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Paivi Elisabeth Pajukanta, M.D., Ph.D.

Work Address:
Gonda Center
Los Angeles, CA 90095 Gonda Center
Los Angeles, CA 90095

Affiliations
Affiliations
Director, Genetics & Genomics GPB Home Area
Professor, Human Genetics
Member, Bioinformatics GPB Home Area, Cell & Developmental Biology GPB Home Area
Research Interests
Dr. Pajukanta's laboratory focuses on genetics of cardiovascular disorders with a particular interest in the premature coronary heart disease (CHD) and familial lipid disorders such as familial combined hyperlipidemia (FCHL) and decreased high-density lipoprotein (HDL)-cholesterol predisposing to premature CHD. During the last 15 years, Dr. Pajukanta's research group has conducted several genome-wide scans for cardiovascular traits, and identified genes for FCHL, hypertriglyceridemia, low HDL-C, obesity, and combined lipase deficiency. Their current studies focus on targeted resequencing, exome sequencing, genomic gene expression and association analysis to identify variants, genes, and pathways for complex cardiovascular traits, utilizing both study samples from diverse populations and a variety of novel and state of the art statistical methods of systems genetics. The characterization of genes for cardiovascular traits has a great potential to develop more accurate diagnostic tools, earlier detection, preventive interventions, and biology-based targeted therapeutical strategies.
Biography

Paivi Pajukanta, MD, PhD, is a Professor of Human Genetics at UCLA. Her research group is identifying biological mechanisms of DNA variants and genes involved in complex cardiovascular and metabolic disorders using integrative genomics approaches. Her research aims to discover gene-environment interactions and context-specific transcriptional and epigenomic effects contributing to cardiometabolic disorders in Mexicans and Europeans by integrating transcriptomics, epigenomics, and genomics data with deep clinical and histology-based phenotype and electronic medical record data. Dr. Pajukanta is especially interested in single cell RNA-sequencing studies of metabolic tissues to decompose cell-type proportions and cell-type specific expression of genes and their connections to cardiometabolic traits; as well as in genomic studies of the admixed Mexican population that has been underrepresented in genomic studies despite their high predisposition to obesity, type 2 diabetes, dyslipidemias, fatty liver disease, and other cardiometabolic disorders. Dr. Pajukanta has served as a principal investigator in several NIH R01 grants and as a Project Leader of an NIH PPG grant. She has trained multiple undergraduate, graduate, and postdoctoral students; taught graduate level courses; and served as a problem-based learning tutor of medical students. She is also the Director of the Genetics and Genomics Home Area of graduate education at UCLA; the Vice Chair in the Department of Human Genetics at UCLA; and the Director of Cardiometabolic Genomics at the Institute for Precision Health at UCLA.

Publications

A selected list of publications:

Jew Brandon, Alvarez Marcus, Rahmani Elior, Miao Zong, Ko Arthur, Garske Kristina M, Sul Jae Hoon, Pietiläinen Kirsi H, Pajukanta Päivi, Halperin Eran   Accurate estimation of cell composition in bulk expression through robust integration of single-cell information Nature communications, 2020; 11(1): 1971.
Mefford Joel, Park Danny, Zheng Zhili, Ko Arthur, Ala-Korpela Mika, Laakso Markku, Pajukanta Päivi, Yang Jian, Witte John, Zaitlen Noah   Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models Journal of computational biology : a journal of computational molecular cell biology, 2020; 27(4): 599-612.
Garske Kristina M, Pan David Z, Miao Zong, Bhagat Yash V, Comenho Caroline, Robles Christopher R, Benhammou Jihane N, Alvarez Marcus, Ko Arthur, Ye Chun Jimmie, Pisegna Joseph R, Mohlke Karen L, Sinsheimer Janet S, Laakso Markku, Pajukanta Päivi   Reverse gene-environment interaction approach to identify variants influencing body-mass index in humans Nature metabolism, 2019; 1(6): 630-642.
Gallois Apolline, Mefford Joel, Ko Arthur, Vaysse Amaury, Julienne Hanna, Ala-Korpela Mika, Laakso Markku, Zaitlen Noah, Pajukanta Päivi, Aschard Hugues   A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context Nature communications, 2019; 10(1): 4788.
Wu Ying, Broadaway K Alaine, Raulerson Chelsea K, Scott Laura J, Pan Calvin, Ko Arthur, He Aiqing, Tilford Charles, Fuchsberger Christian, Locke Adam E, Stringham Heather M, Jackson Anne U, Narisu Narisu, Kuusisto Johanna, Pajukanta Päivi, Collins Francis S, Boehnke Michael, Laakso Markku, Lusis Aldons J, Civelek Mete, Mohlke Karen L   Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution Human molecular genetics, 2019; 28(24): 4161-4172.
Lea Amanda, Subramaniam Meena, Ko Arthur, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Mononen Nina, Raitakari Olli T, Ala-Korpela Mika, Pajukanta Päivi, Zaitlen Noah, Ayroles Julien F   Genetic and environmental perturbations lead to regulatory decoherence eLife, 2019; 8(4): e1008009.
Dahl Andy, Cai Na, Ko Arthur, Laakso Markku, Pajukanta Päivi, Flint Jonathan, Zaitlen Noah   Reverse GWAS: Using genetics to identify and model phenotypic subtypes PLoS genetics, 2019; 15(4): e1008009.
Miao Zong, Alvarez Marcus, Pajukanta Päivi, Ko Arthur   ASElux: an ultra-fast and accurate allelic reads counter Bioinformatics (Oxford, England), 2018; 34(8): 1313-1320.
Rodríguez Alejandra, Pajukanta Päivi   GENOMICS AND SYSTEMS BIOLOGY APPROACHES IN THE STUDY OF LIPID DISORDERS Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2018; 70(5): 217-223.
Pan David Z, Garske Kristina M, Alvarez Marcus, Bhagat Yash V, Boocock James, Nikkola Elina, Miao Zong, Raulerson Chelsea K, Cantor Rita M, Civelek Mete, Glastonbury Craig A, Small Kerrin S, Boehnke Michael, Lusis Aldons J, Sinsheimer Janet S, Mohlke Karen L, Laakso Markku, Pajukanta Päivi, Ko Arthur   Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS Nature communications, 2018; 9(1): 1512.
Freund Malika Kumar, Burch Kathryn S, Shi Huwenbo, Mancuso Nicholas, Kichaev Gleb, Garske Kristina M, Pan David Z, Miao Zong, Mohlke Karen L, Laakso Markku, Pajukanta Päivi, Pasaniuc Bogdan, Arboleda Valerie A   Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits American journal of human genetics, 2018; 103(4): 535-552.
Nikkola Elina, Ko Arthur, Alvarez Marcus, Cantor Rita M, Garske Kristina, Kim Elliot, Gee Stephanie, Rodriguez Alejandra, Muxel Reinhard, Matikainen Niina, Söderlund Sanni, Motazacker Mahdi M, Borén Jan, Lamina Claudia, Kronenberg Florian, Schneider Wolfgang J, Palotie Aarno, Laakso Markku, Taskinen Marja-Riitta, Pajukanta Päivi   Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family Atherosclerosis, 2017; 264(5): 58-66.
Civelek Mete, Wu Ying, Pan Calvin, Raulerson Chelsea K, Ko Arthur, He Aiqing, Tilford Charles, Saleem Niyas K, Stančáková Alena, Scott Laura J, Fuchsberger Christian, Stringham Heather M, Jackson Anne U, Narisu Narisu, Chines Peter S, Small Kerrin S, Kuusisto Johanna, Parks Brian W, Pajukanta Päivi, Kirchgessner Todd, Collins Francis S, Gargalovic Peter S, Boehnke Michael, Laakso Markku, Mohlke Karen L, Lusis Aldons J   Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits American journal of human genetics, 2017; 100(3): 428-443.
Fejzo Marlena Schoenberg, Myhre Ronny, Colodro-Conde Lucía, MacGibbon Kimber W, Sinsheimer Janet S, Reddy M V Prasad Linga, Pajukanta Päivi, Nyholt Dale R, Wright Margaret J, Martin Nicholas G, Engel Stephanie M, Medland Sarah E, Magnus Per, Mullin Patrick M   Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2) Molecular and cellular endocrinology, 2017; 439(3): 308-316.
Laakso Markku, Kuusisto Johanna, Stančáková Alena, Kuulasmaa Teemu, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Mohlke Karen L, Boehnke Michael   The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases Journal of lipid research, 2017; 58(3): 481-493.
Gusev Alexander, Ko Arthur, Shi Huwenbo, Bhatia Gaurav, Chung Wonil, Penninx Brenda W J H, Jansen Rick, de Geus Eco J C, Boomsma Dorret I, Wright Fred A, Sullivan Patrick F, Nikkola Elina, Alvarez Marcus, Civelek Mete, Lusis Aldons J, Lehtimäki Terho, Raitoharju Emma, Kähönen Mika, Seppälä Ilkka, Raitakari Olli T, Kuusisto Johanna, Laakso Markku, Price Alkes L, Pajukanta Päivi, Pasaniuc Bogdan   Integrative approaches for large-scale transcriptome-wide association studies Nature genetics, 2016; 48(3): 245-52.
Rodríguez Alejandra, Gonzalez Luis, Ko Arthur, Alvarez Marcus, Miao Zong, Bhagat Yash, Nikkola Elina, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernández Linda L, Ordóñez-Sánchez Maria-Luisa, Rodriguez-Guillen Rosario, Mohlke Karen L, Laakso Markku, Tusie-Luna Teresa, Aguilar-Salinas Carlos A, Pajukanta Päivi   Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene Arteriosclerosis, thrombosis, and vascular biology, 2016; 36(7): 1350-5.
Kaminska Dorota, Käkelä Pirjo, Nikkola Elina, Venesmaa Sari, Ilves Imre, Herzig Karl-Heinz, Kolehmainen Marjukka, Karhunen Leila, Kuusisto Johanna, Gylling Helena, Pajukanta Päivi, Laakso Markku, Pihlajamäki Jussi   Regulation of alternative splicing in human obesity loci Obesity (Silver Spring, Md.), 2016; 24(10): 2033-7.
Ripatti Pietari, Rämö Joel T, Söderlund Sanni, Surakka Ida, Matikainen Niina, Pirinen Matti, Pajukanta Päivi, Sarin Antti-Pekka, Service Susan K, Laurila Pirkka-Pekka, Ehnholm Christian, Salomaa Veikko, Wilson Richard K, Palotie Aarno, Freimer Nelson B, Taskinen Marja-Riitta, Ripatti Samuli   The Contribution of GWAS Loci in Familial Dyslipidemias PLoS genetics, 2016; 12(5): e1006078.
Hsu William, Gonzalez Nestor R, Chien Aichi, Pablo Villablanca J, Pajukanta Päivi, Viñuela Fernando, Bui Alex A T   An integrated, ontology-driven approach to constructing observational databases for research Journal of biomedical informatics, 2015; 55(9): 132-42.
Wiegman Albert, Gidding Samuel S, Watts Gerald F, Chapman M John, Ginsberg Henry N, Cuchel Marina, Ose Leiv, Averna Maurizio, Boileau Catherine, Borén Jan, Bruckert Eric, Catapano Alberico L, Defesche Joep C, Descamps Olivier S, Hegele Robert A, Hovingh G Kees, Humphries Steve E, Kovanen Petri T, Kuivenhoven Jan Albert, Masana Luis, Nordestgaard Børge G, Pajukanta Päivi, Parhofer Klaus G, Raal Frederick J, Ray Kausik K, Santos Raul D, Stalenhoef Anton F H, Steinhagen-Thiessen Elisabeth, Stroes Erik S, Taskinen Marja-Riitta, Tybjærg-Hansen Anne, Wiklund Olov, Wiklund Olov   Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment European heart journal, 2015; 36(36): 2425-37.
Nikkola Elina, Laiwalla Azim, Ko Arthur, Alvarez Marcus, Connolly Mark, Ooi Yinn Cher, Hsu William, Bui Alex, Pajukanta Päivi, Gonzalez Nestor R   Remote Ischemic Conditioning Alters Methylation and Expression of Cell Cycle Genes in Aneurysmal Subarachnoid Hemorrhage Stroke, 2015; 46(9): 2445-51.
Cuchel Marina, Bruckert Eric, Ginsberg Henry N, Raal Frederick J, Santos Raul D, Hegele Robert A, Kuivenhoven Jan Albert, Nordestgaard Børge G, Descamps Olivier S, Steinhagen-Thiessen Elisabeth, Tybjaerg-Hansen Anne, Watts Gerald F, Averna Maurizio, Boileau Catherine, Borén Jan, Catapano Alberico L, Defesche Joep C, Hovingh G Kees, Humphries Steve E, Kovanen Petri T, Masana Luis, Pajukanta Päivi, Parhofer Klaus G, Ray Kausik K, Stalenhoef Anton F H, Stroes Erik, Taskinen Marja-Riitta, Wiegman Albert, Wiklund Olov, Chapman M John, Chapman M John   [Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society] Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2015; 43 Suppl 1(9): 1-14.
Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Linga Reddy PMV, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen M-R, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P   Amerindian-specific regions under positive selection harbor new lipid variants in Latinos, Nature Communications, 2014; (5): 3983.
Almeda-Valdes Paloma, Cuevas-Ramos Daniel, Mehta Roopa, Muñoz-Hernandez Liliana, Cruz-Bautista Ivette, Perez-Mendez Oscar, Tusie-Luna Maria Teresa, Gomez-Perez Francisco J, Pajukanta Päivi, Matikainen Niina, Taskinen Marja-Riitta, Aguilar-Salinas Carlos A   Factors associated with postprandial lipemia and apolipoprotein A-V levels in individuals with familial combined hyperlipidemia BMC endocrine disorders, 2014; 14(9): 90.
Aguilar-Salinas Carlos A, Tusie-Luna Teresa, Pajukanta Päivi   Genetic and environmental determinants of the susceptibility of Amerindian derived populations for having hypertriglyceridemia Metabolism: clinical and experimental, 2014; 63(7): 887-94.
Cuchel Marina, Bruckert Eric, Ginsberg Henry N, Raal Frederick J, Santos Raul D, Hegele Robert A, Kuivenhoven Jan Albert, Nordestgaard Børge G, Descamps Olivier S, Steinhagen-Thiessen Elisabeth, Tybjærg-Hansen Anne, Watts Gerald F, Averna Maurizio, Boileau Catherine, Borén Jan, Catapano Alberico L, Defesche Joep C, Hovingh G Kees, Humphries Steve E, Kovanen Petri T, Masana Luis, Pajukanta Päivi, Parhofer Klaus G, Ray Kausik K, Stalenhoef Anton F H, Stroes Erik, Taskinen Marja-Riitta, Wiegman Albert, Wiklund Olov, Chapman M John, Chapman M John   Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society European heart journal, 2014; 35(32): 2146-57.
Iulia Iatan, Hong Y. Choi, Isabelle Ruel, MV Prasad Linga Reddy, Kil Hyunsuk, Jaeho Lee, Mohammad Abu Odeh, Zaidoun Salah, Muhannad Abu-Remaileh, Daphna Weissglas-Volkov, Elina Nikkola, Mete Civelek, Zuhier Awan, Carlo M. Croce, Rami I. Aqeilan, Päivi Pajukanta, C. Marcelo Aldaz, Jacques Genest   The WW Domain-containing Oxidoreductase Gene Modulates HDL Metabolism and Lipoprotein Gene Expression, Circulation: Cardiovascular Genetics, 2014; 7: 491-504.
Hegele Robert A, Ginsberg Henry N, Chapman M John, Nordestgaard Børge G, Kuivenhoven Jan Albert, Averna Maurizio, Borén Jan, Bruckert Eric, Catapano Alberico L, Descamps Olivier S, Hovingh G Kees, Humphries Steve E, Kovanen Petri T, Masana Luis, Pajukanta Päivi, Parhofer Klaus G, Raal Frederick J, Ray Kausik K, Santos Raul D, Stalenhoef Anton F H, Stroes Erik, Taskinen Marja-Riitta, Tybjærg-Hansen Anne, Watts Gerald F, Wiklund Olov, Wiklund Olov   The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management The lancet. Diabetes & endocrinology, 2014; 2(8): 655-66.
Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M.   Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men, Diabetes, 2013; (62): 3618-3626.
Daphna Weissglas-Volkov, Carlos A. Aguilar-Salinas, Elina Nikkola, Kerry Deere, Ivette Cruz-Bautista, Olimpia Arellano-Campos, Linda Liliana Muñoz-Hernandez, Lizeth Gomez-Munguia, Maria Luisa Ordoñez-Sánchez, Prasad MV Linga Reddy, Aldons J. Lusis, Laura Riba, Rita M. Cantor, Janet S. Sinsheimer, Teresa Tusie-Luna, Päivi Pajukanta   Genome-wide association study in Mexicans identifies a new locus for triglycerides and refines European lipid loci, Journal of Medical Genetics, 2013; 50: 298-308.
MV Prasad Linga Reddy, Iulia Iatan, Daphna Weissglas-Volkov, Elina Nikkola, Blake E. Haas, Miina Juvonen, Isabelle Ruel, Janet S. Sinsheimer, Jacques Genest, Päivi Pajukanta   Exome sequencing identifies two rare variants for low HDL-C in an extended family, Circulation: Cardiovascular Genetics. , 2012; (5): 538-546.
Alena Stancáková, Mete Civelek, Pasi Soininen, Antti J. Kangas, Henna Cederberg, Jussi Paananen, Jussi Pihlajamäki, Lori L. Bonnycastle, Mario A. Morken, Michael Boehnke, Päivi Pajukanta, Aldons J. Lusis, Francis S. Collins, Johanna Kuusisto, Mika Ala-Korpela and Markku Laakso.   Hyperglycemia and a Common Variant of GCKR Are Associated with the Levels of Eight Amino Acids in 9,369 Finnish Men. , Diabetes, 2012; 61: 1895-1902.
Blake E. Haas, Daphna Weissglas-Volkov, Carlos A. Aguilar-Salinas, Elina Nikkola, Laurent Vergnes, Ivette Cruz-Bautista, Laura Riba, Alena Stancakova, Johanna Kuusisto, Pasi Soininen, Antti J. Kangas, Mika Ala-Korpela, Teresa Tusie-Luna, Markku Laakso, Päivi Pajukanta.   Evidence of how rs7575840 influences apolipoprotein B containing lipid particles, Arteriosclerosis Thrombosis and Vascular Biology, 2011; 31: 1201-1207.
Daphna Weisglass-Volkov, Anna C. Calkin, Teresa Tusie-Luna, Janet S. Sinsheimer, Noam Zelcer, Laura Riba, Ana Maria Vargas Tino, Maria Luisa Ordoñez-Sánchez, Ivette Cruz-Bautista, Carlos A. Aguilar-Salinas, Peter Tontonoz and Päivi Pajukanta.   The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL-receptor degradation in humans, The Journal of Clinical Investigation. , 2011; 121: 3062-3071.
Daphna Weissglas-Volkov, Carlos A. Aguilar-Salinas, Janet S. Sinsheimer, Laura Riba, Adriana Huertas-Vazquez, Maria L. Ordoñez-Sánchez, Rosario Rodriguez-Guillen, Rita M. Cantor, Teresa Tusie-Luna, Päivi Pajukanta.   Investigation of variants identified in Caucasian genome-wide association studies for plasma HDL cholesterol and triglycerides levels in Mexican dyslipidemic study samples, Circulation: Cardiovascular Genetics. , 2010; 3: 31-38.
Christopher L. Plaisier, Steve Horvath, Adriana Huertas-Vazquez, Ivette Cruz-Bautista, Miguel F. Herrera, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Päivi Pajukanta.   A systems genetics approach implicates USF1, FADS3 and other causal candidate genes for familial combined hyperlipidemia. , PLoS Genetics, 2009; Sep;5(9):e1000642.: .
Christopher L Plaisier, Mira Kyttälä, Daphna Weissglas-Volkov, Janet S. Sinsheimer, Adriana Huertas-Vazquez, Laura Riba, Salvador Ramírez-Jiménez, Tjerk W. A. de Bruin, Teresa Tusié-Luna, Bradley E. Aouizerat, Clive R. Pullinger, Mary J. Malloy, John P. Kane, Ivette Cruz-Bautista, Miguel F. Herrera, Carlos Aguilar-Salinas, Johanna Kuusisto, Markku Laakso, Marja-Riitta Taskinen, Carla J. H. van der Kallen, Päivi Pajukanta   Galanin preproprotein is associated with elevated plasma triglycerides, Arteriosclerosis Thrombosis and Vascular Biology, 2009; 29: 147-152.
Sinsheimer Janet S, Plaisier Christopher L, Huertas-Vazquez Adriana, Aguilar-Salinas Carlos, Tusie-Luna Teresa, Pajukanta Päivi, Lange Kenneth   Estimating Ethnic Admixture from Pedigree Data. The American Journal of Human Genetics, 2008; 82(3): 748-55.
Jenny C. Lee, Daphna Weissglas-Volkov, Mira Kyttälä, Zari Dastani, Rita M. Cantor, Eric M. Sobel, Christopher Plaisier, Jamie C. Engert, Marleen M.J. van Greevenbroek, John P. Kane, Mary J. Malloy, Clive R. Pullinger, Adriana Huertaz-Vazquez, Carlos A. Aguilar-Salinas, Teresa Tusie- Luna, Tjerk W. A. de Bruin, Bradley E. Aouizerat, Carla van der Kallen, Carlo M. Croce, Rami I. Aqeilan, Michel Marcil, Jorma S. A. Viikari, Terho Lehtimäki, Olli T. Raitakari, Johanna Kuusisto, Markku Laakso, Marja-Riitta Taskinen, Jacques Genest, Päivi Pajukanta   WW domain-containing oxidoreductase is associated with low plasma HDL-C levels, The American Journal of Human Genetics, 2008; 83: 180-192.
Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D, Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH.   Mutations in the novel LMF1 gene cause combined lipase deficiency and severe hypertriglyceridemia. , Nature Genetics, 2007; 39: 1483-1487.
Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TWA, van Greevenbroek MMJ, Lusis AJ, Brennan M-L, van der Kallen CJH, Hazen SL, Pajukanta P.   USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. Whites with coronary artery disease. , Arteriosclerosis Thrombosis and Vascular Biology, 2007; 27: 2222-2227.
Weissglas-Volkov D, Huertas-Vazquez A, Suviolahti E, Lee J, Plaisier C, Canizales-Quinteros S, Tusie-Luna T, Aguilar-Salinas C, Taskinen M-R, Pajukanta P.   Common hepatic nuclear factor 4 alpha variants are associated with high serum lipid levels and the metabolic syndrome. , Diabetes, 2006; 55: 1970-1977.
Dastani, Z. Quiogue, L. Plaisier, C. Engert, J. C. Marcil, M. Genest, J. Pajukanta, P.   Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21 Arterioscler Thromb Vasc Biol, 2006; 26(2): 392-7.
Cantor, R. M. Chen, G. K. Pajukanta, P. Lange, K.   Association testing in a linked region using large pedigrees Am J Hum Genet, 2005; 76(3): 538-42.
Huertas-Vazquez, A. Aguilar-Salinas, C. Lusis, A. J. Cantor, R. M. Canizales-Quinteros, S. Lee, J. C. Mariana-Nunez, L. Riba-Ramirez, R. M. Jokiaho, A. Tusie-Luna, T. Pajukanta, P.   Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1 Arterioscler Thromb Vasc Biol, 2005; 25(9): 1985-91.
Pajukanta, P. Lilja, H. E. Sinsheimer, J. S. Cantor, R. M. Lusis, A. J. Gentile, M. Duan, X. J. Soro-Paavonen, A. Naukkarinen, J. Saarela, J. Laakso, M. Ehnholm, C. Taskinen, M. R. Peltonen, L.   Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1) Nat Genet, 2004; 36(4): 371-6.
Pajukanta, P. Allayee, H. Krass, K. L. Kuraishy, A. Soro, A. Lilja, H. E. Mar, R. Taskinen, M. R. Nuotio, I. Laakso, M. Rotter, J. I. de Bruin, T. W. Cantor, R. M. Lusis, A. J. Peltonen, L.   Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q Am J Hum Genet, 2003; 72(4): 903-17.
Suviolahti, E. Oksanen, L. J. Ohman, M. Cantor, R. M. Ridderstrale, M. Tuomi, T. Kaprio, J. Rissanen, A. Mustajoki, P. Jousilahti, P. Vartiainen, E. Silander, K. Kilpikari, R. Salomaa, V. Groop, L. Kontula, K. Peltonen, L. Pajukanta, P.   The SLC6A14 gene shows evidence of association with obesity J Clin Invest, 2003; 112(11): 1762-72.
Soro, A. Pajukanta, P. Lilja, H. E. Ylitalo, K. Hiekkalinna, T. Perola, M. Cantor, R. M. Viikari, J. S. Taskinen, M. R. Peltonen, L.   Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families Am J Hum Genet, 2002; 70(5): 1333-40.
Pajukanta, P. Cargill, M. Viitanen, L. Nuotio, I. Kareinen, A. Perola, M. Terwilliger, J. D. Kempas, E. Daly, M. Lilja, H. Rioux, J. D. Brettin, T. Viikari, J. S. Ronnemaa, T. Laakso, M. Lander, E. S. Peltonen, L.   Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland Am J Hum Genet, 2000; 67(6): 1481-93.
Pajukanta, P. Terwilliger, J. D. Perola, M. Hiekkalinna, T. Nuotio, I. Ellonen, P. Parkkonen, M. Hartiala, J. Ylitalo, K. Pihlajamaki, J. Porkka, K. Laakso, M. Viikari, J. Ehnholm, C. Taskinen, M. R. Peltonen, L.   Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels Am J Hum Genet, 1999; 64(5): 1453-63.
Pajukanta, P. Nuotio, I. Terwilliger, J. D. Porkka, K. V. Ylitalo, K. Pihlajamaki, J. Suomalainen, A. J. Syvanen, A. C. Lehtimaki, T. Viikari, J. S. Laakso, M. Taskinen, M. R. Ehnholm, C. Peltonen, L.   Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23 Nat Genet, 1998; 18(4): 369-73.