Keisuke Steven Iwamoto

Mailing Address:
UCLA Rad Onc
BOX 951714
B3-109 CHS
Los Angeles, CA 90095

Affiliations
Affiliations
Director, Defined Flora Mouse Facility
Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Adjunct Professor, Radiation Oncology
Biography:

Dr. Iwamoto was recruited as a professor at the UCLA Department of Radiation Oncology in 1999. He received his PH.D. at UCLA in 1990, and from 1992 until 1999 he worked for the U.S National Academy of Science, Department of Radiation Effects Research Foundation in Hiroshima, Japan. Dr. Iwamoto has a broad background in both the physical and biological sciences with special focus on the interaction of ionizing radiation and cells. He also has extensive experience in radiobiology and the use of animal models for study of radiation oncology.

Publications

A selected list of publications:

Schaue Dörthe, Ratikan Josephine A, Iwamoto Keisuke S, McBride William H   Maximizing tumor immunity with fractionated radiation International journal of radiation oncology, biology, physics, 2012; 83(4): 1306-10.
Schaue Dörthe, Ratikan Josephine A, Iwamoto Keisuke S   Cellular autofluorescence following ionizing radiation PloS one, 2012; 7(2): e32062.
Nakashiba Toshiaki, Cushman Jesse D, Pelkey Kenneth A, Renaudineau Sophie, Buhl Derek L, McHugh Thomas J, Rodriguez Barrera Vanessa, Chittajallu Ramesh, Iwamoto Keisuke S, McBain Chris J, Fanselow Michael S, Tonegawa Susumu   Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion Cell, 2012; 149(1): 188-201.
Kachikwu Evelyn L, Iwamoto Keisuke S, Liao Yu-Pei, DeMarco John J, Agazaryan Nzhde, Economou James S, McBride William H, Schaue Dörthe   Radiation enhances regulatory T cell representation International journal of radiation oncology, biology, physics, 2011; 81(4): 1128-35.
Kim Kwanghee, Pollard Julianne M, Norris Andrew J, McDonald J Tyson, Sun Yingli, Micewicz Ewa, Pettijohn Kelly, Damoiseaux Robert, Iwamoto Keisuke S, Sayre James W, Price Brendan D, Gatti Richard A, McBride William H   High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(23): 7238-45.
Liao Yu-Pei, Wang Chun-Chieh, Schaue Dörthe, Iwamoto Keisuke S, McBride William H   Local irradiation of murine melanoma affects the development of tumour-specific immunity Immunology, 2009; 128(1 Suppl): e797-804.
Brush James M, Kim Kwanghee, Sayre James W, McBride William H, Iwamoto Keisuke S   Imaging of radiation effects on cellular 26S proteasome function in situ International journal of radiation biology, 2009; 85(6): 483-94.
Hafer Kurt, Iwamoto Keisuke S, Schiestl Robert H   Refinement of the dichlorofluorescein assay for flow cytometric measurement of reactive oxygen species in irradiated and bystander cell populations Radiation research, 2008; 169(4): 460-8.
Kim Kwanghee, Brush James M, Watson Philip A, Cacalano Nicholas A, Iwamoto Keisuke S, McBride William H   Epidermal growth factor receptor vIII expression in U87 glioblastoma cells alters their proteasome composition, function, and response to irradiation Molecular cancer research : MCR, 2008; 6(3): 426-34.
Bassler Niels, Alsner Jan, Beyer Gerd, DeMarco John J, Doser Michael, Hajdukovic Dragan, Hartley Oliver, Iwamoto Keisuke S, Jäkel Oliver, Knudsen Helge V, Kovacevic Sandra, Møller Søren Pape, Overgaard Jens, Petersen Jørgen B, Solberg Timothy D, Sørensen Brita S, Vranjes Sanja, Wouters Bradly G, Holzscheiter Michael H   Antiproton radiotherapy Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2008; 86(1): 14-9.
Hafer Kurt, Iwamoto Keisuke S, Iwamoto Keisuke K, Scuric Zorica, Schiestl Robert H   Adaptive response to gamma radiation in mammalian cells proficient and deficient in components of nucleotide excision repair Radiation research, 2007; 168(2): 168-74.
Iwamoto Keisuke S, Barber Chad L   Radiation-induced posttranscriptional control of M6P/IGF2r expression in breast cancer cell lines Molecular carcinogenesis, 2007; 46(7): 497-502.
Iwamoto Keisuke S, Yano Shiho, Barber Chad L, MacPhee Donald G, Tokuoka Shoji   A dose-dependent decrease in the fraction of cases harboring M6P/IGF2R mutations in hepatocellular carcinomas from the atomic bomb survivors Radiation research, 2006; 166(6): 870-6.
Holzscheiter Michael H, Bassler Niels, Agazaryan Nzhde, Beyer Gerd, Blackmore Ewart, DeMarco John J, Doser Michael, Durand Ralph E, Hartley Oliver, Iwamoto Keisuke S, Knudsen Helge V, Landua Rolf, Maggiore Carl, McBride William H, Møller Søren Pape, Petersen Jørgen, Skarsgard Lloyd D, Smathers James B, Solberg Timothy D, Uggerhøj Ulrik I, Vranjes Sanja, Withers H Rodney, Wong Michelle, Wouters Bradly G   The biological effectiveness of antiproton irradiation Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006; 81(3): 233-42.
Mizuno Terumi, Tokuoka Shoji, Kishikawa Masao, Nakashima Eiji, Mabuchi Kiyohiko, Iwamoto Keisuke S   Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations Carcinogenesis, 2006; 27(11): 2286-94.
Wang Chun-Chieh, Liao Yu-Pei, Mischel Paul S, Iwamoto Keisuke S, Cacalano Nicholas A, McBride William H   HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway Cancer research, 2006; 66(13): 6756-62.
Hafer Kurt, Scuric Zorica, Iwamoto Keisuke S, Schiestl Robert H   Point-source irradiation with eccentric rotation causes inhomogeneous dose distribution Radiation research, 2006; 165(5): 616-20.
Pervan Milena, Iwamoto Keisuke S, McBride William H   Proteasome structures affected by ionizing radiation Molecular cancer research : MCR, 2005; 3(7): 381-90.
Liao Yu-Pei, Wang Chun-Chieh, Butterfield Lisa H, Economou James S, Ribas Antoni, Meng Wilson S, Iwamoto Keisuke S, McBride William H   Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells Journal of immunology (Baltimore, Md. : 1950), 2004; 173(4): 2462-9.
McBride William H, Chiang Chi-Shiun, Olson Jennifer L, Wang Chun-Chieh, Hong Ji-Hong, Pajonk Frank, Dougherty Graeme J, Iwamoto Keisuke S, Pervan Milena, Liao Yu-Pei   A sense of danger from radiation Radiation research, 2004; 162(1): 1-19.
McBride William H, Iwamoto Keisuke S, Syljuasen Randi, Pervan Milena, Pajonk Frank   The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene, 2003; 22(37): 5755-73.
Iwamoto Keisuke S   Tracking the errant cell after the atomic bombings: what went wrong? Health physics, 2003; 85(1): 81-3.
Chen Wen-Cheng, McBride William H, Iwamoto Keisuke S, Barber Chad L, Wang Chun-Chieh, Oh Young-Taek, Liao Yu-Pei, Hong Ji-Hong, de Vellis Jean, Shau Hungyi   Induction of radioprotective peroxiredoxin-I by ionizing irradiation Journal of neuroscience research, 2002; 70(6): 794-8.
Tsuyama N, Ide T, Noda A, Iwamoto K S, Mizuno T, Kyoizumi S, Seyama T   X-rays induce dose-dependent and cell cycle-independent accumulation of p21(sdi1/WAF1) Hiroshima journal of medical sciences, 2001; 50(1): 1-7.
Mizuno T, Iwamoto K S, Kyoizumi S, Nagamura H, Shinohara T, Koyama K, Seyama T, Hamatani K   Preferential induction of RET/PTC1 rearrangement by X-ray irradiation Oncogene, 2000; 19(3): 438-43.
Iwamoto K S, Fujii S, Kurata A, Suzuki M, Hayashi T, Ohtsuki Y, Okada Y, Narita M, Takahashi M, Hosobe S, Doishita K, Manabe T, Hata S, Murakami I, Hata S, Itoyama S, Akatsuka S, Ohara N, Iwasaki K, Akabane H, Fujihara M, Seyama T, Mori T   p53 mutations in tumor and non-tumor tissues of thorotrast recipients: a model for cellular selection during radiation carcinogenesis in the liver Carcinogenesis, 1999; 20(7): 1283-91.
Iwamoto K S, Mizuno T, Seyama T, Kyoizumi S   Mutant p53: epigenetic mutator of the T-cell receptor via induction of methylation Molecular carcinogenesis, 1999; 25(2): 113-21.
Yano M, Asahara T, Dohi K, Mizuno T, Iwamoto K S, Seyama T   Close correlation between a p53 or hMSH2 gene mutation in the tumor and survival of hepatocellular carcinoma patients International journal of oncology, 1999; 14(3): 447-51.
Iwamoto K S, Mizuno T, Tokuoka S, Mabuchi K, Seyama T   Frequency of p53 mutations in hepatocellular carcinomas from atomic bomb survivors Journal of the National Cancer Institute, 1998; 90(15): 1167-8.
Mizuno T, Nagamura H, Iwamoto K S, Ito T, Fukuhara T, Tokunaga M, Tokuoka S, Mabuchi K, Seyama T   RNA from decades-old archival tissue blocks for retrospective studies Diagnostic molecular pathology : the American journal of surgical pathology, part B, 1998; 7(4): 202-8.
Umeki S, Kusunoki Y, Cologne J B, Iwamoto K S, Hirai Y, Seyama T, Ohama K, Kyoizumi S   Lifespan of human memory T-cells in the absence of T-cell receptor expression Immunology letters, 1998; 62(2): 99-104.
Iwamoto K S, Mizuno T, Kurata A, Masuzawa M, Mori T, Seyama T   Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers Human pathology, 1998; 29(4): 412-6.
Mizuno T, Kyoizumi S, Suzuki T, Iwamoto K S, Seyama T   Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis Oncogene, 1997; 15(12): 1455-60.
Norman A, Ingram M, Skillen R G, Freshwater D B, Iwamoto K S, Solberg T   X-ray phototherapy for canine brain masses Radiation oncology investigations, 1997; 5(1): 8-14.
Iwamoto K S, Mizuno T, Ito T, Tsuyama N, Kyoizumi S, Seyama T   Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival Cancer research, 1996; 56(17): 3862-5.
Iwamoto K S, Mizuno T, Ito T, Akiyama M, Takeichi N, Mabuchi K, Seyama T   Feasibility of using decades-old archival tissues in molecular oncology/epidemiology The American journal of pathology, 1996; 149(2): 399-406.
Akiyama M, Kyoizumi S, Hirai Y, Kusunoki Y, Iwamoto K S, Nakamura N   Mutation frequency in human blood cells increases with age Mutation research, 1995; 338(1-6): 141-9.
Ito T, Seyama T, Kyoizumi S, Teraoka S, Iwamoto K S, Mizuno T, Tsuyama N, Asahara T, Dohi K, Akiyama M   The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis Cancer letters, 1995; 88(1): 113-7.
Ito T, Seyama T, Iwamoto K S, Mizuno T, Tronko N D, Komissarenko I V, Cherstovoy E D, Satow Y, Takeichi N, Dohi K   Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident Lancet, 1994; 344(8917): 259.
Iwamoto K S, McBride W H   Production of 13-hydroxyoctadecadienoic acid and tumor necrosis factor-alpha by murine peritoneal macrophages in response to irradiation Radiation research, 1994; 139(1): 103-8.
Iwamoto K S, Hirai Y, Umeki S, Kusunoki Y, Kyoizumi S, Kodama T, Ohama K, Nakamura N, Akiyama M   A positive correlation between T-cell-receptor mutant frequencies and dicentric chromosome frequencies in lymphocytes from radiotherapy patients Journal of radiation research, 1994; 35(2): 92-103.
Ito T, Seyama T, Hayashi T, Mizuno T, Iwamoto K S, Tsuyama N, Dohi K, Nakamura N, Akiyama M   HaeIII polymorphism in intron 1 of the human p53 gene Human genetics, 1994; 93(2): 222.
Ito T, Seyama T, Iwamoto K S, Hayashi T, Mizuno T, Tsuyama N, Dohi K, Nakamura N, Akiyama M   In vitro irradiation is able to cause RET oncogene rearrangement Cancer research, 1993; 53(13): 2940-3.
Ito T, Seyama T, Mizuno T, Hayashi T, Iwamoto K S, Dohi K, Nakamura N, Akiyama M   Induction of BCR-ABL fusion genes by in vitro X-irradiation Japanese journal of cancer research : Gann, 1993; 84(2): 105-9.
Iwamoto K S, Norman A, Freshwater D B, Ingram M, Skillen R G   Diagnosis and treatment of spontaneous canine brain tumors with a CT scanner Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1993; 26(1): 76-8.
Iwamoto K S, Bennett L R, Norman A, Villalobos A E, Hutson C A   Linoleate produces remission in canine mycosis fungoides Cancer letters, 1992; 64(1): 17-22.
Norman A, Iwamoto K S, Kagan A R, Wollin M   Radiation sensitive breast cancer patients Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1992; 23(3): 196-7.
Solberg T D, Iwamoto K S, Norman A   Calculation of radiation dose enhancement factors for dose enhancement therapy of brain tumours Physics in medicine and biology, 1992; 37(2): 439-43.
Norman A, Iwamoto K S, Cochran S T   Iodinated contrast agents for brain tumor localization and radiation dose enhancement Investigative radiology, 1991; 26 Suppl 1(2): S120-1; discussion S125-8.
Iwamoto K S, Norman A, Kagan A R, Wollin M, Olch A, Bellotti J, Ingram M, Skillen R G   The CT scanner as a therapy machine Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1990; 19(4): 337-43.
Norman A, Mitchell J C, Iwamoto K S   A sensitive assay for 6-thioguanine-resistant lymphocytes Mutation research, 1988; 208(1): 17-9.
Norman A, Bennett L R, Mead J F, Iwamoto K S   Antitumor activity of sodium linoleate Nutrition and cancer, 1988; 11(2): 107-15.
Iwamoto K S, Cochran S T, Winter J, Holburt E, Higashida R T, Norman A   Radiation dose enhancement therapy with iodine in rabbit VX-2 brain tumors Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1987; 8(2): 161-70.