Stephanie Seidlits, Ph.D.
Assistant Professor, Bioengineering
Member, Brain Research Institute, CTSI

Dr. SeidlitsÂ’ research focuses on developing regenerative therapies for the central nervous system (CNS). Although the CNS has the innate capacity for repair, disease or injury invokes an inflammatory response that transforms the local tissue into an environment that lacks sufficient regenerative factors and contains an abundance of inhibitory factors. Dr. SeidlitsÂ’ laboratory aims to identify differences between the extracellular environment in injured and healthy CNS tissues and to exploit these mechanistic discoveries to develop novel, regenerative therapies that act by directly altering the local environment. To accomplish this, modular design of biomaterial microenvironments is combined with other quantitative, engineering approaches, such as high-throughput measurements, single cell analyses and genetic manipulation, to enable mechanistic discoveries that lead to the development of innovative translational therapies.


A selected list of publications:

Walthers Christopher M, Seidlits Stephanie K   Gene delivery strategies to promote spinal cord repair Biomarker insights, 2015; 10(Suppl 1): 11-29.
Thomas Aline M, Seidlits Stephanie K, Goodman Ashley G, Kukushliev Todor V, Hassani Donna M, Cummings Brian J, Anderson Aileen J, Shea Lonnie D   Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury Integrative biology : quantitative biosciences from nano to macro, 2014; 6(7): 694-705.
Seidlits Stephanie K, Gower Robert Michael, Shepard Jaclyn A, Shea Lonnie D   Hydrogels for lentiviral gene delivery Expert opinion on drug delivery, 2013; 10(4): 499-509.
Thomas Aline M, Kubilius Matthew B, Holland Samantha J, Seidlits Stephanie K, Boehler Ryan M, Anderson Aileen J, Cummings Brian J, Shea Lonnie D   Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury Biomaterials, 2013; 34(9): 2213-20.
Khaing Zin Z, Milman Brian D, Vanscoy Jennifer E, Seidlits Stephanie K, Grill Raymond J, Schmidt Christine E   High molecular weight hyaluronic acid limits astrocyte activation and scar formation after spinal cord injury Journal of neural engineering, 2011; 8(4): 046033.
Seidlits Stephanie K, Drinnan Charles T, Petersen Rebecca R, Shear Jason B, Suggs Laura J, Schmidt Christine E   Fibronectin-hyaluronic acid composite hydrogels for three-dimensional endothelial cell culture Acta biomaterialia, 2011; 7(6): 2401-9.
Yang Youjun, Seidlits Stephanie K, Adams Michelle M, Lynch Vincent M, Schmidt Christine E, Anslyn Eric V, Shear Jason B   A highly selective low-background fluorescent imaging agent for nitric oxide Journal of the American Chemical Society, 2010; 132(38): 13114-6.
Seidlits Stephanie K, Khaing Zin Z, Petersen Rebecca R, Nickels Jonathan D, Vanscoy Jennifer E, Shear Jason B, Schmidt Christine E   The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation Biomaterials, 2010; 31(14): 3930-40.
Kijanka Gregor, Barry Richard, Chen Hong, Gould Edith, Seidlits Stephanie K, Schmid Jasmin, Morgan Maria, Mason David Y, Cordell Jacqueline, Murphy Derek   Defining the molecular target of an antibody derived from nuclear extract of Jurkat cells using protein arrays Analytical biochemistry, 2009; 395(2): 119-24.
Seidlits Stephanie K, Lee Jae Y, Schmidt Christine E   Nanostructured scaffolds for neural applications Nanomedicine (London, England), 2008; 3(2): 183-99.
Kasper F Kurtis, Seidlits Stephanie K, Tang Andrew, Crowther Roger S, Carney Darrell H, Barry Michael A, Mikos Antonios G   In vitro release of plasmid DNA from oligo(poly(ethylene glycol) fumarate) hydrogels Journal of controlled release : official journal of the Controlled Release Society, 2005; 104(3): 521-39.
Seidlits Stephanie K, Reza Tammie, Briand Kevin A, Sereno Anne B   Voluntary spatial attention has different effects on voluntary and reflexive saccades TheScientificWorldJournal, 2003; 3(3): 881-902.