Joseph Gera, Ph.D.

Office Address:
Sepulveda VA Medical Center
Research & Development
16111 Plummer St. (151)
Bldg. 1, Rm. C111A
North Hills, CA 91343

Affiliations
Affiliations
Member, JCCC Signal Transduction and Therapeutics Program Area
Associate Member, Molecular Biology Institute
Adjunct Professor, Greater Los Angeles VA Healthcare System
Research Interests
Research in Dr. Gera's laboratory is focused on understanding the signal transduction mechanisms promoting carcinogenesis and chemotherapeutic resistance in gliomas and the plasma cell neoplasm multiple myeloma. Their group investigates the PI3-kinase/AKT and mTOR signaling pathways and has illuminated crucial molecular determinants involved in tumor cell responses to inhibitors of these cascades. Current research is also centered on elucidating the role of the mTORC2 regulatory subunit Rictor in gliomagenesis.
Publications
Artinian Nicholas, Cloninger Cheri, Holmes Brent, Benavides-Serrato Angelica, Bashir Tariq, Gera Joseph Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness. The Journal of biological chemistry. 2015; 290(32): 19387-401.
Yang Yonghui, Bardeleben Carolyne, Frost Patrick, Hoang Bao, Shi Yijiang, Finn Richard, Gera Joseph, Lichtenstein Alan DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells. Genes & cancer. 2014; 5(11-12): 407-19.
Shi Yijiang, Frost Patrick, Hoang Bao, Yang Yonghui, Bardeleben Carolyne, Gera Joseph, Lichtenstein Alan MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses. PloS one. 2014; 9(4): e94011.
Benavides-Serrato Angelica, Anderson Lauren, Holmes Brent, Cloninger Cheri, Artinian Nicholas, Bashir Tariq, Gera Joseph mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma. Genes & cancer. 2014; 5(11-12): 393-406.
Frost Patrick, Berlanger Eileen, Mysore Veena, Hoang Bao, Shi Yijiang, Gera Joseph, Lichtenstein Alan Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis. Journal of oncology. 2013; 2013(4): 897025.
Weisbart Richard H, Gera Joseph F, Chan Grace, Hansen James E, Li Erica, Cloninger Cheri, Levine Arnold J, Nishimura Robert N A Cell-Penetrating Bispecific Antibody for Therapeutic Regulation of Intracellular Targets. Molecular cancer therapeutics. 2012; .
Bashir Tariq, Cloninger Cheri, Artinian Nicholas, Anderson Lauren, Bernath Andrew, Holmes Brent, Benavides-Serrato Angelica, Sabha Nesrin, Nishimura Robert N, Guha Abhijit, Gera Joseph Conditional astroglial Rictor overexpression induces malignant glioma in mice. PloS one. 2012; 7(10): e47741.
Hansen James E, Chan Grace, Liu Yanfeng, Hegan Denise C, Dalal Shibani, Dray Eloise, Kwon Youngho, Xu Yuanyuan, Xu Xiaohua, Peterson-Roth Elizabeth, Geiger Erik, Liu Yilun, Gera Joseph, Sweasy Joann B, Sung Patrick, Rockwell Sara, Nishimura Robert N, Weisbart Richard H, Glazer Peter M Targeting cancer with a lupus autoantibody. Science translational medicine. 2012; 4(157): 157ra142.
Hoang Bao, Benavides Angelica, Shi Yijiang, Yang Yonghui, Frost Patrick, Gera Joseph, Lichtenstein Alan The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance. The Journal of biological chemistry. 2012; 287(26): 21796-805.
Holmes Brent, Artinian Nicholas, Anderson Lauren, Martin Jheralyn, Masri Janine, Cloninger Cheri, Bernath Andrew, Bashir Tariq, Benavides-Serrato Angelica, Gera Joseph Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cellular signalling. 2012; 24(1): 309-15.
Cloninger Cheri, Bernath Andrew, Bashir Tariq, Holmes Brent, Artinian Nicholas, Ruegg Teresa, Anderson Lauren, Masri Janine, Lichtenstein Alan, Gera Joseph Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma. Molecular cancer therapeutics. 2011; 10(12): 2244-56.
Tanaka Kazuhiro, Babic Ivan, Nathanson David, Akhavan David, Guo Deliang, Gini Beatrice, Dang Julie, Zhu Shaojun, Yang Huijun, De Jesus Jason, Amzajerdi Ali Nael, Zhang Yinan, Dibble Christian C, Dan Hancai, Rinkenbaugh Amanda, Yong William H, Vinters Harry V, Gera Joseph F, Cavenee Webster K, Cloughesy Timothy F, Manning Brendan D, Baldwin Albert S, Mischel Paul S Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer discovery. 2011; 1(6): 524-38.
Gera Joseph, Lichtenstein Alan The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma. Leukemia & lymphoma. 2011; 52(10): 1857-66.
Martin Jheralyn, Masri Janine, Cloninger Cheri, Holmes Brent, Artinian Nicholas, Funk Alexander, Ruegg Teresa, Anderson Lauren, Bashir Tariq, Bernath Andrew, Lichtenstein Alan, Gera Joseph Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity. The Journal of biological chemistry. 2011; 286(18): 16402-13.
Vartanian Raffi, Masri Janine, Martin Jheralyn, Cloninger Cheri, Holmes Brent, Artinian Nicholas, Funk Alex, Ruegg Teresa, Gera Joseph AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation. Molecular cancer research : MCR. 2011; 9(1): 115-30.
Shi Yijiang, Frost Patrick, Hoang Bao, Benavides Angelica, Gera Joseph, Lichtenstein Alan IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1. The Journal of biological chemistry. 2011; 286(1): 67-78.
Hoang Bao, Frost Patrick, Shi Yijiang, Belanger Eileen, Benavides Angelica, Pezeshkpour Gholam, Cappia Susanna, Guglielmelli Tommasina, Gera Joseph, Lichtenstein Alan Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor. Blood. 2010; 116(22): 4560-8.
Frost Patrick, Shi Yijiang, Hoang Bao, Gera Joseph, Lichtenstein Alan Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin. Molecular cancer therapeutics. 2009; 8(1): 83-93.
Shi Yijiang, Frost Patrick J, Hoang Bao Q, Benavides Angelica, Sharma Sanjai, Gera Joseph F, Lichtenstein Alan K IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1. Cancer research. 2008; 68(24): 10215-22.
Jo Oak D, Martin Jheralyn, Bernath Andrew, Masri Janine, Lichtenstein Alan, Gera Joseph Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling. The Journal of biological chemistry. 2008; 283(34): 23274-87.
Martin Jheralyn, Masri Janine, Bernath Andrew, Nishimura Robert N, Gera Joseph Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochemical and biophysical research communications. 2008; 372(4): 578-83.
Masri Janine, Bernath Andrew, Martin Jheralyn, Jo Oak D, Vartanian Raffi, Funk Alexander, Gera Joseph mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer research. 2007; 67(24): 11712-20.
Sharma Anushree, Masri Janine, Jo Oak D, Bernath Andrew, Martin Jheralyn, Funk Alexander, Gera Joseph Protein kinase C regulates internal initiation of translation of the GATA-4 mRNA following vasopressin-induced hypertrophy of cardiac myocytes. The Journal of biological chemistry. 2007; 282(13): 9505-16.
Marderosian M, Sharma A, Funk A P, Vartanian R, Masri J, Jo O D, Gera J F Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene. 2006; 25(47): 6277-90.
Shi Yijiang, Sharma Anushree, Wu Hong, Lichtenstein Alan, Gera Joseph Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. The Journal of biological chemistry. 2005; 280(12): 10964-73.
Gera Joseph F, Mellinghoff Ingo K, Shi Yijiang, Rettig Matthew B, Tran Chris, Hsu Jung-hsin, Sawyers Charles L, Lichtenstein Alan K AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. The Journal of biological chemistry. 2004; 279(4): 2737-46.