Erik S. Schweitzer, M.D., Ph.D.

Work Address:
Life Sciences
Los Angeles, CA 90095 Life Sciences
Los Angeles, CA 90095

Research Interests
The goal of my research is to understand, at a molecular level, the mechanisms responsible for the release of neurotransmitters and neuropeptides at the synapse. This includes early events of sorting and targeting of vesicle contents as well as late events involved with fusion of the vesicle membrane with the presynaptic plasma membrane. Using neuronal (PC12) cells, we have engineered cell lines that express and target foreign secretory proteins to the synaptic vesicles. We have examined the involvement of CaM kinase II in the fusion event, and have most recently discovered and initiated the characterization of a novel component of synaptic vesicles, which we have named synvesiclin, reflecting its presence on both large dense-core and small synaptic vesicles. The data we have obtained to date suggest that synvesiclin plays a fundamental role in synaptic vesicle dynamics, and that analyzing its properties will help to understand the molecular steps responsible for neurosecretion.

A selected list of publications:

Woolf, N.J., Milov, A.M., Schweitzer, E.S., and Roghani, A   Elevation of nerve growht faactor and antisense knockdown of TrkA receptor during contextual memory consolidation, J. Neurosci, 2001; 21: 1047-1055.
Behrstock, SP Anantharam, V Thompson, KW Schweitzer, ES Tobin, AJ   Conditionally-immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation Journal of neuroscience research. , 2000; 60(3): 302-10.
Jeng, CJ McCarroll, SA Martin, TF Floor, E Adams, J Krantz, D Butz, S Edwards, R Schweitzer, ES   Thy-1 is a component common to multiple populations of synaptic vesicles The Journal of cell biology. , 1998; 140(3): 685-98.
Fiala, M Looney, DJ Stins, M Way, DD Zhang, L Gan, X Chiappelli, F Schweitzer, ES Shapshak, P Weinand, M Graves, MC Witte, M Kim, KS   TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier Molecular medicine (Cambridge, Mass.) , 1997; 3(8): 553-64.
Schweitzer, ES Jeng, CJ Tao-Cheng, JH   Selective localization and regulated release of calcitonin gene-related peptide from dense-core vesicles in engineered PC12 cells Journal of neuroscience research. , 1996; 46(5): 519-30.
Schweitzer, ES Sanderson, MJ Wasterlain, CG   Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62 Journal of cell science. , 1995; 108 ( Pt 7): 2619-28.
Liu, Y Schweitzer, ES Nirenberg, MJ Pickel, VM Evans, CJ Edwards, RH   Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells The Journal of cell biology. , 1994; 127(5): 1419-33.
Schweitzer, ES   Regulated and constitutive secretion of distinct molecular forms of acetylcholinesterase from PC12 cells Journal of cell science. , 1993; 106 ( Pt 3): 731-40.