James A Roseboro, Ph.D.

Work Address:
Los Angeles, CA 90095

Assistant Professor, Radiation Oncology
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Research Interests
The current research programs of our group include the study of the band structures, and lattice dynamics of semi-conductors, metals and insulators, both crystalline and amorphous. The technology applied to these samples is applied to the study of biological specimen, including pancreatic cancer cells, DNA, molecular structures in solution, and human tissue. The resulting application of our research findings related to pancreatic cancer will be applied to the diagnosis and treatment of this extremely deadly disease. The linear as well as the non-linear optical interactions of coherent radiation with matter are studied in these systems as well as the surface properties using a range of electron spectroscopes. Facilities for these studies span the spectrum from the soft x-ray to the far infrared using conventional spectrometers as well as high and low power lasers. In addition, high contrast Raman, Brillouin, and Rayleigh scattering systems are employed. Surface analytical facilities employing a range of electron spectroscopes such as: low electron diffraction (LEED), Auger electron spectroscopy (AES), and x-ray photon-electron spectroscopy (ESCA) are operative. These systems are integrated with computers for data acquisition, control and analysis. Low level absorptions in highly transparent solids and liquids are studied by wavelength modulation techniques. Electron spectroscopic techniques are employed to study surfaces and interfaces. Optical-microwave measurements are performed to study non-linear transport phenomena in semi-conductors such as saturation drift velocity.

My interests are multidisciplinary in that they encompass both research and regulatory affairs. My research interests include the bioeffects of ionizing and non-ionizing (including ultrasound) radiation energy as a function of their physical chyaracteristics.

At the same time I have maintained an interest in those areas of regulatory oversight of selected industries under the purview of the U.S. Food and Drug Administration (USFDA). Of particular consultative interests to me are the USFDA regulations which govern the current good manufacturing practices (i.e. CGMPs) of the industries involved in medical devices, biotechnology, institutional review boards (IRBs) and lasers. In addition to the foregoing over the last several years I have led joint efforts to formulate biotechnology research projects including UCLA, the USFDA, and the private sector. These efforts gave dealt with research projects in breast cancer diagnosis and treatment (currently at the West LA VA Medical Center), the application of Fourier Transform Infra-red (FTIR) spectroscopy to characterization of mammalian cells, chromosomes, neoplastic tissue, and selected polymers. The ultimate conclusion to these efforts is the formation of a Cooperative Research and Development Agreement (CRADA) under the auspices of the Federal Technology Transfer Act of 1987.


A selected list of publications:

Roseboro J A, Buchanan P, Norman A, Stern R   Effect of ultrasonic irradiation on mammalian cells and chromosomes in vitro Physics in medicine and biology, 1978; 23(2): 324-31.
Coover S R, Roseboro J A, Watson J E   Electret charger for pocket ion chamber dosimeters Health physics, 1977; 33(2): 474-7.
Joe F L, kline D A, Miletta E M, Roach J A, Roseboro E L, Fazio T   Determination of urethane in wines by gas-liquid chromatography and its confirmation by mass spectrometry Journal - Association of Official Analytical Chemists, 1977; 60(3): 509-16.