David T. Wong, D.M.D., D.M.Sc.

Laboratory Address:
10833 Le Conte Avenue, 73-017 CHS
Los Angeles, CA 90095

Mailing Address:
10833 Le Conte Avenue
73-017 CHS
Los Angeles, CA 90095

Director, Dental Research Institute
Director and Principal Investigator, Center for Oral/Head & Neck Oncology Research
Felix & Mildred Yip Endowed Professor, Dentistry
Professor, Bioengineering, Head and Neck Surgery
Associate Dean for Research, Dentistry
Member, CTSI, JCCC Cancer and Stem Cell Biology Program Area, JCCC Signal Transduction and Therapeutics Program Area
Research Interests
My laboratory currently has three research directions in head and neck cancer research: Discoveries, pathogenesis and oral fluid-based molecular diagnostics. DISCOVERIES: My laboratory spearheads the use of genome-wide and proteome-wide technologies to harness the diagnostic and biological determinants pertaining to the pathogenesis of oral/head and neck cancer. In particular we are focusing on the genomic and proteomic determinants of oral precancer progression. Using a patient-based genome/proteome-wide approaches; we are harnessing the genomic and proteomic determinants that distinguish progressing from non-progression oral precancers. For genomic defects, a concurrent approach to identify gene copy number abnormalities (CNA) by cDNA microarray comparative genomic hybridization (CGH) as well as SNP-based loss of heterozygosity (LOH) using the Affymetrix 100K SNP-based Mapping Arrays. For expression analysis, the Affymetrix 133+ 2 and all exon high-density oligonucleotide arrays are used. For proteomic analysis, LC-MS/MS as well as single cell proteomics are creatively being integrated. A key component to a systems approach to seek for molecular concordance of detectable molecular defects. A cellular gene has to exhibit molecular congruency at the genomic, mRNA expression as well as proteomic levels to qualify as a potential molecular marker. All of these approaches use patient-based materials and laser capture microdissection (LCM) is used to selectively procure homogeneous cell types from tissue sections to minimize contaminations by non-relevant cell types in these sensitive molecular analyses. PATHOGENESIS: We subscribe to the belief that a central defect in human cancer lies in the dysregulation of cell cycle control. Establishing a molecular database of cell cycle regulatory genes dysregulated in head and neck cancer and understanding the molecular and biochemical pathways of these genes are of prime interest. Using differential expression screening assays we have identified a number of cellular genes that are differentially expressed in squamous cell carcinoma. p12CDK2-AP1 is a differentially expressed cellular gene that is currently being studied. p12CDK2-AP1 is a novel gene exhibiting growth suppressor properties. p12CDK2-AP1 exerts its growth suppressor function by negatively regulating the activities of DNA polymerase-��/primase and cyclin-dependent kinase 2 (CDK2). p12CDK2-AP1 associates with DNA polymerase-��/primase suppressing DNA replication, affecting predominantly the initiation step. p12CDK2-AP1 has recently been found to associates with the monomeric non-phosphorylated form of CDK2, suppressing CDK2-associated kinase activities and cell cycle progression. p12CDK2-AP1 also targets CDK2 for proteolysis. Currently we are investigating the detailed biochemical and genetic mechanisms of p12CDK2-AP1 in cell cycle regulation, normal development and carcinogenesis. Most recent excitement of this research include finding that p12CDK2-AP1-nulled mice are embryonically lethal and that p12CDK2-AP1 is necessary for differentiation competency for mouse embryonic stem cells. MOLECULAR DIAGNOSTICS: The ability to monitor by non-invasive mean for the early detection of cancer has been a long time goal for cancer researchers. However progress towards this goal has not met expectations. My research group, with the support from NIDCR, has initiated a series of concerted efforts to spearhead the scientific and translational frontiers of salivary diagnostics. The potential use of saliva, a totally non-invasive biofluid, for oral and systemic disease detection, disease progression and therapeutic monitoring are highly desirable goals. We have harnessed and defined two diagnostic alphabets from human saliva, the salivary proteome and salivary transcriptome. The availability of these diagnostics alphabets greatly enhance the translational utilizations of saliva. In parallel to the biomarker efforts, we have been developing point of care technologies for using saliva for clinical diagnostics applications. The ���Oral Fluid NanoSensor Test (OFNASET)��� is a prototype nanotechnology point of care sensor that will have the ability to detect multiple analytes in saliva for disease detection. The concurrent biomarker and technology development initiatives at UCLA led to the establishment of the ���UCLA Collaborative Oral Fluid Diagnostics Research Center��� to fully explore the scientific, translational and clinical frontiers of salivary diagnostics, salivary pharmacogenomics and salivary pharmacogenomics. The utilization of saliva for personalized individual medicine applications is only footsteps away.

David T.W. Wong DMD, DMSc is Felix & Mildred Yip Endowed Professor and Associate Dean of Research and Director of the Dental Research Institute at UCLA.  Dr. Wong also holds appointment at the Division of Head & Neck Surgery/Otolaryngology, Henry Samueli School of Engineering & Applied Sciences, Molecular Biology Institute and Jonsson Comprehensive Cancer Center.

Dr. Wong joined the ULCA faculty in 2002 after a 16-year career at Harvard University. His recruitment to UCLA is to spearhead and enhance multidisciplinary research and to promote research training and career development of scientists towards oral health research. Dr. Wong is one of the country's leading scientist in oral/head and neck cancer as well as salivary diagnostic research.

Dr. Wong is an active scientist in oral cancer and saliva diagnostics research. His research has been continuously funded by NIH since 1986. He has authored over 280 peer reviewed scientific publications. He is a fellow of the American Association for the Advancement of Sciences (AAAS), past member of the ADA Council of Scientific Affairs and the immediate past president of American Association of Dental Research (AADR).


A selected list of publications:

Wei Fang, Yang Jieping, Wong David T W   Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM) Biosensors & bioelectronics, 2013; 44: 115-21.
Matse Johannes H, Yoshizawa Janice, Wang Xiaoyan, Elashoff David, Bolsher Jan G, Veerman Enno C, Bloemena Elisabeth, Wong David T   Discovery and pre-validation of salivary extracellular microRNA biomarkers panel for the non-invasive detection of benign and malignant parotid gland tumors Clinical cancer research : an official journal of the American Association for Cancer Research, 2013; 251(5): .
Wang Cheng, Liu Xiqiang, Chen Zujian, Huang Hongzhang, Jin Yi, Kolokythas Antonia, Wang Anxun, Dai Yang, Wong David T W, Zhou Xiaofeng   Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma Molecular carcinogenesis, 2013; 52(3): 229-36.
Wong David T   Salivary diagnostics: the enabling factors for detecting oral diseases Journal of the California Dental Association, 2013; 41(2): 94-6.
Yoshizawa Janice M, Wong David T W   Salivary microRNAs and oral cancer detection Methods in molecular biology (Clifton, N.J.), 2013; 936(1): 313-24.
Ai Ji-Ye, Smith Barry, Wong David T W   Bioinformatics advances in saliva diagnostics International journal of oral science, 2012; 4(2): 85-7.
Lau Chang S, Wong David T W   Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro PloS one, 2012; 7(3): e33037.
Vissink Arjan, Bootsma Hendrika, Spijkervet Fred K L, Hu Shen, Wong David T, Kallenberg Cees G M   Current and future challenges in primary Sjögren's syndrome Current pharmaceutical biotechnology, 2012; 13(10): 2026-45.
Zhang Lei, Xiao Hua, Zhou Hui, Santiago Silverio, Lee Jay M, Garon Edward B, Yang Jieping, Brinkmann Ole, Yan Xinmin, Akin David, Chia David, Elashoff David, Park No-Hee, Wong David T W   Development of transcriptomic biomarker signature in human saliva to detect lung cancer Cellular and molecular life sciences : CMLS, 2012; 69(19): 3341-50.
Xiao Hua, Wong David T W   Method development for proteome stabilization in human saliva Analytica chimica acta, 2012; 722(5): 63-9.
Wei Fang, Wong David T W   Point-of-care platforms for salivary diagnostics The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association (CSA), 2012; 15(1): 7-15.
Elashoff David, Zhou Hui, Reiss Jean, Wang Jianghua, Xiao Hua, Henson Bradley, Hu Shen, Arellano Martha, Sinha Uttam, Le Anh, Messadi Diana, Wang Marilene, Nabili Vishad, Lingen Mark, Morris Darly, Randolph Timothy, Feng Ziding, Akin David, Kastratovic Dragana A, Chia David, Abemayor Elliot, Wong David T W   Prevalidation of salivary biomarkers for oral cancer detection Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012; 21(4): 664-72.
Xiao Hua, Zhang Lei, Zhou Hui, Lee Jay M, Garon Edward B, Wong David T W   Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry Molecular & cellular proteomics : MCP, 2012; 11(2): M111.012112.
Xiao Hua, Wong David T W   Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry Analytica chimica acta, 2012; 723(5): 61-7.
Wong David T W   Salivaomics Journal of the American Dental Association (1939), 2012; 143(10 Suppl): 19S-24S.
Bonne Nicolai J, Wong David Tw   Salivary biomarker development using genomic, proteomic and metabolomic approaches Genome medicine, 2012; 4(10): 82.
Brinkmann Ole, Spielmann Nadine, Wong David T W   Salivary diagnostics: moving to the next level Dentistry today, 2012; 31(6): 54, 56-7; quiz 58-9.
Horvath Steve, Nazmul-Hossain Abu Nm, Pollard Rodney Pe, Kroese Frans Gm, Vissink Arjan, Kallenberg Cees Gm, Spijkervet Fred Kl, Bootsma Hendrika, Michie Sara A, Gorr Sven U, Peck Ammon B, Cai Chaochao, Zhou Hui, Wong David Tw   Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model Arthritis research & therapy, 2012; 14(6): R238.
Gorr Sven-Ulrik, Wennblom Trevor J, Horvath Steve, Wong David T W, Michie Sara A   Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base BMC musculoskeletal disorders, 2012; 13(13): 119.
Spielmann Nadine, Ilsley Diane, Gu Jian, Lea Kristi, Brockman Joel, Heater Sheila, Setterquist Robert, Wong David T W   The human salivary RNA transcriptome revealed by massively parallel sequencing Clinical chemistry, 2012; 58(9): 1314-21.
Kim Jeong Kyu, Zhou Hui, Nabili Vishad, Wang Marilene B, Abemayor Elliot, Wong David T W   Utility of multiple sampling in reducing variation of salivary interleukin-8 and interleukin-1β mRNA levels in healthy adults Head & neck, 2012; 12(8): .
Farrell James J, Zhang Lei, Zhou Hui, Chia David, Elashoff David, Akin David, Paster Bruce J, Joshipura Kaumudi, Wong David T W   Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer Gut, 2012; 61(4): 582-8.
Lee Yu-Hsiang, Zhou Hui, Reiss Jean K, Yan Xinmin, Zhang Lei, Chia David, Wong David T W   Direct saliva transcriptome analysis Clinical chemistry, 2011; 57(9): 1295-302.
Sharma Sanjai, Liao Wei, Zhou Xiaofeng, Wong David T W, Lichtenstein Alan   Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells Molecular cancer therapeutics, 2011; 10(9): 1751-9.
Hu Shen, Vissink Arjan, Arellano Martha, Roozendaal Caroline, Zhou Hui, Kallenberg Cees G M, Wong David T   Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays Proteomics, 2011; 11(8): 1499-507.
Brinkmann Ole, Kastratovic Dragana A, Dimitrijevic Milovan V, Konstantinovic Vitomir S, Jelovac Drago B, Antic Jadranka, Nesic Vladimir S, Markovic Srdjan Z, Martinovic Zeljko R, Akin David, Spielmann Nadine, Zhou Hui, Wong David T   Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population Oral oncology, 2011; 47(1): 51-5.
Sugimoto Masahiro, Wong David T, Hirayama Akiyoshi, Soga Tomoyoshi, Tomita Masaru   Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles Metabolomics : Official journal of the Metabolomic Society, 2010; 6(1): 78-95.
Ryan Christopher M, Souda Puneet, Halgand Frederic, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(6): 908-17.
Williams Chloe J, Lui Wing Chi, Li Kenneth K W, Wong David, Lo Amy C Y   Correspondence Retina (Philadelphia, Pa.), 2010; 30(3): 534-5; author reply 535-6.
Zhang Lei, Xiao Hua, Karlan Scott, Zhou Hui, Gross Jenny, Elashoff David, Akin David, Yan Xinmin, Chia David, Karlan Beth, Wong David T   Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer PloS one, 2010; 5(12): e15573.
Halgand Frédéric, Zabrouskov Vlad, Bassilian Sara, Souda Puneet, Wong David T, Loo Joseph A, Faull Kym F, Whitelegge Julian P   Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry Journal of the American Society for Mass Spectrometry, 2010; 21(5): 868-77.
Hu Shen, Gao Kai, Pollard Rodney, Arellano-Garcia Martha, Zhou Hui, Zhang Lei, Elashoff David, Kallenberg Cees G M, Vissink Arjan, Wong David T   Preclinical validation of salivary biomarkers for primary Sjögren's syndrome Arthritis care & research, 2010; 62(11): 1633-8.
Hu Shen, Jiang Jiang, Wong David T   Proteomic analysis of saliva: 2D gel electrophoresis, LC-MS/MS, and Western blotting Methods in molecular biology (Clifton, N.J.), 2010; 666(1): 31-41.
Ai Jiye, Smith Barry, Wong David T   Saliva Ontology: an ontology-based framework for a Salivaomics Knowledge Base BMC bioinformatics, 2010; 11(7): 302.
Zhang Lei, Farrell James J, Zhou Hui, Elashoff David, Akin David, Park No-Hee, Chia David, Wong David T   Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer Gastroenterology, 2010; 138(3): 949-57.e1-7.
Sharma Shivani, Rasool Haider I, Palanisamy Viswanathan, Mathisen Cliff, Schmidt Michael, Wong David T, Gimzewski James K   Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy ACS nano, 2010; 4(4): 1921-6.
Deshpande, Dai, Kim, Kim, Kimlin, Gao, Hendrich, Wong   CDK2AP1 is required for epigenetic silencing of OCT4 during murine embryonic stem cell differentiation The Journal of biological chemistry, 2008; .
Wei Fang, Wang Jianghua, Liao Wei, Zimmermann Bernhard G, Wong David T, Ho Chih-Ming   Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe Nucleic acids research, 2008; 36(11): e65.
Hu Zhanzhi, Zimmermann Bernhard G, Zhou Hui, Wang Jianghua, Henson Bradley S, Yu Weixia, Elashoff David, Krupp Guido, Wong David T   Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids Clinical chemistry, 2008; 54(5): 824-32.
Deshpande Amit M, Wong David T   Molecular mechanisms of head and neck cancer Expert review of anticancer therapy, 2008; 8(5): 799-809.
Tan Winny, Sabet Leyla, Li Yang, Yu Tianwei, Klokkevold Perry R, Wong David T, Ho Chih-Ming   Optical protein sensor for detecting cancer markers in saliva Biosensors & bioelectronics, 2008; 24(2): 266-71.
Wong, D.T.   Saliva Diagnostics, American Scientist, 2008; .
Zimmermann Bernhard G, Wong David T   Salivary mRNA targets for cancer diagnostics Oral oncology, 2008; 44(5): 425-9.
Hu Shen, Arellano Martha, Boontheung Pinmanee, Wang Jianghua, Zhou Hui, Jiang Jiang, Elashoff David, Wei Roger, Loo Joseph A, Wong David T   Salivary proteomics for oral cancer biomarker discovery Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(19): 6246-52.
Hu, Zhou, Jiang, Wang, Elashoff, Gorr, Michie, Spijkervet, Bootsma, Kallenberg, Vissink, Horvath, Wong   Systems biology analysis of sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands Arthritis and rheumatism, 2008; 60(1): 81-92.
Denny Paul, Hagen Fred K, Hardt Markus, Liao Lujian, Yan Weihong, Arellanno Martha, Bassilian Sara, Bedi Gurrinder S, Boontheung Pinmannee, Cociorva Daniel, Delahunty Claire M, Denny Trish, Dunsmore Jason, Faull Kym F, Gilligan Joyce, Gonzalez-Begne Mireya, Halgand Frédéric, Hall Steven C, Han Xuemei, Henson Bradley, Hewel Johannes, Hu Shen, Jeffrey Sherry, Jiang Jiang, Loo Joseph A, Ogorzalek Loo Rachel R, Malamud Daniel, Melvin James E, Miroshnychenko Olga, Navazesh Mahvash, Niles Richard, Park Sung Kyu, Prakobphol Akraporn, Ramachandran Prasanna, Richert Megan, Robinson Sarah, Sondej Melissa, Souda Puneet, Sullivan Mark A, Takashima Jona, Than Shawn, Wang Jianghua, Whitelegge Julian P, Witkowska H Ewa, Wolinsky Lawrence, Xie Yongming, Xu Tao, Yu Weixia, Ytterberg Jimmy, Wong David T, Yates John R, Fisher Susan J   The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions Journal of proteome research, 2008; 7(5): 1994-2006.
Ye Hui, Yu Tianwei, Temam Stephane, Ziober Barry L, Wang Jianguang, Schwartz Joel L, Mao Li, Wong David T, Zhou Xiaofeng   Transcriptomic dissection of tongue squamous cell carcinoma BMC genomics, 2008; 9(3): 69.
Yu, T. Ye, H. Sun, W. Li, K. C. Chen, Z. Jacobs, S. Bailey, D. K. Wong, D. T. Zhou, X.   A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array, BMC Bioinformatics, 2007; 8(1): 145.
Park, N. J. Zhou, X. Yu, T. Brinkman, B. M. Zimmermann, B. G. Palanisamy, V. Wong, D. T.   Characterization of salivary RNA by cDNA library analysis, Arch Oral Biol, 2007; 52: 30-35.
Hu Shen, Yu Tianwei, Xie Yongming, Yang Yanan, Li Yang, Zhou Xiaofeng, Tsung Stephanie, Loo Rachel R, Loo Joseph R, Wong David T   Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry Cancer genomics & proteomics, 2007; 4(2): 55-64.
Molinolo Alfredo A, Hewitt Stephen M, Amornphimoltham Panomwat, Keelawat Somboon, Rangdaeng Samraeung, Meneses García Abelardo, Raimondi Ana R, Jufe Rafael, Itoiz María, Gao Yan, Saranath Dhananjaya, Kaleebi George S, Yoo George H, Leak Lee, Myers Ernest M, Shintani Satoru, Wong David, Massey H Davis, Yeudall W Andrew, Lonardo Fulvio, Ensley John, Gutkind J Silvio   Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative Clinical cancer research : an official journal of the American Association for Cancer Research, 2007; 13(17): 4964-73.
Ye, H. Pungpravat, N. Huang, B. L. Muzio, L. L. Mariggio, M. A. Chen, Z. Wong, D. T. Zhou, X.   Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma Cancer Genet Cytogenet, 2007; 176(2): 100-6.
Zimmermann Bernhard G, Park Noh Jin, Wong David T   Genomic targets in saliva Annals of the New York Academy of Sciences, 2007; 1098(4): 184-91.
Hu, S. Loo, J. A. Wong, D. T.   Human saliva proteome analysis and disease biomarker discovery Expert Rev Proteomics, 2007; 4(4): 531-8.
Hu Shen, Loo Joseph A, Wong David T   Human saliva proteome analysis Annals of the New York Academy of Sciences, 2007; 1098(4): 323-9.
Hu, S. Yen, Yun Ann, David Wong, D.T.   Implications of salivary proteomics for cancer drug discovery, Drug Discovery, 2007; 12: 911-916.
Hu, S. Wong, D. T.   Oral cancer proteomics Curr Opin Mol Ther, 2007; 9(5): 467-76.
Gau Vincent, Wong David   Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform Annals of the New York Academy of Sciences, 2007; 1098(4): 401-10.
Whitelegge Mario A, Zabrouskov Mario A, Halgand Mario A, Souda Mario A, Bassilian Mario A, Yan Mario A, Wolinsky Mario A, Loo Mario A, Wong Mario A, Faull Mario A   Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry International journal of mass spectrometry, 2007; 268(2-3): 190-197.
Park, N. J. Yu, T. Nabili, V. Brinkman, B. M. Henry, S. Wang, J. Wong, D. T.   RNAprotect Saliva: An Optimal Room- Temperature Stabilization Reagent for the Salivary Transcriptome Clin Chem, 2007; 52(12): 2303-4.
Zimmermann, B. G. Wong, D. T.   Salivary mRNA targets for cancer diagnostics Oral Oncol, 2007; .
Hu Shen, Wang Jianghua, Meijer Jiska, Ieong Sonya, Xie Yongming, Yu Tianwei, Zhou Hui, Henry Sharon, Vissink Arjan, Pijpe Justin, Kallenberg Cees, Elashoff David, Loo Joseph A, Wong David T   Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome Arthritis and rheumatism, 2007; 56(11): 3588-600.
Zhou X, Yu T, Cole SW, Wong DT   Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer Expert Rev Mol Diagn, 2006; 6(1): 39-50.
Park NJ, Li Y, Yu T, Brinkman BM, Wong DT   Characterization of RNA in saliva Clin Chem, 2006; 52(6): 988-94.
Brinkman BM, Wong DT   Disease mechanism and biomarkers of oral squamous cell carcinoma Curr Opin Oncol, 2006; 18(3): 228-233.
Figueiredo ML, Dayan S, Kim Y, McBride J, Kupper TS, Wong DT   Expression of cell-cycle regulator CDK2-associating protein 1 (p12(CDK2AP1)) in transgenic mice induces testicular and ovarian atrophy in vivo Mol Reprod Dev, 2006; .
St John MA, Abemayor E, Wong DT   Recent new approaches to the treatment of head and neck cancer Anticancer Drugs, 2006; 17(4): 365-75.
Wong DT   Salivary diagnostics powered by nanotechnologies, proteomics and genomics, J American Dental Association, 2006; 137: 313-321.
Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT   Serum Circulating Human mRNA Profiling and Its Utility for Oral Cancer Detection Journal Clinical Oncology, 2006; In press.
Yang CYm, Brooks E, Li Y, Denny P, Ho CM, Qi F, Shi W, Wolinsky L, Wu B, Wong DT, Montemagno CD   Detection of picomolar levels of interleukin-8 in human saliva by SPR Lab Chip, 2005; 5(10): 1017-23.
Zhou X, Jordan RC, Li Y, Huang BL, Wong DT   Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions Cancer Genet Cytogenet, 2005; 161(1): 86-9.
Zhou X, Cole SW, Rao NP, Cheng Z, Li Y, McBride J, Wong DT   Identification of discrete chromosomal deletion by binary recursive partitioning of microarray differential expression data J Med Genet, 2005; 42(5): 416-9.
Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT   Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry Proteomics, 2005; 5(6): 1714-28.
Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT   Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays Cancer Genet Cytogenet, 2005; 159(1): 53-7.
Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT   The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications Adv Dent Res, 2005; 18(1): 3-5.
Zhou X, Jordan RCK, Mok S, Birrer MJ, Wong DT   DNA Copy Number Abnormality of Oral Squamous Cell Carcinoma Detected by cDNA, Cancer Genetics & Cytogenetics, 2004; 151: 90-92.
Zhou X, Cole SW, Hu S, Wong DT   Detection of DNA copy number abnormality by microarray expression analysis Hum Genet, 2004; 114(5): 464-467.
Hu S, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT   Differentially expressed protein markers in human submandibular and sublingual secretions Int J Oncol, 2004; 25(5): 1423-30.
Shintani S, Ishikawa T, Nonaka T, Li C, Nakashiro K, Wong DT, Hamakawa H   Growth-regulated oncogene-1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer Oncology, 2004; 66(4): 316-22.
St John M, Li Y, Zhou X, Denny P, Ho CM Montemagno CD, Shi W, Qi F, Wu B, Jordan RCK, Sinha U, Park NH Abemayor E, Wong DTW   IL-6 and IL-8: Potential biomarkers for oral cavity and oropharyngeal SCCA, Arch Otolaryngol Head Neck Surg, 2004; 130: 929-935.
Buajeeb W, Zhang X, Ohyam H, Han D, Surarita R, Kim Y, Wong DTW   Interaction of the CDK2 associated protein-1, p12DOC-1/CDK2AP1, with its homolog, p14DOC-1R, Biochem Biophys Res Comm, 2004; 315: 998-1003.
Figueiredo ML, Kim YK, Zhou XZ, Myers JN, Wong DDT   Molecular Mechanisms of Head and Neck Cancer, Mechanism of Diseases, 2004; 1: 273-281.
Kreth JK, Hagerman E, Tam K, Merritt J, Wong D, Wu B M, Myung NV, Shi W, Qi F   Quantitative Analyses of Streptococcus mutans Biofilms Formed under Different Sucrose Concentrations by using quartz crystal microbalance and microjet impingement, Biofilm, 2004; 1: 277-284.
Li Y, Zhou X, St John MA, Wong DT   RNA Profiling of Cell-free Saliva Using Microarray Technology J Dent Res, 2004; 83(3): 199-203.
Zhou X, Li C, Mok S, Chen Z, Wong DTW   Whole Genome LOH Profiling on Oral Squamous Cell Carcinoma by High-Density SNP Array, Cancer Genet & Cytogenet, 2004; 151: 82-84.
Majem Blanca, Li Feng, Sun Jie, Wong David T W   RNA Sequencing Analysis of Salivary Extracellular RNA Methods in molecular biology (Clifton, N.J.), 2017; 1537(1): 17-36.
Kaczor-Urbanowicz Karolina Elżbieta, Martin Carreras-Presas Carmen, Aro Katri, Tu Michael, Garcia-Godoy Franklin, Wong David Tw   Saliva diagnostics - Current views and directions Experimental biology and medicine (Maywood, N.J.), 2017; 242(5): 459-472.
Pu Dan, Liang Hao, Wei Fang, Akin David, Feng Ziding, Yan QingXiang, Li Yin, Zhen Yan, Xu Lin, Dong Gaochao, Wan Huajing, Dong Jingsi, Qiu Xiaoming, Qin Changlong, Zhu Daxing, Wang Xi, Sun Tong, Zhang Wenbiao, Li Canjun, Tang Xiaojun, Qiao Youlin, Wong David T W, Zhou Qinghua   Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study Thoracic cancer, 2016; 7(4): 428-36.
Katsiougiannis Stergios, Chia David, Kim Yong, Singh Ram P, Wong David T W   Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017; 31(3): 998-1010.
Chai Yang D, Zhang Lifeng, Yang Yan, Su Trent, Charugundla Prashant, Ai Jiye, Messadi Diana, Wong David T, Hu Shen   Discovery of potential serum protein biomarkers for lymph node metastasis in oral cancer Head & neck, 2016; 38(1): 118-25.
Tu Michael, Chia David, Wei Fang, Wong David   Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB) The Analyst, 2016; 141(2): 393-402.
Gleber-Netto Frederico Omar, Yakob Maha, Li Feng, Feng Ziding, Dai Jianliang, Kao Huang-Kai, Chang Yu-Liang, Chang Kai-Ping, Wong David T W   Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population Clinical cancer research : an official journal of the American Association for Cancer Research, 2016; 22(13): 3340-7.
Wang Austin, Wang Chris P, Tu Michael, Wong David T W   Oral Biofluid Biomarker Research: Current Status and Emerging Frontiers Diagnostics (Basel, Switzerland), 2016; 6(4): 76-79.