J. 2006; 90(4): 1419-31.
Tsay, J. M. Doose, S. Weiss, S. Rotational and translational diffusion of peptide-coated CdSe/CdS/ZnS nanorods studied by fluorescence correlation spectroscopy. J Am Chem Soc. 2006; 128(5): 1639-47.
Laurence TA, Kong X, Jager M, Weiss S Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins. Proc Natl Acad Sci U S A. 2005; 102(48): 17348-53 .
Kapanidis, A. N. Margeat, E. Laurence, T. A. Doose, S. Ho, S. O. Mukhopadhyay, J. Kortkhonjia, E. Mekler, V. Ebright, R. H. Weiss, S. Retention of transcription initiation factor sigma70 in transcription elongation: single-molecule analysis. Mol Cell. 2005; 20(3): 347-56.
Lee NK, Kapanidis AN, Michalet X, Mukhophadyay J, Ebright RH, Weiss S Accurate FRET Measurements within Single Diffusing Biomolecules Using Alternating-Laser Excitation. Biophys J. 2005; 88(4): 2939-2953.
Lee, N. K. Kapanidis, A. N. Wang, Y. Michalet, X. Mukhopadhyay, J. Ebright, R. H. Weiss, S. Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation. Biophys J. 2005; 88(4): 2939-53.
Kapanidis AN, Laurence TA, Lee NK, Margeat E, Kong X, Weiss S Alternating-laser excitation of single molecules. Accounts of chemical research. 2005; 38(7): 523-33.
Siegmund, O.H.W.; Michalet, X.; Vallerga, J.V.; Jelinsky, P.; Weiss, S. Cross Delay Line Detectors for High Time Resolution Astronomical Polarimetry and Biological Fluorescence Imaging. IEEE Nuclear Science Symposium Conference Record. 2005; N14(55): 448-452.
Tsay, Jm.;, Doose, S.; Pinaud, F.; Weiss, S. Enhancing the Photoluminescence of Peptide-coated Nanocrystals. Nanobiophotonics and Biomedical Applications II. 2005; 5705(Eds. Alexander N. Cartwright, Marek Osinski): 139-147.
Tsay, J.; Doose, S.; Pinaud, F.; Weiss, S. Enhancing the photoluminescence of peptide-coated CdSe nanocrystals with shell composition and UV irradiation. J. Phys. Chem. 2005; 109(5): 1669-1674.
Tsay JM, Doose S, Pinaud F, Weiss S Enhancing the photoluminescence of peptide-coated nanocrystals with shell composition and UV irradiation. J Phys Chem B. 2005; 109(5): 1669-74.
Michalet, X.; Weiss, S. Laser in Physics: Single Molecule Spectroscopy. Chapter in Encyclopedia of Modern Optics 2005; Edited by Bob Guenther, Alan Miller, Leopold Bayvel and John Midwinter(Elsevier Physics): 147-162.
Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Iyer G, Weiss S Peptide-coated semiconductor nanocrystals for biomedical applications. Proceedings of SPIE. 2005; 5704(57): 57-68.
Jager, M.; Michalet, X.; Weiss, S. Protein-protein interactions as a tool for site-specific labeling of proteins. Protein Science. 2005; 14(8): 2059-68.
Bentolila, L.A.; Michalet, X.; Pinaud, F.; Tsay, J.M.; Doose, S.; Li, J.J.; Sundaresan, G.; Wu, A.M.; S.S. Gambhir, S.S.; and Weiss, S. Quantum dots for molecular imaging and cancer medicine. Discovery Medicine. 2005; 5(26): 213-218.
Li JJ, Tsay J, Michalet X, Weiss S Wave-function engineering: from quantum wells to near-infrared type-II colloidal quantum dots synthesized by layer-by-layer colloidal epitaxy. Chemical Physics (Special Issue on Molecular Nanoscience-In Honor of Daniel S. Chemla on his 65th Birthday). 2005; 318(1-2): 82-90.
Doose, S. Tsay, J. M. Pinaud, F. Weiss, S. Comparison of photophysical and colloidal properties of biocompatible semiconductor nanocrystals using fluorescence correlation spectroscopy. Anal Chem. 2005; 77(7): 2235-42.
Michalet, X. Pinaud, F. F. Bentolila, L. A. Tsay, J. M. Doose, S. Li, J. J. Sundaresan, G. Wu, A. M. Gambhir, S. S. Weiss, S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science. 2005; 307(5709): 538-44.
Baer, R.; Neuhauser, D.; Weiss, S. Enhanced Absorption Induced by a Metallic Nanoshell. Nano Letters. 2004; 4(1): 85-88.
Hertzog, D. E.; Michalet, X.; Jager, M.; Kong, X.; Santiago, J.; Weiss, S.; Bakajin, O. Femtomole Mixer for Microsecond Kinetic Studies of Protein Folding. Analytical Chemistry. 2004; 76(24): 7169-7178.
Kapanidis AN,Lee NK, Laurence TA, Doose S, Margeat E, Weiss S Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules. Proceedings of the National Academy of Sciences of the United States of America. . 2004; 101(24): 8936-41.
Laurence, T. A.; Kapanidis, A. N.; Kong, X.; Chemla, D. S.; Weiss, S. Photon arrival-time interval distribution (PAID): A novel tool for analyzing molecular interactions. J. Phys. Chem. B. 2004; 108(9): 3051-3067.
Pinaud, F.; Michalet, X.; Margeat, E.; Moore, H. P.; Weiss, S. Single Molecule Fluorescence Imaging of Raft Associated GPI-anchored Receptors in Live Cells with Semiconductor Nanocrystals. Minerva-Gentner Symposium on Optical Spectroscopy of Biomolecular Dynamics - Banz, Germany 2004; .
Soper, S. A.; Trottier, C.; Davies, M.; Dautet, H.; Wabuyele, M.; Kapanidis, A. N.; Lacoste, T.; Weiss, S. Single Photon-Counting Technology for Single-Molecule Detection Applications in Biotechnology. PharmaGenomics 2004; February: 24-34.
Margeat, E.; Kapanidis, A. N.; Lee, N. K.; Laurence, T. A.; Doose, S.; Tinnefeld, P.; Ho, S.; Wang, Y.; Mukhophadyay, J.; Kortkhonjia, E.; Ebright, R. H.; Weiss, S. Single-molecule analysis of transcription initiation by the RNA polymerase. Minerva-Gentner Symposium on Optical Spectroscopy of Biomolecular Dynamics, Banz, Germany 2004; .
Pinaud, F. King, D. Moore, H. P. Weiss, S. Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides. J Am Chem Soc. 2004; 126(19): 6115-23.
Tsay, J. M. Pflughoefft, M. Bentolila, L. A. Weiss, S. Hybrid approach to the synthesis of highly luminescent CdTe/ZnS and CdHgTe/ZnS nanocrystals. J Am Chem Soc. 2004; 126(7): 1926-7.
Licht, S. S.; Sonnleitner, A.; Weiss, S.; Schultz, P. G. A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis. Biochemistry. 2003; 42(10): 2916-25.
Bentolila, L. A.; Weiss, S. Biological quantum dots go live. Physics World. 2003; 16(3): 23-4.
Laurence, T. A.; Weiss, S How to Detect Weak Pairs. Science. 2003; 299(5607): 667-8.
Michalet X, Kapanidis AN, Laurence T, Pinaud F, Doose S, Pflughoefft M, Weiss S The power and prospects of fluorescence microscopies and spectroscopies. Annual review of biophysics and biomolecular structure. 2003; 32: 161-82.
Kapanidis, A. N.; Weiss, S Fluorescent probes and bioconjugation chemistries for single-molecule fluorescence analysis of biomolecules. J.Chem. Phys. 2002; 117(24): 10953-10964.
Weiss, S. Bioapplications of Nantotechnology. ACS Prospectives Conference 2001; .
Michalet, X.; Weiss, S. Fluorescent semiconductor nanocrystals and their use as biological probes. Les Houches Spring School on Single Molecules, Les Houches, France 2001; .
Weiss, S. High resolution colocalization. DARPA Single Spin Imaging, San Francisco 2001; .
Kelley, A. M.; Michalet, X.; Weiss, S. Perspectives: Chemical physics: Single-molecule spectroscopy comes of age. Science 2001; 292(5522): 1671-2.
Laurence, T. A.; Chemla, D. S.; Weiss, S. Photon arrival time interval distribution analysis (PAID) - a new method to simultaneously analyze brightness, diffusion time, and concentration of biomolecules in solution. 45th Biophysical Society Meeting, Boston 2001; .
Michalet, X.; Pinaud, F.; Lacoste, T. D.; Dahan, M.; Bruchez, M. P.; Alivisatos, A. P.; Weiss, S. Properties of fluorescent semiconductor nanocrystals and their application to biological labeling. Single Molecule 2001; 2(4): 261-76.
Deniz, A. A.; Laurence, T. A.; Dahan, M.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Ratiometric single-molecule studies of freely diffusing biomolecules. Ann.Rev.Phys.Chem 2001; 52: 233-53.
Weiss, S. Shattering the diffraction limit of light: A revolution in fluorescence microscopy. Proc Natl Acad Sci U S A 2001; 97(Commentary): 8747-9.
A. Sonnleitner, S.Licht, X. Michalet, P. G. Schultz, S. Weiss Simultaneous Dual Color Imaging of the C5A-receptor system in living HEK-293 cells. 45th Biophysical Society Meeting, Boston 2001; .
Kapanidis, A. N.; LaCoste, T. D.; Mekler, V.; Mukhopadhyay, J.; Weiss, S.; Ebright, R. H. Single Molecule Fluorescence Studies of Transcription by Escheria Coli RNA Polymerase: Direct Observation of Abortive Initiation. 45th Biophysical Society Meeting, Biophysical Journal 80, 478 17, Boston 2001; .
Licht, S.; Sonnleitner, A.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Structure and Dynamics of Clusters of C5a Receptors formed in response to application of C5a to living HEK-293 cells. 45th Biophysical Society Meeting, Boston 2001; .
Weiss, S. Super-Resolution Co-Localization with Q-Dots. 45th Biophysical Society Meeting Boston 2001; .
Gerion, D.; Pinaud, F.; Williams, S. C.; Parak, W. J.; Zanchet, D.; Weiss, S.; Alivisatos, A. P. Synthesis and Properties of Biocompatible Water-Soluble Silica-Coated CdSe/ZnS Semiconductor Quantum Dots. J. Phys. Chem 2001; 105(37): 8861-8871.
Dahan, M.; Laurence, T.; Herten, D. P.; Schumacher, A.; Chemla, D. S.; Alivisatos, A. P.; Sauer, M.; Weiss, S. Time-gated biological imaging using colloidal quantum dots. Opt. Lett 2001; 26: 825-7.
Michalet, X.; Pinaud, F.; Lacoste, T. D.; Dahan, M.; Bruchez, M. P.; Alivisatos, A. P.; Weiss, S. Ultrahigh Resolution Multicolor Colocalization of Single Fluorescent Nanocrystals. Proceedings of the SPIE 2001; 4258: 8-15.
Michalet, X.; Lacoste, T. D.; Weiss, S. Ultrahigh-resolution colocalization of spectrally separable point-like fluorescent probes. Methods 2001; 25(1): 87-102.
Laurence, T.; Deniz, A. A.; Dahan, M.; Faulhaber, A. E.; Chemla, D. S.; Weiss, S.; Schultz, P. G. End-to-end distance measurements of individual single-stranded DNA polymers. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Dahan, M.; Laurence, T.; Schumacher, A.; Chemla, D. S.; Alivisatos, A. P.; Sauer, M.; Weiss, S. Fluorescence lifetime study of single Qdots. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Weiss, S. Measuring conformational dynamics of biomolecules by single molecule fluorescence spectroscopy. Nat Struct Biol 2000; 7(9): 724-9.
Licht, S.; Sonnleitner, A.; Servant, G.; Bourne, H.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Single molecule imaging and fluorescence correlation spectroscopy of YFP-fused C5A receptors in living HEK-293 cells. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Michalet, X.; Lacoste, T.; Chemla, D. S.; Weiss, S. Single molecule polarization anisotropy study of DNA intercalating and groove-binding dyes in a combed DNA molecule. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Deniz, A. A.; Dahan, M.; Beligere, G. S.; Lawrence, T.; Martin, A. B.; Chemla, D. S.; Dawson, P. E.; Schultz, P. G.; Weiss, S. Single molecule protein folding studies of Chymotrypsin inhibitor 2 by guanidine denaturation. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Weiss, S. Single molecule/Qdot Biophysics. Pittcon 2000 - The Pittsburgh conference on analytical chemistry and applied spectroscopy, New Orleans 2000; .
Weiss, S. Single molecule/Qdot Biophysics. 2nd Linz Conference on Single molecule biophysics, Linz 2000; .
Deniz, A.A., Laurence, T.A., Beligere,G.S., Dahan, M., Martin, A.B., Chemla, D.S., Dawson, P.E., Schultz, P.G., and Weiss S Single-molecule protein folding: Diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2. Proc Natl Acad Sci U S A 2000; 97(10): 5179-84.
Lacoste, T. D.; Michalet, X.; Pinaud, F. F.; Chemla, D. S.; Alivisatos, A. P.; Weiss, S. Super resolution molecular ruler using single Qdots. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Sonnleitner, A.; Mannuzzu, L.; Chemla, D. S.; Weiss, S.; Isacoff, E. The development of single molecule imaging and fluorescence correlation spectroscopy as tools for the study of S4 movement in single shaker K+ channels. 44th Biophysical Society Annual Meeting, New Orleans, February 2000; .
Michalet, X.; Lacoste, T. D.; Pinaud, F.; Chemla, D. S.; Alivisatos, A. P.; Weiss, S. Ultrahigh Resolution Multicolor Colocalization of Single Fluorescent Nanocrystals. talk 4258-03-S1 BiOS 200 Conference, San Jose 2000; .
Lacoste, T. D.; Michalet, X.; Pinaud, F.; Chemla, D. S.; Alivisatos, A. P.; Weiss, S. Ultrahigh-resolution multicolor colocalization of single fluorescent probes. Proc Natl Acad Sci U S A 2000; 97(17): 9461-6.
Michalet, X.; Her, T.; Chemla, D. S.; Weiss, S. Ultrahigh-resolution multicolor two-photon colocalization of single fluorescent probes. talk 4262-32-S6, BiOS 2000 Conference, San Jose, CA 2000; .
Glass, J.; Chemla, D. S.; Weiss, S. Using single molecules as local environmental probes for the study of water-glass interfaces. 44th Biophysical Society Annual Meeting, New Orleans 2000; .
Lacoste, T. D.; Grunwell, J.; Laurence, T.; Glass, J.; Chemla, D. S.; Schultz, P. G.; Weiss, S. ., Induced conformational dynamics of single DNA hairpin molecules. . 43rd Biophysical Society Annual Meeting, Baltimore, MD 1999; .
Ha, T. and S. Weiss Dual- and single-molecule fluorescence spectroscopy: towards kinetic observation of single molecule reactionsDual- and single-molecule fluorescence spectroscopy: towards kinetic observation of single molecule reactions. Mesoscopic Chemistry - a Chemistry for the 21st century monograph 1999; International Union of Pure and Applied Chemistry(edited by Masuhara and De Schryver): 61-74.
U. Banin, M. Bruchez, A.P. Alivisatos, T. Ha, S. Weiss and D.S. Chemla Evidence for a thermal contribution to emission intermittency in single CdSe/CdS core/shell nanocrystals. J.Chem. Phys 1999; 110: 1195-1201.
Weiss, S. Fluorescence spectroscopy of single biomolecules. Science 1999; 283(5408): 1676-83.
Moronne, M. M.; Ben Dahan, M.; Bruchez Jr., M.; Hamamoto, D. J.; Weiss, S.; Alivasatos, A. P. Nanocrystal Phosphors as Biological Probes for Fluorescence Microscopy. 43rd Biophysical Society Annual Meeting, Baltimore, MD 1999; .
Weiss Observing catalytic activity and folding reactions of single biomolecules. Understanding Structure - Program in Mathematics and Molecular Biology (PMMB) VI, Santa Fe, NM 1999; .
Weiss, S. Observing single biomolecule dynamics. The JST International Symposium on Molecular Processes and Biosystems, Tokyo, Japan 1999; .
Weiss, S. Observing single molecule reaction. 218th American Chemical Society National Meeting, New Orleans 1999; .
Weiss, S. Observing single molecule reaction. A Conference on Single molecule biophysics, Tours, France 1999; .
Weiss, S. Observing single molecule reactions. 45th International Conference on Analytical Sciences and Spectroscopy (ICASS), Vancouver 1999; .
Ha, T.; Laurence, T. A.; Chemla, D. S.; Weiss, S. Polarization Spectroscopy of Single Fluorescent Molecules. J. Phys. Chem 1999; 103(33): 6839-6850.
Dahan, M.; Deniz, A.; Grunwell, J.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Ratiometric identification of single molecule conformational states. 43rd Biophysical Society Annual Meeting, Baltimore, MD 1999; .
Dahan, M.; Deniz, A. A.; Ha, T.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Ratiometric measurement and identification of single diffusing molecules. Chemical Physics 1999; 247(1): 85-106.
Deniz, A. A.; Dahan, M.; Ha, T.; Grunwell, J.; Faulhaber, A.; Chemla, D. S.; Weiss, S.; Schultz, P. G. Ratiometric single pair FRET on freely diffusing molecules - observation of Förster distance dependence and of sub-populations. Proc Natl Acad Sci U S A 1999; 96: 3670-3675.
Weiss, S. Single molecule dynamics. A Nobel Conference on Spectroscopy of Single Molecules in Physics, Chemistry and Life Science, Södergarn, Sweden 1999; .
Weiss, S. Single molecule fluorescence resonance energy transfer. A NATO advanced study institute on advances in energy transfer processes, Erice, Italy 1999; .
Ha, T.; Ting, A. Y.; Liang, J.; Caldwell, W. B.; Deniz, A. A.; Chemla, D. S.; Schultz, P. G.; Weiss, S. Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism. Proc Natl Acad Sci U S A 1999; 96(3): 893-8.
Ha, T.; Ting, A. Y.; Liang, J.; Deniz, A. A.; Chemla, D. S.; Schultz, P. G.; Weiss, S Temporal fluctuations of fluorescence resonance energy transfer between two dyes conjugated to a single protein. Chemical Physics 1999; 247(1): 107-118.
Weiss, S. Dual-Molecule Spectroscopy. 6th International Conference on Laser Applications to Chemical and Environmental Analysis, Orlando, Florida 1998; .
Weiss, S. Dual-molecule fluorescence spectroscopy - kinetic observation of single molecule reactions. US-Japan cooperative program on photoconversion and photosynthesis research in the area of Photophysics and photoconversion in small domains by near-field scanning optical microscopy, Napa, CA 1998; .
Ha, T.; Glass, J.; Chemla, D. S.; Weiss, S Hindered rotational diffusion and rotational jumps of single molecules. Phys Rev Lett 1998; 80: 2093.
Enderle, T.; Ha, T.; Chemla, D. S.; Weiss, S Near-field fluorescence microscopy of cells. Ultramicroscopy 1998; 71(1-4): 303-9.
Observing single molecule reactions. Single Molecule Detection Workshop, Leiden, the Netherlands 1998; .
Bruchez, M., Jr.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A. P Semiconductor nanocrystals as fluorescent biological labels. Science 1998; 281(5385): 2013-6.
Weiss, S. Single molecule protein dynamics. The Gordon Conference on Biopolymers, Newport, RI 1998; .
Ha, T.; Ting, A. Y.; Schultz, P. G.; Chemla, D. S.; Weiss, S. Temporal fluctuations in single molecule dipole orientation and single molecule energy transfer as a probe for protein conformational dynamics. Conference on Quantum Electronics and Laser Science (QELS), San Francisco 1998; postdeadline paper: .
Weiss, S. Towards the observation of single molecule reactions. 42nd Biophysical Society Annual Meeting, Kansas City, Kansas 1998; .
Weiss, S.; Ha, T.; Enderle, T.; Selvin, P. R.; Chemla, D. S. Dual molecule spectroscopy with NSOM: multi-color rulers for macromolecules. 4th International Conference on Near-Field Optics, Jerusalem, February 1997; .
Weiss, S. Dual-Molecule Spectroscopy. Workshop on Recent Advances in the Physics of Single Quantum Dots, Naval Research Laboratory, Washington DC 1997; .
Weiss, S.; Ha, T.; Enderle, T.; Selvin, P. R.; Chemla, D. S. Dual-Molecule Spectroscopy: molecular rulers for the study of biological macromolecules. 213th American Chemical Society National Meeting, San Francisco 1997; .
Weiss, S. Dual-molecule fluorescence spectroscopy - kinetic observation of single molecule reactions. 8th International Conference on Unconventional Photoactive Systems, Nara, Japan 1997; .
Ha, T.; Enderle, T.; Selvin, P. R.; Chemla, D. S.; Weiss, S. Room temperature observation of quantum jumps. Chem. Phys. Letters 1997; 271: 1.
Ha, T.; Enderle, T.; Selvin, P. R.; D.S. Chemla; Weiss, S. Room temperature study of single molecule dynamics on a surface. 213th American Chemical Society National Meeting, San Francisco, April 1997; .
Ha, T.; Glass, J.; Enderle, T.; Chemla, D. S.; Weiss, S. Rotational Diffusion of Single Fluorophores Probed by Fluorescence Polarization Anisotropy. 5th International Conference on Methods and Applications of Fluorescence Spectroscopy, Berlin, Germany 1997; .
Ha, T.; Glass, J.; Enderle, T.; Chemla, D. S.; Weiss, S. Single Molecule Spectroscopy in Liquid. III International Workshop on Single molecule detection - basics and applications in life sciences, Berlin, Germany 1997; .
Weiss, S. Single molecule rulers. Yanagida Project Symposium on Single Molecular Process in Bio-systems, Osaka, Japan 1997; .
Ha, T.; Chemla, D. S.; Enderle, T.; Weiss, S. Single molecule spectroscopy with automated positioning. Applied Physics Letters 1997; 70: 782.
Ha, T.; Chemla, D. S.; Enderle, T.; Weiss, S. Strategy for room temperature spectroscopy of single molecules. Bioimaging 1997; 5: 99.
Enderle, T.; Ha, T.; Chemla, D. S.; Magowan, C.; Weiss, S. Surface specific mapping and co-localization of malarial and host proteins in red-blood-cell membrane by dual-color near-field scanning optical microscopy. Proc Natl Acad Sci U S A 1997; 94: 520.
Botkin, D.; Glass, J.; Chemla, D. S.; Ogletree, D. F.; Salmeron, M.; Weiss, S. Advances in ultrafast scanning tunneling microscopy. Applied Physics Letters 1996; 69: 1321.
Enderle, T.; Ha, T.; Chemla, D. S.; Selvin, P. R.; Weiss, S. Emission properties of single fluorophores at room temperature. Single molecule detection - basics and applications in life sciences", Berlin, Germany, October 1996; .
Ha, T.; Enderle, T.; Ogletree, D. F.; Chemla, D. S.; Selvin, P. R.; Weiss, S. Fluorescence Resonance Energy Transfer between a single donor and a single acceptor. XX International Quantum Electronics Conference (IQEC), Sydney, Australia 1996; .
Weiss, S. Fluorescence resonance energy transfer between a single donor and a single acceptor molecule. Pittcon 96, The Pittsburgh conference on analytical chemistry and applied spectroscopy, Chicago 1996; .
Weiss, S. Fluorescence resonance energy transfer of a single donor-acceptor pair. The 4th French-Israeli Symposium on Nonlinear Optics, Les Arcs, France 1996; .
Enderle, T.; Ha, T.; Chemla, D. S.; Magowan, C.; Weiss, S. Membrane Specific Mapping and Co-Localization of Malarial and Host Skeletal Proteins in the Plasmodium falciparum Infected Erythrocyte by Dual-color Near-field Scanning Optical Microscopy. 6th International Congress on Cell Biology, San Francisco, December 1996; .
Probing the interaction between two single molecules: Fluorescence Resonance Energy Transfer between a single donor and a single acceptor. Conference on Quantum Electronics and Laser Science (QELS), Anaheim 1996; .
Ha, T.; Enderle, T.; Ogletree, D. F.; Chemla, D. S.; Selvin, P. R.; Weiss, S. Probing the interaction between two single molecules: fluorescence resonance energy transfer between a single donor and a single acceptor. Proc Natl Acad Sci U S A 1996; 93(13): 6264-8.
Ha, T.; Enderle, T.; Ogletree, D. F.; Selvin, P. R.; Weiss, S.; Chemla, D. S. Room temperature observation of quantum jumps of single molecule into dark states. Conference on Quantum Electronics and Laser Science (QELS), Anaheim, June 1996; .
Ha, T.; Enderle, T.; Ogletree, D. F.; Selvin, P. R.; Weiss, S.; Chemla, D. S. Room temperature observation of quantum jumps of single molecule into dark states. XX International Quantum Electronics Conference (IQEC), Sydney, Australia, July 1996; .
Weiss, S. Single (dual) Molecule Flashlights: a molecular yardstick for biological macromolecules. II International Workshop on Single molecule detection - basics and applications in life sciences, Berlin, Germany 1996; .
Ha, T.; Enderle, T.; Chemla, S.; Selvin, R.; Weiss, S. Single Molecule Dynamics Studied by Polarization Modulation. Physical Review Letters 1996; 77(19): 3979-3982.
Enderle, T.; Ha, T.; Chemla, D. S.; Magowan, C.; Weiss, S. Surface specific mapping and co-localization of malarial and host proteins in red-blood-cell membrane by dual-color near-field scanning optical microscopy. Conference on Quantum Electronics and Laser Science (QELS), Anaheim, postdeadline paper, June 1996; .
Ha, T.; Enderle, T.; Chemla, D. S.; Weiss, S. ual-molecule spectroscopy: molecular rulers for the study of biological macromolecules. IEEE J. Quantum Electron 1996; 2: 1115.
Weiss, S.; Ha, T.; Enderle, T.; Selvin, P. R.; Ogletree, D. F. ., Fluorescence resonance energy transfer of a single donor-acceptor pair. 42nd National Symposium of the American Vacuum Society, Minneapolis 1995; .
Ha, T.; Weiss, S.; Ogletree, D. F.; Botkin, D.; Enderle, T. ., Near Field detection of fluorescence resonance energy transfer between single molecules. Near Field Optics and Related Techniques, Brno, Czech Republic 1995; Published in the European Optical Society 1995 Topical Meetings Digest Series: vol. 8, pg. 135: .
Weiss, S.; Botkin, D.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Design considerations in an ultrafast scanning tunneling microscope. Rev. Sci. Instrum 1995; 66: 4130.
Weiss, S. Near Field detection of Fluorescence Resonance Energy Transfer between Single Donor-Acceptor Pair. National Quantum Electronics Conference QE-12, Southampton, United Kingdom 1995; .
Sucha, G.; Bolton, S. R.; Weiss, S.; Chemla, D. S. Period doubling and quasiperiodicity in additive pulse modelocked lasers. Opt. Lett 1995; 20: 1794.
Botkin, D.; Weiss, S.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S Quantum mechanical capacitance in scanning tunneling microscope. Quantum Electronics Topical Meeting, Dana Point 1995; Published in the OSA 1995 Technical Digest Series, vol. 14, paper QWA3, pg. 34: .
Weiss, S.; Botkin, D.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. The Ultrafast Response of a scanning Tunneling Microscope. Phys. Stat. Sol 1995; 188: 343.
Weiss, S.; Botkin, D.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Advances in ultrafast scanning probe microscopy. Ultrafast Phenomena Topical Meeting, Dana Point 1994; Published in the OSA 1994 Technical Digest Series, vol. 7, paper Wa2, pg. 301: .
Bigot, J. Y.; Mycek, M. A.; Weiss, S.; Ulbrich, R. G.; Chemla, D. S. Amplitude decay and instantaneous frequency dynamics of excitonic polarization in semiconductor quantum wells. Coherent Optical Interactions in Semiconductors 1994; edited by R.T. Phillips: .
Wiesenfeld, J. M.; Weiss, S.; Botkin, D.; Chemla, D. S. Carrier transport effects in multiple quantum well optical amplifiers. Optical and Quantum Electronics 1994; 26: S731.
Weiss, S. Looking at moving atoms. Seventh Lasers and Electro-Optics Society (LEOS) meeting, Boston 1994; .
Botkin, D.; Weiss, S.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Room Temperature quantum mechanical capacitance measured with the ultrafast scanning probe microscope. NANO-3, 41th National Symposium of the American Vacuum Society (NS-AVS), Denver, October 24th 1994; .
Botkin, D.; Weiss, S.; Sucha, G.; Chemla, D. S.; Wiesenfeld, J. M. Ultrafast dynamics of the optical mode of a 1.5mm multiple quantum well optical amplifier. Applied Physics Letters 1994; 65: 2861.
Chemla, D. S.; Bigot, J.; Mycek, M.; Weiss, S.; Schafer, W. Ultrafast phase dynamics of coherent emission from excitons in GaAs quantum wells. Physical Review B. Condensed Matter 1994; 50(12): 8439-8453.
Weiss, S. Ultrafast scanning probe microscopy. Fourth International Workshop on Nonlinear Optics and Excitation Kinetics in Semiconductors (NOEKS), Gosen near Berlin, Germany 1994; .
Botkin, D.; Weiss, S.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Ultrafast scanning probe microscopy. Proceedings of the SPIE 1994; 2116: .
Botkin, D.; Weiss, S.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Ultrafast scanning probe microscopy. SPIE, Los Angeles 1994; .
Weiss, S. Ultrafast scanning probe microscopy. Fourth International Conference on Intelligent Molecular Systems with Controlled Functionality, Okazaki, Japa 1994; .
Weiss, S. Ultrafast scanning probe microscopy - towards ultrafast movies of moving atoms. International Quantum Electronics Conference (IQEC), Anaheim 1994, Published in OSA 1994 Technical Digest Series 1994; Vol. 9(QTh11): 204.
Weiss, S. Ultrafast scanning probe microscopy - towards ultrafast movies of moving atoms. Tenth Interdisciplinary Laser Science Conference (ILS), Dallas 1994; .
Weiss, S. Ultrafast scanning probe microscopy - towards ultrafast movies of moving atoms. Surface and Interface Dynamics Discussion Symposium, University of Pennsylvania, Philadelphia 1994; .
Bigot, J.; Mycek, M.; Weiss, S.; Ulbrich, R. G.; Chemla, D. S. Instantaneous frequency dynamics of coherent wave mixing in semiconductor quantum wells. Physical Review Letters 1993; 70(21): 3307-3310.
Bigot, J. Y.; Mycek, M. A.; Weiss, S.; Ulbrich, R. G.; Chemla, D. S. Instantaneous frequency dynamics of coherent wave mixing in semiconductor quantum wells. NATO Advanced Research Workshop on Coherent Optical Interactions in Semiconductors 1993; .
Sucha, G.; Bolton, S. R.; Weiss, S.; Chemla, D. S. Nonlinear dynamics of additive-pulse mode-locked lasers: period doubling and chaos. Conference on Lasers and Electro-Optics (CLEO), Baltimore, paper JTuC6 1993; Published in OSA Technical Digest Series, vol. 11: .
Bigot, J. Y.; Ulbrich, R. G.; Mycek, M. A.; Weiss, S.; Chemla, D. S. Nonlinear phase dynamics of coherent light scattering from semiconductor quantum wells. Conference on Quantum Electronics and Laser Science (QELS) 1993; Published in OSA 1993 Technical Digest Series(Vol. 12): .
Botkin, D.; Weiss, S.; Chemla, D. S.; Levi, A. F. J.; Tanbun-Ek, T. Phase coherence in inverted semiconductors. Conference on Lasers and Electro-Optics (CLEO), Baltimore, paper JThA5 1993; Published in OSA Technical Digest Series, 1993, vol. 11: .
Weiss, S.; Ogletree, D. F.; Botkin, D.; Salmeron, M.; Chemla, D. S. Towards ultrafast movies of moving atoms. Optics and Photonics News 1993; 36: 4-12.
Weiss, S.; Botkin, D. A.; Chemla, D. S. Ultrafast Scanning Microscopy. Ultrafast Electronics & Optoelectronics Topical Meeting, San Francisco, (1993), paper WA4-1 1993; Published in OSA Technical Digest Conference Edition: .
Weiss, S. Ultrafast scanning probe microscopy. The Gordon Conference on Nolinear Optics and Lasers 1993; .
Weiss, S.; Botkin, D.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Ultrafast scanning probe microscopy. Ninth Interdisciplinary Laser Science Conference (ILS) 1993; .
Weiss, S.; Botkin, D.; Salmeron, M.; Chemla, D. S Ultrafast scanning probe microscopy. 40th National Symposium of the American Vacuum Society (NS-AVS), Orlando, November 15th 1993; .
Weiss, S.; Ogletree, D. F.; Botkin, D.; Salmeron, M.; Chemla, D. S. Ultrafast scanning probe microscopy. 16th Surface/Interface Research Meeting of the NCCAVS, IBM Almaden Research Center, San Jose, June 17th 1993; .
Weiss, S.; Ogletree, D. F.; Botkin, D.; Salmeron, M.; Chemla, D. S. Ultrafast scanning probe microscopy. Applied Physics Letters 1993; 63: 2567.
Weiss, S.; Botkin, D.; Ogletree, D. F.; Salmeron, M.; Chemla, D. S. Weiss, S.; Ogletree, D. F.; Botkin, D.; Salmeron, M.; Chemla, D. S. LEOS summer topical meeting on Optical Microwave Interactions, Santa Barbara 1993; .
Weiss, S.; Wiesenfeld, J.M; Chemla, D.S.; Raybon, G.; Sucha, G.; Wegener, M.; Eisenstein. G; Burrus, C.A.; Dentai, A.G.; Koren, U.; Miller, B.I.; Temkin, H.; Logan, R.A.; and Tanbun-Ek, T Carrier capture times in 1.5m multiple quantum well optical amplifiers. Applied Physics Letters 1992; 60: 9.
Weiss, S.; Mycek, M.; Bigot, J.; Schmitt-Rink, S.; Chemla, D. S. Collective effects in excitonic free induction decay: Do semiconductors and atoms emit coherent light in different ways? . Physical Review Letters 1992; 69(18): 2685-2688.
Weiss, S.; Botkin, D.; Chemla, D. S.; Sucha, G.; Bolton, S.; Weisenfeld, J. M.; Raybon, G.; Koren, U.; Temkin, H.; Logan, R. A.; Tanbun-Ek, T. Differences between the ultrafast TE and TM gain recovery dynamics in quantum well optical amplifiers. Conference on Lasers and Electro-Optics (CLEO), Anaheim, (1992), paper CWK3 1992; Published in OSA Technical Digest Series, 1992 vol. 12: .
Mycek, M. A.; Weiss, S.; Bigot, J. Y.; Schmitt-Rink, S.; Chemla, D. S. Femtosecond free-induction decay of room-temperature excitons in semiconductors. Conference on Quantum Electronics and Laser Science (QELS), Anaheim, paper QTuB5 1992; Published in OSA Technical Digest Series, 1992 vol. 13: .
Mycek, M. A.; Weiss, S.; Bigot, J. Y.; Schmitt-Rink, S.; Chemla, D. S Femtosecond free-induction decay of room-temperature excitons in semiconductors. International Quantum Electronics Conference(IQEC), Vienna 1992; .
Mycek, M. A.; Weiss, S.; Bigot, J. Y.; Schmitt-Rink, S.; Chemla, D. S.; Schaefer, W. Femtosecond time-resolved free-induction decay of room-temperature excitons in GaAs quantum wells. Applied Physics Letters 1992; 60: .
Weiss, S.; Mycek, M. A.; Bigot, J. Y.; Schmitt-Rink, S.; Chemla, D. S. Many-body interactions in the femtosecond free-induction decay of room-temperature excitons. Eighth Interdisciplinary Laser Science Conference (ILS) 1992; .
Weiss, S.; Mycek, M. A.; Bigot, J. Y.; Schmitt-Rink, S.; Chemla, D. S. Observation of many-body effects in the femtosecond temporal profile of quasi-2D exciton free-induction decay. Eighth International Conference on Ultrafast Phenomena, Antibes 1992; .
Weiss, S.; Botkin, D.; Chemla, D. S.; Sucha, G.; Bolton, S.; Weisenfeld, J. M.; Raybon, G.; Koren, U.; Temkin, H.; Logan, R. A.; Tanbun-Ek, T. Self focusing and thermalization effects in semiconductor quantum well optical amplifiers. International Quantum Electronics Conference(IQEC), Vienna 1992; .
Botkin, D.; Weiss, S.; Chemla, D. S.; Weisenfeld, J. M.; Raybon, G.; Koren, U.; Temkin, H.; Logan, R. A.; Tanbun-Ek, T. Time resolving self-focusing effects in semiconductors quantum well optical amplifiers. Conference on Lasers and Electro-Optics (CLEO), Anaheim, (1992), paper JThF2 1992; Published in OSA Technical Digest Series, 1992 vol. 12Published in OSA Technical Digest Series, 1992 vol. 12: .
Weiss, S.; Weisenfeld, J. M.; Chemla, D. S.; Raybon, G.; Sucha, G.; Eisenstein, G.; Burrus, C. A.; Dentai, A. G.; Koren, U.; Miller, B. I.; Temkin, H.; Logan, R. A.; Tanbun-Ek, T. Comparison of gain recovery dynamics among multiple quantum well optical amplifiers with different confinement structures. Conference on Quantum Electronics and Laser Science (QELS), Baltimore, (1991), paper QThD3 1991; Published in OSA 1991 Technical Digest Series, vol. 11: .
Sucha, G.; Weiss, S.; Chemla, D. S. Femtosecond continuum generation near 1.5mm from a color-center oscillator/amplifier system. Conference on Lasers and Electro-Optics (CLEO), Baltimore, paper TUO1 1991; Published in OSA Technical Digest Series(Vol. 10): .
Weisenfeld, J. M.; Weiss, S.; Chemla, D. S.; Eisenstein, G.; Koren, U.; Raybon, G.; Sucha, G.; Wegener, M. Structure dependence of carrier replenishment in multiple quantum well optical amplifiers. Topical meeting on Quantum OptoElectronics, Salt Lake City, paper WB1 1991; Published in OSA 1991 Technical Digest Series, vol. 7: .
Weiss, S.; Fischer, B. Dynamics of photorefractive nonlinear two-beam coupling and feedback effects. Optical and Quantum Electronics 1990; 22(Spec. Issue): S17-S45.
Sucha, G.; Wegener, M.; Weiss, S.; Chemla, D. S. Kilohertz amplification of femtosecond pulses near 1.551mm to microjoule energies. Topical meeting on Ultrafast Phenomena, Monterey 1990, Published in Springer series in Chemical Physics, Vol. 53, Ultrafast Phenomena VII, 1990, p. 32, paper WC11-1 1990; .
Weiss, S.; Fischer, B. Photorefractive optical bistability and instabilities. Conference on Lasers and Electro-Optics (CLEO), Anaheim, 1990, paper CTUD1 1990; Published in OSA Technical Digest Series(Volume 7): .
Eisenstein. G; Wiesenfeld, J.M; Wegener, M.; Sucha, G.; Chemla, D.S.; Weiss, S. Ultrafast gain dynamics in 1.5m multiple quantum well optical amplifiers. Applied Physics Letters 1990; 58: 158.
Weisenfeld, J. M.; Eisenstein, G.; Wegener, M.; Chemla, D. S.; Raybon, G.; Weiss, S. Weiss, S., Gain compression and recovery dynamics in multiple quantum well optical amplifiers. Topical meeting on Ultrafast Phenomena, Monterey paper ThC23- 1990; Published in Springer series in Chemical Physics, Vol. 53, Ultrafast Phenomena VII, 1990, p. 60: .
Weiss, S.; Werner, O.; and Fischer, B. Analysis of coupled photorefractive wave-mixing junctions. Opt. Lett 1989; 14: 186.
Fischer, B.; Weiss, S.; Werner, O. Coupled double phase conjugate mirrors in photorefractive materials. Conference on Lasers and Electro-Optics (CLEO), Baltimore, Published in OSA Technical Digest Series 1989; 11: Paper TU13.
Weiss, S.; Fischer, B. Instabilities and self-pulsation in a ring cavity with a photorefractive wave mixer. Opt. Lett 1989; 14(21): 1213-15.
Fischer, B.; Sternklar. S.; and Weiss, S. Photorefractive Oscillator. IEEE J. Quantum Electron 1989; QE-25: 550.
Weiss, S.; Fischer, B. Photorefractive Stark effect and its applications. Conference on Quantum Electronics and Laser Science (QELS), Baltimore, Published in OSA Technical Digest Series, Postdeadline Papers 1989; PD4-1.
Weiss, S.; Segev, S.; Sternklar, S.; Fischer, B. Photorefractive dynamical optical interconnects. Proc. of the 1988 Electro-Optic and Magneto-Optic Materials Conference, SPIE, Hamburg 1989; .
Weiss, S.; Fischer, B. Photorefractive saturable absorptive and dispersive optical bistability. IEEE, the 16th Conference of Electrical and Electronics Engineers in Israel, Proceedings, 4.5.2 1989; .
Weiss, S.; Fischer, B. Photorefractive saturable absorptive and dispersive optical bistability. Optics Communications 1989; 70(6): 515-21.
Fischer, B.; Segev, S.; Weiss, S Unique nonlinear wave mixing effects in photorefractive waveguides and bulks. Conference on Lasers and Electro-Optics (CLEO), Baltimore, paper TUO1 1989; Published in OSA Technical Digest Series(Volume 11): .
Weiss, S.; Segev, M.; Fischer, B. Line narrowing and self frequency scanning of laser diode arrays coupled to a photorefractive oscillator. IEEE J. Quantum Electron 1988; QE-24: 706.
Weiss, S., Segev, M.,Sternklar, S., and Fischer, B. Photorefractive Dynamic Optical Interconnects. Applied Physics Letters 1988; 27: 3422.
Weiss, S.; Fischer, B. Photorefractive dynamical optical interconnects. Proc. of the 1988 Electro-Optic and Magneto-Optic Materials Conference, Hamburg 1989. Proceedings of the SPIE 1988; 1018: .
Fischer, B.; Weiss, S. Solvable optimized four-wave mixing configuration with cubic photorefractive crystals. Applied Physics Letters 1988; 53: 257.
Segev, M.; Weiss, S.; Fischer, B. Coupling of diode laser arrays with photorefractive passive phase conjugate mirrors. Applied Physics Letters 1987; 50(20): 1397-9.
Segev, M.; Weiss, S.; Fischer, B. Diode laser array coupling. IEEE, the 15th Conference of Electrical and Electronics Engineers in Israel, Proceedings, 3.5.1 1987; .
Fischer, B.; Sternklar, S.; Weiss, S Filtering effects of spatialy modulated beams in photorefractive oscillators. Conference on Lasers and Electro-Optics (CLEO), Baltimore, Published in OSA Technical Digest Series 1987; 14: 158.
Weiss, S.; Sternklar, S.; Fischer, B. Optical image processing and spatial filtering by nonlinear wave mixing. IEEE, the 15th Conference of Electrical and Electronics Engineers in Israel, Proceedings 3.5.5 1987; .
Sternklar, S.; Weiss, S.; Fischer, B. Optical information processing with the double phase conjugate mirror. Optical Engineering 1987; 26(5): 423-7.
Segev, M.; Weiss, S.; Fischer, B. Semiconductor laser array coupling by photorefractive wave-mixing. Conference on Lasers and Electro-Optics (CLEO), Baltimore 1987; .
Fischer, B.; S., W.; Sternklar, S. Spatial light modulation and filtering effects in photorefractive wave mixing. Applied Physics Letters 1987; 50: 483.
Sternklar, S.; Weiss, S.; Segev, M.; Fischer, B. Beam clean-up, beam combining and laser coupling using nonlinear wave-mixing. Optical Society of America Meeting, Seattle 1986; .
Sternklar, S.; Weiss, S.; Segev, M.; Fischer, B., Beam coupling and locking of lasers using photorefractive four-wave mixing. Opt. Lett 1986; 11: 528.
Sternklar, S.; S., W.; Fischer, B. Double phase conjugate mirror: analysis, demonstration, and applications. Opt. Lett 1986; 12: 114.
Sternklar, S.; Weiss, S.; Segev, M.; Fischer, B Image bearing photorefractive oscillators. Proc. of the 1986 International Optical Computing Conference, Jerusalem 1986. Proceedings of the SPIE 1986; 700: 173.
Sternklar, S., Weiss, S., Segev, M. and Fischer, B. Mach-Zehnder interferometer with multimode fibers using the double phase conjugate mirror. Appl. Optics 1986; 25: 4518.
Fischer, B.; Sternklar, S.; Weiss, S., Photorefractive oscillation with intracavity image and multimode fiber. Applied Physics Letters 1986; 48(23): 1567-9.
Fischer, B.; Sternklar, S. Theoretical and experimental study of frequency detuning in photorefractive oscillators. Optical Society of America Meeting, Seattle 1986; .
Sternklar, S.; S., W. Tunable frequency shifts of photorefractive oscillators. Opt. Lett 1986; 11: 165.
Sternklar, S.; S., W.; Fischer, B., Controlling the self-frequency shift and intensity of oscillations with photorefractive crystals. Appl. Optics 1985; 24: 3121.