Tzung K Hsiai, M.D., Ph.D.
Director, Cardiovascular Engineering Research Laboratory, SEAS
Professor, Bioengineering
Member, CTSI, California NanoSystems Institute, Molecular, Cellular & Integrative Physiology GPB Home Area

Dr. Hsiai received his undergraduate education from Columbia University and his MD from the University of Chicago. He completed his internship, residency and NIH-funded cardiovascular fellowship at UCLA School of Medicine, during which he also obtained a PhD in Biomedical Engineering in 2001. Dr. Hsiai is board certified by the American Board of Internal Medicine and Cardiovascular Disease. He also holds a joint appointment with the Henry Samueli School of Engineering and Applied Science at the Department of Bioengineering. His research program is funded by the National Institutes of Health and American Heart Association. He is the Chair of the American Physiological Society Joint Meeting with Biomedical Engineering Society, Member of the American Society for Clinical Investigation, a Fellow of Americal College of Cardiology, and the recipient of an NIH Physician-Scientist Career Development Award and an American Heart Association John J. Simpson Outstanding Research Achievement Award.


A selected list of publications:

Cao Hung, Kang Bong, Lee Chia-An, Shung K Kirk, Hsiai Tzung   Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration IEEE reviews in biomedical engineering, 2015; .
Yang Hongbo, Fang Longhou, Zhan Rui, Hegarty Jeffrey M, Ren Jie, Hsiai Tzung K, Gleeson Joseph G, Miller Yury I, Trejo JoAnn, Chi Neil C   Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development Developmental biology, 2015; .
Zhao Yu, Cao Hung, Beebe Tyler, Zhang Hemin, Zhang Xiaoxiao, Chang Honglong, Scremin Oscar, Lien Ching-Ling, Tai Yu-Chong, Hsiai Tzung K   Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts Biomedical microdevices, 2015; 17(2): 40.
Zhang Xiaoxiao, Beebe Tyler, Jen Nelson, Lee Chia-An, Tai Yuchong, Hsiai Tzung K   Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening Biosensors & bioelectronics, 2015; 71: 150-157.
Li Rongsong, Navab Kaveh, Hough Greg, Daher Nancy, Zhang Min, Mittelstein David, Lee Katherine, Pakbin Payam, Saffari Arian, Bhetraratana May, Sulaiman Dawoud, Beebe Tyler, Wu Lan, Jen Nelson, Wine Eytan, Tseng Chi-Hong, Araujo Jesus A, Fogelman Alan, Sioutas Constantinos, Navab Mohamed, Hsiai Tzung K   Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine Environmental health perspectives, 2015; 123(1): 34-41.
Lee Juhyun, Cao Hung, Kang Bong Jin, Jen Nelson, Yu Fei, Lee Chia-An, Fei Peng, Park Jinhyoung, Bohlool Shadi, Lash-Rosenberg Lian, Shung K Kirk, Hsiai Tzung K   Hemodynamics and ventricular function in a zebrafish model of injury and repair Zebrafish, 2014; 11(5): 447-54.
Li Rongsong, Beebe Tyler, Jen Nelson, Yu Fei, Takabe Wakako, Harrison Michael, Cao Hung, Lee Juhyun, Yang Hongbo, Han Peidong, Wang Kevin, Shimizu Hirohito, Chen Jaunian, Lien Ching-Ling, Chi Neil C, Hsiai Tzung K   Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos Arteriosclerosis, thrombosis, and vascular biology, 2014; 34(10): 2268-75.
Cao Hung, Yu Fei, Zhao Yu, Zhang Xiaoxiao, Tai Joyce, Lee Juhyun, Darehzereshki Ali, Bersohn Malcolm, Lien Ching-Ling, Chi Neil C, Tai Yu-Chong, Hsiai Tzung K   Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium Integrative biology : quantitative biosciences from nano to macro, 2014; 6(8): 789-95.
Hsiai Tzung, Li Song, Bursac Nenad   Introduction to the special issue on tissue engineering and regenerative medicine Annals of biomedical engineering, 2014; 42(7): 1355-6.
Dickover Michael, Hegarty Jeffrey M, Ly Kim, Lopez Diana, Yang Hongbo, Zhang Ruilin, Tedeschi Neil, Hsiai Tzung K, Chi Neil C   The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis Developmental biology, 2014; 389(2): 182-91.
Cao Hung, Yu Fei, Zhao Yu, Scianmarello Nick, Lee Juhyun, Dai Wangde, Jen Nelson, Beebe Tyler, Li Rongsong, Ebrahimi Ramin, Chang Donald S, Mody Freny V, Pacella John, Tai Yu-Chong, Hsiai Tzung   Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits Biosensors & bioelectronics, 2014; 54(2): 610-6.
Jen Nelson, Yu Fei, Lee Juhyun, Wasmund Steve, Dai Xiaohu, Chen Christina, Chawareeyawong Pai, Yang Yongmo, Li Rongsong, Hamdan Mohamed H, Hsiai Tzung K   Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function Biomechanics and modeling in mechanobiology, 2013; 12(4): 735-45.
Du Yunfeng, Navab Mohamad, Shen Melody, Hill James, Pakbin Payam, Sioutas Constantinos, Hsiai Tzung K, Li Rongsong   Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS Biochemical and biophysical research communications, 2013; 436(3): 462-6.
Li Rongsong, Navab Mohamad, Pakbin Payam, Ning Zhi, Navab Kaveh, Hough Greg, Morgan Todd E, Finch Caleb E, Araujo Jesus A, Fogelman Alan M, Sioutas Constantinos, Hsiai Tzung   Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice Journal of lipid research, 2013; 54(6): 1608-15.
Yu Fei, Lee Juhyun, Jen Nelson, Li Xiang, Zhang Qian, Tang Rui, Zhou Qifa, Kim Eun S, Hsiai Tzung K   Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions Biosensors & bioelectronics, 2013; 43(6): 237-44.
Li Rongsong, Mittelstein David, Kam Winnie, Pakbin Payam, Du Yunfeng, Tintut Yin, Navab Mohamad, Sioutas Constantinos, Hsiai Tzung   Atmospheric ultrafine particles promote vascular calcification via the NF-κB signaling pathway American journal of physiology. Cell physiology, 2013; 304(4): C362-9.
Lee Juhyun, Moghadam Mahdi Esmaily, Kung Ethan, Cao Hung, Beebe Tyler, Miller Yury, Roman Beth L, Lien Ching-Ling, Chi Neil C, Marsden Alison L, Hsiai Tzung K   Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis PloS one, 2013; 8(8): e72924.
Yu Fei, Zhao Yu, Gu Jie, Quigley Katherine L, Chi Neil C, Tai Yu-Chong, Hsiai Tzung K   Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts Biomedical microdevices, 2012; 14(2): 357-66.
Li Rongsong, Mittelstein David, Lee Juhyun, Fang Karen, Majumdar Rohit, Tintut Yin, Demer Linda L, Hsiai Tzung K   A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases American journal of physiology. Cell physiology, 2012; 302(4): C658-65.
Li Rongsong, Mittelstein David, Fang Karen, Beebe Tyler, Quigley Katherine, Berliner Judith, Hsiai Tzung K   Angiopoeitin-2 modulates Survivin expression in OxLDL-induced endothelial cell apoptosis Biochemical and biophysical research communications, 2012; 417(1): 619-22.
Yu Fei, Dai Xiaohu, Beebe Tyler, Hsiai Tzung   Electrochemical impedance spectroscopy to characterize inflammatory atherosclerotic plaques Biosensors & bioelectronics, 2011; 30(1): 165-73.
Li Rongsong, Jen Nelson, Yu Fei, Hsiai Tzung K   Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.], 2011; Chapter 9(1): Unit9.37.
Takabe Wakako, Jen Nelson, Ai Lisong, Hamilton Ryan, Wang Sky, Holmes Kristin, Dharbandi Farhad, Khalsa Bhavraj, Bressler Steven, Barr Mark L, Li Rongsong, Hsiai Tzung K   Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling Antioxidants & redox signaling, 2011; 15(5): 1379-88.
Yu Fei, Ai Lisong, Dai Wangde, Rozengurt Nora, Yu Hongyu, Hsiai Tzung K   MEMS thermal sensors to detect changes in heat transfer in the pre-atherosclerotic regions of fat-fed New Zealand white rabbits Annals of biomedical engineering, 2011; 39(6): 1736-44.
Yu Fei, Li Rongsong, Ai Lisong, Edington Collin, Yu Hongyu, Barr Mark, Kim E S, Hsiai Tzung K   Electrochemical impedance spectroscopy to assess vascular oxidative stress Annals of biomedical engineering, 2011; 39(1): 287-96.
Yu Fei, Huang Jie, Adlerz Katrina, Jadvar Hossein, Hamdan Mohamed H, Chi Neil, Chen Jau-Nian, Hsiai Tzung K   Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity Zebrafish, 2010; 7(4): 325-31.
Ai Lisong, Zhang Lequan, Dai Wangde, Hu Changhong, Shung K Kirk, Hsiai Tzung K   Real-time assessment of flow reversal in an eccentric arterial stenotic model Journal of biomechanics, 2010; 43(14): 2678-83.
Masood Syed O, Wasmund Stephen L, Akoum Nazem W, Egger Marlene J, Hsiai Tzung, Hamdan Mohamed H   The effects of rate and rhythm control on blood pressure and antihypertensive drug usage in patients with atrial fibrillation and hypertension enrolled in the AFFIRM trial Journal of cardiovascular electrophysiology, 2010; 21(10): 1094-8.
Li Rongsong, Ning Zhi, Cui Jeffrey, Yu Fei, Sioutas Constantinos, Hsiai Tzung   Diesel exhaust particles modulate vascular endothelial cell permeability: implication of ZO-1 expression Toxicology letters, 2010; 197(3): 163-8.
Yu Fei, Li Rongsong, Parks Elizabeth, Takabe Wakako, Hsiai Tzung K   Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals Annals of biomedical engineering, 2010; 38(7): 2346-57.
Li Rongsong, Ning Zhi, Majumdar Rohit, Cui Jeffery, Takabe Wakako, Jen Nelson, Sioutas Constantinos, Hsiai Tzung   Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling Particle and fibre toxicology, 2010; 7(7): 6.
Takabe Wakako, Li Rongsong, Ai Lisong, Yu Fei, Berliner Judith A, Hsiai Tzung K   Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(3): 436-41.
Li Rongsong, Beebe Tyler, Cui Jeffrey, Rouhanizadeh Mahsa, Ai Lisong, Wang Pin, Gundersen Martin, Takabe Wakako, Hsiai Tzung K   Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD Biochemical and biophysical research communications, 2009; 388(2): 406-12.
Ai Lisong, Yu Hongyu, Takabe Wakako, Paraboschi Anna, Yu Fei, Kim E S, Li Rongsong, Hsiai Tzung K   Optimization of intravascular shear stress assessment in vivo Journal of biomechanics, 2009; 42(10): 1429-37.
Ai Lisong, Yu Hongyu, Dai Wangde, Hale Sharon L, Kloner Robert A, Hsiai Tzung K   Real-time intravascular shear stress in the rabbit abdominal aorta IEEE transactions on bio-medical engineering, 2009; 56(6): 1755-64.
Sun Ping, Zhang Yolanda, Yu Fei, Parks Elizabeth, Lyman Althea, Wu Qiong, Ai Lisong, Hu Chang-Hong, Zhou Qifa, Shung Kirk, Lien Ching-Ling, Hsiai Tzung K   Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart Annals of biomedical engineering, 2009; 37(5): 890-901.
Ai Lisong, Hsiai Tzung K   Spatial mapping of real-time quantitative shear stress with vascular oxidative stress Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009; 2009(6): 6557-9.
Li Rongsong, Ning Zhi, Cui Jeffery, Khalsa Bhavraj, Ai Lisong, Takabe Wakako, Beebe Tyler, Majumdar Rohit, Sioutas Constantinos, Hsiai Tzung   Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation Free radical biology & medicine, 2009; 46(6): 775-82.
Hsiai Tzung K, Wu Joseph C   Hemodynamic forces regulate embryonic stem cell commitment to vascular progenitors Current cardiology reviews, 2008; 4(4): 269-74.
Hamilton Ryan T, Asatryan Liana, Nilsen Jon T, Isas Jose M, Gallaher Timothy K, Sawamura Tatsuya, Hsiai Tzung K   LDL protein nitration: implication for LDL protein unfolding Archives of biochemistry and biophysics, 2008; 479(1): 1-14.
Ai Lisong, Rouhanizadeh Mahsa, Wu Joseph C, Takabe Wakako, Yu Hongyu, Alavi Mohammad, Li Rongsong, Chu Yi, Miller Jordan, Heistad Donald D, Hsiai Tzung K   Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration American journal of physiology. Cell physiology, 2008; 294(6): C1576-85.
Hsiai Tzung K   Mechanosignal transduction coupling between endothelial and smooth muscle cells: role of hemodynamic forces American journal of physiology. Cell physiology, 2008; 294(3): C659-61.
Rouhanizadeh Mahsa, Takabe Wakako, Ai Lisong, Yu Hongyu, Hsiai Tzung   Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies Methods in enzymology, 2008; 441(3): 111-50.
Hsiai Tzung, Berliner Judith A   Oxidative stress as a regulator of murine atherosclerosis Current drug targets, 2007; 8(12): 1222-9.
Chang Gwendolen Y, Cao Feng, Krishnan Manickam, Huang Mei, Li Zongjin, Xie Xiaoyan, Sheikh Ahmad Y, Hoyt Grant, Robbins Robert C, Hsiai Tzung, Schneider Michael D, Wu Joseph C   Positron emission tomography imaging of conditional gene activation in the heart Journal of molecular and cellular cardiology, 2007; 43(1): 18-26.
Hsiai Tzung K, Hwang Juliana, Barr Mark L, Correa Adria, Hamilton Ryan, Alavi Mohammad, Rouhanizadeh Mahsa, Cadenas Enrique, Hazen Stanley L   Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration Free radical biology & medicine, 2007; 42(4): 519-29.
Hwang Juliana, Hodis Howard N, Hsiai Tzung K, Asatryan Liana, Sevanian Alex   Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins Atherosclerosis, 2006; 189(1): 76-82.
Lin Tiantian C, Tintut Yin, Lyman Althea, Mack Wendy, Demer Linda L, Hsiai Tzung K   Mechanical response of a calcified plaque model to fluid shear force Annals of biomedical engineering, 2006; 34(10): 1535-41.
Hwang Juliana, Rouhanizadeh Mahsa, Hamilton Ryan T, Lin Tiantian C, Eiserich Jason P, Hodis Howard N, Hsiai Tzung K   17beta-Estradiol reverses shear-stress-mediated low density lipoprotein modifications Free radical biology & medicine, 2006; 41(4): 568-78.
DeMaio Lucas, Rouhanizadeh Mahsa, Reddy Srinivasa, Sevanian Alex, Hwang Juliana, Hsiai Tzung K   Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells American journal of physiology. Heart and circulatory physiology, 2006; 290(2): H674-83.
Rouhanizadeh Mahsa, Hwang Juliana, Clempus Roza E, Marcu Laura, Lassègue Bernard, Sevanian Alex, Hsiai Tzung K   Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase Free radical biology & medicine, 2005; 39(11): 1512-22.
Rouhanizadeh Mahsa, Lin Tiantian C, Arcas Diego, Hwang Juliana, Hsiai Tzung K   Spatial variations in shear stress in a 3-D bifurcation model at low Reynolds numbers Annals of biomedical engineering, 2005; 33(10): 1360-74.
Rouhanizadeh Mahsa, Tang Tao, Li Chao, DeMaio Lucas, Zhou Chongwu, Hsiai Tzung   Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004; 1(2): 204-7.
Soundararajan Gopikrishnan, Hsiai Tzung K, DeMaio Lucas, Chang Michael, Chang Stanley   MEMS shear stress sensors for cardiovascular diagnostics Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2004; 4(2): 2420-3.
Hsiai Tzung K, Cho Sung K, Wong Pak K, Ing Michael H, Salazar Adler, Hama Susan, Navab Mohamad, Demer Linda L, Ho Chih-Ming   Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses Annals of biomedical engineering, 2004; 32(2): 189-201.
Hwang Juliana, Ing Michael H, Salazar Adler, Lassègue Bernard, Griendling Kathy, Navab Mohamad, Sevanian Alex, Hsiai Tzung K   Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation Circulation research, 2003; 93(12): 1225-32.
Hsiai Tzung K, Cho Sung K, Wong Pak K, Ing Mike, Salazar Adler, Sevanian Alex, Navab Mohamad, Demer Linda L, Ho Chih-Ming   Monocyte recruitment to endothelial cells in response to oscillatory shear stress FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003; 17(12): 1648-57.
Hsiai Tzung K, Cho Sung K, Honda Henry M, Hama Susan, Navab Mohamad, Demer Linda L, Ho Chih-Ming   Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt) Annals of biomedical engineering, 2002; 30(5): 646-56.